Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

연구논문 : 만성 바이러스간질환에서 간섬유화의 다양한 비침습 혈청표지자검사의 비교

김선민 ( Sun Min Kim ),손주현 ( Joo Hyun Sohn ),김태엽 ( Tae Yeob Kim ),노영욱 ( Young Wook Roh ),은창수 ( Chang Soo Eun ),전용철 ( Yong Cheol Jeon ),한동수 ( Dong Soo Han ),오영하 ( Young Ha Oh ) 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.4

목적: 만성 바이러스간질환에서 병의 경과와 예후를 평가하고 치료반응을 예측함에 있어 간섬유화의 진단은 중요하다. 최근 간섬유화 평가에 표준방법이지만 침습적 간생검을 대신하여 여러 가지 비침습적 진단법이 이용되고 있고, 또한 새로운 검사법들이 개발되고 있다. 저자들은 만성 B형 및 C형간염 환자를 대상으로 임상에서 광범위하게 흔히 시행하는 혈액검사와 임상 소견을 이용한 아래와 같은 진단법들만으로 간섬유화를 얼마나 정확하게 평가할 수 있는지 알아보고, 단일 검사로 간섬유화를 평가하는 데 유용하다고 알려져 있는 hyaluronic acid(HA)와 IV형 콜라겐 농도와 비교하여 그 임상적 유용성을 평가하였다. 대상과 방법: 2002년 3월부터 2007년 2월까지 만성 바이러스간 질환으로 간생검을 시행받은 225명의 환자(HBV 180명, HCV 43명, HBV+HCV 2명)를 대상으로 분석하였다. 간생검을 시행하는 날에 말초혈액검사, 혈액응고검사, 혈청생화학검사를 시행하고, 혈중 HA, IV형 콜라겐 농도를 측정하였다. 간섬유화의 정도는 F0(섬유화가 없음), F1(문맥역 섬유화), F2(문맥주변부 섬유화), F3(섬유성 격막) 및 F4(간경변증)의 4단계로 구분하였다. 대상 환자를 F0-1, F2-4 혹은 F0-2, F3-4의 두 집단으로 분류하여 두 집단을 구분하고자 할 때 AAR(AST/ALT ratio), API(age-platelet index), APRI(AST to platelet index), CDS(cirrhosis discriminant score), platelet count, HA, IV형 콜라겐의 예측능을 area under the receiver operating characteristic curve (AUROC)값을 이용하여 비교하였다. 결과: 대상환자의 섬유화의 단계는 F0 집단은 17명, F1 집단은 40명, F2 집단은 61명, F3 집단은 74명, F4 집단은 33명이었다. 의미 있는 간섬유화를 F2 이상으로 판단할 때, 의미 있는 섬유화의 예측에 대한 AUROC 값은 APRI=0.822, CDS=0.776, platelet count=0.773, API=0.756, HA=0.749, IV형 콜라겐=0.718, AAR=0.642 순이었고, F3 이상의 광범위한 섬유화 예측에 대한 AUROC값은 CDS=0.835, platelet count=0.795, API=0.794, HA=0.766, AAR=0.711, IV형 콜라겐=0.697, APRI=0.691 순으로 관찰되었다. 결론: 만성 바이러스간질환에서 간섬유화를 평가하는 데 임상 소견 및 혈액검사를 이용한 방법들이 비침습적 진단법 중 단독 검사로도 유용한 것으로 알려져 있는 혈중 HA와 IV형 콜라겐 농도와 비교하여 우월하거나 대등하였다. 특히 APRI는 다른 인자들에 비해 F2 이상의 의미 있는 섬유화를 예측하는 데 가장 유용하였고, CDS는 F3 이상의 광범위한 섬유화를 예측하는 데 가장 유용하였다. Background/Aims: The aim of this study was to determine the clinical performances of noninvasive serum markers for the prediction of liver fibrosis in chronic viral liver diseases. Methods: We analyzed a total of 225 patients with chronic viral liver diseases (180 with hepatitis B virus, 43 with hepatitis C virus, and 2 with hepatitis B+C virus) who underwent a liver biopsy procedure at the Hanyang University Guri Hospital between March 2002 and February 2007. Serum was also obtained at the time of liver biopsy. Liver fibrosis was staged according to the scoring system proposed by the Korean Study Group for the Pathology of Digestive Diseases. Various noninvasive serum markers were evaluated, including the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), age-platelet (AP) index, AST/platelet ratio index (APRI), cirrhosis discriminant score (CDS), platelet count, hyaluronic acid (HA), and type IV collagen. Results: There were 17, 40, 61, 74, and 33 patients at stages F0, F1, F2, F3, and F4, respectively. The overall diagnostic accuracies of each marker, as determined by the area under receiver operating characteristics curves, were APRI=0.822, CDS=0.776, platelet count=0.773, AP index=0.756, HA=0.749, type IV collagen=0.718, and AAR=0.642 for predicting significant fibrosis (≥F2); and CDS=0.835, platelet count=0.795, AP index=0.794, HA=0.766, AAR=0.711, type IV collagen=0.697, and APRI=0.691 for predicting extensive fibrosis (≥F3). Conclusions: Conclusions: All noninvasive serum markers evaluated in this study were useful for predicting significant or extensive liver fibrosis in chronic viral liver diseases. In particular, APRI was most useful for the prediction of significant fibrosis, and CDS was most useful for the prediction of extensive fibrosis. (Korean J Hepatol 2009;15:454-463)

