백서에서 척수손상이 뇌하수체-고환호르몬 축에 미치는 영향

박양일,노준화,오봉렬,유명식 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.10

O‐GlcNAcase is essential for embryonic development and maintenance of genomic stability

Yang, Yong Ryoul,Song, Minseok,Lee, Ho,Jeon, Yoon,Choi, Eun‐,Jeong,Jang, Hyun‐,Jun,Moon, Hyo Youl,Byun, Ha‐,Young,Kim, Eung‐,Kyun,Kim, Dae Hyun,Lee, Mi Nam,Koh, Ara,Ghim, Jaewa Blackwell Publishing Ltd 2012 Aging cell Vol.11 No.3

<P><B>Summary</B></P><P>Dysregulation of O‐GlcNAc modification catalyzed by O‐GlcNAc transferase (OGT) and O‐GlcNAcase (OGA) contributes to the etiology of chronic diseases of aging, including cancer, cardiovascular disease, type 2 diabetes, and Alzheimer’s disease. Here we found that natural aging in wild‐type mice was marked by a decrease in OGA and OGT protein levels and an increase in O‐GlcNAcylation in various tissues. Genetic disruption of OGA resulted in constitutively elevated O‐GlcNAcylation in embryos and led to neonatal lethality with developmental delay. Importantly, we observed that serum‐stimulated cell cycle entry induced increased O‐GlcNAcylation and decreased its level after release from G2/M arrest, indicating that O‐GlcNAc cycling by OGT and OGA is required for precise cell cycle control. Constitutively, elevated O‐GlcNAcylation by OGA disruption impaired cell proliferation and resulted in mitotic defects with downregulation of mitotic regulators. OGA loss led to mitotic defects including cytokinesis failure and binucleation, increased lagging chromosomes, and micronuclei formation. These findings suggest an important role for O‐GlcNAc cycling by OGA in embryonic development and the regulation of the maintenance of genomic stability linked to the aging process.</P>

舟村 申?의 『保幼新編』 편찬과 『舟村新方』

양승률(Yang Seung-ryoul) 한국학중앙연구원 2011 장서각 Vol.0 No.25

이 글은 조선 후기의 유학자 舟村 申?(1620∼1669)의 생애 및 의료 활동과 그가 저술한 것으로 전하는 의약서인 『舟村新方』과 『保幼新編』에 대해 살펴본 것이다. 『주촌신방』은 原本이 없이 筆寫本, 鉛活字本, 『宜彙』, 『(增補)單方新編』 등에 전하고 있어 원본의 복원에 어려움이 있었다. 필자는 새로 발굴한 『舟村集』과 『保幼新編』 필사본 등을 통해서 신만의 생애와 의료 활동, 그의 저서로 전하는 『주촌신방』의 원본에 보다 가까이 다가갈 수 있었다. 신만은 아버지 申翊隆의 병환 치료 목적으로 復泉 姜鶴年에게서 醫術을 배운 후 의료에 대한 관심을 갖고 의서를 섭렵했다. 1639년경에는 아버지와 함께 懷德 宋村(현 대전광역시 대덕구 송촌동)에 이주한 후 同春堂 宋浚吉이 중심이 되어 설립한 醫局(舍)에 깊이 관여했다. 더 나아가 의국과 관련하여 의료 활동을 하였고 이를 토대로 의서 편찬을 결심한 것으로 보인다. 또한 자신의 아이를 천연두로 잃은 뼈아픈 경험은 『보유신편』을 편찬하는 중요한 계기가 되었다. 신만은 1659년경 鎭岑 舟村(현 대전광역시 유성구 용계동 일대)에 거주하면서부터는 직접 약초 재배와 臨床을 거치면서 1669년 죽을 때까지 새로운 의서의 완성에 심혈을 기울인 것으로 추정된다. 『주촌신방』 서문을 포함하고 있는 『보유신편』 범례는 그의 저술 의도와 향촌민을 위한 실용적인 경험 처방의 생성 과정을 간결하고 정확하게 표현한 것이다. 또한 『보유신편』 필사본은 그동안 그의 저서로 알려진 『주촌신방』의 원본일 것이며, 明(成)無忌가 편찬한 것으로 전하는 『보유신편』 판본은 신만이 편찬한 것이 잘못 전해진 것으로 판명되었다. 결국 그동안 신만의 저서로 알려진 『주촌신방』은 이를 포함하는 『보유신편』이고, 『보유신편』은 신만이 그의 아버지와 자식의 치료과정에서 얻은 처방과 일반 백성을 치료하면서 지은 의서로 전래 古方과 민간 처방과 임상을 통한 方門의 집대성이라 볼 수 있다. 또한 『보유신편』의 원본 복원은 현존 『보유신편』 필사본과 『주촌신방』의 필사본, 연활자본, 『의휘』, 『(증보)단방신편』 등에 대한 정밀한 비교 검토로 가능할 것이다.

