법랑질 인공우식병소에서 APF gel과 CPP-ACP 제제의 재광화 효과

강지선,이난영,이상호 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

많은 연구에서 불소 이온을 이용한 치아우식증의 예방 및 재광화 효과에 대해 밝힌 바 있다. 불소는 치아우식을 예방하고 재광화를 촉진하는 대표적 인 성분이다. 하지만 불소를 이용한 재광화는 하부의 탈회 병소를 충분히 광화시키지 못하며 다공성으로 인해 불완전한 광화를 보인다. 또한 그 적용 과정에서 과량이 섭취되었을 경우에 발생할 수 있는 독성도 고려해야 한다. 한편 CPP-ACP(Casein Phosphopeptides-Amorphous Calcium Phosphate)는 초기의 우식병소를 재광화 시키며 우유 단백질인 casein으로부터 추출한 성분으로 섭취되어도 인체에 무해하다. 본 연구의 목적은 APF gel과 CPP-ACP 제제의 재광화 효과를 비교해 보고자 하는 것이다. 본 실험에서는 법랑질 인공우식 병소에 Acidulated Phosphate Fluoride(APF) gel과 CPP-ACP 제제를 각 도포 방법에 따라 적용하였다. 14일 후, 표면미세경도를 측정하고 편광 현미경 하에서 재광화 병소를 관찰하여 다음과 같은 결과를 얻었다. 1. 실험 전후 표면미세경도를 측정하여 비교한 결과, 모든 군에서 실험 후에 표면미세경도가 증가하였다(P<0.05). 2. CPP-ACP 제제를 도포한 군에서 불소를 도포한 군에 비해 표면미세경도 증가 폭이 유의하게 컸다(P<0.05). 3. 편광현미경 하에서 관찰한 결과 불소도포 군은 불규칙하고 얇은 재광화 층을, CPP-ACP제제를 도포한 군은 균일하고두터운 재광화 층을 보였다. Many operations have been carried out using the fluohde ion to prevent and reverse dental caries, It certainlyencourages remineralization and also prevents dental caries. However, the remineralization developed by these means is superficial only leaving lower levels of demineralized lesion with a degree of porosity and incomplete mineralization. We must consider its toxic effects when it isingested for overdose. The CPP-ACP paste is able to remineralize the incipient lesion and has no harmful effectswhen it is ingested, because it was made form casein which is from the protein of milk. The purpose of this article is to compare the remineralization effects between APF gel and the CPP-ACPpaste. we applicated the APF gel and CPP-ACP paste on the artificial enamel carious lesion. After 14 days. we measured the surface microhardness and observed the reminei-alized lesion under polarized light microscope. The results were as follows: 1. The surface microhardness ofgroup III was the highest. followed by gi'oup II. and I(p<0.05). 2. The surface microhardness ofgroup III was significantly higher than those ofgroup I, and II(p<0.05). 3. We could observe thin and irregular remineralization layer ofgroup II, and regular and moderate remineral-ization layer ofgroup III under polihzed light microscope.

유전치 치근단 병소에의한 계승 영구치배의 변위

최선아,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

유치의 치수 감염을 적절히 치료하지 않으면 영구 계승치의 저형성이나 저석회화 같은 법랑질 형성부진, 치배의 위치변화, 맹출 부진이나 맹출 정지 같은 많은 합병증을 초래할 수 있다 이 중에서도 계승 영구치배의 위치변화는 선행 유치의 변성핀치수로 인한 위치변화가 가장 많다. 본 증례는 조선대학교 치과병원 소아치과에 내원한 환아 중 유전치의 치근단 병소로 인해 계승영구전치 치배의 위치변화가 초래된 것으로 사료되어 유치 치료의 중요성을 문헌고찰과 함께 보고하는 바이다. The effect of primary tooth infection on permanent teeth was reported by many previous study. It is seen histologic change in the enamel forming organ and in the surrounding sac, thus produce the defect as either hypoplasia or hypocalcification and alter the eruption of the permanent teeth. The periapical inflammation cause permanent tooth displacement in various direction and can be classified in-to the three categories : rotation, deflection, inversion. This study reported case which displacement of succedaneous teeth may be caused by periapical infection of primary dentition and concluded that treatment procedure of infected primary tooth is selected and performed by importance to retain the tooth for space maintain, possibility to successfully restored, evidence of abnormal developement of the succedaneous tooth.

