16주간의 자전춤 참여가 중년비만고혈압여성의 관상동맥위험인자에 미치는 영향

곽정자(Kwak Jung-Ja),김종경(Kim Jong-Kyung),최현민(Choi Hyun-Min),노호성(Nho Ho-Sung) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.2

It is generally known that cardiovascular and metabolic diseases such as hypertension, diabetes, hyperlipidemia increase morbidity and mortality in postmenopausal women. This study investigated the effects of Jajun-Dance to coronary heart disease of middle age women with hypertension. Thirteen sedentary women (55.8±5.2 yrs) were recruited for this study, and completed 16 weeks of Jajun-Dance program. All subjects were diagnosed as essential hypertension patients. Blood-sugar level (FBG), total cholesterol (TC), triglyceride (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP) and visceral fat area (VFA) were measured. The Jajun-Dance program included 10 minutes warm up (exercise for flexibility), 40 minutes Jajun-Dance, and 10 minutes cool down. The subjects participated in Jajun-Dance program three times a week. Exercise was maintained at exercise intensity corresponding to rating of perceived exertion (RPE) 13-15. The results showed that FBG, SBP, and DBP (6.0 ㎜Hg) were significantly decreased after Jajun-Dance program. TG and VFA tended to decrease, but there were no significant differences. This study suggests that hypertensive middle-aged women could modify coronary risk factors with regular exercise, and that the aerobic Jajun-Dance program could effectively reduce high blood pressure.

간호대학생의 영적안녕에 관한 연구

강은실(Kang Eun-Sil),김숙자(Kim Sook-Ja),강성년(Kang Sung-Nyun),최성은(Choi Sung-Eun) 고신대학교 전인간호과학연구소 2008 전인간호과학학술지 Vol.3 No.-

The purpose of this study was to describe the spiritual well-being of nursing students to provide a basic data for the development the curriculum of Spiritual Nursing Care in nursing collages. The subjects for this study were consist of 58 nursing students in K University of Pusan city in Korea. All of them were educated about Spiritual Nursing Care for 100 minutes in a week, during totally 8 weeks in one semester. The data were collected during 7days from July 11 to July 18,2004 by using structured questionnaire method. The measurement of the spiritual well-being was performed with 6 points-index which is composed of 21 items and is modified by Sang-Soon Choi(1990)from Palau tzian & Ellison(1983) s. Its high score means that the degree of spiritual well-being of the subject is high. The data were analyzed by using the SPSS WIN 10.1 program according to the purpose of this study. The general characteristics of the subjects were analyzed by calculating the real quantity and the percentage, and the spiritual well-being scores were identified through calculating the mean value of individual domain. The significant difference of the general characteristics with the spiritual well-being was analyzed by t-test and ANOVA, Scheffe s test. The results of this study were as follow; 1.The spiritual well-being of the subjects The average value for the spiritual well-being of the subjects was 97.78(SD=±10.53) among the possible ranges of 21-126. The mean value of all items was 4.66(SD=±0.502) and high relatively. 2. The spiritual well-being according to general characteristics of subjects The analysis of the spiritual well-being according to general characteristics of the subjects showed statistically significant difference on the degree of life satisfaction in faith(F=4.327, P= .004),the degree of recognition about God s initiation in their daily life(F=3.933, P= .013),the degree of satisfaction about Nursing as their major(F=6.608, P= .000), their assurance of salvation(t=4.557,P= .037). among the personal religious actions, praising(F=3.32,p= .017), The group of nursing students responded that they were satisfied in their faith life, always God has the initiative in their daily lives personally, they were satisfied about Nursing as their major very much, and they have their assurance of salvation showed the highest degree of the spiritual well-being than any other group. In conclusion, in this study we observed that the spiritual well-being of nursing students was high relatively. The general characteristics of subjects were related to the spiritual well-being of them were the degree of satisfaction in their faith lives,their recognition about God s initiation in their daily life, their satisfaction about Nursing as their major, among the personal religious actions, regular praising and their assurance of salvation. Therefore this study s results can be used for developing a spiritual nursing education and program to strengthen nursing student s spirituality to practice in spiritual nursing care.

