근막 결손의 복원과 자궁천골인대 고정을 통한 전자궁적출술 후 질탈출의 성공적 교정

문화숙(Hwa Sook Moon),최진국(Jin Koo Choi),김경서(Kyung Seo Kim),박근식(Kyun Sik Park),황지영(Ji Young Hwang),문성은(Sung Eun Moon),한지원(Ji Won Han),김상국(Sang Gook Kim),김상갑(Sang Gap Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7

목적 : 본 연구는 전자궁적출술 후 질탈출을 부위-특이적인 결함의 개념에 입각하여 치골경부 근막과 직장질 격막의 연결을 통한 골반내 근막의 복원과 자궁천골인대 고정술을 이용한 질탈출의 성공적인 수술적 교정의 방법과 결과를 보고하고자 한다. 연구 방법 : 1999년부터 2001년 8월까지 자궁적출술 후 질궁탈출 증상으로 문화병원 산부인과를 내원, 탈출된 질의 근막을 재건시킨 다음, 이를 자궁천골인대에 고정시킴으로써 질의 부위-특이적인 교정술을 받은 3명의 환자를 대상으로 하였다. 3명중 1명은 개복술을 하였고 2명은 내시경 수술을 하였다. 결과 : 환자의 연령 분포는 49-67세였으며, 수술시간은 평균 113분 (105-125)이었다. 세 환자 모두 수술 후 질의 상태가 해부학 및 기능적으로 정상이었으며, 9일째 특이사항 없이 퇴원하였다. 수술 후 HRT를 시행한 1명을 포함한 3명 모두 각각 24개월, 12개월, 7개월간의 추적 검사에서도 특이한 합병증이나 재발 없이 좋은 경과를 보였다. 결론 : 골반 근막 결손의 복원과 자궁천골인대 고정술은 전자궁적출술 후 질탈출의 교정에 매우 안전하고 효과적이며, 기능적인 방법으로 사료되며, 자궁천골인대를 질탈출 교정에 이용한 연구는 본 연구가 국내에서 처음이다. Objective : To report the method and efficacy of the site specific-defects repair in the endopelvic fascia and uterosacral ligament suspension for the correction of posthysterectomy vaginal vault prolapse. Methods : This study was performed in 3 patients with posthyterectomy vaginal vault prolapse who underwent the surgery for the reconstruction of endopelvic fascia and the correction of vault prolapsed vagina by using uterosacral ligament suspension at the department of Obstetrics and Gynecology in Moon-Hwa Hospital. Among them, 1 patient was treated by laparotomy, and 2 patients were treated by laparoscope. Results : The age of patients ranged from 49 to 67 years. The mean operation time was 111 minutes (105-120 minutes). The status of postoperative vagina was normal in all 3 patients, who were discharged 9 days after operation without symptoms. No complication or recurrence were found in them despite long-term follow-up for 24 months, 12 months, 7 months, respectively after operation. One patient has been treated with HRT therapy. Conclusion : The reconstruction of the defect of endopelvic fascia and uterosacral ligament fixation may be very safe, effective, and functional in the correction of vaginal vault prolapse. This study reports the treatment of vaginal vault prolapse using uterosacral ligament within Korea for the first time.

상수원수 수질변화에 따른 전오존 처리효과 및 경제성 평가

최동훈 ( Dong Hoon Choi ),박진식 ( Jin Sik Park ),문추연 ( Choo Yeun Moon ),이재용 ( Jae Yong Lee ),유동춘 ( Dong Choon Ryu ),장성호 ( Seong Ho Jang ),권기원 ( Ki Won Kwon ),이수애 ( Soo Ae Lee ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.4

This study, changes in raw water quality is to indicate on the efficiency of ozone treatment of each pollutant as compared to derive the appropriate operating measures. The appropriate selection for injection rate of pre-ozone and did not inject pre-ozone assess changes in the water. When good water quality, you not injected of pre-ozone to evaluate the economic efficiency of electricity and put the most cost-effective ozone concentration were evaluated. Evaluation remove organic matter and chlorophyll-a concentration level in experiments with each factor of the water DOC> 2.5㎎ / L, THMFP> 70㎍ / L, Chl-a> 30㎎/㎥or less constant process, if you do not need to put pre-ozone showed little impact. It also does not put you in pre-ozone appropriate produce enough power rate savings was calculated as approximately 90 million won. Ability to remove organic materials and the ability to produce disinfection byproducts, and cost-effective decisions by considering the concentration of injection if pre-ozone 1 mg/L was investigated by the appropriate concentration of ozone injection.

