各種波長可視光線照射時의 家兎尿中 17-Ketosteroid排泄量의 變動 및 Chlorpromazine投與時의 影響

申萬鍊,金在完,張禮世 최신의학사 1959 最新醫學 Vol.2 No.4

The wide use of glamercus illumination in architecture and the overexpeure oi the human bode to the lighting has fecuscd aitcrition on ex? rim ental works to find some biological changes which rn.g -t occur by various visible rays. Since Messer first described in i943 that the functional changes of the autonomic nervous system are caused by certain visible rays, many works have accumlated to indicate that animals flashed with a red visiblc ray develop parasym pathicotony, while do the flashing with a blue ray sympathicotony. Based on these facts, this experiment was attempted to find out bodily functional changes to be caused by various visible rays through the quantitative measurement of 17-ketosteroid in urine. 17-ketosteroid is one of metabolites of corticoid excreted in urine and if the light act as a kind of extrinsic stresses, it might cause easily oversecretion of ACTH in the pituitary glands by which stimulates the adrenal cortex. In experiment, the various visible rays as classified with blue, green, yellow,and red were flashed to rabbits. The rabbits were devided into 3 groups; the 1st was the group irradiated with various rays. the 2nd was the group irradiated after administration of chlorpromazine and t,o-d vhiis the contrr: flashed with the natural compound ray. The results can be summarized as :c flows' 1. The urinary excretion of 17-Ketosteroid rabbits increased to a significant degree by the irradiation with various visible rays as compared with rabbits under the natural compound ray 2. The values of 17-Ketosteroid In urine varied ac-cording to the wave-length of the light, this seems to indicate that there exist some difference in the intensity of light stresses caused by each isolated single ray. 3. The irradiation of various visible rays has given no change in the value of 17-ketosteroids in Urine of the rabbit, previously injected with chlorpromazine. This indicates that the light stress can be blocked by administration of chlorpromazine.

Histopathological changes of Korea cultured olive flounder, <i>Paralichthys olivaceus</i> due to scuticociliatosis caused by histophagous scuticociliate, <i>Philasterides dicentrarachi</i>

Jin, Chang-Nam,Harikrishnan, Ramasamy,Moon, Young-Gun,Kim, Man-Chul,Kim, Ju-Sang,Balasundaram, Chellam,Azad, I.S.,Heo, Moon-Soo Elsevier 2009 Veterinary parasitology Vol.161 No.3

<P><B>Abstract</B></P><P>Recently, mass mortality due to histophagous scuticociliate, <I>Philasterides dicentrarachi</I> in olive flounder, <I>Paralichthys olivaceus</I> occurred in aquaculture farms of Jeju Island, South Korea. We have artificially induced infection through immersion on day 12, the density of ciliates slowly decreased in the experimental tanks; on day 28 to 2300cells/ml in 3cm group and 1800cells/ml in 5cm group. The survival rate of <I>P. olivaceus</I> on days 24 and 28 of infection in the 3cm group was decreased to 4 and 6, respectively; however, no mortality was recorded in the 5cm group. In the control group 100% survival in the chosen period of both groups occurred except in the 3cm group whereas on days 24 and 28 the death rate was 1 and 2, respectively. Many ciliates with ingested red blood cells were observed in the gills, skeletal muscle, skin, fins and brains of infected flounder. The parasites were also observed in the lamina propria of the digestive tract, pharynx, peritoneal fluid, cerebrospinal fluid and cornea. Histopathological and inflammatory changes were characterized by swelling and generalized erythema and muscle tissue necrosis. Affected fish showed varying levels of tissue damage including severe epidermal and dermal necrotic lesions. Loss of scales, appearance of bleached spots that coalesced to form brownish patches, haemorrhagic and severe dermal necrotic lesions were the major clinico-pathological manifestations. The parasite was also seen distributed extensively in the entire brain causing widespread nerve necrosis after a prolonged period of infection. These results appear to support the hypothesis that the <I>P. dicentrarchi</I> may be penetrating via the gills or the skin, and then travel via the bloodstream to other parts of the body, including the body cavity.</P>

Design and calibration of a wireless laser-based optical sensor for crack propagation monitoring

S.H. Man,C.C. Chang,M. Hassan,A. Bermak 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.15 No.6

In this study, a wireless crack sensor is developed for monitoring cracks propagating in two dimensions. This sensor is developed by incorporating a laser-based optical navigation sensor board (ADNS-9500) into a smart wireless platform (Imote2). To measure crack propagation, the Imote2 sends a signal to the ADNS-9500 to collect a sequence of images reflected from the concrete surface. These acquired images can be processed in the ADNS-9500 directly (the navigation mode) or sent to Imote2 for processing (the frame capture mode). The computed crack displacement can then be transmitted wirelessly to a base station. The design and the construction of this sensor are reported herein followed by some calibration tests on one prototype sensor. Test results show that the sensor can provide sub-millimeter accuracy under sinusoidal and step movement. Also, the two modes of operation offer complementary performance as the navigation mode is more accurate in tracking large amplitude and fast crack movement while the frame capture mode is more accurate for small and slow crack movement. These results illustrate the feasibility of developing such a crack sensor as well as point out directions of further research before its actual implementation.

