AO Synthes 금속판을 이용한 전방 경추 유합술후 발생한 지연성 식도 천공

송하헌,김태균,심대무 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

Esophageal perforation after anterior cervical discectomy operation has a rare incidence. Also Delayed Esophageal perforation after anterior cervical discectomy has a very rare incidence. Esophageal perforaton is usually characterized as being due to the surgical exposure, metallic implant, bone graft, fractured vertebrae and polymethylmethacrylate. Esophageal perforaton result in fatal mediastinitis, which may lead to die from sepsis. The mortality rate continues to be more than 20%. Factors that adversely affect the outcome include the location and severity of the esophageal injury] associated injuries and delayed diagnosis and treatment. The purpose of this report is to present the our case of a patient who had delayed esophageal perforation by irritation of metallic screw and 3 weeks post operatively, and to know how can we get a early diagnosis and treatment in delayed esophageal perforation.

장벽경색이 선행한 Henoch-Schonlein 자반증 1례

한헌석,하태선,송형근,이상전,안묘순,박범수 충북대학교 의과대학 충북대학교 의학연구소 1993 忠北醫大學術誌 Vol.3 No.1

Henoch-Schonlein 자반증은 피부, 위장관, 관절, 신장 등을 주로 침범하며 소혈관염을 기본 병리 소견으로하는 전신성 혈관 장애 질환이다. 위장관계 증상으로는 복통, 오심 및 구토, 잠혈, 토혈, 흑색변 등이 있을 수 있고, 이러한 증상은 합병증 없이 회복되는 것이 보통이나 드물게는 장중첩증, 장벽경색 및 괴사, 장천공 등의 심한 합병증을 동반할 수도 있다. 이러한 위장관계 증상들은 특징적인 피부 소견에 선행하여 나타날 수도 있으며, 이때는 급성복증에 대한 감별진단이 중요하다. 저자들은 장벽경색이 선행하여 감별진단에 어려움을 겪고 시험적개복술을 시행한 이후에 특징적인 피부 자반이 발현되어 Henoch-Schonlein 자반증으로 진단할 수 있었던 증례를 경험하였기에 이를 보고하고자 한다. 본 증례는 입원 1일전부터 시작된 복통을 주소로 입원한 5세 남아가 배꼽 주위에 심한 경련성 복통을 지속적으로 호소하였고 이학적 소견상 배꼽주위의 압통, 장음의 감소, 흑색변 등이 있었으며 소장조영술상 공장 부위에 미만성의 불규칙한 점막비후 소견을 보여 제 8병일에 시험적개복술을 시행한 결과 근위 공장에 국한된 장괴사의 소견이 발견되어 절제 및 문합술을 실시 하였다. 병리학적 검사에서는 장벽경색의 소견을 보였다. 수술후에 복통은 완화되었으나 경미하게 지속되었고, 제 13병일경에 급성 부고환염이 병발되었다가 회복되었고 제 15병일경에는 하지에서부터 발현된 자반이 3일간 지속되었다. 결구 Henoch-Schonlein 자반증과 이의 합병증으로 발생한 근위 공장의 장벽경색으로 진단하였다. Colicky abdominal pain as symptom of Henoch-Schonlein purpura occurs in up to 70% of patients, and results from submucosal edema and hemorrhage. Abdominal pain and other GI symptoms such as nausea, vomiting, melena and hematemesis resolve mostly without any complications. But rarely life-threatening GI complications such as intussusception, intestinal mural infarction and necrosis, and massive hemorrhage may develope. In 14% of patients, abdominal pain may precede other symptoms, and creats diagnostic difficulties. We reports a case of the Henoch-Schonlein purpura presented with colicky abdominal pain which resulted from intestinal mural infarction and preceded characteristic purpuric skin lesion by several weeks. This 5 year old male patient complained of colicky abdominal pain, nausea and melena. Exploratory laparatomy was done and revealed intestinal mural infarction in proximal jejunum. One week later operation, purpuric skin lesion develiped in both leg and feet, and then, Henoch-Schonlein purpura was diagnosed.

Toxic Goiter 환자에서 골다공증 발생에 따른 대퇴골 간부 골절 : 1례 보고 A Case Report

김태균,송하현 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

In thyroid problems, thyroid acropachy that having clubbing fingers on distal phalanges, periosteonic new bone formation, swelling of soft tissues in bony changes can be developed, exopthalmos and pretibial myxedema is a part of this syndrome, in addition, osteoporosis can be accompanied in maltreated hyperthyroidism. It was happened fracture of femur shaft in a 30year-old man treated under the diagnosis of toxic goiter. He has severe osteoporosis but no clubbing finger and soft tissue swelling. The femur fracture treated by closed reduction and internal fixation with metal nail. We report one case of femur fracture due to osteoporosis developed from the toxic goiter with a review of the literature.

