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Ryu, Hyung Won,Park, Mi Hyeon,Kwon, Ok-Kyoung,Kim, Doo-Young,Hwang, Jung-Yeon,Jo, Yang Hee,Ahn, Kyung-Seop,Hwang, Bang Yeon,Oh, Sei-Ryang Elsevier 2019 Bioorganic chemistry Vol.92 No.-
<P><B>Abstract</B></P> <P> <I>Broussonetia papyrifera</I> has been used as a diuretic, tonic and suppressor of edema. Bioactivity-guided fractionation and metabolite investigation of root bark extracts of this plant resulted in the isolation and identification of six 1,3-diphenylpropanes (<B>1</B>, <B>2</B>, <B>8</B>, <B>10</B>, <B>17</B>, <B>20</B>), flavanone (<B>3</B>), two chalcones (<B>4, 5</B>), five flavans (<B>6</B>, <B>11</B>, <B>14</B>–<B>16</B>), dihydroflavonol (<B>7</B>) and five flavonols (<B>9</B>, <B>12</B>, <B>13</B>, <B>18</B>, <B>19</B>), including five new compounds (<B>5</B>, <B>7</B>, <B>8</B>, <B>19</B>, <B>20</B>) that inhibit NO production in LPS-induced RAW264.7 cells. The structures of compounds <B>1</B>–<B>20</B> were elucidated on the basis of spectroscopic data (1D and 2D NMR, MS, MS/MS, and HRMS). In particular, compounds <B>3</B>, <B>5</B>, <B>7</B>, <B>12</B>, and <B>20</B> exhibited significant inhibitory effects on the NO, iNOS, and pro-inflammatory cytokine (TNF-α and IL-6) production. Therefore, this study suggests that the flavonoid-rich products of <I>B. papyrifera,</I> including the new compounds, could be valuable candidates for the development of pharmaceuticals or functional foods in the prevention and treatment of anti-inflammatory disease.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The potent anti-inflammation was observed on <I>Broussonetia papyrifera</I> root bark. </LI> <LI> Five new and fifteen known compounds were isolated from the active fractions of <I>B. papyrifera</I>. </LI> <LI> The compounds were evaluated for inhibition of NO, iNOS, and pro-inflammatory cytokines. </LI> <LI> The new compounds <B>5</B>, <B>7</B>, <B>8</B>, and <B>20</B> showed anti-inflammatory effects dose-dependently. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
AHN, EUN HEE,KIM, DAE WON,SHIN, MIN JEA,RYU, EUN JI,YONG, JI IN,CHUNG, SEOK YOUNG,CHA, HYUN JU,KIM, SANG JIN,CHOI, YEON JOO,KIM, DUK-SOO,CHO, SUNG-WOO,LEE, KEUNWOOK,CHO, YOON SHIN,KWON, HYEOK YIL,PARK UNKNOWN 2016 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.38 No.1
<P>Antioxidant 1 (ATOX1) functions as an antioxidant against hydrogen peroxide and superoxide, and therefore may play a significant role in many human diseases, including diabetes mellitus (DM). In the present study, we examined the protective effects of Tat-ATOX1 protein on streptozotocin (STZ)-exposed pancreatic insulinoma cells (RINm5F) and in a mouse model of STZ-induced diabetes using western blot analysis, immunofluorescence staining and MTT assay, as well as histological and biochemical analysis. Purified Tat-ATOX1 protein was efficiently transduced into RINm5F cells in a dose-and time-dependent manner. Additionally, Tat-ATOX1 protein markedly inhibited reactive oxygen species (ROS) production, DNA damage and the activation of Akt and mitogen activated protein kinases (MAPKs) in STZ-exposed RINm5F cells. In addition, Tat-ATOX1 protein transduced into mice pancreatic tissues and significantly decreased blood glucose and hemoglobin A1c (HbA1c) levels as well as the body weight changes in a model of STZ-induced diabetes. These results indicate that transduced Tat-ATOX1 protein protects pancreatic beta-cells by inhibiting STZ-induced cellular toxicity in vitro and in vivo. Based on these findings, we suggest that Tat-ATOX1 protein has potential applications as a therapeutic agent for oxidative stress-induced diseases including DM.</P>
Wto-phase segmentation of color image using region merging constraints
Ryu, Chang-Yeon,Kwak, Nae-Joung,Park, Won-Bae,Ahn, Jae-Heyong 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.11 No.3
In this paper, we propose a method to segment color images in two phase using region merging constraints. First, the proposed method selects initial regions using vector quantization to reduce non-homogeneity and color information of an original image. From the initial regions, we merge regions by applying two-phase processing. In the first phase, we transform the original image from the RGB space to the HSI space and use hue component of HSI description to merge the initial regions. To consider the boundary of objects and reduce low saturation and intensity, we apply region merging constraints to the region merging algorithm. In the second phase, we merge regions obtained from the first phase by using Euclidean distance between adjacent regions for vector quantized images in the RGB space. We use a label table in two-phase region merging to reduce the processing time by decreasing iterative processes. Experimental results have demonstrated the superiority of the proposed method in segmenting results for various kinds of images.