Ehlers - Danlos 증후군

주용진,최성문,최영자,성호석 ( Yoing Jin Joo,Sung Moon Choi,Young Ja Choi,Ho Suk Sung ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5

A Case of Ehlers-Danlos syndrome Yoing Jin Joo, M.D., Sung Moon Choi, M.D., Young Ja Choi*, M.D., Ho Suk Sung, M.D. Department of Dermatology, Clooego of Medicine, Inje University, Pusan, Korea We presented a case of Ehlers-Danlos syndrome in a 25-year old female, who had hyperextensibility of skin, skin fragility, cigarette paper-like atrophic scar, joint hyperextensibility and skeletal abnormality of scoliosis since birth. There was no family history. Microscopic and electron microscopic examinations of the skin biopsy specimens from normal appearing skin on the forearm and the site of subcutaneous nodule was compatible with finding of Ehlers-Danlos syndrome. Although the manifestations of this case including marked extensibility of skin, joint, skin fraility and atrophic scar might be in accord with type Ⅰ(gravis) Ehlers-Danlos syndrome, skeletal abnormality of scoliosis did not correspond to this type, but to type Ⅳ(hydroxylysine deficient) Ehlers-Danlos syndrome. We consider this case as a type Ⅳ Ehlers-Danlos syndrome.

Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation

Ja-Young Jang,Tae-Su Kim,Jingmei Cai,Jihyun Kim,Youngeun Kim,Kyungha Shin,Kwang Sei Kim,Sung Kyeong Park,Sung-Pyo Lee,Ehn-Kyoung Choi,Man Hee Rhee,Yun-Bae Kim 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.4

The effects of nattokinase on the in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin. Rabbit platelet-rich plasma was incubated with nattokinase and aggregation inducers collagen and thrombin, and the platelet aggregation rate was analyzed. Nattokinase significantly inhibited both the collagen- and thrombin-induced platelet aggregations. Nattokinase also reduced thromboxane B2 formation from collagen-activated platelets in a concentration-dependent manner. Rats were orally administered with nattokinase for 1 week, and their carotid arteries were exposed. Arterial thrombosis was induced by applying 35% FeCl3-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Nattokinase delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 160 mg/kg. In addition, a high dose (500 mg/kg) of nattokinase fully prevented the occlusion, as achieved with aspirin (30 mg/kg). The results indicate that nattokinase extracted from fermented soybean inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is suggested that nattokinase could be a good candidate without adverse effects for the improvement of blood flow.

Trends in Helicobacter pylori eradication rates by first-line triple therapy and related factors in eradication therapy

( Sung Eun Kim ),( Moo In Park ),( Seun Ja Park ),( Won Moon ),( Youn Jung Choi ),( Ji Hyun Cheon ),( Hye Jung Kwon ),( Ki Hwan Ku ),( Chang Hun Yoo ),( Jae Hyun Kim ),( Gyu Won Lee ),( Sung Eun Song 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: Trends in successful eradication of Helicobacter pylori using first-line triple therapy, consisting of a proton pump inhibitor, amoxicillin, and clarithromycin, have been understudied. We evaluated H. pylori eradication rates at a single center over the last 10 years and identified risk factors related to eradication failure. Methods: This study included 1,413 patients who were diagnosed with H. pylori infection and received 7 days of triple therapy between January 2003 and December 2012. We investigated H. pylori eradication rates retrospectively with respect to the year of therapy, as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 weeks after the completion of triple therapy. Results: The overall H. pylori eradication rate was 84.9%. Annual eradication rates from 2003 to 2012 were 93.5%, 80.0%, 87.2%, 88.5%, 92.0%, 88.3%, 85.7%, 84.1%, 83.7%, and 78.8%, respectively, by per-protocol analysis. The eradication rate with first-line triple therapy decreased during the last 10 years (p = 0.015). Multivariate analysis showed that female gender (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.12 to 2.55) and smoking (OR, 1.61; 95% CI, 1.05 to 2.47) were associated with the failure of H. pylori eradication therapy. Conclusions: The efficacy of first-line triple therapy for H. pylori infection has decreased over the last 10 years, suggesting an increase in antibiotic-resistant H. pylori strains. Thus, other first-line therapies may be necessary for H. pylori eradication in the near future.

Anti-angiogenic and anti-proliferative effects of Diosmetin on tumor

Ja Wun Choi,Yang Gyu Park,Sang Hyun Yoon,Sang Yoeul Park,Jae Won Seol 대한수의학회 2017 대한수의학회 학술대회발표집 Vol.2017 No.-

Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation

Ja-Young Jang,Tae-Su Kim,Jingmei Cai,Jihyun Kim,Youngeun Kim,Kyungha Shin,Kwang-Sei Kim,Sung-Pyo Lee,Myung-Hwa Kang,Ehn-Kyoung Choi,Man-Hee Rhee,Yun-Bae Kim 한국실험동물학회 2014 Laboratory Animal Research Vol.30 No.1

