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유산소성 운동이 노인들의 신체조성과 등속성 슬관절 근력 및 요부근력에 미치는 영향
한종우(Jong Woo Han),이상석(Sang Sug Lee),송분도(Bun Do Song),지용석(Yong Suk Ji),김난수(Nan Su Kim),서경호(Kyeong Ho Seo) 한국사회체육학회 2000 한국사회체육학회지 Vol.13 No.-
This study was designed to investigate the effect of a year aerobic exercise training on body composition, isokinetic knee and trunk muscular strength of elders. The subjects for this study were eighty healthy elderly people who were members of seniors tower at Song-Do Hospital and didn`t have any history of cardiorepiratory disease. Subjects have been trained three times a week for a year. The exercise program was made up of a 15-minute warm-up, cool-down. Stretching was performed every eight minutes for the prevention of injuries which could occur during the main exercise and quick recovery of the used muscle. Aerobic training was performed for each 15-20minutes using the treadmill and cycle ergometer at the intensity of 50-70% HRmax. For the data, all the measurements were represented by mean and standard deviation using SAS package(version 6.12). Statistical techniques for data analysis were paired t-test to determine the difference between pre and post exercise program. The 5% level of significance was used as the critical level for acceptance of hypotheses for the study. The following results were obtained from this study. 1. There is a statistically significant difference in the VO_2max, fat mass, lean mass and %body fat both old men and women after a year training. 2. There is not a statistically significant difference in the weight, WHR and thigh circumference both old men and women after a year training. 3. There is a statistically significant difference in the right knee flexor/extensor peak torque, peak torque % body weight, total work and total work % body weight both old men and women after a year training. 4. There is a statistically significant difference in the left knee flexor/extensor peak torque, peak torque % body weight, total work and total work % body weight both old men and women after a year training.
( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
The effect of low temperature on Lycorma delicatula (Hemiptera:Fulgoridae) egg hatchability
Song Myung-Kyu,Sang-Cheol Lim,Ki-Su Ahn,Kyeong-Hee Lee,Gil-Hah Kim 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.10
The occurrence and rapid range expansion of a fulgorid, Lycorma delicatula(White), has recently been reported in korea. It was previously known to occur in China, Japan, Vietnam and India. The first occurrence fo L. delicatula was reported in 2004 in the Cheonan. It has one generation per year and overwinters as egg masses on the bark of host trees. The number of egg per egg mass was 32.69±6.49. The cumulative ratio of hatchability at different temperature was the highest at 25℃ and the lowest at 10, 30℃. The egg hatchability was investigated in different regions in Chung-buk. Since L. delicatula eggs has been stored in -20±1, 0±1, 5±1℃ conditions for 1 ∼60 days, the cumulative ratio of hatchability was 2% stored in -20±1℃ for 3days, But hatchability was 52, 48% stored in 0±1℃ for 3, 14days and 82, 68% stored in 5±1℃ for 3, 14days. And hatchability was 0% for 60days. By straight regression equation(the growth ratio/treatment degree) the growth zero degree of L. delicatula was 10.4℃. The hatchability of L. delicatula in Cheongwon-gun, Okcheon-gun, Cheongju-city where’s winter lowest temperature was over -19℃ was over 79%. But The hatchability of L. delicatula in Jincheon-gun where’s winter lowest temperature was less than -19℃(continuos two days) was 35%.
( Su Hwan Lee ),( Moo Suk Park ),( Joo Han Song ),( Kyung Soo Chung ),( Young Sam Kim ),( Jin Gu Lee ),( Hyo Chae Paik ),( Song Yee Kim ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-
Introduction: Lung transplantation (LTx) is only curative treatment option for end-stage lung disease, and LTx is steadily increasing. The aim of this study is to evaluate preoperative factors related with 1 year mortality after LTx. Methods: Sixty nine consecutive patients who underwent LTx without preoperative ECMO treatment at one tertiary hospital in South Korea between October 24, 2012 and October 16, 2015 were analyzed retrospectively. Results: Forty five patients (65.2%) lived more than 1 year after LTx. Median age of total patients is 55 years (range, 16-75) and total patients consisted of 40 (58%) male patients. Major cause of LTx is idiopathic pulmonary fibrosis (47.8%). Other causes of LTx are interstitial lung disease related with connective tissue disease (17.4%) and bronchiolitis obliterans after stem cell transplantation (15.9%). In univariate analysis, higher median age (54.5 vs. 62.0, P < 0.001), male sex (46.7% vs. 79.2%, P = 0.009), lower preoperative albumin level (<3g/dL) (22.2% vs. 45.8%, P = 0.042) and higher median E/E` on preoperative echocardiography (9 vs. 11.5, P = 0.048) are significantly related with 1-year mortality after LTx. After adjusting, old age was only factor related with 1-year mortality after LTx. Especially, oldest group (age ≥ 65 years) showed significantly different 1-yr survival rate compared to youngest group (age < 55 group) (hazard ratio, 10.92; 95% CI, 1.52-78.27). Conclusions:Advanced age of recipients in lung transplantation is associated with 1 year mortality after LTx and we should contemplate about LTx in old patient.
