위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

지역냉방 시스템용 초고효율 판형 열교환기 개발에 관한 연구

박재홍(Jae-Hong Park),임혁(Hyug-Lim),조성열(Sung-Youl Cho),강인성(In-Sung Kang),김정규(Jung-Kyu Kim),허인은(In-Eun Hur),고성규(Seong-Kyu Ko),곽승식(Sung-Sik Kwak),김종재(Jong-Jae Kim) 한국마린엔지니어링학회 2010 한국마린엔지니어링학회 학술대회 논문집 Vol.2010 No.10

Plate heat exchanger consists of thin, rectangular, pressed sheet metal plates that are sandwiched between full peripheral gaskets and clamped together in a frame. The frame has a fixed end-cover plate, fitted with the connecting ports, which is bolted together with a movable cover plate to hold the embossed plates in between; the top and bottom carrying bars allow proper alignment of the plate stacks. When compared with the well-established shell and tube heat exchangers, the plate heat exchanger shows a lot of advantages like high NTU values, compactness, low cost, multi duties and reduced fouling etc. Plate heat exchangers are often used to transfer heating or cooling water which is produced in the energy production( district heating or district cooling) facilities to residential areas and industrial parks. The district cooling systems of Middle East are the biggest market of plate heat exchanger, but the technical specifications for cooling system are different from the domestic one. To achieve its specifications, the new plate heat exchanger was developed, and its thermal performance results are introduced in this paper.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

Xanthomonas sp. EPS-1의 Exopolysaccharide생산을 위한 무기염류의 영향

박석규,손봉수,이상원,서권일,김홍출 순천대학교 기초과학연구소 1995 基礎科學硏究誌 Vol.6 No.-

For the production of high viscosity exopolysaccharide from Xanthomonas sp. EPS-1 which isolated and identified from soils, optimum concentration of inorganic salts were investigated : 0.2% KH_2PO_4, 0.05% MgSO_4·7H_2O, 0.3% NaCl, 0.005% CaCO_3, 0.007% FeSO_4·7H_2O, 0.005% MnSO_4·7H_2O. When EPS-1 strain was cultivated at 30℃ for 72 hours in a jar fermentor (impeller speed 300 rpm, aeration rate 3 vvm, 2 liter), polymer content, product rate and yield(Y_p/s) was 18.4g/ℓ, 0.26g/ℓ/h and 37%, respectively.

시민권규약과 한국법

박홍규 嶺南大學校附設 社會科學硏究所 1992 社會科學硏究 Vol.12 No.2

노동법과 자기결정권

박홍규 嶺南大學校 附設 社會科學硏究所 1998 社會科學硏究 Vol.18 No.1

<요약문> 근로자의 '인간다운 생활'을 보장한다는 이념 하에서 사용자의 의사만이 아니라 근로자의 의사에 반해서도 근로조건의 최저기준을 실현하고자 하는 근로조건법은 노동법 중에서도 자기결정의 이념과 가장 동떨어진 영역으로 볼 수 있다. 그래서 자기결정권을 중시하는 경우 근로조건법 상의 규제를 완화하거나 그 탄력화를 주장하는 견해가 생겨난다. 그러나 자기결정권을 중시하는 것이 필연적으로 규제완화의 요구와 직결되는 것이 아님을 주의하여야 한다. 우리는 근로조건법의 여러 조항을 자기결정권과 관련하여 재검토할 필요가 있음은 부정하지 않는다. 그러나 그것은 근로조건법에 의한 자기결정에 대한 과도한 제한을 검증하는 것만이어서는 안 된다. 도리어 그것은 현행법에 의한 규제의 의의를 명확하게 밝히고, 그것에 더욱 강고한 기초를 부여하는 것이어야 한다. 곧 자기결정이념과 근로자보호이념이라고 하는 두 개의 축을 염두에 두면서 현행법을 추상적으로 평가할 것이 아니라, 현실 노사관계 하에서 당해 규정의 기능을 신중하게 검토하여야 한다. 그러한 검토에 의하면 자기결정을 위한 규제완화 보다도 도리어 자기결정을 후퇴시킨 규제 강화가 요구되는 경우도 있다. 특히 한국에서는 근로자의 자기결정을 보장하기 위하여 해고제한의 강화, 개별적 동의없는 전직 및 시간외근로의 금지, 권리행사를 이유로 하는 불이익취급의 금지 등과 같은 규제가 필요하다.학문분류기호: C1108(노동법)

국제노동법의 연혁과 조직

박홍규 嶺南大學校附設 社會科學硏究所 1995 社會科學硏究 Vol.14 No.2

數式表示法에 依한 船型의 初期計劃에 關한 硏究

朴魯植,曺奎鍾,洪性完 울산대학교 1977 연구논문집 Vol.8 No.2

本 硏究는 韓國 商工部 標準型船 中 G.T. 10,000?級 Liner船型에 數式表示法을 適用하여, 原船型과 數式表示에 依해 얻은 船型과를 比較檢討하여, 本 方法이 船型의 初期設計에 實用 可能性이 있음을 確認하였고 本法의 應用에 必要한 program 및 각 parameter들의 變化에 따른 水線形狀의 變化를 調査하였다. This paper applied the liner form of G.T. 10,000 ton class ship included in the standard ship forms of the Cmooerce and Industry Ministry, to represent the ship form mathematical mehtod. This discription compared with and inspected both this results and original lines. and , It was investigated that the variations of waterline form in accordance with the varing water line paramenters and form parameters in order to adopt the datafor the applications of this method.

음악 감상을 통한 열린 교육

박홍규,화성인 晋州敎育大學校 初等敎育硏究所 1997 初等敎育硏究 Vol.7 No.-