세치제 평가에 있어서 변형실험치은염모형의 안전성

황수정 ( Soo Jeong Hwang ),백대일 ( Dai Il Paik ),김현덕 ( Hyun Duck Kim ),진보형 ( Bo Hyoung Jin ),배광학 ( Kwang Hak Bae ),김남희 ( Nam Hee Kim ) 대한예방치과·구강보건학회 2010 大韓口腔保健學會誌 Vol.34 No.2

연구목적. 일부 연구자들은 치은염 예방 또는 치료 성분이 포함되어 있는 특수세치제의 치은염 억제 효과를 입증하기 위하여 Loe의 실험치은염모형을 변형한 변형실험치은염 모형을 사용하고 있으나, 변형실험치은염모형에 대한 안전성 검토는 미비한 상태이다. 따라서, 본 연구는 3주간 구강분할동시현상비교연구법(split mouth method)을 사용하여 변형실험치은염모형의 안전성을 검토하고 치은염의 일부 기구를 알아보고자 하였다. 연구방법. 성인남자 59명을 대상으로 3주 동안 잇솔질시 잇솔질방지판과 세치제를 편측 소구치부위에 착용하여 기계적 잇솔질을 금지한 실험치은염을 발생시켜 잇솔질방지하악소구치부와 잇솔질허용하악소구치부의 치은염지수, 치면세균막지수, 치은열 구액내의 MMP-9의 농도, IL-1β의 농도를 비교 검토하였다. 연구결과. 잇솔질방지하악소구치부는 3주간의 실험기간동안 실험시작 후 2주차 때 치은염지수와 치면세균막지수가 가장 높았으며 시간에 따라 차이변화가 유의하였으며(p<0.02) 실험 종료 후 초기상태로 회복되었다. 3주간의 실험기간동안 잇솔질방지하악 소구치부와 잇솔질허용하악소구치부 사이에서는 치은열구액내 염증지표인 MMP-9의 농도변화는 유의하지 않았고 염증전단계지표인 IL-1β의 농도변화는 유의하였으나(p=0.03) 잇솔질방지하악소구치부의 MMP-9의 농도와 IL-1β의 농도는 유의한 상관 관계를 보였다. 결론. 잇솔질방지하악소구치부내 MMP-9의 농도는 유의하게 변화하지 않았으므로 치은의 직접적인 파괴는 나타나지 않은 것으로 사료되어 변형실험치은염모형은 세치제의 효과를 평가함에 있어 안전한 모형으로 사료되었다.

운동장애형 기능성 소화불량증 환자에서의 식도내압검사 성적

황일란,김진홍,이광재,김정민,함기백,조성원 대한소화관운동학회 1998 Journal of Neurogastroenterology and Motility (JNM Vol.4 No.1

구강 악성 흑색종에서 PCNA 발현에 관한 면역조직화학적 연구

황경균,남윤우,이재일,이종호,심광섭,김명진 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.6

Malignant melanoma arising from the mucosa of head and neck region was rare and showed poor prognosis. Some of malignant melanoma were transformed from benign melanotic lesion. Malignant melanoma had high cellular proliferation and rapid growth. The percentage of PCNA-positive cell (labeling index) is high in many malignant tumor. So we compared the pattern of PCNA expression in the melanotic lesion. We performed the immunohistochemical study in malignant melanoma(19 cases), benign melanotic macule(24 cases) and normal mucosa(20 cases) were diagnosed in Seoul National University Dental Hospital between 1980 and 2000. Positive PCNA staining was found mainly in malignant melanoma. The mean PCNA expression in malignant melanoma, melanotic macule, normal tissue were 29.2%, 1.4%, 0%, respectively. Significant differences in PCNA expression were noted between malignant melanoma and melanotic macule(p<0.01), normal mucosa(p<0.01). These result suggested that the PCNA expression seems to be used as a diagnostic indicator for malignancy in malignant melanoma and melanotic lesion.

CNUOS subset으로서의 DOS program들의 Multitasking

황영원,김봉환,이광일,김상하 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.1

A number of softwares have been being developed under DOS on personal computer. CNUOS is a distributed system that is designed to provide the environment upon which application programs developed under heterogeneous operating systems including DOS can be executed simultaneously. Protection is necessary for reliable mutitasking and can be used to prevent tasks from interfering with each other. In this paper, we will introduce two modules as a subset of CNUOS: the protection module and the DOS emulation module which is able to support the multiprogramming of DOS programs.

熱倂合發電시스템의 運轉方法에 따른 建物用途別 에너지節約可能性 評價에 관한 연구

황광일 대한건축학회 2004 대한건축학회논문집 Vol.20 No.4

The purpose of this study is on the evaluations of the energy saving effects by cogeneration system in the view point of its operating methods and building needs. The followings are the results of this study. ①6 building needs (apartment, office, hospital, hotel, department, and complex(hotel+department)) are specified and every each hourly cooling, heating and electricity loads and heat-electricity ratio(HER) also are calculated. In apartment, monthly and hourly HERs are scattered, and in office, monthly HER is converged but hourly is scattered. But in hotel, monthly and hourly HERs are all converged. ②The operating methods are specified and energy flow diagram is completed. And also energy saving equations are introduced from the diagram. As the result of computational evaluation, ③the most expected energy saving effect is happened at the condition of apartment with fuel-cell type cogeneration operating by heat-loads following method. ④With heat-electricity balance operation, hotel and hospital is expected as highly effect of energy saving. ⑤In the most cases, fuel-cell type cogeneration system shows the highest energy saving effect. ⑥This study recommends, the most effective operating method for apartment is heat-loads following operating method, for office is electricity-loads following method. And for hotel, it depends on the cogeneration system.

