『東文選』에 나타난 麗末鮮初 지식인의 對日認識

조정효 조선통신사학회 2011 조선통신사연구 Vol.13 No.-

암 관련 삶의 질 평가도구에 관한 연구 현황

조정효,손창규,이연월,유화승,성정현,김소영,이명민,강위창,조종관,Cho, Jung-Hyo,Son, Chang-Gue,Lee, Yeon-Weol,Yoo, Hwa-Seung,Sung, Jung-Hyeon,Kim, So-Young,Lee, Myong-Min,Kang, Wee-Chang,Cho, Chong-Kwan 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1

The importance of measurement of health-related quality of life (HRQL) cannot be overemphasized. However, efforts to implement HRQL measurement often fail because of differences in definition and insufficient information about available measures. In this paper, many available HRQL measures are reviewed, which have been designed for, or frequently used with, people with cancer in order to aid in the evaluation of effects of oriental medicine on cancer patients. A total of 28 articles were selected from three different databases. The selected articles were analyzed according to three aspects of application of the Korean version of HRQL measures, namely generic, disease specific and symptoms related instruments. Nine HRQL measures are completed with Korean validation and data collection under contact and permission of the author. However, research studies that reported data on quality of life (QOL) in cancer patients treated with oriental medicine were wholly lacking. It is recommended that further studies be performed, using methods of data collection whose validity and reliability has been confirmed.

심층강화학습을 이용한 Convolutional Network 기반 전산화단층영상 잡음 저감 기술 개발

조정효(Jenonghyo Cho),임도빈(Dobin Yim),남기복(Kibok Nam),이다혜(Dahye Lee),이승완(Seungwan Lee) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.7

전산화단층영상 품질 개선을 위해 사용되는 지도학습 기반의 딥러닝 기술은 사전 학습을 위해 많은 양의 데이터를 필요로 하는 단점이 있다. 또한 지도학습 기반의 딥러닝 기술은 학습에 사용된 영상의 특징과 학습된 모델에 입력된 영상의 특징이 다른 경우 영상 내부 구조적 왜곡이 유발되는 한계점이 있다. 본 연구에서는 기존 지도학습 기반 딥러닝 기술의 단점을 보완하고 전산화단층영상의 잡음을 감소시킬 수 있는 심층강화학습 기반 영상화 모델을 개발하였다. 심층강화학습 기반 영상화 모델은 shared, value 및 policy 네트워크로 구성하였으며, 영상 잡음 특징 추출 및 모델의 성능 향상을 위해 합성곱, rectified linear unit(ReLU) 활성화 함수, dilation factor 및 게이트순환유닛을 사용하였다. 또한 기존 지도학습 기반 딥러닝 기술을 통해 획득한 영상의 영상품질 비교를 통해 본 연구에서 개발한 영상화 모델의 성능을 평가하였다. 연구결과 기존 기술에 비해 본 연구에서 개발한 영상화 모델 적용 시 전산화단층영상의 정량적 정확도는 큰 폭으로 향상, 잡음은 큰 폭으로 감소함을 확인하였다. 또한 영상화 모델 학습 시 사용한 영상과 구조적 특징이 다른 영상에 대해서도 잡음 감소 효과를 확인하였다. 따라서 본 연구에서 개발한 심층강화학습 기반 영상화 모델을 통해 전산화단층영상의 구조적 특징을 보전함과 동시에 잡음을 감소시킬 수 있다. Supervised deep learning technologies for improving the image quality of computed tomography (CT) need a lot of training data. When input images have different characteristics with training images, the technologies cause structural distortion in output images. In this study, an imaging model based on the deep reinforcement learning (DRL) was developed for overcoming the drawbacks of the supervised deep learning technologies and reducing noise in CT images. The DRL model was consisted of shared, value and policy networks, and the networks included convolutional layers, rectified linear unit (ReLU), dilation factors and gate rotation unit (GRU) in order to extract noise features from CT images and improve the performance of the DRL model. Also, the quality of the CT images obtained by using the DRL model was compared to that obtained by using the supervised deep learning model. The results showed that the image accuracy for the DRL model was higher than that for the supervised deep learning model, and the image noise for the DRL model was smaller than that for the supervised deep learning model. Also, the DRL model reduced the noise of the CT images, which had different characteristics with training images. Therefore, the DRL model is able to reduce image noise as well as maintain the structural information of CT images.

