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Ko Nayeon,Lee Hyun Haeng,Kim Kyungmin,Kim Bo-Ram,Moon Won-Jin,이종민 대한뇌신경재활학회 2021 뇌신경재활 Vol.14 No.3
Cortical lesions of the supplementary motor area (SMA) are important in balance control and postural recovery in stroke patients, while the role of subcortical lesions of the SMA has not been studied. This study aimed to investigate the subcortical projections of the SMA and its relationship with ataxia in supratentorial stroke patients. Thirty-three patients with hemiparesis were divided into 3 groups (severe ataxia, n = 9; mild to moderate ataxia, n = 13; no ataxia, n = 11). Ataxia severity was assessed using the Scale for Ataxia Rating Assessment. Diffusion tensor imaging analysis used the fractional anisotropy (FA) values and tract volume as parameters of white matter tract degeneration. The FA values of regions related to ataxia were analyzed, that is the SMA, posterior limb of the internal capsule, basal ganglia, superior cerebellar peduncle, middle cerebellar peduncle, inferior cerebellar peduncle, and cerebellum. Tract volumes of the corticostriatal tract and cortico-ponto-cerebellar (CPC) tract originating from the SMA were evaluated. There were significant differences among the 3 groups in FA values of the subcortical regions of the CPC tract. Furthermore, the volume of the CPC tract originating from the SMA showed significant negative correlation with ataxia severity. There was no correlation between ataxia and corticostriatal tract volume. Therefore, we found that subcortical lesions of the CPC tract originating from the SMA could contribute to ataxia severity in stroke patients with ataxic hemiparesis
Postoperative anti-PD-1 antibody treatment to reduce recurrence in a cancer ablation surgical wound
Choi, Nayeon,Shin, Da-Yong,Kim, Hye Jin,Moon, Uk Yeol,Baek, Kwan-Hyuck,Jeong, Han-Sin Elsevier 2018 The Journal of surgical research Vol.221 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Postoperative radiation and chemotherapy are routinely applied for microscopic residual diseases; however, treatment outcomes are not optimal, and patients frequently suffer from treatment-related toxicities. To search for an effective and less-toxic adjuvant treatment for patients with high risk of recurrence, the preventive effect of anti-programmed cell death protein 1 (PD-1) treatment was evaluated in an in vivo animal model of post-surgical tumor recurrence.</P> <P><B>Materials and methods</B></P> <P>An animal model of postsurgical tumor recurrence (SCCVII tumors in C3H mice) was established by reinoculating tumor cells (10<SUP>5</SUP> cells) into surgical wound of primary tumor resection. Initial and recurrent tumors were compared by an immunohistochemistry and complementary DNA microarray. Using this <I>in vivo</I> model, tumor recurrence rates were evaluated in the animals receiving anti-PD-1 treatments. Animals were rechallenged with tumor cells, and interferon gamma secretion from spleen cells was analyzed to determine tumor-specific antitumor immunity.</P> <P><B>Results</B></P> <P>FoxP3<SUP>high</SUP> cell population was significantly elevated in recurrent tumors compared with that in primary tumors. Some immune response–related factors (granzyme F, neuronal leucine-rich repeat protein 1, myosin heavy chain 3, and transmembrane protein 8C) showed significant differences between primary and recurrent tumors. In this animal model, anti-PD-1 treatments significantly suppressed tumor recurrence. Importantly, tumor induction was significantly reduced when anti-PD-1–treated mice were rechallenged with tumor cells. Tumor cell–specific interferon gamma production was increased in these animals.</P> <P><B>Conclusions</B></P> <P>Postoperative anti-PD-1 treatment significantly reduced recurrence in a cancer ablation surgical wound in an <I>in vivo</I> model of tumor recurrence. Our data lay the preclinical groundwork for the future clinical validation of adjuvant anti-PD-1 treatments in patients.</P>
알러지 저감밀 오프리 밀가루의 품질 특성과 제빵 및 제면 적성
문유진 ( Yujin Moon ),조혜진 ( Hyejin Cho ),백나연 ( Nayeon Baek ),샤톈이 ( Tianyi Xia ),권미라 ( Meera Kweon ) 한국식품조리과학회 2021 한국식품조리과학회지 Vol.37 No.6
Purpose: This study aimed to explore the quality characteristics and bread-making and noodle-making properties of low allergy wheat (‘O-free’) flour. Methods: ‘O-free’ flour and three commercial wheat flours (high-H, medium-M, low-L gluten strength) were used. Solvent retention capacity (SRC), sodium dodecyl sulfate (SDS)-sedimentation volume, pasting and gelatinization properties using rapid visco analyzer and differential scanning calorimetry, and dough mixing property using a mixograph of the flour samples were determined. In addition, their bread- and noodle-making performance was evaluated. Results: The SRC values in all four solvents and the SDS-sedimentation volume of ‘O-free’ flour were lower than those of H and M flour and higher than those of L flour. The pasting and gelatinization properties of ‘O-free’ flour starch were similar to those of the other flour samples. The dough mixing property and bread-making performance of the ‘O-free’ flour were inferior to the H and M flour but superior to the L flour. On the other hand, the noodle-making performance of the ‘O-free’ flour was inferior to all three flours. Conclusions: Overall, it was confirmed that ‘O-free’ flour, which lacks omega-gliadin, has inferior gluten protein quality and processing performance compared to H or M flours that are mainly used for making bread and noodles. Performance improvement was necessary by controlling other basic ingredients and processing conditions.
Can we predict preterm birth by analyzing the vaginal microbiome using machine learning techniques?
( Sunwha Park ),( Jeongsup Moon ),( Nayeon Kang ),( Young Min Hur ),( Young-ah You ),( Soo Min Kim ),( Gain Lee ),( Yun Ji Jung ),( Young-han Kim ),( Taesung Park ),( Young Ju Kim ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-
Development of End-spliced Dimeric Nanodiscs for the Improved Virucidal Activity of a Nanoperforator
Mi Soo KIM,Hyunseok OH,Seokoh MOON,Soomin KIM,Jeonghui MOON,NaYeon KIM,Dae-Hyuk KWEON 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Lipid-bilayer nanodiscs (NDs) wrapped in membrane scaffold proteins (MSPs) have primarily been used to study membrane proteins of interest in a physiological environment. Recently, NDs have been employed in broader applications including drug delivery, cancer immunotherapy, bio-imaging, and therapeutic virucides. Here, we developed a method to synthesize a dimeric nanodisc, whose MSPs are circularly end-spliced, with long-term thermal stability and resistance to aggregation. The end-spliced nanodiscs (esNDs) were assembled using MSPs that were self-circularized inside the cytoplasm ofEscherichia colivia highly efficient protein trans-splicing. The esNDs demonstrated a consistent size and 4-5-fold higher stability against heat and aggregation than conventional NDs. Moreover, cysteine residues on trans-spliced circularized MSPs allowed us to modulate the formation of either monomeric nanodiscs (essNDs) or dimeric nanodiscs (esdNDs) by controlling the oxidation/reduction conditions and lipid-to-protein ratios. When the esdNDs were used to prepare an antiviral nanoperforator that induced the disruption of the viral membrane upon contact, antiviral activity was dramatically increased, suggesting that the dimerization of nanodiscs led to cooperativity between linked nanodiscs. We expect that controllable structures, long-term stability, and aggregation resistance of esNDs will aid the development of novel versatile membrane-mimetic nanomaterials with flexible designs and improved therapeutic efficacy.