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      • Temporal Trends and Future Prediction of Breast Cancer Incidence Across Age Groups in Trivandrum, South India

        Mathew, Aleyamma,George, Preethi Sara,Arjunan, Asha,Augustine, Paul,Kalavathy, MC,Padmakumari, G,Mathew, Beela Sarah Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6

        Background: Increasing breast cancer (BC) incidence rates have been reported from India; causal factors for this increased incidence are not understood and diagnosis is mostly in advanced stages. Trivandrum exhibits the highest BC incidence rates in India. This study aimed to estimate trends in incidence by age from 2005-2014, to predict rates through 2020 and to assess the stage at diagnosis of BC in Trivandrum. Materials and Methods: BC cases were obtained from the Population Based Cancer Registry, Trivandrum. Distribution of stage at diagnosis and incidence rates of BC [Age-specific (ASpR), crude (CR) and age-standardized (ASR)] are described and employed with a joinpoint regression model to estimate average annual percent changes (AAPC) and a Bayesian model to estimate predictive rates. Results: BC accounts for 31% (2681/8737) of all female cancers in Trivandrum. Thirty-five percent (944/2681) are <50 years of age and only 9% present with stage I disease. Average age increased from 53 to 56.4 years (p=0.0001), CR (per $10^5$ women) increased from 39 (ASR: 35.2) to 55.4 (ASR: 43.4), AAPC for CR was 5.0 (p=0.001) and ASR was 3.1 (p=0.001). Rates increased from 50 years. Predicted ASpR is 174 in 50-59 years, 231 in > 60 years and overall CR is 80 (ASR: 57) for 2019-20. Conclusions: BC, mostly diagnosed in advanced stages, is rising rapidly in South India with large increases likely in the future; particularly among post-menopausal women. This increase might be due to aging and/or changes in lifestyle factors. Reasons for the increased incidence and late stage diagnosis need to be studied.

      • Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors

        Mathew, Bijo,Baek, Seung Cheol,Grace Thomas Parambi, Della,Pil Lee, Jae,Joy, Monu,Annie Rilda, P. R.,Randev, Rugma V.,Nithyamol, P.,Vijayan, Vijitha,Inasu, Sini T.,Mathew, Githa Elizabeth,Lohidakshan, The Royal Society of Chemistry 2018 MedChemComm Vol.9 No.11

        <P>A series of 13 phenyl substituted thiosemicarbazones (SB1-SB13) were synthesized and evaluated for their inhibitory potential towards human recombinant monoamine oxidase A and B (MAO-A and MAO-B, respectively) and acetylcholinesterase. The solid state structure of SB4 was ascertained by the single X-ray diffraction technique. Compounds SB5 and SB11 were potent for MAO-A (IC50 1.82 ± 0.14) and MAO-B (IC50 0.27 ± 0.015 μM), respectively. Furthermore, SB11 showed a high selectivity index (SI > 37.0) for MAO-B. The effects of fluorine orientation revealed that SB11 (<I>m</I>-fluorine) showed 28.2 times higher inhibitory activity than SB12 (<I>o</I>-fluorine) against MAO-B. Furthermore, inhibitions by SB5 and SB11 against MAO-A and MAO-B, respectively, were recovered to near reference levels in reversibility experiments. Both SB5 and SB11 showed competitive inhibition modes, with <I>K</I>i values of 0.97 ± 0.042 and 0.12 ± 0.006 μM, respectively. These results indicate that SB5 and SB11 are selective, reversible and competitive inhibitors of MAO-A and MAO-B, respectively. Compounds SB5, SB7 and SB11 showed moderate inhibition against acetylcholinesterase with IC50 values of 35.35 ± 0.47, 15.61 ± 0.057 and 26.61 ± 0.338 μM, respectively. Blood-brain barrier (BBB) permeation was studied using the parallel artificial membrane permeation assay (PAMPA) method. Molecular docking studies were carried out using AutoDock 4.2.</P>