Castleman 질환 1례

안묘순,송형근,박범수,한헌석,하태선 충북대학교 의과대학 충북대학교 의학연구소 1993 忠北醫大學術誌 Vol.3 No.1

Castleman 질환은 주로 종격동 임파선을 침범하여 임상적, 조직학적으로 흉성종과 유사한 소견을 보이는 질환이다. 보통 침범된 임파선은 3cm에서 7cm의 크기를 보이며 경계가 뚜렷한 종양으로 나타난다. 조직학적 소견상 hyaline-vascular형(H-V형)과 plasma cell형의 두가지로 나눈다. 임상적으로는 hyaline-vascular형은 별증상이 없으며 보통 우연히 발견되고 드물게 기도와 기관지를 압박하는 증세를 보이기도 한다. plasma cell형은 빈혈, 적혈구침강속도의 증가, 고감마글로불린혈증, 저알부민혈증, 그리고 저트란스페린혈증을 보이기도 한다. 저자들은 생후 2개월부터 반복되는 호흡기 감염과 거친 숨소리를 보이면서, 성장 및 발육장애를 보인 14개월된 남아에서, 기도에서 우측 주기관지까지를 압박하고 있는 종양을 흉부 전산화단층촬영에서 발견하고 떼어낸 후 조직소견상 hyaline-vascular형의 giant lymph node hyperplasia의 소견을 보이는 Castleman 질환 1례를 경험하였기에 보고하는 바이다. Castleman's disease(angiofollicular lymph node hyperplasia) can arise from lymph nodes or extranodal tissues and can be classified histologically into the hyaline-vascular form, characterized by hyaline follicle-like structures interspersed with vascular tissue, or the plasma cell variant, in which the follicle-like structures are seperated by sheets of plasma cells amidst vascular interfollicular tissue. The clinical manifestations of the multicentric variant can be protean and inculude fever, night sweats, weight loss, lymphadenopathy, hepatosplenomegaly, pleural effusion, ascites, anemia, thrombocytopenia, polyclonal hypergammaglobulinemia, and neurological and renal abnormalities. We report a case of Castleman's disease in 14-month old male patient with the chief complaints of recurrent respiratory symptoms and delayed growth and development, who was diagnosed as having a hyaline-vascular form of above disease after the excision of pulmonary mass which compressed the right main bronchus.

흰쥐 척수손상 후 운동회복 양식의 도식적 분석

김상수,김하용,심대무,송하헌,차상도,김종환 대한척추외과학회 1997 대한척추외과학회지 Vol.4 No.1

Objectives : To understand the motor recovery pattern after spinal cord injury, We designed the quantitative measuring method of locomotion recovery using computerized motion analysis combined with video recordings. Materials and Methods : Using computerized motion analysis technique, locomotions of the 10 cord-hemisected Sprague-Dawley rats on the treadmill were graphically analyzed. Patterns of foot trajectories were plotted on two dimensions before and after unilateral spinal cord hemisecion at T7 level. Result : Immediately following dorsal hemisection, patterns of foot trajectories altered dramatically. Walking speed, stride length and height of hindfoot movements were markedly reduced. Coordination of left and right hindlimb was also disrupted. Although the lesions were unilateral, locomotor behavior was distrubed bilaterally. However, by six weeks, stride length and coordination of hindlimbs returned to near normal but vertical movement of the hindlimb recovered very little. Forelimb-hindlimb coordination was also initially disrupted but partially returned within three weeks. Conclusion : Computerized motion analysis is a sensitive technique for the detection of minor motor deficits following nerve injuries.