느타리속 버섯류의 영양성분 및 생리활성

엄수나(Suna Um),진경언(Gyoung-ean Jin),박계원(Kye Won Park),유영복(Young-bok Yu),박기문(Ki-Moon Park) 한국식품과학회 2010 한국식품과학회지 Vol.42 No.1

일반 느타리 13품종과 색상 느타리 5품종을 사용하여 아미노산 및 polyphenol, β-glucan 함량을 분석하고, 생리활성으로 항산화 및 항암, 항고혈압, 항혈전, 항당뇨, 항염활성을 측정하였다. 느타리버섯 18종의 아미노산 분석결과 전반적으로 감칠맛을 내는 glutamic acid 함량이 비교적 많이 함유되어 있었고, 필수아미노산 성분도 고르게 분포되어 있었다. Polyphenol 함량에서는 전 품종에서 20 mg% 함량이상을 나타냈으며, 노랑느타리(R)가 39.13±0.82 mg%로 가장 높았다. β-glucan 함량은 노랑느타리(R)에서 37.67±0.22%로 가장 높았으며, 그 외에 원형1(C), 장안PK(A)에서 각각 28.75±0.61%, 27.95±0.33%의 순으로 나타났다. 전자공여능에서는 노랑느타리(R) 버섯의 DPPH IC50값이 2.93±0.44 mg/mL로 가장 낮아 항산화 활성이 가장 우수한 것으로 나타났으며, 세포독성 실험에서는 노랑느타리(R) 에탄올 추출물 1% 처리시 신장 암세포에 대해 36.90%의 세포 억제율을 보였다. ACE 저해활성의 경우 노랑느타리(R) 에탄올 추출물 1%농도에서 60.5±0.2%의 저해율이 측정되었고, 흑평(B) 56.7±1.1%, 여름(H) 52.4±1.3% 수준으로 나타났다. 항혈전 활성에서는 3%농도에서 흑평(B)과 삼복(G)을 제외한 나머지 느타리버섯 에탄올 추출물에서 50%이상의 용해 활성을 보였으며 노랑느타리(R)에서 거의 plasmin과 동등한 활성을 나타냈다. 항당뇨 활성에서는 노랑느타리(R)의 경우 50.5±0.8%의 비교적 높은 효소저해율이 측정되었고, 항염활성에서는 노랑느타리(R)에서 68.4±0.3%의 억제율이 측정되었다. 이상의 결과로 일반 느타리 13 품종과 육종 재배된 색상 느타리 5품종 중 노랑느타리(R)가 가장 우수한 생리활성을 나타내 향후 기능성 소재로의 활용가능성이 기대되었다. In this study, the anti-oxidant, anti-tumorigenic, anti-hypertensive, anti-thrombic, anti-diabetic, and antiinflammatory properties of 18 different species of genus Pleurotus were investigated. In addition, the amino acid, β-glucan, and polyphenol content were also measured. All species contained more than 20 mg% of polyphenol with the highest contents found in Pleurotus cornucopiae var. citrinopileatus (yellow pleurotus) (39.13±0.82 mg%). The β-glucan contents was also the highest in yellow Pleurotus (37.67±0.22%) followed by Won-Hyeong1 (C, 28.75±0.61%) and Jang-an PK (A, 27.95±0.33%). The yellow Pleurotus exhibited the highest antioxidant activity as assessed by the DPPH scavenging rate with an IC50 value of 2.94±0.44 mg/mL. Ethanol extracts from the yellow Pleurotus treated at 1% concentration showed cytotoxic activity up to 36.9% in the human embryonic kidney 293T cell lines. The yellow Pleurotus also showed the highest inhibitory effects on ACE activity (60.52±0.2%). Finally, the yellow Pleurotus exhibited anti-diabetic and antiinflammatory properties as shown by inhibition of α-amyloglucosidase activity (50.5±0.8%) and nitric oxide production (68.4±0.3%). Taken together, our data indicate the yellow pleurotus is a promising functional food ingredients.