The inhibitory effects of perilla oil on the platelet aggregation in vitro and thrombosis in vivo were investigated in comparison with aspirin, a well-known blood flow enhancer. Rabbit platelet-rich plasma was incubated with perilla oil and aggregation inducers collagen or thrombin, and the platelet aggregation rate was analyzed. Perilla oil significantly inhibited both the collagen- and thrombin-induced platelet aggregations, in which the thromboxane B₂ formation from collagen-activated platelets were reduced in a concentration-dependent manner. Rats were administered once daily by gavage with perilla oil for 1 week, carotid arterial thrombosis was induced by applying 35% FeCl₃-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Perilla oil delayed the FeCl₃-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 0.5 mL/kg. In addition, a high dose (2 mL/kg) of perilla oil greatly prevented the occlusion, comparable to the effect of aspirin (30 mg/kg). The results indicate that perilla oil inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is proposed that perilla oil could be a good candidate without adverse effects for the improvement of blood flow.

The protective efficacy of the enterotoxigenic Escherichia coli vaccine candidate by GI24 against neonatal piglet colibacillosis

Choi, Yeong Hwan,Moon, Ja Young,Seo, Byoung Joo,Kim, Won Kyung,Cho, Jeong Sang,Choi, Min Su,Lim, Jae Sam,Kim, Sung Bok,Kim, Won Il,Hur, Jin The Korean Society of Veterinary Service 2017 韓國家畜衛生學會誌 Vol.40 No.4

Enterotoxigenic Escherichia coli (ETEC) strains producing each F4, F5, F6 and F41 fimbriae were lysed by GI24 peptide. The lysate cells were used as ETEC vaccine candidate. This study was carried out to examine whether intramuscular (im) immunization of pregnant sows with the novel vaccine candidate could effectively protect their neonatal piglets against ETEC colibacillosis. All pregnant sows were primed at 11 weeks and were boosted at 14 weeks of pregnancy. Group A sows were im inoculated with PBS. Group B sows were im immunized with $2{\times}10^9$ the mixture. Seral IgG, colostral IgA and IgG titers from group B sows, and seral IgG and IgA levels in group B piglets were significantly higher than those of group A sows and piglets, respectively. After challenge with wild-type ETEC, diarrhea and mortality was not observed in group B piglets. However, diarrhea was observed in 66.7% of group A piglets, and 33.3% mortality was observed. These findings indicate that im immunization of sows with the mixture of the novel vaccine candidate can effectively protect their offspring from ETEC colibacillosis.

Utilization of hydrolysate from dilute acid pretreatment of barley straw to produce cepahlosporin C by Acremonium chrysogenum M35

Sung Bong KIM,Hah Young YOO,Xiaoguang YANG,Ja Hyun LEE,Han Suk CHOI,Dong Sup KIM,Ju Hun LEE,Seung Wook KIM 한국생물공학회 2014 한국생물공학회 학술대회 Vol.2014 No.4

Quality of Life after Endoscopic Submucosal Dissection for Early Gastric Cancer: A Prospective Multicenter Cohort Study

( Sang Gyun Kim ),( Seon Mi Ji ),( Na Rae Lee ),( Seung-Hee Park ),( Ji Hye You ),( Il Ju Choi ),( Wan Sik Lee ),( Seun Ja Park ),( Jun Haeng Lee ),( Sang-Yong Seol ),( Ji Hyun Kim ),( Chul-Hyun Lim ) 대한소화기학회 2017 Gut and Liver Vol.11 No.1

Background/Aims: Endoscopic submucosal dissection (ESD) has been an established treatment for indicated early gastric cancer (EGC) without deterioration of quality of life (QOL) compared with surgical resection. The aim of this study was to evaluate long-term QOL in patients undergoing ESD for EGC. Methods: Patients scheduled to undergo curative ESD for EGC were prospectively enrolled from 12 institutions between May 2010 and December 2011. Assessments of QOL with Korean versions of the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire- core (QLQ-C30) and a gastric cancer-specific questionnaire (STO22) were performed at baseline and at 7 days, 3 months, and 6 months after ESD. Results: A total of 666 subjects were assessed for QLQ-C30 and QLQ-STO22. The mean QLQ-C30 score was 69.5 at baseline, 68.8 at 7 days, 73.1 at 3 months, and 73.2 at 6 months. The global health status on the EORTC QLQ-C30 was significantly improved after 3 and 6 months (p=0.0003 and p<0.0001, respectively). The QLQ-C30 and STO22 scores were not significantly different, or they only slightly deteriorated between before and immediately after ESD, but they were significantly improved after 3 and 6 months (p<0.05). Conclusions: QOL did not deteriorate immediately after ESD, and it improved more significantly at up to 6 months in patients who underwent curative ESD for EGC without significant complications. (Gut Liver 2017;11:87-92)