중, 고등학생의 한국판 상태-특성 불안척도의 적용 연구

이영진,방수영,최선,이해국,김병후,김원,이상혁 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5

Objectives : This study aimed to investigate the validity and standardize the Spielberger State-Trait Anxiety Inventory (STAI) in middle and hi? school students and find the factors which influenced their anxiety. Methods : 1,033 middle and hi? school students were selected randomly from 7 regions around the country. The State-Trait Anxiety Inventory (STAI) was applied in all subjects and the Beck Anxiety Inventory (BAI) was applied with it to calculate the coexistence validity. To find the causes of adolescent anxiety, Beck Depression Inventory (BDI), Subjective Happiness Scale, The Satisfaction With Life Scale, Rosenberg Self-Esteem Scale (RES), Parent-Adolescent communication family inventories, In family social scene were all applied and correlation with STAI was investigated. Results : Reliability issues, such as internal coherence, the coherence between specific phobia and anxiety state were Satisfactory and the coexistence validity with BAI was high. The result of factor analysis shows that factor structures were similar to previous studies. High school students showed higher anxiety levels than middle school students, and girls higher than boys. For socio-economical factors, Poverty and poor grades related to higher anxiety. Among psychological factors, happiness and Self-esteem showed high correlation wi anxiety. Conclusion : The State-Trait Anxiety Inventory (STAI) showed high validity and reliability in middle and hi? school students and proved itself a reliable scale. When treating their anxiety, age, sex, socio-economical and psychological factors should all be considered.

Topical 0.03% Tacrolimus for Treatment of Pemphigus Erythematosus in a Korea Jindo Dog

BHANG, Dong-Ha,CHOI, Ul-Soo,JUNG, Yun-Chan,KIM, Min-Kyu,CHOI, Eun-Wha,SEO, Kyoung-Won,KANG, Min-Soo,HWANG, Cheol-Yong,KIM, Dae-Yong,YOUN, Hwa-Young,LEE, Chang-Woo Japanese Society of Veterinary Science 2008 The Journal of veterinary medical science Vol.70 No.4

<P>Topical 0.03% tacrolimus was used for treatment of a Korea Jindo dog diagnosed with pemphigus erythematosus. The dog was slowly improved following application of tacrolimus but did not achieve complete remission until end of this study. No adverse effects on clinical or laboratory parameters were noted during the topical tacrolimus therapy period.</P>

Predictors of Success at 6-Month Follow Up at a Public Adolescent Smoking Cessation Clinic in South Korea

Soo-Young Bhang,Sam-Wook Choi,Joon-Ho Ahn,Hye-Kyeong Park,Mi-Kyeong Lee 대한소아청소년정신의학회 2012 대한소아청소년정신의학회 학술대회논문집 Vol.2012 No.5

22q11 Deletion Syndrome을 동반한 정신분열병 1예

방수영,김창윤,주연호,서을주,유한욱 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.4

It has been well known that 22q deletion syndrome (22qDS), encompasses several genetic syndromes associated with microdeletions at chromosome 22q11.2 became relatively generally identified in the 1990s through the availability of specialized chromosomal studies, and it includes such syndromes as velocardiofacial syndrome (VCFS), DiGeorge syndrome (DGS), Shprintzen syndrome, CATCH 22. The syndrome is characterized by distinctive dysmorphology, congenital heart disease, athymia, parathyroid disease, other congenital diseases, learning difficulties and various psychiatric illnesses. This syndrome is a common genetic condition often accompanied by mild cognitive impairment. Learning difficulties and anger outburst are also common in adolescence with this syndrome, In addition, a prevalence of major psychiatric disorders in adults' individuals are high, especially schizophrenia, schizoaffective disorder, bipolar disorder and other psychiatric illnesses, including simple or social phobia, depression, obsessive-compulsive disorder. We report a patient with facial dysmorphology, cleft lip and palate, ventricular septal defect, borderline IQ, poor impulse control and psychotic symptoms who was diagnosed schizophrenia and 22qDS by FISH analysis which finds 22q11.2 microdeletion.