Pathomechanisms of Atrophy in Insular Cortex in Alzheimer’s Disease

Moon, Yeonsil,Moon, Won-Jin,Han, Seol-Heui SAGE Publications 2015 American journal of Alzheimer's disease and other Vol.30 No.5

<P>The insular cortex is associated with neuropsychiatric symptoms, changes in cardiovascular and autonomic control, and mortality in Alzheimer’s dementia. However, the insular cortex does not provide information on the contribution of the other cortices to cognitive decline. We hypothesized that the factors that affect to atrophy in insular cortex are different from other cortical regions. A total of 42 patients with probable Alzheimer’s dementia were included in the analyses. The manual drawing of regions of interest was used to detect insular cortex located in the deep gray matter and to avoid coatrophy. Covariates, which could affect to the atrophy of the cerebral cortex, were selected based on previous studies. Any of the demographic factors, vascular risk factors, and the severity scales of dementia was not associated with any insular volume ratio. We suggest that the pathomechanisms of atrophy in insular cortex are different from those of other cortex regions in Alzheimer’s disease.</P>

Undifferentiated pleomorphic sarcoma: Non-skin origin malignancy that dermatologists can meet

( Jin-hwa Son ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Hoon-soo Ki 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Undifferentiated pleomorphic sarcoma (UPS) is a rare moderately aggressive mesenchymal neoplasm capable of invading soft tissue, skeletal, and retroperitoneal structures. It most commonly occurs in extremities and relatively few cases have been reported arising in the skin. Dermatologists could meet non-skin origin malignancy as skin tumor on extremities. Here, we report as case of UPS presented with subcutaneous mass on the forearm. A 70-year-old man had a large hard subcutaneous mass on the left forearm presented 3 years ago. The protruding mass was insidious at onset and increased in size progressively. On examination, 7cm-sized mass with pain was noted and it was fixed to underlying structures. Histopathological examination showed tumor composed of highly pleomorphic spindle-shaped cells arranged in sheets and irregular fascicles with myxoid stroma. Immunohistochemical stain showed that some tumor cells were focal positive for smooth muscle actin, desmin, epithelial membrane antigen and pan cytokeratin. These findings were suggestive of UPS. Necrotic soft tissue mass with adjacent muscle invasion was revealed but no metastatic lesions were detected on several imaging tests (CT, MRI and PET-CT). Therefore, skin tumor of extremities could be considered the possibility of non-skin origin malignancy such as UPS. If it is suspected, dermatologists should be able to perform further evaluation and refer to other specialists.

Evaluation of setup accuracy for prone breast radiotherapy with a three-dimensional surface imaging system

Moon Young-Min,Kang Jin Kyu,Yu To-Sol,Jeon Wan,Choi Chul Won,Kim Jin Young,Chung Jin Beom,Kang Sang Won,Park Sung Kwang,Han Moo Jae,Yang Seung Woo 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.11

It has been shown that the detection of fat body surfaces (thorax, pelvis) using the three-dimensional optical surface imaging system (3D–OSIS) is less accurate than curved surfaces (head, neck). Here, we evaluated the applicability and technical performance of the 3D–OSIS for prone breast radiotherapy using silicon cup markers. Three silicon cups were attached on the dorsal surface of a female atom phantom. We evaluated the data reproducibility with these marker cups and compared the accuracy with or without their use. For the reproducibility test, we scanned an object 11 times every 15 s with the 3D– OSIS and registered the diferences. For the accuracy test, we positioned the phantom on the table and manually moved it in the X, Y, and Z directions to predetermined values. These values were compared to those measured with the 3D–OSIS. This process was repeated 21 times and the diferences of the measured values were compared according to the presence or absence of markers. In reproducibility test, the mean variations for the shifts in the lateral, longitudinal, and vertical directions were 0.15±0.22 mm, 0.47±0.13 mm, and 0.34±0.19 mm, respectively. And the mean deviations elicited based on the accuracy test for the manually applied and the measured shifts in the lateral, longitudinal, and vertical directions were (a) 0.23±0.1 mm, 0.044±0.39 mm, and 0.18±0.1 mm with the use of markers, and (b) 0.44±0.33 mm, 0.97±0.55 mm, and 0.63±0.55 mm without the markers, respectively. The use of silicon cup markers yielded highly accurate results in the 3D–OSIS. The use of 3D–OSIS and silicon cups has potential in achieving precise patient setup and in reducing the CBCT frequency in prone breast radiotherapy.