서울시 아파트地區를 對象으로 한 低溫未利用에너지 活用시스템 導入可能地區 選定에 관한 硏究

황광일 대한건축학회 2003 대한건축학회논문집 Vol.19 No.11

The purpose of this study is on the possibilities of using the low-temperature renewable energy system for the apartment districts(500m×500m) in Seoul in the view of energy savings. The followings are the results of this study. ①It is found out that the annual cooling loads' densities are very high in the district of Nowon and Dobong in northern of Seoul, Kangnam, Kangdong, Kangseo, Songpa, Yangchun in southern. ②After making definitions of the renewal energy, the river Han's estimated cooling capacity is evaluated as a heat sink. ③Energy saving equations are defined. ④As a result of the calculation of energy saving, Ichon-dong, Kui-dong are estimated as the most desirable districts to adopt the renewal energy system substituting for the normal electrical cooler. ⑤144 districts which are expected to be able to save energy with renewal energy system are located within 2 km from the river Han. It means the distance between the heat source and the designed area is the most important variable to decide whether the renewal energy being useful or not.

꽃게껍질로 제조된 키토산의 항균효과

황용일,이광현,이승철,하정욱 慶南大學校 附設 工業技術硏究所 1998 硏究論文集 Vol.15 No.3

고분자당류인 chitosan은 가식성 포장제, 항암제, 생물응집제, 항균물질 등으로 폭넓은 이용성을 갖는다. 다량으로 폐기되고 있는 갑각류의 껍질을 효율적으로 이용하게 위하여 꽃게 껍질에서 chitin을 분리정제한 후 탈아세틸화하여 chitosan을 제조하였다. 제조된 chitosan중에서 분자량 42,000이 Escherichia coli O157:NM에 항균력이 가장 우수하였다. 이들 결과로 부터 각종 식중독균에 대하여 항균력을 조사하였다 항균력시험으로 부터 식중독균 중에서 Gram음성균 보다 양성균에 대하여 효과적이 였으며, Gram음성균 중에서도 균종에 따라 상이한 항균력을 보였다. Chitosan was well known as an available material preparing for edible film, antiturmor agent, biocoagulant, and antimicrobiotics etc. For the effective use of Crustacean shell, chitin was prepared from the shell of Blue crab, and chitosan was made through the deacetylation of above chitin. Prepared chitosan with 42,000 M.W. showed most antibacterial effect for Escherichia coli O157 : NM. From this result, chitosan was tested its antibacterial reaction for some Gram prositive and negative food-poisoning bacteria. Antibacterial effect of chitosan was more higher for Gram positive bacteria than Gram negative bacteria and its antibacterial reactions were different for species of Gram negative bacteria.

CNUOS의 원형 설계

황영원,김봉환,이광일,김상하 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.1

An operating system is program modules within a computer system that govern the control of equipment resources such as processors, main storage, secondary storages, input/output devices, and files. CNUOS is a research project on distributed operating systems being carried out at Chungnam National University. Its goal is to investigate capability-based, object oriented systems and to build a working prototype system to use and evaluate. In this system, user-level server processes provide functions that have been traditionally provided by the operating system. This approach leads to a small(hence more reliable)kernel and makes it easier to provide, modify, and test new services. In this paper, The kernel prototype of CNUOS will be proposed.

일반 산술식 계산을 위한 병렬 알고리즘의 작업시간 스케쥴링 표현

이광일,김봉환,황영원,김상하 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.1

Work Time scheduling representation is a kind of describing tool for parallel algorithms in the limited number of processors. Most people believe that it is trivial to convert from a parallel algorithm under assumption of the unlimited number of processors to the one in limited version. In this paper we will discuss what the problem is on this conversion and show how the general arithmetic expression is correctly represented by Work Time Scheduling as an example.

외기요법이 체표온도 변화에 미치는 영향

노일호,김병완,정광조,曺政孝,黃相畯,吳旼錫 대전대학교 한의학연구소 2003 한의학연구소 논문집 Vol.12 No.1

This study is about the relationship between the effect of Radiating Qui Therapy on human body and the resulting subjective qui sensation. Patients were between 30 and 50 years of age. n=21 persons received DITI (n=14 patients were provided, n=9 control group) twice examination with Radiating Qui Therapy. First all patients were examined by DITI. After treatment with Radiating Qui Therapy (n=14) both the treated and the control groups were eaxmined again. Radiating Qui Therapy is provided upright position. After Radiating Qui Therapy 92% of the treated group felt a significant qui sensation and 43.5 % felt a warmth at the abdomen and over the whole body. A data of this study show Radiating Qui Therapy has s stimulating effect on human skin temperature. As disease region and Qui sensation are very closely related to each other results strongly suggest that Radiating Qui Therapy could be used as a treatment for a several disease.