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Papaverine이 저분극된 토끼 유두근의 수축력과 활동전압에 미치는 영향
임인자,조성일,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.3
In Partially deppolarized, isolated papillary muscle from rabbit heart, the effect of papaverine on contractile force and calcium mediated slow action potential was investigated. Results were as follows; 1. Papaverine induced the negative inotropic effect dose-dependently in the majority of preparations, although some preparations showed the opposite namely positive inotropic response. The significant correlation was found between the degree of depression in tension and increase that of in drug concentration. 2. The contractile force depressed by papaverine was restored by calcium(4 mM). 3. In partially depolarized papillary muscle, papaverine reduced slightly both action potential amplitude and upstroke velocity (dV/dt_max). The duration of action potential (duration of 90% repolarization) was also increased by papaverine in a dose-dependent manner. 4. The resting membrane potential was not altered in low concentrations (10^-7∼5X 10^-6M) of papaverine, however, it was significantly decreased in high concentration (10^-5∼5X 10^-5M) of the drug. The slightly increased overshoot potential was also observed in the above at high concentration range. From these results, it is suggested that in papillary muscle of rabbit heart, inhibitory effect of papaverine on the contractility may be attributable to its antagonistic action on the calcium current rather than its inhibitory effect on the phosphodiesterase activity. The local anesthetic property of the drug may also contribute to the papaverine induced decreases in both contractile force and upstroke velocity. The prolongation of action potential duration brought by papaverine appears to be induced not by increase in calcium currents but by a decrease in K^+ conductance.
조태웅,민영돈,김경종,정권율,강성인,류소연,임성철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1
Obturator hernia is a rare pelvic hernia, occuring most frequently in elderly, extra-thin or debilitated women. Because of the anatomic character of the obturator foramen and the nonspecific symptoms in the presence of the hernia, the risk of strangulation of the herniated bowel is high, which leads to high morbidity and mortality rate. The authors experienced an unusual case of left obturator hernia with strangulation of the small bowel in an 80-year old female. The hernia was diagnosed by abdomino-pelvic computed tomography (CT) scan. Through the lower midline transperitoneal approach, resecting the strangulated small bowel, the hernia sac was ligated and the obturator foramen was repaired using adjacent broad ligament. We report these findings with a brief review of the literature.
송근영,강길,박정희,김경종,민영돈,박치영,임성철 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2
Gastric small cell carcinoma(SCC) is defined as poorly-differentiated neuroendocrine tumor of the stomach, and their morphologic and biologic features arc similar to those of the lung. It is known that this tumor has poor prognosis even in early pathologic stage, It acounts for only 3% of all gastrointestinal SCC. that has been reported only 33 cases outside and 6 cases inside of the comitiy. Most of these reports are related to advanced gastric SCC. as pathologic stage IIIb or IV. This report describes a case of early gastric SCC. pathologic stage Ib.
Lim, Sung Don,Hwang, Jin-Gyu,Jung, Chang Gyo,Hwang, Sun-Goo,Moon, Jun-Cheol,Jang, Cheol Seong Oxford University Press 2013 DNA research Vol.20 No.3
<P>A large number of really interesting new gene (RING) E3 ligases contribute to the post-translational modification of target proteins during plant responses to environmental stresses. However, the physical interactome of RING E3 ligases in rice remains largely unknown. Here, we evaluated the expression patterns of 47 <I>Oryza sativa</I> RING finger protein (<I>OsRFP</I>) genes in response to abiotic stresses via semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and <I>in silico</I> analysis. Subsequently, molecular dissection of nine <I>OsRFPs</I> was performed by the examination of their E3 ubiquitin ligase activity, subcellular localization, and physical interaction with target proteins. Most of the OsRFPs examined possessed E3 ligase activity and showed diverse subcellular localization. Yeast two-hybrid analysis was then employed to construct a physical interaction map of seven OsRFPs with their 120 interacting proteins. The results indicated that these OsRFPs required dynamic translocation and partitioning for their cellular activation. Heterogeneous overexpression of each of the <I>OsRFP</I> genes in <I>Arabidopsis</I> suggested that they have functionally diverse responses to abiotic stresses, which may have been acquired during evolution. This comprehensive study provides insights into the biological functions of OsRFPs, which may be useful in understanding how rice plants adapt to unfavourable environmental conditions.</P>