      • KCI등재

        Dissecting Inchoatives and Causatives: English get constructions

        Barrie Michael Jonathan Mathew,성문현 한국언어정보학회 2018 언어와 정보 Vol.22 No.3

        Barrie, Michael Jonathan Mathew and Sung, Moonhyun. 2018. Dissecting Inchoatives and Causatives: English get Constructions. Language and Information, 22.3. 91-108. In this paper, we present data from English get-constructions and from Northern Iroquoian to challenge the recent consensus that in no languages are causatives built on inchoatives. Our data suggest the need for distinct functional projections for the causative and inchoative. We argue that while they are bundled in other situations, the functional heads for the causative and inchoative can be split as described in the present paper. This line of research follows recent trends in investigating the fine structure of the vP layer (Alexiadou et al. 2015, Harley 2013, Kim 2011, Marantz 2013, Pylkkänen 2008, Ramchand 2008, Legate 2014). We propose a syntactic mechanism for bundling and, in doing so, account for differences in the range of possible meanings with adverbs between canonical causatives and get-causatives. Briefly, get-causatives have unbundled causative and inchoative heads and have a wider ranger of adverbial meanings due to the projection of independent CausP and InchP. Canonical causatives have a bundled Caus-Inch head, projecting a single Caus/InchP, which leads to fewer sites for adverbs to adjoin and accordingly to a narrower range of adverbial meanings. (Sogang University)

      • KCI등재

        Numeral Classifiers in Eastern Tamang

        Barrie Michael Jonathan Mathew,전재현 대한언어학회 2022 언어학 Vol.30 No.1

        Barrie, Michael Jonathan Mathew & Jun, Jaehyun. (2022). Numeral classifiers in Eastern Tamang. The Linguistic Association of Korea Journal, 30(1), 113-131. In this paper, we examine numeral classifiers and number marking in one dialect of Eastern Tamang. As Tamang is a relatively understudied dialect continuum, we give a basic description of the empirical facts. We then employ various diagnostics from the literature and one we created ourselves to determine whether classifiers compose with nouns or with numerals. We conclude that since the classifier composes with numerals, the numeral classifier is a constituent that composes with the NP. We also examine number marking and observe that the plural marker is obligatory in some environments for animate nouns, but not for inanimate nouns. We conclude by making some tentative remarks that this dialect of Eastern Tamang might be undergoing a transition from a classifier language to a number language.

      • SCISCIESCOPUS
      • KCI등재

        Comparative analysis of noise from three Falcon 9 launches

        Mathews, Logan T.,Gee, Kent L.,Hart, Grant W.,Rasband, Reese D.,Novakovich, Daniel J.,Irarrazabal, Francisco I.,Vaughn, Aaron B.,Nelson, Pauline The Acoustical Society of Korea 2020 韓國音響學會誌 Vol.39 No.4

        This study investigates the far-field noise from three Falcon 9 vehicle launches from Vandenberg Air Force Base, CA, USA, as measured from the same location within the nearby community of Lompoc. The overall sound pressure levels for the three launches are shown to be similar, but some differences in the early launch period are thought to be weather-related. The peak directivity angle in overall level is approximately 65 deg, which is consistent with horizontally-fired, static rocket data. For the third launch, waveforms and spectra are analyzed for different events during the launch sequence. The measured spectral bandwidth decreases with time, but spectral levels remain above the ambient noise throughout the main-engine firing. Additionally, late-launch phenomena observed in the data appear to be correlated with main-engine cutoff and second-stage engine start. 본 연구에서는 미국 캘리포니아주 소재 반덴버그 공군기지(Vandenberg Air Force Base)에서 3차례 발사된 Falcon 9의 원거리장 소음에 대해 논하였다. 발사 소음은 3회 모두 롬폭(Lompoc) 도시 인근의 동일 위치에서 측정되었다. 전체 음압레벨(overall sound pressure level)은 3회 모두 유사하지만 기상조건과 관련된 차이점이 발사 초반부에 관찰되었다. 음압레벨 기준 최대 지향성은 약 65°로서 수평 정적 연소시험으로부터 얻어진 결과와 일치하였다. 세번째 발사 소음에 대하여 각 발사 단계에 따른 파형 및 스펙트럼을 분석하였다. 1단 엔진 추진 구간에서 소음의 대역폭은 시간에 따라 감소하였으나 그 크기는 모든 주파수에 걸쳐 주변 소음레벨을 상회하였다. 또한, 발사 후반부 데이터에서 관찰되는 특이 경향은 1단 엔진 정지 및 2단 로켓 점화와 연관이 있는 것으로 추정되었다.