抗癌丹을 投與한 各種 癌患者 320例에 對한 考察

曺政孝,兪和承,李淵月,孫彰奎,趙鍾寬 대전대학교 한의학연구소 2004 혜화의학회지 Vol.12 No.2

The purpose of this study was to investigate the effects of Hangamdan(抗癌丹). The clinical study was carried out 320 cases of patients with cancer treated by Hangamdan(抗癌丹) from May 1st 1998 to September 1st 1999. The results were summarized as follows; 1. The effects of improvement in the symptoms with traditional oriental cancer therapy(47.6%) were higher than combined treatment of western and oriental therapy(37.4%). 2. In the analysis of hematology, maintenance and increasing of WBC(86.2%), Hgb(87.2%), Platelet(97.6%) RBC(81.1%) were Observed. In the analyses of tumor marker, maintenance and decreasing of CEA(76%), CA19-9(88.8%), AFP(69.2%) were observed. 3. In the analysis of safety, maintenance and decreasing of AST(93.1%), AL.T(95%), BUN(92.2%), Creatinine(93.6%) were observed. 4. In the analysis of QOL attached by cancer, combined treatment of western and oriental therapy(maintenance and improvement; 91.8%) was higher than traditional oriental cancer therapy(maintenance and improvement; 79.3%) 5. In the analysis of survival in patients with terminal cancer, above 6 months(46.3%), 12 months( 19.2%). 6. In the analysis of antitumor effects, combined treatment of western and oriental therapy(maintenance 71.6% improvement 12.8%) was higher than traditional oriental therapy (maintenance 66.7% improvement 9.5%). 7. In the analysis of curative evaluation, combined treatment of western and oriental therapy(maintenance 40.4% improvement 41.8%) was higher than traditional oriental therapy (maintenance 23.8% improvement 46.1%). 8. In the analysis of IL-12 and IFN-γ attached by cancer, increasing of IL-12(32.3%), IFN-γ(41.5%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for cancer patients by combination with western therapy or alone.

慢性 肝疾患者 57例에 대한 臨床報告

조정효(Jung-Hyo Cho),이용연(Yong-Yeon Lee),서상훈(Sang-Hoon Seo),유화승(Hwa-Seung Yoo),최우진(Woo-Jin Choi),이연월(Yeon-Weol Lee),손창규(Chang-Kyu Son),조종관(Chong-Kwan Cho) 대한한의학회 2000 대한한의학회지 Vol.21 No.4

癌의 發生과 免疫에 대한 考察

조정효,손창규,조종관 대전대학교 한방병원 2001 惠和醫學 Vol.10 No.1

Most cancers are thought to originate from a single cell that has undergone a somatic mutation, but the progeny of this cell must undergo further changes, probably requiring several additional mutations, before they become cancerous. This phenomenon of tumor progression, which usually takes many years, reflects the operation of evolution by mutations and natural selection among somatic cells. The rate of the process is accelerated both by mutagenic agents (tumor initiators) and by certain nonmutagenic agents (tumor promoters). Thus many factors contribute to the development of a given cancer, and since some of these factors are avoidable features of the environment, a large proportion of cancers are in principle preventable.