超音波 心音響圖에 의한 鬱血性 心不全症의 左心室機能의 硏究

이난우,백선재,한통석,김혜순,김병학 최신의학사 1983 最新醫學 Vol.26 No.1

사지마비환자에서 체중부하운동후 감소된 고칼슘뇨증

백선재,이난우,한통석,김혜순,김병학 최신의학사 1983 最新醫學 Vol.26 No.1

뇌경색 환자에서의 혈장 지질과 항산화 영양소 상태에 관한 연구

최영선,이난희,서정규,박의현,조성희 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

뇌경색 환자의 생활 습관, 혈장 지질 및 적혈구 지질 및 적혈구 지질의 지방산 조성과 혈장 지질과산화물 농도, 항산화영양소인 비타민 E, A, β-carotene 상태를 측정하여 대조군의 자료화 비교함으로써 뇌경색 환자의 혈장 지질과 항산화영양소 상태를 조사하였다. 18명의 남자 환자군의 평균연령은 65.7(45~76)세였으며 36명의 건강한 남자대조군의 평균연령은 59.2(55~65)세였으며, 체중, 신장 및 BMI는 대조군과 환자군 간에 유의한 차이가 없었다. 환자군의 발병전 흡연 정도와 음주정도는 대조군보다 유의하게 높았으며, 적혈구지방산 조성에 있어서 포화지방산의 비가 유의하게 높았고 다불포화지방산의 비는 유의하게 낮았으며, 통계적인 유의성은 없으나 항산화 영양소 상태가 대조군에 비하여 불량하고 혈장 과산화지질의 종도가 높은 경향을 보였다. 이의 원인으로서는 환자군이 대조군에 비해 흡연율이 높고 음주량이 많으며 운동부족 등 부적합한 생활습관이 주요한 요인으로 작용한 것으로 판단되며, 따라서 바람직한 생활습관이 뇌경색질환의 예방에 기본요건이 된다고 사료된다. To investigate antioxidant and lipid staus of patients with cerebral infarction, 18 male patients admitted to Kyungpook National University Hospital from March to October, 1995 were compared to 36 healty male control subjects. The percentages of heavy smoking, heavy drinking and nonexercise before diagnosis of the disease in the patient group were significantly higher compared to the current status of the control group. Total cholesterol, LDL cholesterol and lipoprotein(a) were significantly higher in the patients than the control subjects. For the fatty acid composition of erythrocytes, total saturated fatty acids(% by weight) were significantly higher and total polyunsaturated fatty acids lower in the patient group than in the control group. Plasma levels of retinol, α-tocopherol and β-carotene were not significantly different between the patient group and the control group at the level of P<0.05 Alpha-tocopherol/total cholesterol of plasma was lower in the patient group with the statistical significance of P=0.054, and the plasma level of TBARS of the patient group was 1.98 nmol MDA/mL as compared to the level of the control, 1.60 nmol MDA/mL(P=0.066). Our results indicate that oxidative stress was increased in the patients with cerebral infraction, and such outcome might have resulted from undesirable life styles.

역위 매복된 상악 중절치의 자발적 맹출유도 : CASE REPORT

최선아,이난영,이창섭,이상호 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.3

영구 상악 절치의 매복은 매복이 흔한 제3대구치와 상악 견치에 비해서 드물지만 상악 중절치 미맹출을 주소로 내원한 학동기 아동에서 종종 관찰된다. 매복을 유발시키는 원인에 대해서는 많은 논란이 있으나 주 요인으로는 유치의 외상과 유치의 치근단 감염이 보고되고 있다. 특히 유치의 치근단 감염에 의한 매복설이 유력한데 병소의 압력에 의한 계승영구치의 회전, 변위등의 위치변화가 일어날 수 있다고 보고되고 있다. 매복치는 무엇보다도 조기에 발견하여 치료하는 것이 이로 인해 발생되는 부정교합이나 그 밖의 부작용을 예방할 수 있다. 일단 매복이 진단되면 방사선 검사를 통하여 위치 확인을 정확히 하는 것이 중요하며 치료에 앞서 전반적인 공간분석과 치료계획을 세워야 한다. 치료로는 교정적 견인, 또는 자가이식등이 있으며, 역위 매복된 경우가 아니라면 공간 확보만으로도 50%의 자발적 맹출을 보고하고 있다. 본 증례는 유치의 치근단 감염에 의해 역위 매복된 것으로 보이는 상악 중절치를 교정력을 이용해 정상적인 맹출로로 바로 잡아준 결과 4-5개월만에 자발적으로 맹출하였기에 이에 보고하는 바이다. Inverted Impaction of the permanent maxillary central incisor is rare. The causes of impaction are trauma and periapical inflammation of primary maxillary incisor teeth. Treatment options for a inverted incisor is extraction, surgery and orthodontic traction transplantation, and spontaneous eruption guidance. Treatment depends on the incisor's root development and the space available for eruption. If root development is immature, prognosis would be good. We reported successful treatment for inverted maxially central incisor of proper eruption and normal root development by correction of a eruption route. But further observation will be required to evaluate the final root development state and amount of attachment gingiva.

