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배나리 ( Bae Na-ri ),조철기 ( Cho Chul-ki ) 한국사진지리학회 2018 한국사진지리학회지 Vol.28 No.2
이 연구는 지리를 통한 지속가능발전교육의 방향을 탐색한 것이다. 먼저 지속가능발전교육은 환경교육과 어떤 차별성이 있는지를 검토하였다. 그후 우리나라 교육과정에서 지속가능발전교육이 언제 등장하여 어떻게 전개되어 왔는지를 살펴본 후, 고등학교 사회 교과서에 나타난 지속가능발전교육의 특징을 분석하였다. 지속가능발전은 환경적, 경제적, 사회적 측면을 함께 고려하는 개발이다. 오랜 전통을 지닌 환경교육이 주로 환경적 측면에 집중해왔다면 지속가능발전교육은 이들 세 측면을 모두 아우르는 미래지향적 교육이다. 그리고 지속가능발전교육은 특정 교과만을 위한 것이 아니며 전체 교육과정과 학교에 통합되어야 하는 교육의 패러다임적 전환이다. 그렇지만 지속가능발전교육은 특히 지리 교과와 밀접한 관련을 가진다. 왜냐하면 지리는 지역, 국가, 글로벌과 같은 다양한 스케일의 관계적 측면과 인간과 환경과의 관계적 측면을 탐색하는 홀리스틱 교과로서 지속가능발전교육의 지향점과 매우 잘 부합하기 때문이다. 지리를 통한 지속가능발전교육은 전지구적 차원에서 환경정의 실현에 중요한 기여를 할 것이다. This study explored the direction of education for sustainable development through geography. First, the paper examined how education for sustainable development differs from environmental education. After analyzing when and how education for sustainable development emerged in curriculum of Korea, the paper analyzed characteristics of education for sustainable development in high school social studies textbooks. Sustainable development is a development that considers the environmental, economic and social aspects together. If environmental education with a long tradition has been focused on environmental aspects, sustainable development education is a future-oriented education that encompasses all three aspects. And education for sustainable development is not only for specific subjects, it is a paradigm shift of education that must be integrated into the whole curriculum and school. However, education for sustainable development is closely related to geography. This is because geography coincides very well with the orientation of education for sustainable development as a holistic subject that explores relational aspects of various scales such as local, country, and global and relational aspects of human and environment. Education for sustainable development through geography will make an important contribution to the realization of environmental justice on a global scale.
( Na-ri Ha ),( Eui-ju Hong ),( Si-yun Ryu ),( Cheolho Sim ),( Joon-seok Chae ),( Hyeon-cheol Kim ),( Jinho Park ),( Kyoung-seong Choi ),( Do-hyeon Yu ),( Bae-keun Park ) 한국가축위생학회 2017 韓國家畜衛生學會誌 Vol.40 No.3
Acanthocephalan worms were harvested from the posterior intestines of the cultured marine fishes from January to July 2016 in a fish market located in Daejeon metropolitan city, Republic of Korea. Totally 450 cultured fishes (rock fish 100, olive flounder 250, red sea bream 100) were surveyed. Of the 100 red sea bream fish, 37 fishes (37%) were diagnosed as positive for Longicollum pagrosomi by light, electron microscopic and molecular examination. The number of worm was 25∼78 (mean 51±13). However, we can`t found any worm from the cultured rock fish and olive flounder. After sequencing, none of Pomphorhynchidae family are not identical based on 18S rRNA gene, and this data were identified with the first report for 18S rRNA gene sequence of L. pagrosomi. Furthermore, we confirmed that L. pagrosomi of the cultured red sea bream in Republic of Korea is very common parasite.
Prognostic value of pretreatment hemoglobin Level in patients with early cervical cancer
( Na Ri Shin ),( Yoo Young Lee ),( Seung Hyun Kim ),( Chel Hun Choi ),( Tae Joong Kim ),( Jeong Won Lee ),( Duk Soo Bae ),( Byoung Gie Kim ) 대한산부인과학회 2014 Obstetrics & Gynecology Science Vol.57 No.1
Objective The purpose of this study is to investigate the prognostic role of pretreatment anemia in patients with early cervical cancer who underwent radical hysterectomy. Methods In this study, we retrospectively enrolled patients with early cervical cancer (International Federation of Obstetrics and Gynecology stage IB to IIA) who were treated at Samsung Medical Center, Seoul, Korea, from 1996 to 2007. Results We retrospectively enrolled 805 patients. Median pretreatment hemoglobin (Hb) level was 12.8 g/dL (4.0?16.9) in all patients. Ninety-ninth out of 805 patients had pretreatment anemia (12.3%). Pretreatment anemia was significantly associated with large tumor size, advanced clinical stage, and parametrial invasion. In multivariate analysis, higher pretreatment Hb entailed better prognostic significance in disease free survival (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.078?0.99) but not in overall survival (HR, 0.94; 95% CI, 0.80?1.10). Conclusion In conclusion, we found that the negative association between pretreatment Hb level and tumor size and the impact of anemia before treatment on disease free survival adjusted for other factors including clinical stage and pathological findings in early stage cervical cancer.
