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Ko Nayeon,Lee Hyun Haeng,Kim Kyungmin,Kim Bo-Ram,Moon Won-Jin,이종민 대한뇌신경재활학회 2021 뇌신경재활 Vol.14 No.3
Cortical lesions of the supplementary motor area (SMA) are important in balance control and postural recovery in stroke patients, while the role of subcortical lesions of the SMA has not been studied. This study aimed to investigate the subcortical projections of the SMA and its relationship with ataxia in supratentorial stroke patients. Thirty-three patients with hemiparesis were divided into 3 groups (severe ataxia, n = 9; mild to moderate ataxia, n = 13; no ataxia, n = 11). Ataxia severity was assessed using the Scale for Ataxia Rating Assessment. Diffusion tensor imaging analysis used the fractional anisotropy (FA) values and tract volume as parameters of white matter tract degeneration. The FA values of regions related to ataxia were analyzed, that is the SMA, posterior limb of the internal capsule, basal ganglia, superior cerebellar peduncle, middle cerebellar peduncle, inferior cerebellar peduncle, and cerebellum. Tract volumes of the corticostriatal tract and cortico-ponto-cerebellar (CPC) tract originating from the SMA were evaluated. There were significant differences among the 3 groups in FA values of the subcortical regions of the CPC tract. Furthermore, the volume of the CPC tract originating from the SMA showed significant negative correlation with ataxia severity. There was no correlation between ataxia and corticostriatal tract volume. Therefore, we found that subcortical lesions of the CPC tract originating from the SMA could contribute to ataxia severity in stroke patients with ataxic hemiparesis
Nayeon Ko,Hansu Park,Hyejung Jung,Go Iwahana,Alexander Fedorov,Jinho Ahn 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10
Multiple geochemical analyses may provide important implication about the ice-wedge formation and in-situ greenhouse gas (GHG) production mechanisms. Here we present new results from ice-wedge ice sampled at Zyryanka, Northeastern Siberia (65°93’N, 150°89’E). To constrain the age of the ice wedge, plant residues and CO₂ gas in the ice were analyzed for 14C dating and we obtained ~ 4000 and ~ 1000 years before 1950 CE for the side and center parts of the ice wedge, respectively. The δ(N2/Ar) of the ice wedges ranges from -43.9 to -1.8% with regard to modern air, indicating that the Zyryanka ice wedge was formed by both liquid water and dry snow. Using the δ(N₂/Ar) we calculate the melting fraction of gas species. The melting fraction is well supported by bubble shapes and orientation: In areas where melting fractions are relatively high the bubble are elongated with preferred orientation. The δ(O₂/Ar) value of the Zyryanka ice wedges ranges from -99.1 to -37.6% with regard to modern air, implying oxygen gas might have been consumed considerably by respiration of microorganisms in the ice wedge ice. We observe a negative correlation between CO₂ and O₂ gas concentrations (r=-0.92, p=0.01), indicating microbial respiration within the ice wedge ice. N₂O and CO₂ concentrations shows a weak positive correlation (r = 0.23, p = 0.0003), as does the correlation between CH₄ and CO₂ correlation (r = 0.35, p = 0.0007). We also observe a weak negative correlation between N₂O and CH₄ (r =-0.39, p = 0.04). The δ<SUP>18</SUP>O of ice melt ranges from -28.6 to -19.1‰, and the horizontal profile shows a symmetric structure with high δ<SUP>18</SUP>O values in the side parts and low in the center part. We will continue to scrutinize ice wedge formation process with additional stable water isotope data of modern precipitates at Zyryanka. Our study shows that the gas mixing ratios in ice wedges and stable water isotope analysis may help better understanding the biogeochemical environments during and after the formation of ice wedges.