      • SCOPUSKCI등재

        Synthesis and Characterisation of Hole Transporting Materials Based on N,N,N-Tris-[4-(Naphthalen-1-yl-phenylamino)Phenyl]-N,N,N-Triphenylbenzene-1,3,5-Triamine

        Mathew, Siji,Haridas, Karickal R. Korean Chemical Society 2010 대한화학회지 Vol.54 No.6

        Two derivatives of star shaped compounds based on naphthylamine benzene고리에 methoxy기와 ethoxy기가 치환기로 연결되어있는 naphthylamine 관련 화합물을 합성하였다. 합성한 화합물의 전자 및 열적특성을 cyclic voltametry (CV) 및 differential scanning calorimetry (DSC)를 이용하여 조사하였다. Two derivatives of star shaped compounds based on naphthylamine with symmetric trisubstituted benzene as core, methoxy and ethoxy as end substitutions are synthesized. The synthesized compounds are characterized by UV-visible, FT-IR and NMR spectrometric techniques. The electronic and thermal properties of the compounds are studied using cyclic voltametry (CV) and differential scanning calorimetry (DSC) respectively. The data's obtained have similarity with the arylamines that have been already used in optoelectronic devices. So these compounds are interesting materials for applications in such devices.

      • Exploring Sport Management as an Academic Profession: A Critical Review of Occupational Theory

        Mathew Dowling 글로벌지식마케팅경영학회 2018 Journal of Global Sport Management Vol.3 No.4

        The discussions surrounding the current state of sport management as an academic discipline have traditionally been the responsibility of key addresses and editorials. In drawing upon the sociological and management literature surrounding professions, this article critically reflects upon the characteristics of the field and the extent to which it can be viewed as a profession. More specifically, Abbott's general theory of the profession and Greenwood's five attributes (systematic theory, authority, community sanction, ethical codes, and professional culture) that characterize a professionalized occupation are drawn upon and discussed in relation to the evolution and current state of the field. The findings elucidate the complexities of the professionalization process surrounding occupations and suggest that there are burgeoning signs of a profession emerging within sport management academia, but the field, at best, can be labelled a semi or quasi-profession. The implications of these findings for the future direction of the field are discussed.

      • KCI등재

        ON THE RATE OF CONVERGENCE OF VISCOSITY IMPLICIT ITERATIVE ALGORITHMS

        Mathew O. Aibinu,Jong Kyu Kim 경남대학교 기초과학연구소 2020 Nonlinear Functional Analysis and Applications Vol.25 No.1

        An essential numerical method for solving ordinary differential and differential algebraic equations is the implicit midpoint rule. Comparing the rate of convergence of the implicit midpoint rules by using numerical examples is common in the literatures. Under suitable conditions imposed on the control parameters, it is shown in this paper that certain two implicit iterative sequences converge to the same fixed point of a nonexpansive mapping in uniformly smooth Banach spaces. Moreover, analytical comparison for the rate of convergence of the implicit iterative sequences to a fixed point of a nonexpansive mapping in uniformly smooth Banach spaces is presented. The implicit iterative sequence which converges faster is determined by an analytical method which is more general than the numerical methods.

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