뇌혈관질환 환자의 후유증의 개선에 대한 Propentofylline(HWA 285)의 임상 연구

최영빈,박정욱,한시령,양동원,나정호,김범생 최신의학사 1994 最新醫學 Vol.37 No.6

The factors that effect the freeze-drying rate and the stability of Salmonella typhi Ty21a

SR Kim,DW Park,HR Jeon,HJ Kim,SS Han,KH Kim,HJ Kim 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

척추후만곡증에 동반된 임신의 임상적 고찰

김승룡(SR Kim),이경구(KK Lee),유중배(JB Yoo),김경태(KT Kim),문형(H Moon),김두상(DS Kim) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.11

한양대학교 의과대학 산부인과학교실에서는 1977년 1월부터 1988년 12월사이 본원에 입원하 여 분만한 척추만곡증을 동반한 임신 10예를 분석하여 다음과 같은 결론은 얻었다. 1. 동기간중 분만건수는 21790예로 척추만곡증과 동반된 임신의 빈도는 1/2179이었다. 2. 산모의 평균연령운 28.5세, 평균신장은 140.5cm, 체중은 42.3kg이엇으며 초산부 9예, 경산 부 1예였다 3. 척추후만곡증의 부위는 흉추 7예, 흉요추부 2예, 요추 1예였고 원인은 외상 4예, 소아마비 1예, 나머지 5예는 병력상 원인을 알수 없었다. 4. 분만전에 심폐부전을 보인예는 2예로 모두 임신 35주경부터 소견이 있었고, 다른 2예에서 는 임신성고혈압을 동반하였다. 5. 분만시의 임신주수는 평균 39.3주였으며 1예에서는 심부전증으로 인하여 37주에 조산을 하였다. 6. 10예모두 제왕절개술로 분만하였으며 이중 2예에서 고전적제왕절개술을 시행하였다. 7. 출생아의 평균체중은 2730gm이었고 자궁내 태아발육지연은 5예에서 있었다. 8. 분만후 심폐부전이 새로이 발생한 예는 없엇으나 1예는 분만전 발생한 심부전이 회복되 지 않아 8개월후에 사망하였고, 다른 1예는 분만후 2일까지 빈호흡의 증상을 보였으나 호흡 하였다. From January 1977 to December, 1988, 10 cases of pregnancy associated with kyphoscoliosis were experinced at Hanyang Univircity Hospital and their clinical characteristics were analysed. During this period , the frequency of pregnancy associated with kyphoscoliosis was 1 to 2179 delivery. Mean height and weight of mother were 140.5cm and 42.3kg respectively. Affectived sites of spine were thoracic in 8 thoracolumbar in 2 and lumbar in 1, the causes of kyphoscoliosis wer trauma in 4, poliomyelitis in 1, and unknown in 5. The mean duration of disease was 24.4year . Cardiopulmonary decompensation symptoms developed in two patients at neat term and were managed conservatively to delivery. All the patients were delivery by cesarean section between 38 and 41 weeks . The mean birth weight was 2730 gm. Five of 10 babies showed intrauterine growth retardation . Nine patients showed uneventful postoperative course, but one patients who had shown antepartal decompensatory symptom died of cardiac failure 8 months later

Eagle's syndrome의 치험 1례

김인숙(Kim IS),최동주(Choi DJ),국승걸(Kuk SK),김성용(Kim SR),김성철(Kim SC),김도일(Kim DI) 대한치과의사협회 1996 대한치과의사협회지 Vol.34 No.12

An Accelerator Mass Spectrometry-Enabled Microtracer Study to Evaluate the First-Pass Effect on the Absorption of YH4808

Kim, A,Yu, B-Y,Dueker, SR,Shin, K-H,Kim, HS,Ahn, H,Cho, J-Y,Yu, K-S,Jang, I-J,Lee, H C. V. Mosby 2017 Clinical pharmacology and therapeutics Vol.102 No.3

Sertoli-Leydig 세포종양 1 예

김승룡,김경태,이재억,유중배,황정혜,김진조 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.12

저자 등은 중등도로 분화된 Sertoli-Leydig세포종양 1예를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. Sertoli-Leydig cell tumors belog to sex-cord storomal tumor and account for less than 0.5% of all ovarian tomors but are very interesting from pathologic and clinical point of view. Recently we experienced a stage Ia Sertoli-leydig cell tumor with intermediate differentiation. We present this case with review of related literatures.

