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( Keun Young Min ),( Min Bum Lee ),( Seong Hwi Hong ),( Dajeong Lee ),( Min Geun Jo ),( Ji Eon Lee ),( Min Yeong Choi ),( Jueng Soo You ),( Young Mi Kim ),( Yeong Min Park ),( Hyuk Soon Kim ),( Wahn S 생화학분자생물학회 2021 BMB Reports Vol.54 No.10
IL-10<sup>+</sup> regulatory B (Breg) cells play a vital role in regulating the immune responses in experimental autoimmune encephalomyelitis, colitis, and contact hypersensitivity (CHS). Several stimulants such as lipopolysaccharide (LPS), CD40 ligand, and IL-21 spur the activation and maturation of IL-10<sup>+</sup> Breg cells, while the epigenetic mechanism for the IL-10 expression remains largely unknown. It is well accepted that the histone acetylation/ deacetylation is an important mechanism that regulates the expression of IL-10. We found that entinostat, an HDAC inhibitor, stimulated the induction of IL-10<sup>+</sup> Breg cells by LPS in vitro and the formation of IL-10<sup>+</sup> Breg cells to suppress CHS in vivo. We further demonstrated that entinostat inhibited HDAC1 from binding to the proximal region of the IL-10 expression promoter in splenic B cells, followed by an increase in the binding of NF-κB p65, eventually enhancing the expression of IL-10 in Breg cells. [BMB Reports 2021; 54(10): 534-539]