Comparing Attention and Cognitive Function in School Children across Noise Conditions

Soo-young Bhang,Jaekook Yoon,Joohyun Sung,Cheolin Yoo,Changsun Sim,Changmyung Lee,Jaewon Lee,Jiho Lee 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.6

Objective The effect of acute noise on cognitive function has long been a topic of study, yet these effects remain a serious problem for learning performance in school children. Methods From November 15, 2010 to December 8, 2010, we enrolled 268 students from three elementary schools (135 boys and 133 girls, 10–12 years old) in Ulsan, Korea. The study subjects were divided into two groups according to their test conditions (background versus additional noise), and tests were conducted using psychological examination tools. Chi-square tests and general linear models were used to assess the differences of impacts on cognition between the two groups. Results After adjusting for socio-demographic covariates, the noise significantly affected the results of full-scale IQ, verbal IQ, Continuous Performance Test scores, and Children’s Color Trails Test and Stroop test scores. The groups at high risk of learning difficulties were more affected by noise than low-risk groups. Conclusion These findings suggest that noise is hazardous to the attention and performance of elementary school students, particularly for groups at greater risk for poor academic achievement. Additional studies are needed to identify subject-specific levels of noise that can affect attention and cognitive function.

Locally Delivered Growth Factor Enhances the Angiogenic Efficacy of Adipose-Derived Stromal Cells Transplanted to Ischemic Limbs

Bhang, Suk Ho,Cho, Seung-Woo,Lim, Jae Min,Kang, Jin Muk,Lee, Tae-Jin,Yang, Hee Seok,Song, Young Soo,Park, Moon Hyang,Kim, Hyo-Soo,Yoo, Kyung-Jong,Jang, Yangsoo,Langer, Robert,Anderson, Daniel G.,Kim, Wiley (John WileySons) 2009 Stem Cells Vol.27 No.8

<P>Ischemia is a potentially fatal medical event that is associated with as many as 30% of all deaths. Stem cell therapy offers significant therapeutic promise, but poor survival following transplantation to ischemic tissue limits its efficacy. Here we demonstrate that nanosphere-mediated growth factor delivery can enhance the survival of transplanted human adipose-derived stromal cells (hADSCs) and secretion of human angiogenic growth factors per cell, and substantially improve therapeutic efficacy of hADSCs. In vitro, in hypoxic (1% oxygen) and serum-deprived conditions that simulate in vivo ischemia, fibroblast growth factor-2 (FGF2) significantly reduced hADSC apoptosis and enhanced angiogenic growth factor secretion. In vivo, hADSCs delivered intramuscularly into ischemic hind limbs in combination with FGF2 resulted in significant improvements in limb survival and blood perfusion, as well as survival of the transplanted hADSCs and secretion of human angiogenic growth factors (i.e., vascular endothelial growth factor, hepatocyte growth factor, and FGF2). Interestingly, the majority of transplanted hADSCs were localized adjacent to the microvessels rather than being incorporated into them, suggesting that their major contribution to angiogenesis might be to increase paracrine secretion of angiogenic growth factors. This study demonstrates the potential of hADSCs in combination with growth factors for use in the treatment of ischemia.</P>

Relationship between Environmental Phthalate Exposure and the Intelligence of School-Age Children

Cho, Soo-Churl,Bhang, Soo-Young,Hong, Yun-Chul,Shin, Min-Sup,Kim, Boong-Nyun,Kim, Jae-Won,Yoo, Hee-Jung,Cho, In Hee,Kim, Hyo-Won National Institute of Environmental Health Science 2010 Environmental health perspectives Vol.118 No.7

<P><B>Background</B></P><P>Concern over phthalates has emerged because of their potential toxicity to humans.</P><P><B>Objective</B></P><P>We investigated the relationship between the urinary concentrations of phthalate metabolites and children’s intellectual functioning.</P><P><B>Methods</B></P><P>This study enrolled 667 children at nine elementary schools in five South Korean cities. A cross-sectional examination of urine phthalate concentrations was performed, and scores on neuropsychological tests were obtained from both the children and their mothers.</P><P><B>Results</B></P><P>We measured mono-2-ethylhexyl phthalate (MEHP) and mono(2-ethyl-5-oxohexyl)phthalate (MEOHP), both metabolites of di(2-ethylhexyl)phthalate (DEHP), and mono-<I>n</I>-butyl phthalate (MBP), a metabolite of dibutyl phthalate (DBP), in urine samples. The geometric mean (ln) concentrations of MEHP, MEOHP, and MBP were 21.3 μg/L [geometric SD (GSD) = 2.2 μg/L; range, 0.5–445.4], 18.0 μg/L (GSD = 2.4; range, 0.07–291.1), and 48.9 μg/L (GSD = 2.2; range, 2.1–1645.5), respectively. After adjusting for demographic and developmental covariates, the Full Scale IQ and Verbal IQ scores were negatively associated with DEHP metabolites but not with DBP metabolites. We also found a significant negative relationship between the urine concentrations of the metabolites of DEHP and DBP and children’s vocabulary subscores. After controlling for maternal IQ, a significant inverse relationship between DEHP metabolites and vocabulary subscale score remained. Among boys, we found a negative association between increasing MEHP phthalate concentrations and the sum of DEHP metabolite concentrations and Wechsler Intelligence Scale for Children vocabulary score; however, among girls, we found no significant association between these variables.</P><P><B>Conclusion</B></P><P>Controlling for maternal IQ and other covariates, the results show an inverse relationship between phthalate metabolites and IQ scores; however, given the limitations in cross-sectional epidemiology, prospective studies are needed to fully explore these associations.</P>