Su Bin Park,Ha Na Kim,Gwang Hun Park,Ho-Jun Son,Hyun Ji Eo,Jeong Ho Song,Hun Min Song,Ji Ae Park,Jin Boo Jeong 한국자원식물학회 2018 한국자원식물학회지 Vol.31 No.3
In this study, we investigated the effect of the extracts from Vaccinium oldhamii on cell proliferation and the regulatory mechanisms of cyclin D1 protein level in human cancer cells. The branch extracts from Vaccinium oldhamii (VOB) showed higher inhibitor effect against the cell growth than leave extracts (VOL) and fruit extracts (VOF) in human colorectal cancer, breast cancer, prostate cancer, non-small lung cancer, pancreatic cancer and liver cancer cells. In addition, VOB decreased cyclin D1 level at both protein and mRNA level. MG132 treatment attenuated VOB-mediated cyclin D1 downregulation. A point mutation of threonine-286 to alanine attenuated cyclin D1 degradation by VOB. In addition, the inhibition of nuclear export by leptomycin B (LMB) attenuated cyclin D1 degradation by VOB. But, the treatment of PD98059 (ERK1/2 inhibitor), SB203580 (p38 inhibitor), SP600125 (JNK inhibitor), LiCl (GSK3β inhibitor), LY294002 (PI3K inhibitor) or BAY 11-7082 (IκK inhibitor) did not affect VOB-induced cyclin D1 degradation. In conclusion, VOB induced cyclin D1 degradation through redistribution of cyclin D1 from the nucleus to cytoplasm via T286 phosphorylation of cyclin D1, which resulted in the inhibition of cancer cell proliferation.
( Su Hyun Song ),( Tae Ryom Oh ),( Hong Sang Choi ),( Chang Seong Kim ),( Dong Ryeol Ryu ),( Sung Gyun Kim ),( Sun-hee Park ),( Seong Kwon Ma ),( Soo Wan Kim ),( Eun Hui Bae ) 대한신장학회 2021 Kidney Research and Clinical Practice Vol.40 No.3
Background: Minimal change disease (MCD) is one of the most common causes of nephrotic syndrome worldwide. Hyperuricemia increases the end-stage renal disease (ESRD) risk in glomerulonephritis. In this study, we aimed to determine the effect of high serum uric acid levels on the progression to ESRD in MCD. Methods: A total of 800 patients diagnosed with MCD by kidney biopsy were retrospectively analyzed. We determined the relation-ship of hyperuricemia with the progression to ESRD in MCD using the Cox proportional hazard model and Kaplan-Meier survival anal-ysis. The primary outcome was defined as the initiation of dialysis or kidney transplantation. Results: A total of 42 patients (5.3%) progressed to ESRD during the follow-up period. In the restricted cubic spline curve, serum uric acid levels exhibited a positive correlation with ESRD progression in patients with MCD. In the fully adjusted model, the risk of MCD progression increased by 29% for every 1 mg/dL increase in the baseline serum uric acid level (hazard ratio [HR], 1.29; 95% confi-dence interval [CI], 1.09-1.54; p = 0.004). Falling into the high uric acid group (serum uric acid level > 7 mg/dL in men and > 6 mg/ dL in women) was also a risk factor for progression of MCD to ESRD (HR, 3.40; 95% CI, 1.59-7.31; p < 0.001). Conclusion: Our study shows that hyperuricemia is an independent risk factor for the progression to ESRD in patients with MCD.
A Case of Ectopic ACTH Syndrome Associated with Small Cell Lung Cancer
Song, Hyun-Ju,Ryu, Kum-Hei,Kim, Su-Hyun,Yoon, Su-Jin,Kim, Do-Yeun,Im, Seock-Ah,Seong, Chu-Myong,Koo, Heasoo,Lee, Soon-Nam 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2
We report a case of extensive stage SCLC with EAS confirmed by immunohistochemical stain of ACTH in tumor cells who died early due to rapidly progressive acute respiratory distress and pneumonia before the start of chemotherapy and corticosteroid blocking agent. Through our case, we learn how important early diagnosis and treatment of EAS associated with SCLC are and hope to apply to other cases from now on. 이소성 ACTH(adrenocorticotropic hormone)증후군은 ACTH를 분비하는 비뇌하수체종양으로 고코르티졸혈증을 보인다. 소세포폐암에서 ACTH를 분비하는 부종양 증후군은 비교적 흔하지만, 임상적으로 의미있는 고코르티졸혈증은 1~5% 정도로 매우 드물다. 이소성 ACTH 증후군은 소세포폐암이 전형적인 쿠싱증후군이 나타나기도 전에 빨리 진행하므로 전형적인 월상안, 복부비만, 골다공증 등의 증상을 나타낼 때까지 생존하는 경우가 매우 드물며, 체중 감소, 부종, 근위축 등 비전형적인 임상 양상을 나타내어 신속히 진단하여 치료하기가 어렵다. 도한 이소성 ACTH 증후군에 의한 고코르티졸혈증은 항암제에 잘 반응하지 않고 치료 중에 소화기 궤양, 출혈, 천공, 폐렴 등의 치명적인 합병증이 동반되므로평균 수명이 4개월 미만으로 예후가 매우 불량하다. 따라서, 소세포폐암에서 이소성 ACTH 증후군의 조기 발견 및 치료는 예후 향상을 위해 매우 중요하다. 이에 저자들은 61세의 비전형적인 쿠싱 증후군의 증상으로 발현된 진행성 소세포폐함의 환자에서 급격히 악화되는 임상 경과를 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.