비정상 임신 중기 혈청 태아 당단백치를 보이는 산모에서 태아 염색체 이상의 빈도 및 주산기 예후에 관한 연구

김승룡,황윤영,정성노,이춘근,황정혜,김종호,조율희 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.4

1992년 1월부터 1997년 6월 사이에, 모체 혈청 AF P이 2.5 MoM 이상이거나 0.5 MoM 이하로 측정되었으나, 초음파검사에서 태아의 신경관계 결손이나 다운증후군의 소견을 보이지 않았던 임신 14∼20주의 산모 88명을 대상으로 양수천자를 시행하여 태아의 핵형을 분석하고 최종 분만 결과을 조사하여 다음과 같은 결론을 얻었다. 1. 산모의 나이는 21∼43세(평균 29.4세)였으며 이 들 88명의 혈청 내 AFP의 최고치와 최저치는 각각 13.7 MoM과 0.2 MoM이었다. 2. AFP 증가군(n=42)에서의 AFP치는 2.5∼13.7 MoM (평균, 3.7 MoM), AFP 감소군(n=46)에서의 AFP 치는 0.2∼0.48 MoM(평균, 0.39 MoM)의 범위였다. 3. 88명 중 태아의 염색체 이상은 3명에서 발견되 었다. 이 중에는 염색체 수의 이상이 1예, 염색체 구 조의 이상이 2예였다. AFP 증가군에서 1예(2.4%), A FP 감소군에서 2예(4.3%)의 염색체 이상이 있었다. 4. AFP 증가군(n=42)에서는 1예의 태아 염색체 이상이 발견되었는데 46 XX inv(9)이었고, 이 산모의 AFP치는 2.6 MoM이었다. 5. AFP 감소군(n=46)에서의 태아 염색체 이상은 2예였고, 47 XXY, 46 XY inversion(9)이었으며, 이 산 모들의 MSAFP치는 각각 0.38과 0.4 MoM이었다. 6. 전체 88예 중 35세 이상의 산모는 11예(12%)로 써 high AFP군에서 6예, low AFP군에서 5예 있었으 나, 이들 중 염색체 이상은 없었다. 7. MSAFP 증가군의 주산기 예후를 보면 자궁 내 발육지연 4예, 조기분만 3예, 사산 2예, 임신성 고혈 압 2예, 선천성 기형 1예(Williams syndrome)였다. MSAFP 감소군 중에서는 자궁내 발육지연 2예, 사산 1예, 임신성 고혈압 1예, 과숙아분만 1예, 과대아 1 예가 발견되었다. 8. MSAFP 증가한 군에서는 MSAFP 감소군에 비 하여 자궁내 태아사망, 태아발육지연, 조산 등이 2배 정도 증가되는 경향을 보였으나, 통계적인 의의는 없는 것으로 생각된다. 또한 선천성 기형, 태반 유착 의 증가는 발견되지 않았다. 따라서 비정상적으로 AFP이 증가 또는 감소된 산 모의 경우, 태아 염색체 이상의 빈도가 증가하기 때 문에 초음파검사에서 이상이 발견되지 않아도 이들 에 대한 양수검사 및 태아 핵형검사는 필요한 것으 로 사료된다. 한편 AFP이 증가된 산모의 경우 주산 기 예후가 불량하여 태아사망, 발육지연, 조산 등이 증가하기 때문에 비록 태아기형이나, 태아 염색체 이상이 발견되지 않는다고 하여도 이들에 대한 산전 관리는 세심한 주의를 기울여야 할 필요가 있다고 사료된다. Purpose: The purpose of this study was to investigate the incidence of fetal chromosomal abnormality and perinatal outcome in pregnancy with unexplained midtrimester abnormal maternal serum alpha-fetoprotein (MSAFP) level. Methods: Eighty eight patients with high (> 2.5 MoM) (n=42) or low (< 0.5 MoM) AFP (n=46) but without any abnormal fetal sonographic findings underwent amniocentesis at 14∼20 weeks of pregnancy at the department of Obstetrics and Gynecology, Hanyang university hospital between January 1992 and June 1997. Their chromosomal analyses and perinatal outcomes were reviewed retrospectively. Results: The incidence of abnormal karyotyping was 3.4% (3/88). In high MSAFP group, it was 2.4% (1/42) and in low MSAFP group, it was 4.3% (2/46). Three abnormal karyotypes were 47 XXY, 46 XX inv (9), and 46 XY inv (9). Abnormal perinatal outcomes were found in 20.5% (18/88). In high MSAFP group, one congenital anomaly (2.4%), 2 intrauterine fetal deaths (4.8%), 4 IUGRs (9.5%), 2 PIHs (4.8%), 3 preterm deliveries (7.1%) were found. In low MSAFP group, 1 intrauterine fetal death (2.2%), 2 IUGRs (4.4%), 1 PIH (2.2%), 1 LGA (2.2%) were found. Conclusion: The risk of chromosomal abnomality were increased 4∼7 times in patients with unexplained abnormal AFP level. So, amniocentesis and fetal karyotyping are recommended for these patients. Furthermore, close observation were needed for pregnancy with abnormal MSAFP because perinatal outcomes were poorin this group.

