[논문]Operational Characteristics of CO2 Laser Adopted by Superposing-Discharge

Hee-Je Kim,Hyun-Ju Chung,Byoung-Dae Min,Jong-Han Joung,Sung- lun Park 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

오늘날 현저한 CO2 레이저의 응용 추세에 발맞추어 보다 다양한 형태의 출력 제어 기술이 대두되고 있다. 본연구에서는multi-Pulse Superposing-Discharge 기술을 이용하여 다양한형태의 CO2 레이저의 펄스를 성형 하였다. 펄스 성형을 위한 방법으로 PIC one-chip microprocessor를 이용하여 삼중 PFN 모률의 SCR을 각각 고유의 지연시간을 가지도록 제어하였다. 실험에 사용된 삼중 PFN 모률의 전원 회로는 각각 캐패시터 인덕터,SCR,고압 펄스 트랜스 그리고 고압 트랜스 2차측에 브릿지 정류기로 구성 하였다. 고압 펼스 트랜스의 1차측을 제어하므로서 PFN 모률의 동작을 저 전압에서 수행 할 수 있다. 트랜스의 2차측에 연결된 전파 정류기는 펄스 에너지를 부하에 지속적으로 전달한다. 본 연구에서는 삼중 PFN 모률의 각각의 SCR을 다른 시간 가격을 두고 트리거 하므로서 다양한 Long pulse shaping을 실현하였다. 또한 약 250-1000μs 의 주기를 가지는 다양한 펄스형 레이저 빔을 얻었다.

HBV : Dynamic Change of HBsAg Titer during Anti-Viral Therapy in Treatment-Na?ve Patients with Chronic Hepatitis B

( Han Wook Chung ),( Yu Jin Ko ),( Sang Wook Lee ),( Hyun Woong Lee ),( Hyung Joon Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background/Aims: Quantitative HBsAg (qHBsAg) titers are emerging as useful tools for measuring viral load and predicting predicting virologic response (VR). This study aimed to determine whether serial monitoring of HBsAg levels could predict virologic response to entecavir(ETV) & clevudine(CLV) therapy in treatment-naive patients with CHB Methods: A total of 157 treatment-naive patients with CHB, who visited Chung-Ang University Hospital between January 2007 and December 2008, were enrolled in this study (100 males). 97 patients(69 males, mean age 48) were treated with ETV for average 53 months, and 60 patients (31 males, mean age 43) were treated with CLV for 26months average. HBsAg levels were measured at baseline, week 12, 24, and 48. All patients were assessed for virological response (HBV DNA<140 copies/mL). Serum HBV DNA was quantified using the real time PCR assay (Artus HBV LC PCR Kit, Roche Diagnostics, lower limit of quantification, 140 copies/mL). Results: In 97 ETV-treated patients, the rates of virological response were 56.7% (55/97) at 48months and 60 CLV-treated patients, 30% (18/60) at 24 months, respectively. Mean reduction of baseline HBV DNA was -5.3, and -4.9 log10 copies/mL. In 55 VR patients treated with ETV, 43(78.1%) patients showed early decline of HBsAg titer and 31(56.3%) patients had lower baseline HBsAg levels (< 3.7 log IU/mL). In 18 VR patients treated with CLV, 9(50%) patients showed early decline of HBsAg titer and 11(61.1%) patients had also lower baseline HBsAg levels (< 3.7 log IU/mL) . Conclusions: Early decline of HBsAg was useful for predicting VR, and baseline HBsAg could be indicative as well in CHB patients treated with ETV than patients treated with CLV.

고조리서와 종가의 무김치 비교 연구

이현진,이상원,전형주,정혜정,Lee, Hyun-Jin,Lee, Sang-won,Jeon, Hyeong-ju,Chung, Hea-jung 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.5

The purpose of this research aims to reveal how radish kimchi (Jong-ga) differs in Jong-ga recipes and old cookbooks. To accomplish this, old cookbooks ("Soowoonjabbang", "Jusiksiui", "Eumsikbangmunnira", "Siuejunsuh", "Banchandeungsok", and "Buinpilji") were reviewed and 8 Jong-ga recipes (Seogye Park Se-dang from the Bannam Park clan Jong-ga, Myungsukgong from the Changnyeong Jo clan Jong-ga, Nampa Park Jae-gyu from the Milyang Park clan Jong-ga, Geunggudang Kim Joong-jeung from the Gwangsan Kim clan Jong-ga, Dongchundang Song Jun-gil from the Eunjin Song clan Jong-ga, Myeongjae Yun Jung from the Papyung Yun clan Jong-ga, Daeseunggong Ryu Cha-dal from the Munhwa Ryu clan Jong-ga, Inmukjae Son Sung-jeung from the Milseong Son clan Jong-ga) from five areas were reviewed. We classified the radish kimchi into five categories, radish kimchi, Dongchimi, kkakdugi, Seokbakji and Nabak kimchi and other kimchi. According to old cookbooks, most kimchi was made with radish, cabbage, cucumber, pear, yuju, fish meat, and salt. Modern Jong-ga is made of seasoned radish, sticky rice paste, seafood, sugar, powdered pepper, fish sauce and salt. This study helps to understand notable clans' cultures via their recipes for kimchi.

