Conducting and interface characterization of carbonate-type organic electrolytes containing EMImBF4 as an additive against activated carbon electrode

Mingyeong Kim,Kyungmin Kim,Seok Kim 한국탄소학회 2015 Carbon Letters Vol.16 No.1

Carbonate-type organic electrolytes were prepared using propylene carbonate (PC) and dimethyl carbonate (DMC) as a solvent, quaternary ammonium salts, and by adding different contents of 1-ethyl-3-methyl imidazolium tetrafluoroborate (EMImBF4). Cyclic voltammetry and linear sweep voltammetry were performed to analyze conducting behaviors. The surface characterizations were analyzed by scanning electron microscopy method and X-ray photoelectron spectroscopy. From the experimental results, increasing the EMImBF4 content increased the ionic conductivity and reduced bulk resistance and interfacial resistance. In particular, after adding 15 vol% EMImBF4 in 0.2 M SBPBF4 PC/DMC electrolyte, the organic electrolyte showed superior capacitance and interfacial resistance. However, when EMImBF4 content exceeded 15 vol%, the capacitance was saturated and the voltage range decreased.

Enzyme-mediated tissue adhesive hydrogels for meniscus repair

kim, Su-Hwan,An, Young-Hyeon,Kim, Hwan D.,Kim, Kyungmin,Lee, Sang-Hyuk,Yim, Hyun-Gu,Kim, Byung-Gee,Hwang, Nathaniel S. Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.110 No.-

<P><B>Abstract</B></P> <P>Meniscus tissues have limited regenerative capacity once damaged. The treatment options for the meniscus tissue regeneration have been limited to arthroscopic meniscectomy or surgical interventions. The injectable hydrogels based system would provide an alternative to the conventional meniscus therapy by providing a minimally invasive treatment alternative. Here we utilized enzyme-based approaches to fabricate tissue adhesive hydrogels for meniscus repair. Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking <I>in vitro</I> and <I>in vivo</I>. Importantly, mechanical properties and degradation kinetics are modulated by the TA substitution and TYR concentrations. In addition, TYR −mediated crosslinking displayed tissue-adhesive properties. Furthermore, fibrochondrocyte-laden and TYR-crosslinked hydrogels demonstrated strong biocompatibility and resulted in enhancement of cartilage-specific gene expression and matrix synthesis. Overall, this represents a potential application of enzyme-mediated crosslinking hydrogels for meniscus tissue engineering.</P>

Effect of activating transcription factor 3 on inflammatory response and differentiation of keratinocytes

( Kyungmin Kim ),( Doyeon Kim ),( Jung-min Shin ),( Dongkyun Hong ),( Kyung Eun Jung ),( Young-joon Seo ),( Chang Deok Kim ),( Young Lee ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.74 No.1

Recommendations for SARS-CoV-2 testing and organ procurement from deceased donors in the Republic of Korea

Kim Si-Ho,Wi Yu Mi,문치숙,Kang Ji-Man,Kim Minhwa,Kim Jungok,김종만,Seok Hyeri,Shi Hye Jin,Lee Su Jin,Lee Ji Yeon,Jeong Su Jin,Choe Pyoeng Gyun,Huh Kyungmin,Lee Sang-Oh,Kim Sang Il 대한이식학회 2023 Korean Journal of Transplantation Vol.37 No.3

We present a summary of the evidence on testing for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and organ procurement from deceased donors and provide recommendations based on current clinical data and the guidelines from major transplant organizations. Because of the limited historical experience with coronavirus disease 2019 (COVID-19), certain recommendations in this document are based on theoretical rationales rather than clinical data. The recommendations in this manuscript may be subject to revision as subsequent clinical studies provide definitive evidence regarding COVID-19 in organ procurement.

Revised Korean Society of Infectious Diseases/National Evidence-based Healthcarea Collaborating Agency Guidelines on the Treatment of Patients with COVID-19

Kim Sun Bean,Ryoo Seungeun,Huh Kyungmin,Joo Eun-Jeong,Kim Youn Jeong,Choi Won Suk,Kim Yae-Jean,Yoon Young Kyung,Heo Jung Yeon,Seo Yu Bin,Jeong Su Jin,Park Dong-ah,Yu Su-Yeon,Lee Hyeon-Jeong,Kim Jimin 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.1

Despite the global effort to mitigate the spread, coronavirus disease 2019 (COVID-19) has become a pandemic that took more than 2 million lives. There are numerous ongoing clinical studies aiming to find treatment options and many are being published daily. Some effective treatment options, albeit of variable efficacy, have been discovered. Therefore, it is necessary to develop an evidence-based methodology, to continuously check for new evidence, and to update recommendations accordingly. Here we provide guidelines on pharmaceutical treatment for COVID-19 based on the latest evidence.

Development of Organic Thin-film Transistors on a Biocompatible Parylene-C Substrate

KyungMin Kim,Sookyeong Kim,Ah-Hyun Hong,Yoojeong Ko,Hyowon Jang,Hyeok Kim,Dong-Wook Park 대한전자공학회 2023 Journal of semiconductor technology and science Vol.23 No.1

Organic thin-film transistors (OTFTs) fabricated on a biocompatible Parylene-C substrate can be applied to biosensors using a simple and cost-effective process. In this study, we developed biocompatible OTFTs by using organic materials to fabricate the substrate, gate dielectric, channel, and passivation layer. Poly(3-hexylthiophene) (P3HT) was used to fabricate the OTFTs on a Parylene-C-based platform. As the gate dielectric, Parylene-C showed promising insulation properties. Finally, we generated a cyclic olefin polymer (COP) passivation layer to protect P3HT from oxygen and moisture, and the effect of the COP passivation layer on the P3HT channel was analyzed. The proposed materials and fabrication methods will be useful for various bio-applications of OTFTs.