『일본왕환일기(日本往還日記)』의 사행문학적 성격 연구

조정효 ( Jung Hyo Cho ) 문창어문학회 2010 문창어문논집 Vol.47 No.-

This is a study of 『Ilbonwanghwanilgi(日本往還日記)』, a record of envoy`s visit, which is recorded after diplomatic mission on 1596 by director of the visit Hwangshin. His visit was different from other envoy`s visit, which result on distintion of the 『Ilbonwanghwanilgi』. Here is the summary of this study. First of all, to discover the background of a creation of 『Ilbonwanghwanilgi』, it was needed to see Hwangshin`s literary attainments and diplomatic ability. This helped to discover the unique literary achievements. In the 『Ilbonwanghwanilgi』, there is an exhaustive record which is based on objective point of view. Mostly it is described according to the order of ``date-weather-track``. Even though there is no change in a course, he recorded the date and weather, which shows his will to report. His blurred position as a envoy and vassal, and unclear cause made him feel embarrassed. So he couldn`t help doing self-justification by careful recording. This made the 『Ilbonwanghwanilgi』 show reproduction technique and biographical method. In the record of Hwangshin, there is two aspects of description. One is reportage character, and the other is that a personal feeling was written in the record by literature. Hwangshin put himself in observer for objective description. It means, as a director of the envoy`s visit, he used objectification strategy to report the experiences without making any adjustments. This will to report show up across all the records. 「Seohaemun」 and 「Chupojip」 include four poems about envoy`s visit and they have Hwangshin`s personal feeling toward the visit. The poems cover missing for home, and they express anguish and conflict of a director. Also they contain the will to overcome trials against positional difficulties, and it is found in 「Seohaemun」, which is written on the way to Daemado. There are two features of content in Hwangshin`s record. First, he shows a ambivalence attitude toward Japan. Actually, intelligentsia in the early period of the Joseon Dynasty didn`t have hostility against Japan. In 『Ilbonwanghwanilgi』, in spite of Toyotomi Hideyoshi`s inhospitable treatment, there is signs of effort to see the Japanese culture with an objective point of view. Second, there is his diplomatic conflict and anguish as a director of the visit. As Toyotomi Hideyoshi refused to meet Tonshinsa, he felt diplomatic tension. In the strained relations, he revealed the will to perform the work assigned to him. And he expressed the will even unto death, in case of failure. But such attitude created a conflict between Hwangshin and envoies of Ming Dynasty. This story was reflected in 『Ilbonwanghwanilgi』 faithfully, and made it have both literary value and value of history of diplomacy. Lastly, based on the study above, historical meaning of Hwangshin`s literature is studied. First, there are unique features of 1596 envoy`s visit in his literature. Before his visit, envoy`s visit was focused on a relationship between the Joseon Dynasty and Japan. On the other hand, envoy`s visit on 1596 covers relationships between the Ming Dynasty and the Joseon Dynasty and Japan. So there are more complex diplomatic conflicts in the 『Ilbonwanghwanilgi』. Second, Hwangshin`s 『Ilbonwanghwanilgi』 shows different aspects of perception toward Japan. It provided a wider perspective for noblemen of the day. Also, it can be an important material to see the changes of perception toward Japan. This study covers the backgrounds of creation, strategies of description, and features of content to establish the status of record of the envoy`s visit. The ultimate goal of this study is making the envoy`s visit on 1596, which was neglected until now, the full-scale research theme.

New Drug Development using Korean Herbal Formulae: A model role study

조정효,WANG JINGHUA,손창규 대한한의학회 2009 대한한의학회지 Vol.30 No.6

Objectives:Traditional Korean herbal formulae are composed of multiple medicinal plants. This situation of multiple-ingredient mixtures has been considered as a major obstacle to new drug development using herbal formulae in the world market, despite the effectiveness of such mixtures. This study reviewed Liv-52 as a representative model of successful drug development using a multiple-herb mixture. Methods:All articles for Liv-52 were collected from the PubMed database. The history, composition of Liv-52, its pharmaceutical efficacy and mechanisms, and data from clinical studies including its market size were analyzed. Results:Liv-52 is composed of seven herbal plants and it is the best known in Ayurvedic medicine for treating liver disorders. Since its 1955 introduction, forty four international papers have been published based on pre-clinical and clinical trials. The efficacy and mechanisms of Liv-52 were intensively studied. Currently, Liv-52 is one of the top-selling products, with over 10 million dollars sales annually, in the world market. Conclusions:These results indicate that Korean herbal formulae could be new global drugs if scientific evidence for efficacy and standardization are produced via literature researches.

『청성잡기(靑城雜記)』에 반영된 조일(朝日) 관련 기사 연구

조정효 조선통신사학회 2020 조선통신사연구 Vol.29 No.-

急性 骨髓性 白血病 患者 1例에 對한 臨床報告

조정효,유화승,최우진,이용연,서상훈,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

AML is the most common type of leukemia in adults. AML(acute myeloid leukaemia) is characterised by a rapid accumulation of abnormal white blood cells in the blood and bone marrow, resulting in severe anemia, and possibly infection, and hemorrhage during the course of the disease. In general the prognosis of patient with relapsed AML is poor. At this time, however, the only potentially curative therapy for relapsed patients is allogeneic BMT(bone marrow transplantation). This clinical study were carried out 1 case of female patient aged 44 with relapsed AML treated by herb medicine. At the time of admission, she complained of mild fever, nausea, vomitting, abdominal pain, anorexia and no sign of bleeding. For the 10 days of admission, she was treated with Oriental-Western medicine and all the symptoms were disappeared. After that, the syptoms were aggravated because of secondary infection. Anyway, above result showed the possibility of Oriental therapy as Supportive Care in AML.