Patterning of Periodic Ripples in Monolayer MoS2 by Using Laser Irradiation

Sung Won Kim,Jeong Hyeon Na,Won Lyeol Choi,Hyun-Jong Chung,Sung Ho Jhang,Soo Ho Choi,Woochul Yang,Sang Wook Lee 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.10

We have investigated the effect of laser irradiation on monolayer MoS2 and observed the swellingup of the monolayer from the SiO2 substrate upon laser illumination. The mismatch in the thermal expansion between the substrate and MoS2 can result in the structural deformation. Employing this method, one can induce structural deformation in a desired pattern, and one can demonstrate the patterning of periodic ripples in monolayer MoS2 by using laser irradiation. The controlled fabrication of the ripple structure may be instrumental in understanding the effect of ripples on the interesting physical properties of monolayer MoS2.

Comparison of 5-Year Outcomes of Robot-Assisted Laparoscopic and Laparoscopic Partial Nephrectomy in Patients With Localized Renal Cell Carcinoma

Chung Un Lee,Minyong Kang,Hyun Hwan Sung,Hwang Gyun Jeon,Deok Hyun Han,Byung Chang Jeong,Seong Soo Jeon,Hyun Moo Lee,Han Yong Choi,Seong Il Seo 대한비뇨기종양학회 2017 대한비뇨기종양학회지 Vol.15 No.3

Purpose: To compare the 5-year oncologic and functional outcomes of robot-assisted laparoscopic partial nephrectomy (RALPN) and laparoscopic partial nephrectomy (LPN) as treatment for localized renal cell carcinoma (RCC). Materials and Methods: We analyzed the records of 181 patients with localized RCC who underwent RALPN (n=97) or LPN (n=84) between 2007 and 2011. Demographic and preoperative data with estimated glomerular filtration rate (eGFR), intraoperative data including warm ischemic time (WIT) and complications, oncologic outcomes (recurrence, metastasis), and rate of eGFR preservation at most recent follow-up were examined. Results: WIT was shorter in the RALPN group (27±9.1 minutes) than the LPN group (31±10 minutes, p=0.019). Intraoperative complication rates were also lower in RALPN patients than LPN patients (4.1% vs. 14.3%). The eGFR preservation rate was higher in the RALPN group (84.6%) than in the LPN group (81.5%, p=0.049). Particularly, a relatively high difference in the eGFR preservation rate was observed in the RALPN group compared with the LPN group according to R.E.N.A.L. score 7–10 values (RALPN, 86.5±12.9 vs. LPN, 76.7±16.0; p=0.003). During the follow-up period, there was no local recurrence in either group and distant metastases only occurred in one patient in the RALPN group and in 2 patients in the LPN group. Conclusions: RALPN and LPN showed similar 5-year oncologic outcomes, but RALPN was superior to LPN in terms of WIT, intraoperative complications, and long-term eGFR preservation rate, especially in complex cases.

New diagnostic criteria for the diagnosis of hepatocellular carcinoma

Sung Eun Kim,Hyun Joo Park,Han Chu Lee,Kang Mo Kim,Young Suk Lim,Young Hwa Chung,Yung Sang Lee,Dong Jin Suh 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.3(S)

Influence of Collapse and Re-ventilation of Lung on the Development of Pulmonary Edema

Sang Hyun Kwak,Won Jong Jin,Hong Beom Bae,Seong Wook Jeong,Sung Su Chung,Chang Young Jeong Korean Society of Critical Care Medicine 2004 Acute and Critical Care Vol.19 No.1

BACKGROUND: This study was to clarify the influence of collapse and re-ventilation of lung on the development of pulmonary edema in rabbit. METHODS: Animals were randomly assigned to one of three groups: Sham group receiving two lung ventilation (n=14), Collapse group receiving collapse of right lung (n=14), Reventilation group receiving collapse of right lung for 3 hours followed by reventilation of collapsed right lung for 3 hours (n=14). The lung of rabbits were ventilated with 50% oxygen through the tracheostomy. Right main bronchus was secured by thoracotomy in all animal. Collapse and reventilation were performed using by bulldog forcep. Mean arterial pressure, heart rate, arterial oxygen tension (PaO2), peripheral blood leukocyte and platelet counts were recorded at 0, 1, 2, 3, 4, 5 and 6 hour after the start of experiment. The wet to dry (W/D) weight ratio of lung, lung injury score and leukocyte counts, percentage of polymorphonuclear leukocyte (PMNL), concentration of albumin, and interleukin-8 (IL-8) in bronchoalveolar lavage fluid (BALF) were measured 6 hour after the start of experiment in both lung. RESULTS: W/D weight ratio of lung, lung injury score and leukocyte counts, percentage of PMNL, concentration of albumin and IL-8 in BALF were significantly increased in both lung of reventilation group. And the degree of increases is more significant in right than left lung. CONCLUSIONS: These findings suggest that reventilation of collapsed lung causes the bilateral pulmonary edema in rabbit mainly by activating neutrophil and IL-8 responses, which may play a central role in non cardiogenic pulmonary edema.