Sunirmal Sheet(Sunirmal Sheet ),Hana Kim(Hana Kim),Minjeong Ko(Minjeong Ko),Nayeon Kim(Nayeon Kim),서경원(Kyoung-Won Seo),Bong-Hwan Choi(Bong-Hwan Choi),이경태(Kyung-Tai Lee) 한국예방수의학회 2022 예방수의학회지 Vol.46 No.1
The prevalence of cancer in companion dogs is growing nowadays with the increasing worldwide population of domestic dogs. Since there is a less established standard of care in veterinary medicine, investigational treatments, such as the development of biomarkers can be considered as a therapeutic intervention for early diagnosis. Despite the enormous efforts that have been invested in the search of biomarkers, still, there is a need for easy detection of significant biological markers for predicting canine cancers at an early stage. In this study, we have analyzed the expression pattern of previously reported 46 canine cancer-associated candidate genes in blood specimens using real-time qPCR. We hypothesized that analysis of gene expression in blood would provide preliminary evidence of local or systemic immunogenic response which further contribute to the easy and early diagnosis of canine cancer from blood specimen as an analytical tool. The datasets included a total of 22 blood samples collected from different breeds of dogs diagnosed with cancer and five from healthy normal dogs. RT-qPCR analysis was performed by employing the SYBR Green PCR mix to assess the expression of these 46 genes in a total of 27 samples. From our result, a total of nine genes (ROS1, C1QA, CD48, IL1b, TLR2, IL2R, CHI3L1, CTSS, and TLR7) were found to be significantly up-regulated (p < 0.05 and p < 0.01) in the cancer samples compared to non-cancer samples. The relative expression level of ROS1, C1QA, CD48, IL1b, TLR2, IL2R, CHI3L1, CTSS, and TLR7 genes was 5.74, 4.78, 3.94, 2.94, 2.57, 2.53, 2.50, 2.04, and 2.57, respectively, in cancer samples compared to non-cancer samples. Thus, our results reveal several highly expressed cancer genes that can be therapeutic target genes for further testing in canine cancers.
Effect of norgalanthamine on renal injury induced by carbon tetrachloride in mice
Nayeon Yang,Myungsoon Ko,Minhwa Jang,Eunjun Jang,Dowook Yu,Wootaek Hong,Seongbeom Bae,Jieun Ryoo,Taekyun Shin,Meejung Ahn 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Norgalanthamine is a major component of Crinum asiaticum var. japonicum that exhibits several biological activities. This study evaluated the anti-inflammatory and anti-oxidative properties of norgalanthamine in mice with carbon tetrachloride (CCl4)-induced renal injury. Norgalanthamine (1 and 10 mg/kg) was orally administered to mice for 7 or 14 days, after which renal injury was induced by CCl4 (1.5 ml/kg, i.p.). The vehicle and positive controls consisted of phosphate-buffered saline and silymarin (100 mg/kg), respectively. In CCl4-injured mice, norgalanthamine pretreatment significantly reversed the increases in serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels, and the decrease in the serum glucose level. The histopathological evaluation and Iba-1 immunoreactivity also supported the protective effects of norgalanthamine against CCl4-induced kidney injury. These results suggest that norgalanthamine ameliorates oxidative renal injury, possibly through reducing enhancing antioxidant enzymes, and suppressing infiltrated macrophages.
Ginsenoside Rk1 is a novel inhibitor of NMDA receptors in cultured rat hippocampal neurons 490
Nayeon Ryoo,Md. Ataur Rahman,Hongik Hwang,Sung Kwon Ko,Seung-Yeol Nah,Hyoung-Chun Kim,Hyewhon Rhim 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.3
Background: Ginsenoside Rk1, a saponin component isolated from heat-processed Panax ginseng Meyer,has been implicated in the regulation of antitumor and anti-inflammatory activities. Although ourprevious studies have demonstrated that ginsenoside Rg3 significantly attenuated the activation ofNMDA receptors (NMDARs) in hippocampal neurons, the effects of ginsenosides Rg5 and Rk1, which arederived from heat-mediated dehydration of ginsenoside Rg3, on neuronal NMDARs have not yet beenelucidated. Methods: We examined the regulation of NMDARs by ginsenosides Rg5 and Rk1 in cultured rat hippocampalneurons using fura-2ebased calcium imaging and whole-cell patch-clamp recordings. Results: The results from our investigation showed that ginsenosides Rg3 and Rg5 inhibited NMDARswith similar potencies. However, ginsenoside Rk1 inhibited NMDARs most effectively among the fivecompounds (Rg3, Rg5, Rk1, Rg5/Rk1 mixture, and protopanaxadiol) tested in cultured hippocampalneurons. Its inhibition is independent of the NMDA- and glycine-binding sites, and its action seems toinvolve in an interaction with the polyamine-binding site of the NMDAR channel complex. Conclusion: Taken together, our results suggest that ginsenoside Rk1 might be a novel componentcontributable to the development of ginseng-based therapeutic treatments for neurodegenerativediseases.