Effect of Recombinant Lactobacillus Expressing Canine GM-CSF on Immune Function in Dogs

Jin Young Chung,Eui Jae Sung,Chun Gyu Cho,Kyoung Won Seo,Jong Soo Lee,Dong Ha Bhang,Hee Woo Lee,Cheol Yong Hwang,Wan Kyu Lee,Hwa Young Youn,Chul Joong Kim 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.11

기초학습부진으로 의뢰된 일 광역시의 일반학급 초등학생의 심리, 정신과적 평가 및 부모의 특성

방수영(Soo-Young Bhang),박정환(Jung-Whan Park),임재인(Jae-In Lim) 대한소아청소년정신의학회 2011 소아청소년정신의학 Vol.22 No.1

Objectives:This study examined the prevalence of psychiatric problems in children with scholastic difficulties who had been referred for mental health services from the Office of Education in Ulsan Metropolitan City. Methods:Child psychiatrists evaluated the referred children using the DSM-IV. Evaluation tools included the Wechsler Intelligence Scale for Children-III, the Children’s Depression Inventory, the Korean form of the State-trait anxiety Inventory for children, the ADHD rating. Results:Seventy-six children consisting of 64 boys (84.2%) and 12 girls (15.8%) participated in the study. The average age was 10.3 (SD=0.93) years old. Approximately 74% of the children referred for scholastic difficulties were diagnosed with mental retardation. The Axis I diagnosis among these children were ADHD (86.8%), depression (21.1%), learning disorder (9.2%), communication disorder (4.8%), pervasive developmental disorder (3.6%), internet addiction (1.3%), and mood disorder (1.3%). Their overall measure according to the Child Depression Inventory was 22.7 (SD=16.8), that for the State-Trait Anxiety Inventory for Children was 33.3 (SD=7.9)/32.4 (SD=9.5), and that for the ADHD rating scale was 18.9 (SD=10.9). Conclusion:These results suggest that many children with scholastic difficulties have both complex psychiatric and educational problems.

간;바이러스간염 환자에서 복강경소견과 조직학적 소견의 비교관찰

박수헌,이영길,정규원,김부성,조세현,한준열,선희식,방춘상 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.2

Background/Aims: The authors compared laparoscopic changes of the diseased liver surface according to Shimadas classification with laparoscopic needle biopsy in order to clarify whether the two diagnostic criteria have consistency or discrepancy in each other. By serologicai tests the patients with chronic hepatitis B were 179 cases, chronic hepatitis C 22 cases and NBNC hepatitis 54 cases. Histologically the patients with non-specific reactive hepatitis were 35 cases, chronic lobular hepatitis 20 cases, chronic persistent hepatitis 18 cases, chronic active hepatitis 8~5 cases, subacute hepatic necrosis 32 cases, circumscribed hepatic necrosis 9 cases and liver cirrhosis 56 cases. Methods: We performed laparoscopy on 255 patients with chronic hepatitis and laparoscopic guided liver needle biopsy was done in all cases. Results: 1) Age incidence of chronic viral hepatitis was peak in chronic hepatitis C, and then that in chronic hepatitis B and NBNC heatitis in decreasing order. 2) Code numbers of liver surfaces were mainly numbers between 200 and 300 in chronic hepatitis B and NBNC hepatitis, but those of chronic hepatitis C were numbers between 300 and 400 which meant advanced patterns. 3) Comparing macroscopic fmdings of liver surfaces with histologic diagnosis by guided liver biopsy, the consistency of two criteria was 83.9% in all cases and the discrepancy was 16.1%. 4) Among the cases with diagnostic discrepancy, the patients showing macroscopically chronic hepatitis but histologically liver cirrhosis were predominant in chronic hepatitis B under the age of 40. In contrast to this, the cases showing surface changes of liver cirrhosis but histologically chronic hepatitis was mainly in chronic hepatitis C over the age of 40. Conclusions: The above results suggest that laparoscopy and guided liver biopsy may be very useful diagnostic tools to determine correct diagnosis, adequate treatment and prognosis.