초등 체육수업을 소홀히 하는 원인 분석

양갑렬(Gab Ryoul Yang) 한국체육교육학회 2000 한국체육교육학회지 Vol.4 No.2

The purpose of this research was to analyze the causes neglected in physical education classes of elementary school. To achieve the purpose of this study, the research method used in this study was the qualitative case study. Participants of this study were consisted of six elementary school teachers(3 males and 3 female) in Kyunggi Province, Korea. In order to collect the data needed for the study, qualitative research data collection methods were used: nonparticipant observation, documents gathering and in-depth interview. Colby`s cause-chain approach were transform into used to analyze collected data where by the methods of transcription, encoding, categorization, subject formation. The validity and the reliability of this study were verified by triangulation, member checking and peer debriefing. And make effort to enhance the research`s morality. The analysis resulted in the fact that physical education class neglect was sub-categorized into the cause of 10 kinds. The major results of the analyses on this study are as follows. why the physical education classes neglected at elementary schools was, in summary, its poor connectivity to other subjects, teachers` recognition that it is less important than other subjects, lack of teachers` professional skills and teaching materials, climatic conditions and frequent school events and miscellaneous tasks likely to act as heavy burden upon teachers.

초등교사의 체육수업 내용선택과 수업대체 분석

양갑렬(Gab Ryoul Yang),김종욱(Jong Wook Kim) 한국스포츠교육학회 1999 한국스포츠교육학회지 Vol.6 No.1

The purpose of this study was to understand the trend of teachers` curricular choices and class substitution of elementary physical education class. Total of 311 elementary school teachers were participated in this study. The revised questionnaire developed by Faucette(1990) was used to collect data regarding curricular choice and class substitution. SPSS PC+ 8.0 package program was used to analyze data. Chi square was used to reveal statistical differences on class substitution between sexes, and teaching career The findings of this study were as follows: 1) Teachers` PE class curricular activity sphere was mainly "other activities" such as football, dodgeball, kickball, free play, folk play which are not included in national level curriculum of 6th grade. 2) About 80% of teachers substitute PE class at least once a week 3) The curricular choices was significantly different between teaching careers. 4) Class substitution was significantly different between teaching careers, and sexes To implement curriculum appropriately, the quality of teacher training program regarding physical education should be enhacned. In addition, placement of PE spcialized teacher should be facilitated in future.

左則 上두骨 및 頰骨에 發生한 殲維性 骨異形成症의 治驗例

梁棟奎,朴相俊,金秉民,金基元,金鍾烈 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

Fibrous dysplasia is an idiopathic skeletal disorder in which medullary bone is replaced and disturbed by poorly organized, structually unsound fibroosseous tissue, which may produce cortical expansion. When facial bones are involed, considerable esthetic deformity may result. The term monostotic fibrous dysplasia has been applied when one bone is involved : when more than one bone is affected, the term polyostotic used. The polyostotic form may be accomplished by pigmented skin lesion (Jaffe type), or by pigmented skin lesions with endocrine disturbance (Albright syndrome). No general agreement exists on the cause of fibrous dysplasia. A few authors have suggested that fibrous dysplasia arises as a resujlt of trauma. It occurs predominantly in infant, adolescent females and runs a variable clinical course. When several bones are involed, it tends to be unilateral. Involements of alveolar bone may produce displacement of teeth with malocclusion, or loss of teeth, or both. Radiographycally, ti shows an indistinctly delimited osteolytic defect with a bubble - like pattern, but without a sclerotic rim. The preferred treatment is almost always surgery. If the lesion is extensive, surgical intervention with use of recontouring procedures aimed at the correction of esthetic or funtional disturbances is preferred treatment. Now, we present a case of fibrous dysplasia on the left maxilla and the zygoma treated by bony contourign via hemicoronal flap and intraoral approach with good results.

경부도상 피판을 이용한 구강내 결손부의 재건

양동규,신상훈,서종천,이성근,김종렬 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.3

Various cutaneous as well as myocutaneous flaps have been designed for the reconstruction of tissue defects caused by the excision of oral cancer. Among these flaps, cervical island skin flap have been introduced by Farr et al and more have developed by Tashiro et al. This flap has many advantages. The flap minimizes donor size by use of cervical operation wound, flap size available is adequate for most oral defects and the procedure is relatively simple and time saving. However, this flap is not applicable in patients where there are large tissue defects and metastasis is suspected. We used this flap for it's rapid simple, and effective, primary closure of oral defects after cancer ablation and we have found this flap very useful for the reconstruction of relatively small oral defects.

전립선비대증과 남성형탈모증의 연관성

오봉렬,김성진,문재동,김형남,권동득,원영호,류수방,박양일 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.6

BPH 치료에 있어서 Terazosin의 효과

오봉렬,정승일,권동득,박광성,류수방,박양일,최찬 최신의학사 2000 最新醫學 Vol.43 No.4

흰쥐 방광내 BCG 주입 후 Nitric Oxide Synthase 유전자 및 단백질 발현의 변화

오봉렬,권동득,류수방,박양일,안규윤,김형진 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.4