뇌동맥류 파열의 계절적 변동과 유발인자에 대한 임상분석

김윤,전용선,이남영 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The author investigated activities and events of the patients as well as diurnal and seasonal variation in the onset of aneurysmal rupture in 124 consecutive patients. The result showed that the onset of aneurysmal rupture was associated with nonactive state(sleep, rest) in 17.9%, working on job or house in 12.8%, bathing and/ or washing up in 7.2%. Diurnal variation of the onset of aneurysmal rupture showed two broad peak from 6 to 12 a. m. (32.2%) and from 7 to 11 p. m. (24.1%). The seasonal variation of onset of aneurysmal rupture showed the large peak in from late winter to early spring. The 22.6% patients rebleeded after initial bleeding, the first day rebleeding rate is 17.9% and rebleeding in a week is 71.4%. We concluded that onset of the aneurysmal rupture is related not only to physiol ogical circadian periodicity of blood pressure change but also to the activities or event which induced a sharp rising blood pressure and changing the venous and cerebrospinal fluid pressure.

Surpassing Tradeoffs by Separation: Examples in Transmission Line Resonators, Phase-Locked Loops, and Analog-to-Digital Converters

Nan Sun,William F. Andress,Kyoungho Woo,Donhee Ham 대한전자공학회 2008 Journal of semiconductor technology and science Vol.8 No.3

We review three examples (an on-chip transmission line resonator [1], a phase-locked loop [2], and an analog-to-digital converter [3]) of design tradeoffs which can in fact be circumvented; the key in each case is that the parameters that seem to trade off with each other are actually separated in time or space. This paper is an attempt to present these designs in such a way that this common approach can hopefully be applied to other circuits. We note reader that this paper is not a new contribution, but a review in which we highlight the common theme from our published works [1-3]. We published a similar paper [4], which, however, used only two examples from [1] and [2]. With the newly added content from [3] in the list of our examples, the present paper offers an expanded scope.

A Population-based Case-control Study on Risk Factors for Gastric Cardia Cancer in Rural Areas of Linzhou

Sun, Chang-Qing,Chang, Yu-Bo,Cui, Ling-Ling,Chen, Jia-Jun,Sun, Nan,Zhang, Wei-Jie,Jia, Xiao-Can,Tian, Yuan,Dai, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Gastric cancer is the second most common cause of cancer-related deaths in the world. Although certain dietary factors and lifestyles have been suggested to be associated with gastric carcinogenesis, there have been few investigations focusing on rural areas. A case-control study was therefore carried out to investigate the risk factors of gastric cardia cancer (GCC) in rural areas of Linzhou. A total of 470 newly diagnosed cases of GCC and 470 healthy controls were included. Face-to-face interviews were conducted, using a uniform questionnaire containing questions on demographics, per capita income, living habits, dietary habits and family history of tumors. The relationship between putative risk factors and GCC was assessed by odds ratios (OR) and their 95% confidence intervals (95%CI) derived from conditional logistic regression model by the COXREG command using SPSS 12.00. Multivariate logistic regression analysis was used to evaluate simultaneously the effects of multiple factors and other potential confounding factors. Multivariate logistic analysis showed that smoking (OR=1.939, 95%CI:1.097-3.426), alcohol drinking (OR=2.360, 95%CI: 1.292-4.311), hot food consumption (OR=2.034, 95%CI: 1.507-2.745), fast eating (OR=1.616, 95%CI: 1.171-2.230), mouldy food (OR=4.564, 95%CI: 2.682-7.767), leftover food (OR=1.881. 95%CI: 1.324-2.671), and family history of tumor (OR=2.831, 95%CI: 1.588-5.050) were risk factors for GCC. High per capita income (OR=0.709, 95%CI: 0.533-0.942), high education level (OR=0.354, 95%CI: 0.163-0.765), consumption of fresh fruits (OR=0.186, 95%CI: 0.111-0.311) and vegetables (OR=0.243, 95%CI: 0.142-0.415), and high BMI (OR=0.367, 95%CI: 0.242-0.557) were protective factors for GCC. Our data indicate that unhealthy lifestyle and dietary habits might be important contributors to GCC in this population.

Phenolic components from the stem of Acanthopanax koreanum and their inhibitory effects on NF-kappa B.

Sun, Ya Nan,Li, Wei,Yan, Xi Tao,Yang, Seo Young,Song, Seok Bean,Kim, Young Ho Japan Society for Bioscience, Biotechnology, and A 2014 Bioscience, Biotechnology, and Biochemistry Vol.78 No.3

<P>Two novel phenolic glucosides (1-2), as well as seven known compounds (3-9), were isolated from the stem of Acanthopanax koreanum; their chemical structures were determined by chemical and spectroscopic methods and subsequently compared with previously reported data. Their inhibition of nuclear factor kappa B (NF-κB) was measured in human embryonic kidney (293T) cells by using an NF-κB luciferase assay.</P>