Bae, Sang-Eun,Kim, Dae-Hyeon,Lee, Na-Ri,Park, Tae-Hong,Kim, Jong-Yun The Electrochemical Society 2016 Journal of the Electrochemical Society Vol.163 No.2
<P>Electrochemical behavior of ytterbium cations in a LiCl-KCl melt was investigated by electrochemical and UV-VIS absorption spectroscopy methods. In the LiCl-KCl melt, ytterbium exists with divalent and trivalent oxidation states. The electrochemical results showed that the electrochemical reactions of the Yb2+/3+ are reversible and controlled by their diffusion rates. UV-VIS absorption spectroscopy results indicate that the Yb2+ and Yb3+ ions in the LiCl-KCl melt have a few strong absorption bands below 400 nm. Additionally, the molar absorptivities of these electronic transitions of Yb2+ and Yb3+ in LiCl-KCl melt are reported. (C) 2015 The Electrochemical Society.</P>
GO-44 : Prognostic value of pre-treatment Hb level in patients with early cervical cancer
( Na Ri Shin ),( Yoo Young Lee ),( Kyoung A Lee ),( Seung Hyun Kim ),( Ji Young Kim ),( Chel Hun Choi ),( Tae Joong Kim,),( Jeong Won Lee ),( Duk Soo Bae ),( Byoung Gie Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
The purpose of this study is to investigate the prognostic role of pre-treatment anemia in patients with early cervical cancer who underwent radical hysterectomy In this study, we retrospectively enrolled patients with early cervical cancer (FIGO stage IB to IIA) who were treated at Samsung Medical Center, Seoul, Korea, from 1996 to 2007. We retrospectively enrolled 805 patients. Median pre-treatment Hb level was 12.8 g/dL (4.0-16.9) in all patients. 99 out of 805 patients had pre-treatment anemia (12.3%). Pre-treatment anemia was significantly associated with large tumor size, advanced clinical stage, and parametrial invasion. In multivariate analysis, higher pre-treatment Hb entailed better prognostic significance in disease free survival (HR, 0.88; 95% CI, 0.078-0.99) but not in overall survival (HR, 0.94; 95% CI, 0.80-1.10). In conclusion, we found that the negative association between pre-treatment Hb level and tumor size and the impact of anemia before treatment on disease free survival adjusted for other factors including clinical stage and pathological findings in early stage cervical cancer.
( Na Ri Park ),( Jung Hoon Cha ),( Jeong Won Jang ),( Jong Young Choi ),( Seung Kew Yoon ),( Si Hyun Bae ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The character of metastatic cells is strongly correlated to epithelial- mesenchymal transition (EMT) and cell adhesion molecules such as cadherin and CD44. CD44 is a receptor for hyaluronic acid, plays a role in migration, metastasis, and invasion. Moreover, transforming growth factor beta (TGF-β) signaling acts as the main factor in EMT. We investigate the correlation between high CD44 and TGF-β1 during EMT in HCC cell lines. Methods: We determined the expression of CD44 by FACS and expression of TGF-β1 from the cell supernatant by ELISA. To investigate synergy effect of CD44 and TGF-β1, we induced EMT by TGF-β1 treatment. Also, we inhibited EMT by shCD44 and TGF-β1 inhibitors. Morphological changes were evaluated using microscopy and expression of EMT-related proteins detected by western blot. Also, EMT characteristics analyzed with sphere formation and migration assay. Results: At the FACS analysis, the CD44 was highly expressed in SNU-354 and SNU-368 cell lines. TGF-β1 was only expressed in SNU-368 but not in SNU-354. SNU-368 CD44+ cells show EMT through up-regulation of AKT/GSK3β/β-catenin pathway. By comparison, SNU-354 CD44+ cells increased expression of N-cadherin but did not decrease the expression of E-cadherin, and then AKT/GSK3β pathway showed down-regulation. But, TGF-β1-treated SNU-354 cells exhibited morphological changes and accompanied by loss of E-cadherin and gain of N-cadherin with increased AKT/GSK3β/β-catenin. Also, TGF-β1-treated SNU-354 cells enhanced sphere formation and migration. On the other hand, TGF-β1-inhibited SNU-368 cells showed reduced N-cadherin and AKT/GSK3β/β -catenin. Also, TGF-β1 inhibition decreased sphere formation and migration. Moreover, the treatment with both shCD44 and TGF-β1-inhibitors reduced N-cadherin and AKT/β-catenin pathway and decreased migration in SNU-368 cells. Conclusions: TGF-β1 increased the expression of EMT-related proteins with CD44 in SNU-354 cells. TGF-β inhibitors showed reversed EMT in SNU-368. In addition, co-expression of TGF-β1 and CD44 were needed for tumor metastasis because it significantly increased sphere formation and migration.
Na, Hae‐,Ri,Kim, SangYun,Choi, Seong‐,Hye,Yang, Dong‐,Won,Bae, Hee‐,Joon,Kim, Jung‐,Eun,Park, Mee‐,Young,Shim, Yong‐,Soo,Kim, Byung‐,Kun,Kwon, Jaeȁ Blackwell Publishing Asia 2011 GERIATRICS & GERONTOLOGY INTERNATIONAL Vol.11 No.1
<P><B>Aim: </B> Donepezil has not been evaluated in Korean patients with Alzheimer's disease (AD) for up to 1 year. The objectives of this study were to evaluate the differential efficacy of donepezil in Korean AD patients with and without concomitant cerebrovascular lesions (CVL).</P><P><B>Methods: </B> This study was a 48‐week open‐label trial of donepezil in patients with probable AD of mild to moderate severity. CVL were evaluated through magnetic resonance imaging (MRI) findings within 3 months. Efficacy analyses were performed for cognitive, behavioral and functional outcome measures.</P><P><B>Results: </B> Concomitant CVL were documented in 35 (30.7%) of the patients on MRI. Seventy‐nine (69.3%) of the patients were considered not to have concomitant CVL. The mean Mini‐Mental State Examination scores of both patients with and without CVL showed improvement at each evaluation. However, there was no statistical difference in improvement between the groups.</P><P><B>Conclusion: </B> The presence of CVL should not deter clinicians from treating AD with donepezil. <B>Geriatr Gerontol Int 2011; 11: 90–97.</B></P>