수도 웅성불임에 관한 연구

이만상(Man Sang Lee),김종호(C . H . Kim),정명수(M . S . Chang) 원광대학교 생명자원과학연구소 1985 농대논문집 Vol.8 No.-

N/A

Inhibitory mechanism of a newly synthesized proton pump inhibitor, YJA20379 -8

(Sang K. Sohn),(Man S. Chang),(Young K. Chung),(Kyu B. KIm),(Tae W. Woo),(Sung K,Kim),(Wahn S. Choi) 한국응용약물학회 1997 학술대회 Vol.1997 No.1

增分 Galerkin法에 의한 固定板의 座屈 및 座屈後 擧動 解析

白点基,李晩承,金昌烈 부산대학교 공과대학 1991 工大論文集 Vol.42 No.-

In the previous papers [1-2], the first author developed Incremental Galerkin Method(IGM) in order to analyse the elastic large deflection behaviour of simply supported plates. In this method, the incremental expression of the differential equation which governs the large deflection behaviour of plates with initial deflection is derived. Then the incremental governing equation is solved by using Galerkin method. IGM may be very useful tool in both accuracy and computing time when buckling and post-buckling behaviour of plates with initial deflection is analyzed. Also, using IGM the influence of initial imperfections affecting the large deflection behaviour can be investigated. In the present study, the use of IGM is extended to clamped plates. An accurate Fourier Series function which stands for the deflected shape of clamped plates is assumed. Using the assumed deflection function, the incremental governing equation is solved. A computer program is completed based on the present theory. The preparation of the input data for the use of the computer program is very simple. Then the computer program is applied to the analysis of buckling and post-buckling behaviour of a clamped square plate. A comparison of large deflection behaviours between simply supported and clamped plates is made. It is concluded that the present method gives an accurate solution in the short computing time.

Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes.

Ro, Seung-Hyun,Jung, Chang Hwa,Hahn, Wendy S,Xu, Xin,Kim, Young-Mi,Yun, Young Sung,Park, Ji-Man,Kim, Kwan Hyun,Seo, Minchul,Ha, Tae-Youl,Arriaga, Edgar A,Bernlohr, David A,Kim, Do-Hyung Landes Bioscience 2013 Autophagy Vol.9 No.12

<P>ULK1 (unc-51 like kinase 1) is a serine/threonine protein kinase that plays a key role in regulating the induction of autophagy. Recent studies using autophagy-defective mouse models, such as atg5- or atg7-deficient mice, revealed an important function of autophagy in adipocyte differentiation. Suppression of adipogenesis in autophagy-defective conditions has made it difficult to study the roles of autophagy in metabolism of differentiated adipocytes. In this study, we established autophagy defective-differentiated 3T3-L1 adipocytes, and investigated the roles of Ulk1 and its close homolog Ulk2 in lipid and glucose metabolism using the established adipocytes. Through knockdown approaches, we determined that Ulk1 and Ulk2 are important for basal and MTORC1 inhibition-induced autophagy, basal lipolysis, and mitochondrial respiration. However, unlike other autophagy genes (Atg5, Atg13, Rb1cc1/Fip200, and Becn1) Ulk1 was dispensable for adipogenesis without affecting the expression of CCAAT/enhancer binding protein ? (CEBPA) and peroxisome proliferation-activated receptor gamma (PPARG). Ulk1 knockdown reduced fatty acid oxidation and enhanced fatty acid uptake, the metabolic changes that could contribute to adipogenesis, whereas Ulk2 knockdown had opposing effects. We also found that the expression levels of insulin receptor (INSR), insulin receptor substrate 1 (IRS1), and glucose transporter 4 (SLC2A4/GLUT4) were increased in Ulk1-silenced adipocytes, which was accompanied by upregulation of insulin-stimulated glucose uptake. These results suggest that ULK1, albeit its important autophagic role, regulates lipid metabolism and glucose uptake in adipocytes distinctly from other autophagy proteins.</P>

