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Sohn, Sang-Kwon,Chang, Man-Sik,Chung, Young-Kuk,Kim, Kyu-Bong,Woo, Tae-Wook,Kim, Sung-Gyu,Choi, Wahn-Soo The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.3
This study was designed to determine biochemical and pharmacological properties of a newly synthesized benzimidazole derivative, 2-amino-4, 5-dihydropyrido [1, 2-a] thiazolo [5, 4-g] benzimidazole (YJA20379-5) in vitro and in vivo. In the leaky membrane vesicles of pig gastric mucosa, YJA20379-5 inhibited the $K^+$-stimulated $H^+$, $K^+$-ATPase activity in a concentration- and time-dependent manner, with $IC_{50}$ values being $43{\mu}\textrm{M}$ and $43{\mu}\textrm{M}$ at pH 6.4 and 7.4, respectively. YJA20379-5, given intraduodenally, had a potent inhibitory effect on the gastric acid secretion in pylorus-ligated rats. The $ED_{50}$ value for acid secretion was 15.4 mg/kg. YJA20379-5, administered orally, also suppressed gastric damages induced by water-immersion stress, indomethacin and ethanol, and duodenal damage induced by mepirizole in rats; the $ED_{50}$ values were 17.6, 4.7, 3.0 and 18.7 mg/kg, respectively. Furthermore, repeated oral administration of YJA20379-5 accelerated the spontaneous healing of acetic acid-induced gastric ulcers in rats. It is concluded that the a-ntisecretory activity of YJA20379-5 appears to be associated with inhibition of $H^+$, $K^+$-ATPase, while its antigastric and antiduodenal lesion activities are primarily related to the antisecretory effect.
Software Functional Requirements and Architectures of Microgrid Energy Management System
Sohn, Jin-Man,Yun, Sang-Yun Korea Electric Power Corporation 2016 KEPCO Journal on electric power and energy Vol.2 No.2
Distribution management system or microgrid energy management system plays an important role in monitoring, operation and control of electrical distribution systems by utilizing IT infrastructure. Nowadays, the rapid increase of the distributed resources makes the conventional management system have some additional functionality for the reliable operation due to intermittent renewables and the efficient operation on the economical purpose. In this paper, the brief standard software functional requirements of microgrid energy management system are provided through survey of the recent commercial products of the major vendors, and furthermore the architectures of microgrid energy management system are provided in comparison with major suppliers' microgrid energy management system. The summary of investigation will be able to make the developers and researchers focus on the specific functionality in the real world.
Nano-structuring of Transparent Materials by Femtosecond Laser Pulses
Sohn, Ik-Bu,Lee, Man-Seop,Chung, Jung-Yong,Cho, Sung-Hak Optical Society of Korea 2005 Current Optics and Photonics Vol.9 No.1
Using tightly focused femtosecond laser pulses, we produce an optical waveguide and optical devices in transparent materials. This technique has the potential to generate not only channel waveguides, but also three-dimensional optical devices. In this paper, an optical splitter and U-grooves, which are used for fiber alignment, are simultaneously fabricated in a fused silica glass using near-IR femtosecond laser pulses. The fiber aligned optical splitter has a low insertion loss, less than 4㏈, including an intrinsic splitting loss of 3㏈ and excess loss due to the passive alignment of a single-mode fiber. Finally, we demonstrate the utility of the femtosecond laser writing technique by fabricating gratings at the surface and inside the silica glass.
네트워크외부성이 소비자 선택행동에 미치는 영향에 관한 연구: 디지털카메라를 중심으로
한상만 ( Sang Man Han ),손용석 ( Yong Seok Sohn ),이영승 ( Young Seung Lee ) 한국소비자학회 2004 소비자학연구 Vol.15 No.3
Consumers are supposed to consider the intrinsic value incurring from multi-attribute of the product than any other in a decision making process. However there are many products with the value which is more than the intrinsic value, as the network effect grows. Therefore, it is an important issue to take a deep consideration into the network externalities as well as the intrinsic value of products under the purchasing situation. This research is to exam the network externalities when consumers make choice of a digital camera. Do the network externalities have an effect on making-decision process? In general, it is said that the network externalities have some features which we want to make sense those. We would draw a comparison between the intrinsic values and the network externalities through consumers` choice behaviors.