페라이트 도금법으로 제작된 Ni_(x)Fe_(3-x)O₄박막의 자외선차단 효과에 대한 연구

하태욱,이용희,최종정,차정원 한국공업화학회 2003 응용화학 Vol.7 No.2

Nickel-ferrite Ni_(x)Fe_(3-x)O₄ thin film was fabricated by ferrite plating method in order to make sunglass which intercept ultraviolet ray and electromagnetic field. The transmittance of nickel-ferrite Ni_(x)Fe_(3-x)O₄ thin film is down clearly below 400㎚. And it shows that the nickel-ferrite thin film of x=0.09 in nickel composition rate was intercepted ultraviolet ray. We expect that sunglass coated with Ni_(x)Fe_(3-x)O₄ thin film will use for interception of ultraviolet ray and electromagnetic field.

광촉매 TiO₂의 구조가 TCE 광분해에 미치는 영향

하진욱,김태룡 순천향대학교 부설 산업기술연구소 1999 순천향 산업기술연구소논문집 Vol.5 No.2

The photocatalytic degradation of trichloroethylene(TCE) in water on various type of TiO₂was studied. Surface properties of Ti0₂were characterized by XRD, SEM, and BET in our previous work23). TiO₂from Aldrich has 100% pure anatase, TiO₂from KIER has 100% pure rutile structure, and P25-TiO₂from Degussa has mixed structure of anatase(75 %) and rutile(25 %). Firstly, optimum conditions for TCE degradation were examined. Results showed that optimum loading amount of catalyst was 0.1 wt% and recirculation flow rate of mixture(distilled water and TCE) was 200cc/min. Secondly, the effect of TiO₂structure on TCE degradation was examined. Results revealed that anatase structure generally has better photocatalytic activity than rutile structure. And mixed structure(Degussa TiO₂) has better activity than those of pure anatase and rutile structure due to small particle size and large surface area.

광촉매 TiO₂의 표면특성 고찰

김태룡,하진욱 순천향대학교 부설 산업기술연구소 1999 순천향 산업기술연구소논문집 Vol.5 No.2

Refractory organic contaminants have been often reported that come from increasing consumption of organic materials. Lots of researches have been done for complete mineralization to CO₂and H₂O by attack of active radical species, generated on the UV irradiated TiO₂surface. In this study, surface properties of photocatalyst TiO₂were fully characterized by XRD, SEM, and BET, XRD results showed that Aldrich TiO₂was pure anatase, KIER TiO₂was pure rutile structure, and Degussa TiO₂was mixed structure of anatase(75%) and rutile(25%). SEM results revealed that particle size of anatase structure was smaller than that of rutile structure. Surface area of Degussa TiO₂ was much larger than that of both Aldrich and KIER TiO₂.