Susceptibility of various Helicobacter pyloris to New Antiulcer Agents

(Tae W . Woo),(Han Y . Yoo),(Man S . Chang),(Young K . Chung),(Kyu B . Kim),(Sang K . Son),(Sung K . Kim),(Dae P . Kang),(Wahn S . Choi) 한국응용약물학회 1996 학술대회 Vol.1996 No.1

Use of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus infection and severe renal impairment

Desmond Y. H. Yap,Kevin S. H. Liu,Yu-Chun Hsu,Grace L. H. Wong,Ming-Chang Tsai,Chien-Hung Chen,Ching-Sheng Hsu,Yee Tak Hui,Michael K. K. Li,Chen-Hua Liu,Yee-Man Kan,Ming-Lung Yu,Man-Fung Yuen 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4

Background/Aims: Data on treatment efficacy and safety of glecaprevir/pibrentasvir (GLE/PIB) for chronic hepatitis C virus (HCV) infection in Asian patients with severe renal impairment are limited. This study aimed to study the treatment and side effects of GLE/PIB in these patients infected with non-1 genotype (GT) HCV. Methods: We prospectively recruited patients with Child’s A cirrhosis and eGFR <30 mL/min/1.73 m2 in Hong Kong and Taiwan during 2017–2018 to receive GLE/PIB treatment. Results: Twenty-one patients (GT2, n=7; GT3, n=6; and GT6, n=8) received GLE/PIB for 11.2±1.8 weeks. All except one were treatment-naïve. GLE/PIB was initiated in 16 patients while on dialysis (seven on peritoneal dialysis [PD] and nine on hemodialysis) and in five patients before dialysis. One patient died of PD-related peritonitis during treatment and two were lost to follow up. The SVR12 rate in the remaining 18 patients was 100%. All patients achieved undetectable levels at 4-, 12-, 24- and 48-week after treatment. Patients with deranged alanine aminotransferase showed normalization after 4 weeks and the response was sustained for 48 weeks. No significant adverse event was observed. Conclusions: GLE/PIB treatment was associated with high efficacy and tolerability in HCV-infected patients with severe renal impairment.

Intranasal Adenovirus-Vectored Vaccine for Induction of Long-Lasting Humoral Immunity-Mediated Broad Protection against Influenza in Mice

Kim, Eun Hye,Park, Hae-Jung,Han, Gye-Yeong,Song, Man-Ki,Pereboev, Alexander,Hong, Jeong S.,Chang, Jun,Byun, Young-Ho,Seong, Baik Lin,Nguyen, Huan H. American Society for Microbiology 2014 Journal of virology Vol.88 No.17

<P>Influenza vaccines aimed at inducing antibody (Ab) responses against viral surface hemagglutinin (HA) and neuraminidase (NA) provide sterile immunity to infection with the same subtypes. Vaccines targeting viral conserved determinants shared by the influenza A viruses (IAV) offer heterosubtypic immunity (HSI), a broad protection against different subtypes. We proposed that vaccines targeting both HA and the conserved ectodomain of matrix protein 2 (M2e) would provide protection against infection with the same subtype and also HSI against other subtypes. We report here that single intranasal immunization with a recombinant adenovirus (rAd) vector encoding both HA of H5 virus and M2e (rAdH5/M2e) induced significant HA- and M2e-specific Ab responses, along with protection against heterosubtypic challenge in mice. The protection is superior compared to that induced by rAd vector encoding either HA (rAdH5), or M2e (rAdM2e). While protection against homotypic H5 virus is primarily mediated by virus-neutralizing Abs, the cross-protection is associated with Abs directed to conserved stalk HA and M2e that seem to have an additive effect. Consistently, adoptive transfer of antisera induced by rAdH5/M2e provided the best protection against heterosubtypic challenge compared to that provided by antisera derived from mice immunized with rAdH5 or rAdM2e. These results support the development of rAd-vectored vaccines encoding both H5 and M2e as universal vaccines against different IAV subtypes.</P><P><B>IMPORTANCE</B> Current licensed influenza vaccines provide protection limited to the infection with same virus strains; therefore, the composition of influenza vaccines has to be revised every year. We have developed a new universal influenza vaccine that is highly efficient in induction of long-lasting cross-protection against different influenza virus strains. The cross-protection is associated with a high level of vaccine-induced antibodies against the conserved stalk domain of influenza virus hemagglutinin and the ectodomain of matrix protein. The vaccine could be used to stimulate cross-protective antibodies for the prevention and treatment of influenza with immediate effect for individuals who fail to respond to or receive the vaccine in due time. The vaccine offers a new tool to control influenza outbreaks, including pandemics.</P>