Plasminogen kringle (angiostatin) 분획의 유효부분 분석

최영기,서원덕,이종수,신광순,김철중 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

In order to inhibit the growth of the malignant tumor, the development of various drugs against the malignant tumors has been archived. The combination of these drugs made the tumor therapy possible, but in many cases, secondary matastasis of the tumor to the other organs after its removal has been frequently reported. The angiostain, recently purified and cloned, not only promtes the angiogenesis of the tumor itself in the primary tumor but also inhibits the angiogenesis and metastasis of the secondary tumors. In this study, the nucleic acid sequences of the angiostatin was investigated. And the angiostain gene was expressed in a prokayotic expression system(E. coli) and a eukayotic expression system(Pichia pastoris). The angiostain gene was futher subcloned into 6 clones to characterize its biological activity. In the near future the biological activity and the biochemical property of the protein encoded by each clone will be elucidated.

지반-구조물 상호작용에서의 JOINT 요소에 대한 연구

최광순,손영호,김종주,최광규 동아대학교 건설기술연구소 1999 硏究報告 Vol.22 No.2

The direct boundary element method has been formulated In which the symmetry condition is introduced. The displacement approach of the finite element method has been reviewed where the joint stiffness formulation is included. The coupling of boundary and finite element methods is derived for both equivalent boundary and finite element approaches. A computer program based on the coupling of boundary and finite element methods was developed to analyze the elastic behavior of a structure. Another computer program based on the finite element method alone was developed to solve the same soil mass which were assumed to be linearly elastic, isotropic, and homogeneous. The characteristics of joint elements are that they will separate in response to tension, slide in response to shear, and transmit any force in response to compression. The limitation of no transfer of tensile stresses across soil/structure interface was ensured by employing iterative schemes on joint elements. The iterative solution to simulate real properties of joint elements is based on the so called "load transfer method" An example problem of soil-structure interaction problem has been analyzed using the two numerical methods indicated above. Comparison of the results of nodal displacements obtained from both techniques and the software CRISP demonstrates the accuracy and validity of the coupling of boundary and finite element methods. Due to the fact that the dimensionality of the boundary element region is reduced, the equations generated by the coupling of boundary and finite element methods are fewer than the equations generated by the finite element method alone in acquiring the same acruracy. Therefore, the coupling of boundary and finite element methods is more efficient than the finite element method alone in solving a complex soil-structure interaction problem.

일반 경비지도사의 교육훈련체계와 만족도와의 관계

최중철,권봉안,정순광 한국안전교육학회 2001 한국안전교육학회지 Vol.4 No.2

The purpose of this article was to identify the training participants through the training status for security guard instructors. This study set 350 security guard instructors taking the basic training for security guard instructors located in Seoul as a population, and selected the sample using a cluster random sampling, the probability sampling method with the same probability including the individual factors if population. The survey instrument of this study was a questionnaire, which was prepared using the survey questionnaire regarding the Korea Civil Security Guard Training Commands presented by Kang, Gil-hoon(1998). The questionnaire was composed of 3 items on demographical characteristics, 30 items on training system, and 10 items on training satisfaction, and reliability between the total questionnaire items, Cronbach α was high as .90. Collected data was analyzed using the SPSS/PC Windows 10.0 statistical program. At first, in demographical characteristics, its satisfaction was examined through frequency analysis and average and standard deviation of remaining factors through mono-variable analysis and LSD, and correlation in the training program, program, assessment and method was analyzed, Based on the above research procedures and data analysis, following conclusion was obtained The training satisfaction according to demographical characteristics differed by age(.001), service term(.001) and study level(.001). The security guard instructors' satisfaction to curricula differed by age(.001), service term(.001) but did not differ by study level(.160). The security guard instructors' satisfaction to training programs by age(.001), but did not differ by service term(071), study level(.109). The security guard instructors' satisfaction to training assessment differed by age(.001), service term(.001) and study level(.001). The security guard instructors' satisfaction to training method differed by age(.001), service term(.001) and study level(.001).

Arch교의 橫桁連結部 局部應力과 疲勞擧動에 관한 硏究

최광순,조호근,손영호,최광규 동아대학교 건설기술연구소 1997 硏究報告 Vol.21 No.2

In this paper, the relation between the local stress and the fatigue behavior at gusset plate connected with main girder and floor beam in arch bridges was obtained. The conclusion was as follows : (1) In-plane bending moment and out-of-plane bending moment are higher than other internal stress resultants. (2) When a vehicle crosses the bridges, the change of out-of-plane bending moment corresponds with the change of relative difference in displacement in the longitudinal direction between the tie-girder and stringer. (3) The change of in-plane bending moment corresponds with the change of the displacement in the transverse direction of arch-rib. (4) Fatigue crack can be initiated by in-plane bending stress that Is produced by out-of-plane bending moment at the toe of gusset plate. (5) Fatigue crack can be initiated by tension stress that is produced by in-plane bending moment at the toe of gusset plate.