고분자 수지를 이용한 자동차 에어컨용 압축기의 씰에 관한 연구

정태형,하영욱 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.5

The existing compressor steel seal used in automotive air-conditioner has the problem of oil leakage and deterioration in shielding performance, due to the abrasion and corrosion of the material. A new type of polymer resin seal studied in this research has the characteristics of high anti-abrasiveness and anti-corrosiveness, which can overcome the defects of the steel seal. In addition, the seal needs lower manufacturing cost and is appropriate to mass production, because it is made by the injection molding method requiring no mechanical processing. The profile generation program for seal mold has been developed using the gradient method, and the molding characteristics of the seal have analyzed through the flow analysis and the warpage analysis. The program has been verified by comparing the analysis results with the measured data of the test product. The research might be said to provide the basic method to produce the polymer resin seals with various types and dimensions.

PEI계 복합 재료를 이용한 탄자 운반체의 사출 성형 기술 개발에 관한 연구

정태형,이범재,하영욱,이성계 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

This research covers the development of new technique for composite injection molding of high stiffness Sabot. An analysis of polymer resin is performed by means of making test specimen mold and doing test with accordance of ASTM test guidelines. Structural analysis and simulation of injection molding process are carried out in order not only to estimate but also to predict the characteristics of molding stresses what both product and structure of mold may have. For structural analysis software, Mold flow and LS-dyna are used and universal test machine is utilized for evaluating performance of sabot. Cases of adopting this material to sabot are not announced yet in domestic academic world. In addition to that, materials for polymer-metal mixed injection molding are imported on the whole due to deficient level of domestic technology. Therefore, this new developed injection molding technique using PEI material can make it available to ensure the technology of making mold, injection and design. Finally, this technique may be applicable to another sabot having different radius of warheads from now on.

고분자 수지를 이용한 자동차 에어컨용 압축기의 씰에 관한 연구

정태형,하영욱 한국공작기계학회 2002 한국공작기계학회 춘계학술대회논문집 Vol.2002 No.-

The existing compressor steel seal used in automotive air-conditioner has the problem of oil leakage and the deterioration in shielding performance, due to the abrasion and the corrosion of the material. A new type of polymer resin seal is studied in the research. The polymer resin seal has the characteristics of high anti-abrasiveness and anti-corrosiveness, which can overcome the defects of the steel seal. In addition, the seal needs lower manufacturing cost and is appropriate to mass production, because it is made by the injection molding method requiring no mechanical processing. The profile generation program for seal mold has been developed using the gradient method, and the molding characteristics of the seal have analyzed through the flow analysis and the warpage analysis. The program has been verified by comparing the analysis results with the measured data of the test product. The research might be said to provide the basic method to produce the polymer resin seals with various types and dimensions.

200-MHz 10-bit 복소수 승산-누적기

김태원,신경욱,김호하 金烏工科大學校 1997 論文集 Vol.18 No.-

A 10-bit complex-number multiplier-accumulator (CMAC) has been designed using 0.8-㎛ CMOS technology, which can be used as an arithmetic core for the baseband signal processing of modern digital communication systems. To achieve high-speed operation as well as low-power dissipation, a new vector multiplication algorithm is proposed, which is based on radix-4 Booth recoding scheme and redundant binary (RB) arithmetic. The proposed algorithm reduces the arithmetic complexity by half as compared with the conventional direct method that is based on real-number multipliers and adders. It leads to a highly parallel architecture with modularity and a simplified circuit, resulting in fast operation and low power dissipation. The designed CMAC core contains about 18,000 transistors on the area of about 1.60×1.93㎟. The HSPICE simulation results show that the CMAC core can safely operate with 200-MHz clock at VDD=3.3-V, and it's estimated power dissipation is about 50-mW.

플라스틱 기어의 피로수명 평가 및 수명 예측

정태형,강성규,하영욱 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

Through the fatigue test of plastic gears using polyacetal polymer, this research aims at providing basic data for not only specifying operation conditions of plastic gears, but also designing dimensions of plastic gears with giving fatigue life and the estimated equation of fatigue life of plastic gears. That is, from the fatigue life curves, the estimated equation of fatigue life of plastic gears is taken out. For the estimated equation of fatigue life of plastic gears, this research provides two test methods; one is preserving non-limited temperature of tooth flank, the other is preserving limited temperature of tooth flank. As results, how the temperature of tooth flank affects the fatigue life is shown. In addition, based on the endurance limit, the essential factors of the unit load and K-factor are determined, which are needed in the design of gear by bending strength and surface durability.