증상을 동반한 비골하 부골에 대한 Mini-Acutrak을 이용한 해부학적 정복술

송하헌 ( Ha Heon Song ),김동철 ( Dong Churl Kim ),김정우 ( Jung Woo Kim ),권석현 ( Seok Hyen Kweon ),김창수 ( Chang Su Kim ) 대한스포츠의학회 2006 대한스포츠의학회지 Vol.24 No.2

P-86 Lung cancer with hypertrophic pulmonary osteoarthropathy mimicking acromegaly

( Sung Heon Song ),( Ha Hun Song ),( Chang Won Ha ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

A 46-year old man visited our facility for acromegaly-like appearance. His both hands, both feet, and both ankles were enlarged. His fingers and toes Were clubbed. His face was little big and coarse. He smoked for 20 pack-years. Simple X-rays for hand, foot, leg and thigh showed periosteal proliferation of new bone. Whole body bone scan showed increased and diffuse uptake along cortical margins of diaphysis and metaphysic of both femurs and both tibias. Serum rheumatoid factor and anti- cyclic citrullinated petidie antibody were in normal range. Serum insulin growth factor 1 level was 112.0ng/mL in normal range (87 to 267ng/mL), so acromegaly was ruled out. Chest X-ray showed tumor like lesion in right upper lobe of the lung and chest computer tomography (CT) showed 4.5cm sized tumor in right upper lobe with atelectasis and mediastinal and right hilar lymphadenopathy. The peripheral needle approached biopsy was performed and biopsy specimen showed adenocarcinoma of mucinous type and lepidic pattern. Additional brain MRI showed multiple distant metastases to brain. Finally, he was diagnosed with stage IV (clinically T3N2M1b) adenocarcinoma of the lung. He had received systemic combination chemotherapy with pemetrexed and cisplatin. After 4 cycles of chemotherapy, painful swelling of both hands, both feets, and both ankles disappeared and chest CT scans showed partial response. Consecutively, he has received maintenance chemotherapy with pemetrexed.

Quantification of inhaled aerosol particles composed of toxic household disinfectant using radioanalytical method

Shim, Ha Eun,Lee, Jae Young,Lee, Chang Heon,Mushtaq, Sajid,Song, Ha Yeon,Song, Lee,Choi, Seong-Jin,Lee, Kyuhong,Jeon, Jongho Elsevier 2018 CHEMOSPHERE - Vol.207 No.-

<P><B>Abstract</B></P> <P>To assess the risk posed by a toxic chemical to human health, it is essential to quantify its uptake in a living subject. This study aims to investigate the biological distribution of inhaled polyhexamethylene guanidine (PHMG) aerosol particle, which is known to cause severe pulmonary damage. By labeling with indium-111 (<SUP>111</SUP>In), we quantified the uptake of PHMG for up to 7 days after inhalation exposure in rats. The data demonstrate that PHMG is only slowly cleared, with approximately 74% of inhaled particles persisting in the lungs after 168 h. Approximately 5.3% of inhaled particles were also translocated to the liver after 168 h, although the level of redistribution to other tissues, including the kidneys and spleen, was minimal. These observations suggest that large uptake and slow clearance may underlie the fatal inhalation toxicity of PHMG in humans.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Polyhexamethylene guanidine (PHMG), a humidifier disinfectant, was labeled with In-111. </LI> <LI> Aerosol particles comprising radiolabeled PHMG was exposed to rats for biodistribution study. </LI> <LI> Biological uptake and translocation level of inhaled PHMG was quantified for 1 week. </LI> <LI> Approximately 74% of inhaled PHMG was retained in the lungs 1 week after exposure. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

인라인 스케이트와 관련된 손상

송하헌 ( Ha Heon Song ),전철홍 ( Churl Hong Chun ),김동철 ( Dong Churl Kim ),김정우 ( Joung Woo Kim ),조용우 ( Yong Woo Cho ) 대한스포츠의학회 2005 대한스포츠의학회지 Vol.23 No.1

Regulation of retinal angiogenesis by endothelial nitric oxide synthase signaling pathway

Ha, Jung Min,Jin, Seo Yeon,Lee, Hye Sun,Shin, Hwa Kyoung,Lee, Dong Hyung,Song, Sang Heon,Kim, Chi Dae,Bae, Sun Sik The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.5

Angiogenesis plays an essential role in embryo development, tissue repair, inflammatory diseases, and tumor growth. In the present study, we showed that endothelial nitric oxide synthase (eNOS) regulates retinal angiogenesis. Mice that lack eNOS showed growth retardation, and retinal vessel development was significantly delayed. In addition, the number of tip cells and filopodia length were significantly reduced in mice lacking eNOS. Retinal endothelial cell proliferation was significantly blocked in mice lacking eNOS, and EMG-2-induced endothelial cell sprouting was significantly reduced in aortic vessels isolated from eNOS-deficient mice. Finally, pericyte recruitment to endothelial cells and vascular smooth muscle cell coverage to blood vessels were attenuated in mice lacking eNOS. Taken together, we suggest that the endothelial cell function and blood vessel maturation are regulated by eNOS during retinal angiogenesis.