Ryu, Seungmi,Kim, Hyunbum,Kang, Seokyung,Shin, Kwangsoo,Jung, Seon-Yeop,Heo, Jiwoong,Han, Jin,Yoon, Jeong-Kee,Lee, Ju-Ro,Hong, Jinkee,Ahn, Kyung Hyun,Hyeon, Taeghwan,Hwang, Nathaniel Suk-Yeon,Kim, Byu American Chemical Society 2017 Chemistry of materials Vol.29 No.12
<P>Current heterogeneous cell assembly techniques in coculture systems rely on irreversible cell layering or a cell separation membrane. However, the techniques possess major drawbacks of inefficiency in direct interactions of the assembled cell layers and cell separation following coculture, which hamper characterization and therapeutic applications of the cells following coculture. Here, we develop a reversible cell layering platform for assembly of heterogeneous cells that allows both active direct cell cell interactions and facile cell separation. Anionic maleimide-chondroitin-sulfate is grafted onto the surface membrane of myogenic C2C12 cells and human mesenchymal stem cells (hMSCs) to modify the surface charge of the cells without cytotoxicity. A highly porous chitosan thin film is formed in situ interspacing between the heterogeneous cell layers via ionic cross-linking of cationic chitosan and anionic functionalized cells, forming compactly assembled double-layered cell constructs. The chitosan film enables layering of the cells, which allows active direct interactions between the cell layers, and facile delayering of the cells through simple treatment with mild shear stress. The developed platform promotes the myogenic commitment of hMSCs via direct contact with C2C12 cells, mimicking the interactions that trigger stem cell differentiation in vivo. Delivery of the myogenic committed cells to muscle injured animal models shows evident muscle regeneration.</P>
생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색
류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-
Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.
고도비만 환자에서 복강경 위소매절제술 후 발생한 누공의 내시경 치료 1예
류민선,심기남,조원영,김찬용,강현주,김미연,안소영,이윤표,조형원,정성애,이주호 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.2
Laparoscopic sleeve gastrectomy can reduce morbidity and mortality in patients with morbid obesity, but it can cause complications such as a gastrointestinal leak. A 30-year-old morbidly obese female who had type 2 diabetes mellitus and hypertension with estimated body mass index of 40.2 kg/m2 was admitted. Laparoscopic sleeve gastrectomy was performed. On postoperative day 19, a leak was suspicious on physical examination and radiologic findings. Conservative management was performed, but the patient was hemodynamically unstable and imminently septic. After laparoscopic drainage procedure, esophagogastroduodenoscopy was performed and revealed the fistula opening at staple line just below gastroesophageal junction. Fibrin tissue adhesive was injected around the fistula and the esophageal covered stent was inserted to cover the leak. At 14th days after stent insertion, the barium study confirmed no more leak. In this case, we experienced that the esophageal stent insertion with fibrin tissue adhesive injection may reduce recovery time of the fistula developed after laparoscopic sleeve gastrectomy
Structure and properties of graphene oxide/cellulose hybrid fibers via divalent metal ions treatment
Ryu, Jisu,Lim, Jin Seong,Ahn, Seokhoon,Jo, Seong Mu,Ko, Frank K.,Lee, Joong Hee,Hwang, Jun Yeon Springer-Verlag 2018 Cellulose Vol.25 No.1