Improvement of Gamma-ray Analysis Procedures for Reducing Human Error and Workload Using Automation

Kyungmin Kim,Jong Soo Nam,Sang-Mo Hwang,Hyo-Jong Kim,Duckha kim,Cheongyeon Cho,Hongrae Jeon 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.1

Radioactive waste can be classified according to the concentration level for radionuclides, and the disposal method is different through the level. Gamma analysis is inevitably performed to determine the concentration of radioactive waste, and when a large amount of radioactive waste is generated, such as decommissioning nuclear facilities, it takes a lot of time to analyze samples. The performance of a lot of analysis can cause human errors and workload. In general, gamma analysis is performed using by HPGe detector. Recently, for convenience of analysis, commercial automatic sample changers applicable to the HPGe detectors were developed. The automatic sample changers generate individual analysis reports for each sample. In this study, gamma analysis procedure was improved using the application of the automatic sample changer and the automated data parsing using by Python. The application of automatic sample changers and data parsing technique can solve the problems. The human errors were reduced to 0% compared to the previous method by improving the gamma analysis procedure, and working time were also dramatically reduced. This automation of analysis procedure will contribute to reducing the burden of analysis work and reducing human errors through various improvements.

Interim Guidelines on Antiviral Therapy for COVID-19

Kim Sun Bean,Huh Kyungmin,Heo Jung Yeon,Joo Eun-Jeong,Kim Youn Jeong,Choi Won Suk,Kim Yae-Jean,Seo Yu Bin,Yoon Young Kyung,Ku Nam Su,Jeong Su Jin,Kim Sung-Han,Peck Kyong Ran,Yeom Joon Sup 대한감염학회 2020 Infection and Chemotherapy Vol.52 No.2

Since the first case was reported in Wuhan, Hubei Province, China on December 12, 2019, Coronavirus disease 2019 (COVID-19) has spread widely to other countries since January 2020. As of April 16, 2020, 10635 confirmed cases have been reported, with 230 deaths in Korea. COVID-19 patients may be asymptomatic or show various clinical manifestations, including acute symptoms such as fever, fatigue, sore throat; pneumonia presenting as acute respiratory distress syndrome; and multiple organ failure. As COVID-19 has such varied clinical manifestations and case fatality rates, no standard antiviral therapy regimen has been established other than supportive therapy. In the present guideline, we aim to introduce potentially helpful antiviral and other drug therapies based on in vivo and in vitro research and clinical experiences from many countries.

Korean Society of Infectious Diseases/National Evidence-based Healthcare Collaborating Agency Recommendations for Anti-SARS-CoV-2 Monoclonal Antibody Treatment of Patients with COVID-19

Kim Sun Bean,Kim Jimin,Huh Kyungmin,Choi Won Suk,Kim Yae-Jean,Joo Eun-Jeong,Kim Youn Jeong,Yoon Young Kyung,Heo Jung Yeon,Seo Yu Bin,Jeong Su Jin,Yu Su-Yeon,Peck Kyong Ran,Choi Miyoung,Yeom Joon Sup 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.2

Neutralizing antibodies targeted at the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein have been developed and now under evaluation in clinical trials. The US Food and Drug Administration currently issued emergency use authorizations for neutralizing monoclonal antibodies in non-hospitalized patients with mild to moderate coronavirus disease 2019 (COVID-19) who are at high risk for progressing to severe disease and/or hospitalization. In terms of this situation, there is an urgent need to investigate the clinical aspects and to develop strategies to deploy them effectively in clinical practice. Here we provide guidance for the use of anti-SARS-CoV-2 monoclonal antibodies for the treatment of COVID-19 based on the latest evidence.

Tissue adhesive, rapid forming, and sprayable ECM hydrogel via recombinant tyrosinase crosslinking

Kim, Su-Hwan,Lee, Sang-Hyuk,Lee, Ju-Eun,Park, Sung Jun,Kim, Kyungmin,Kim, In Seon,Lee, Yoon-Sik,Hwang, Nathaniel S.,Kim, Byung-Gee Elsevier 2018 Biomaterials Vol.178 No.-

<P><B>Abstract</B></P> <P>We report on a tissue adhesive hydrogel based on novel recombinant tyrosinase mediated crosslinking. The adhesive hydrogels were fabricated by the site-directed coupling of tyramine-conjugated hyaluronic acid (HA_t, 1% w/v) and gelatin (3% w/v) (HG_gel) with novel tyrosinase derived from <I>Streptomyces avermitilis</I> (SA_Ty). The enzyme-based crosslinking by SA_Ty was fast, with less than 50 s for complete gelation, and the SA_Ty based crosslinking enhanced the physical properties and adhesive strength of the hydrogel significantly with the native tissue samples. Furthermore, by optimizing the injection conditions, we tailored the enzyme-based crosslinking hydrogels to be injectable and sprayable with a medical syringe and commercial airbrush nozzle, respectively. An <I>in vivo</I> analysis of the adhesive hydrogel showed a negligible immune reaction. In this study, demonstrate that the novel enzyme-based crosslinking hydrogel has a robust potential in tissue engineering and regenerative medicine.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>