자궁경부암 환자에 있어 telomerase 활성도의 임상측명

김승룡,김경태,조삼현,황윤영,문형,유중배,김기성,라명재 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.4

A current hypothesis gaining prominence proposes that activation of the telomerase is necessarey for cells to become immortal, or be capable of proliferating indefinitely. The theory suggersts that that almost all cancer cells must attain immortality for progression to malingnant state and, hence, require activation of telomerase. To assess the role of telomerase in the development of mailignant transformation of the uterine cervical carcinoma, telomerase activeiy was measured by using a recently developed sensitive RPR-based telomerase assay(telomeric repeat amplification protocol; TRAP)in benign uterine condition and invasive uterine cervical carcinoma tissues revealed to be telomerase positive (14/16, 88%) which represents a characteristic 6 bp ladder pattern, while none of the 4 cervical tissues with the nonspecific pathologic findings or just chronic cervictis which were obtained by simple bysterenctomy under the diagnoses of benign myoma or uterine prolapse showed any telomerase actiovity. These findings suggest that this enzyme activity may play a key role in the establishment and progression of the uterine cervical carcinoma. This activity of telomerase may influence from the initial stage of tumorigenesis of uterine cervical carcinoma because poitive findings were noticed from the early stage (stage (i 1a1) to the advanced stage. The results of neoadjuvant chemotherpy which were revealed in final histopathologic specimens following radical hysterectomuy, pelvic and raraaortic lymph nodes dissection (suggestion by Rosen et al,) were one grade IV wiht telomerase poistive, 2 grade III with all positivie, 5grade II with 3 positive 2 negative. The two cases of pelvic lymph node metastasis belong to the group of grade II and their activeities of telomerase were 1 positive and 1negative. The situation of apoptosis induced by antineoplastic chemotherapy has not been related to that of telomerase activeity. Furthemore, the late recurrences has been noticed over 5years follow-up following neoadjuvant chemotherapy and radical surgery for the management of the high risk group of patients (not shown in this study) This measn that the nowday`s regimen for induction tumoricidals may have been operating as dual effects (partial restoring and redamaging) to the cell cycle chekpoint. Therefore if telomerase inhibitor will be applied combined whit the induction chemotherapy, unexpected benefits mignt be obtained for the patient with the advanced uterine cervical carcinoma.

자궁경부암 환자에서 말초혈액 임파구를 이용한 림프킨활성살세포의 항암 효과 및 그 표현형에 대한 연구

김승룡,김경태,조삼현,황윤영,이재억,문형,김정목,조양자 대한부인종양 콜포스코피학회 1992 Journal of Gynecologic Oncology Vol.2 No.1

In adoptive immunotherapy of cancer using lymphokine-activated killer(LAK) cells induced from patients own peripheral blood, the efficient cytotoxicity of LAK cells is a principal requirement. Peripheral blood lyrnphocytes were obtained from 15 patients with cervical cancer and 13 normal women as a control, and LAK cells were induced with r-interleukin-2(rlL-2). Cytotoxic activity of cultured cells were measured by a 4h-51 Cr release assay using NK(natural killer)-sensitive K-562 cell line and NK-resistant RAJI target cells, and their surface phenotypes were determined by an imrnunofluorescence significantly increased compared with those activity without rIL-2. Despite the ratio between effector and target cells, the cytotoxic potential of NK and LAK cells of normal women were significantly higher than those of cervical cancer patients. (FO) However, LAK ce11 activity was relatively low but increased significantly in patients with cervical cancer. NK cell and LAK cell cytotoxicity in the group of tumor mass, 4 cm were significantly decreased compared with those in the group of tumor mass 4 cm. (Effector: target ratio = 50:1, NK: P=0.038, LAK : P = 0. 033) Surface phenotypes of peripheral lymphocytes and LAK cells were examined with indirect immunofluorescence method, The CD 3 subpopulations which are known to be major components af LAK cells were not diminished. After LAK cell induction with IL-2, the percentages of CD l6(Natural killer cell) populations were significantly increased in normal(11.2% vs 48.3%) and cervical cancer patients(11.8% vs 47.8 %). These data suggest that 1) the decline of NK and LAK cell act.ivity in cervical cancer patients, 2) the decreasing cytotoxicity with the increasing tumor mass, 3) the percentage of natural killer cell subpopulation dramatically increased with surface phenotype of LAK cells, 4) LAK cells may be applied for passive adoptive immunotherapy.

Annual and perennial life history strategies of Zostera marina populations under different light regimes

Kim, SH,Kim, JH,Park, SR,Lee, KS Inter-Research 2014 Marine ecology progress series Vol.509 No.-