<P>Cellulose hybrid fibers (CeHFs), hybridized via graphene oxide (GO) and metal ions (Ca2+), are synthesized by dry-jet wet spinning. The synthesized GO-Ca2+-CeHFs exhibit the tensile strength and the breaking elongation of 551 +/- 37.5 MPa and 5.9 +/- 0.4%, respectively, while the GO/cellulose composite fibers (GO-CeFs) show the tensile strength of 403 +/- 76.0 MPa and the elongation of 4.5 +/- 0.5%; thus, the GO-Ca2+-CeHFs demonstrate improved mechanical properties over GO-CeFs by 37 and 31% in terms of tensile strength and elongation, respectively. These results are attributed to the metal ions that form a good interfacial interaction between the functional groups of cellulose and GO. In addition, the tensile strength of GO-Ba2+-CeHFs is as high as 580 +/- 25 MPa, which is induced by the difference in the ionic radius. Therefore, the high mechanical properties of the synthesized cellulose-based fibers have the potential to be used as sustainable alternative to the synthetic fibers used in the industrial applications.</P>
( Yeon-hee Park ),( Ri Ryu ),( Seung-geun Ahn ),( Kyoung-a Kim ),( Jae-min Seo ) 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 2020 Oral Biology Research (Oral Biol Res) Vol.44 No.3
Stevens-Johnson syndrome (SJS) is a cytotoxic immune disorder that causes serious damage to the skin and mucous membranes. SJS is a rare disorder that is triggered by particular medications or infections. De Man (1979), for the first time, described an abnormal root development due to SJS. While systemic complications were frequently reported, the abnormal root development in SJS has been rarely reported as an oral and maxillofacial complication of SJS. In this case report, a 26-year-old woman who had experienced SJS at the age of 9 year exhibited excessive tooth wear on whole dentition. While multiple teeth with incomplete root development showed slightly increased mobility, these teeth were not pathological and were erupted up to their normal functional position. Therefore, full-mouth rehabilitation procedures were completed to protect the worn dentition and improve the masticatory function and anterior esthetics.
Ryu, Ka Yeon,Sung, Dan-Bi,Won, Suk-Young,Jo, Ara,Ahn, Kyusang,Kim, Hyun Yeong,ArulKashmir, Arulraj,Kwak, Kyungwon,Lee, Chongmok,Kim, Won-Suk,Kim, Kyungkon Elsevier 2018 Dyes and pigments Vol.149 No.-
<P><B>Abstract</B></P> <P>New small molecular semiconductors with small band gap and low-lying highest occupied molecular orbital (<I>E</I> <SUB>HOMO</SUB>), namely TBDPPOT, TBDPPEH, and TBDPPEHT4 were synthesized by incorporating the B←N bridged thienylthiazole and diketopyrrolopyrrole (DPP) derivatives. TBDPPOT and TBDPPEH were prepared, respectively, using two different DPPs having 1-octyl and 2-ethylhexyl moiety as the solubilizing group. In addition, the band gap of the TBDPPEH is further reduced by introducing planar thienothiophene unit, which was used for the preparation of TBDPPEHT4. These synthesized SMs are blended with fullerene derivative to construct a photo-active layer for organic photovoltaics. Among OPVs utilizing those SMs, the TBDPPEH exhibits highest power conversion efficiency of 3.21% with an exceptionally high <I>V</I> <SUB>OC</SUB> of 0.92 V, which is ascribed to low-lying HOMO energy level of −5.62 eV. It is expected that the utilization of TBDPPEH as a photo-active layer for OPVs would enhance the oxidation stability of the OPVs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Small molecular semiconductors with low-lying HOMO were synthesized. </LI> <LI> These molecules contain B←N bridged thienylthiazole and diketopyrrolopyrrole derivatives. </LI> <LI> Solar cell based on those molecules exhibited high <I>V</I> <SUB>OC</SUB> values. </LI> </UL> </P>