Generalized pustular psoriasis in a 1-month-old boy

( Won Ku Lee ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Generalized pustular psoriasis (GPP) is a rare type of psoriasis, and it is very rare in children. A safe and consistently effective treatment regimen has not been identified, although many treatment modalities have been suggested so far. To our knowledge, the earliest onset of GPP in childhood that has been reported in the literature is 1.5months. Herein, we report a case of GPP in a child with the earliest onset of age. A healthy 2-month-old boy developed diffuse erythematous scaly patch with tiny pustules on whole body starting at 4 weeks after birth. Pustules were pin head-sized, and the lesions had rapidly progressed to large exuding areas. The clinical findings and histopathological examinations were consistent with the diagnosis of GPP. With topical steroid, the lesions repeated improvement and deterioration resulting lost to follow-up. After 1.5 years, the patient revisited the clinic with severe flare of erythematous lesions and pustules on whole body. The pustular lesions almost disappeared with the treatment of methylprednisolone and cyclosporine. Generalized erythematous eruption in neonate can be the manifestation of various diseases such as atopic dermatitis, seborrheic dermatitis, Leiner disease, and Langerhans cell histiocytosis. We suggest GPP should also be considered in differential diagnosis for neonatal erythroderma.

Enhanced Charge Transfer Through Polypyrrole Electropolymerized on Poly(acrylonitrile-co-butadiene)/Pt Electrodes

Won-Seok Chae,Jung-Nim Moon,Kang-Jin Kim 한국분석과학회 1995 분석과학 Vol.8 No.4

Effect of corticosteroid therapy in the early phase of acute respiratory distress syndrome: a propensity-matched cohort study

( Moon Seong Baek ),( Yunkyoung Lee ),( Sang-bum Hong ),( Chae-man Lim ),( Younsuck Koh ),( Jin Won Huh ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1

Background/Aims: It is unclear whether corticosteroid use in patients with acute respiratory distress syndrome (ARDS) improves survival. This study aimed to investigate whether the administration of corticosteroids to patients in the early phase of moderate to severe ARDS is associated with improved outcomes. Methods: We analyzed the data of patients who received corticosteroids within 7 days of the onset of ARDS between June 2006 and December 2015 at a single tertiary teaching hospital. A total of 565 patients admitted with moderate to severe ARDS were eligible. The outcomes of patients treated with methylprednisolone 40 to 180 mg/day or equivalent (n = 404) were compared to those who did not receive steroids (n = 161). The primary and secondary outcomes were 28- and 90-day mortality rates, respectively. Propensity scores were used to adjust for baseline covariates. Results: The overall mortality at 28 days was not significantly different between the corticosteroid-treated and control groups (43.8% vs. 41%, p = 0.541). At 90 days, the overall mortality rate was higher in the corticosteroid-treated group than in the control group (59.2% vs. 48.4%, p = 0.021). However, on propensity score matching, corticosteroid therapy was not associated with a higher 28-day mortality rate (odds ratio, 1.031; 95% confidence interval, 0.657 to 1.618; p = 0.895) and 90 days (odds ratio, 1.435; 95% confidence interval, 0.877 to 2.348; p = 0.151). Conclusions: Corticosteroid therapy was not associated with 28- or 90-day mortality in the early phase of moderate to severe ARDS on propensity score matching analysis.

A Condition-Based Real time Monitoring Systems for Precision equiopments with Ball-Screw via Vibration Signal

Won Gi Lee,YongHo Jeon,Jin Woo Lee,Hye-Jin Lee,Moon G. Lee 한국생산제조학회 2014 한국생산제조시스템학회 학술발표대회 논문집 Vol.2014 No.9(2)