Comparisons of Renoprotective Activities between White Ginseng Radix and Rootlet in Spontaneously Hypertensive Rats with Diabetes

Sung Hyun Chung,Sung Kwon Ko.,Se Ho Park 대한생리학회-대한약리학회 2002 The Korean Journal of Physiology & Pharmacology Vol.6 No.1

<P> The renoprotective activities of white ginseng radix and rootlet were compared in spontaneously hypertensive rat (SHR) with diabetes. During oral administration of white ginseng radix (Ginseng Radix Alba, GRA) and white ginseng rootlet (Ginseng Radix Palva, GRP) for four weeks, arterial blood pressure and blood glucose levels were determined at every 10 days. In both GRA- and GRP-treatment groups, arterial blood pressures started to go down after 10 days of administration and maintained throughout the study period. After four weeks administrations of GRA and GRP, diastolic blood pressures were significantly decreased with 17% and 9%, respectively. GRA treatment also decreased blood glucose levels after 10 days of administration when compared with diabetic SHR group. At the end of the experiment, serum creatinine (Scr) and blood urea nitrogen (BUN) were not significantly different between the groups, except 62% higher value of BUN in diabetic SHR group when compared with SHR group. In the diabetic SHR group, the excretion of urinary albumin was increased significantly when compared with SHR. The level of urinary albumin in GRA treated group was markedly reduced when compared with diabetic SHR group (67.8⁑4.7 <I>vs</I>. 131.3⁑13.5 mg/24 h). To examine the effects of ginseng radices on an overt diabetic nephropathy, index of kidney hypertrophy and transforming growth factor-β1 (TGF-β1) protein levels were evaluated. The glomerular and tubular cells stained positive for TGF-β1 seemed to be more abundant in diabetic SHR than in those with SHR, and GRA treated rats showed somewhat less TGF-β1 protein in glomerular and tubular cells when compared with diabetic SHR. Our results suggest that GRA might be a useful antihypertensive and antidiabetic agent with renoprotective effect.

A Case of Focal Segmental Glomerulosclerosis Associated with Aplastic Anemia

Chung Jong Hoon,Kim Dong Min,Cho Young Sin,Yoon Sung Ho,Chung Choon Hae,Kim Hyun Lee,Park Chi Young 대한의학회 2004 Journal of Korean medical science Vol.19 No.6

Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss

Sang-Yeon Lee,Hyun Been Choi,Mina Park,Il Soon Choi,Jieun An,Ami Kim,Eunku Kim,Nahyun Kim,Jin Hee Han,Min young Kim,Seung min Lee,Doo-Yi Oh,Bong Jik Kim,Nayoung Yi,Nayoung, K. D. Kim,Chung Lee,Woong-Y 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Loss-of-function variant in the gene encoding the KCNQ4 potassium channel causes autosomal dominant nonsyndromic hearing loss (DFNA2), and no effective pharmacotherapeutics have been developed to reverse channel activity impairment. Phosphatidylinositol 4,5-bisphosphate (PIP2), an obligatory phospholipid for maintaining KCNQ channel activity, confers differentialpharmacological sensitivity of channels to KCNQ openers. Through whole-exome sequencing of DFNA2 families, we identified three novel KCNQ4 variants related to diverse auditory phenotypes in the proximal C-terminus (p.Arg331Gln), the C-terminus of the S6 segment (p.Gly319Asp), and the pore region (p.Ala271_Asp272del). Potassium currents in HEK293T cells expressing each KCNQ4 variant were recorded by patch-clamp, and functional recovery by PIP2 expression or KCNQ openers was examined. In the homomeric expression setting, the three novel KCNQ4 mutant proteins lost conductance and were unresponsive to KCNQ openers or PIP2 expression. Loss of p.Arg331Gln conductance was slightly restored by a tandem concatemer channel (WT-p.R331Q), and increased PIP2 expression further increased the concatemer current to the level of the WT channel. Strikingly, an impaired homomeric p.Gly319Asp channel exhibited hyperactivity when a concatemer (WT-p.G319D), with a negative shift in the voltage dependence of activation. Correspondingly, a KCNQ inhibitor and chelation of PIP2 effectively downregulated the hyperactive WTp. G319D concatemer channel. Conversely, the pore-region variant (p.Ala271_Asp272del) was nonrescuable under any condition. Collectively, these novel KCNQ4 variants may constitute therapeutic targets that can be manipulated by the PIP2 level and KCNQregulating drugs under the physiological context of heterozygous expression. Our research contributes to the establishment of a genotype/mechanism-based therapeutic portfolio for DFNA2.