Arch교의 橫桁連結部 局部應力과 疲勞擧動에 관한 硏究

최광순,조호근,손영호,최광규 東亞大學校 建設技術硏究所 1997 硏究論文集 Vol.21 No.2

In this paper, the relation between the local stress and the fatigue behavior at gusset plate connected with main girder and floor beam in arch bridges was obtained. The conclusion was as follows : (1) In-plane bending moment and out-of-plane bending moment are higher than other internal stress resultants. (2) When a vehicle crosses the bridges, the change of out-of-plane bending moment corresponds with the change of relative difference in displacement in the longitudinal direction between the tie-girder and stringer. (3) The change of in-plane bending moment corresponds with the change of the displacement in the transverse direction of arch-rib. (4) Fatigue crack can be initiated by in-plane bending stress that is produced by out-of-plane bending moment at the toe of gusset plate. (5) Fatigue crack can be initiated by tension stress that is produced by in-plane bending moment at the toe of gusset plate.

NMR을 이용한 LAS와 AES의 혼합비결정에 대한 연구

권순자,최광훈 慶熙大學校 1980 論文集 Vol.10 No.-

The mixture of alcohol ether sulfate (AES) are linear aekylhenzene sulfate (LAS), raw materials of syndets were reacted with methylene blue (MB). From the NMR spectrum of the products obtained, the mixing ratio of LAS to AES was determined and the presence of branched alkylbenzene sulfate(ABS) in LAS was determined.

심한 변비와 복부팽만으로 발견된 소아 크론병 1예

성명순,강석정,최광해 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Crohn's disease is a chronic inflammatory bowel disease that mainly affects children and young adults, Its cause remains unknown. The incidence of pediatric Crohn's disease is increasing, so it is important for clinicians to be aware of the presentation of this disease in the pediatric population The majority of patients complain of abdominal pain (72%), with only 25% Presenting with the 'classical triad' of abdominal pain, weight loss, and diarrhea. Many children with Crohn's disease present in a 'non-classical' manner, with vague complaints such as lethargy or anorexia, which may be associated with only mild abdominal discomfort Other symptoms include fever, nausea, vomiting, growth retardation, malnutrition, delayed Puberty, Psychiatric symptoms, arthropathy, and erythema nodosum. Severe constipation and abdominal distension are uncommon symptoms at diagnosis. We report a case of pediatric Crohn's disease, which was diagnosed after the patient presented with severe constipation and abdominal distension.

Azithromycin으로 치료한 임신 중 쓰쓰가무시병 1예

김광석,최진욱,서호종,김기훈,박성호,서광섭,고성만,김순혜,김호정 대한감염학회 2001 감염 Vol.33 No.5

We report a case of tsutsugamushi disease in a 26 year-old pregnant woman who was treated with azithromycin. Her gestation period was 27 weeks and she admitted with fever, rash, and eschar on the right shoulder. Currently recommended medications for the treatment of scrub typhus are doxycycline or chloramphenicol. But, these drugs are class D drugs according to the U.S. Food and Drug Administration (FDA) Fetal Risk Summary, so they couldn't be used to treat pregnant women. Recently, a few case reports suggested that azithromycin, a relatively new macrolide antibiotic, was effective and safe for the treatment of scrub typhus in pregnant women. And, there is no evidence that azithromycin causes harmful effects to the developing fetus or to children. On the basis of current in vivo test that confirms the effectiveness of azithromycin, it may be the drug of choice for the treatment of scrub typhus in pregnant women and children. (Korean J Infect Dis 33:380-382, 2001)

응급실환자 내원행태 및 중증도에 관한 조사 연구

유순규,최혜경,김광한 서울보건대학 1999 서울보건대학 부설 병원경영연구소 논문집 Vol.4 No.2

To solve the problem of tertiary emergency medical center. overcrowding and long hospital stay. it is very important to analyze arrival pattern of the emergency patients who visited tertiary emergency medical center and to reviewed 312 cases of patients who visited the four places emergency medical center which emergency medicine department specialist always stays in. of Seoul and Suwon teritory, from March 1 to May 31. 1997. The results were as follow : 1. Considering sexual distribution, male patients were 60.3% and female patients were 39.7% and the most common age group was 2th decade. 2. The result of symptom severity classification of patients coming emergency medical center was urgent patients 12.8%, emergency patients 29.8%, non-emergency patients 57.4% 3. The peak time of patient's enterance in emergency medical center was between 8: 00PM and 12:00 PM(26.7%), and most patients visited between 4:00 PM and 12:00 PM (out patients coming time) 4. In a week. Monday was the most crowding day (25.0%) 5. The most patients who visited emergency medical center needed surgical care due to injury & poisoning(27.9%) and second disease of them had circulatory system (17.6%) 6. The admission rate was 42.9% and 46.4% of admitted patients were non-emergency patients. 7. The rate of the urgent patients making use of 119 ambulance was 62.5%. emergency patients rate was 47.3% 8. The treatment result of patients in emergency medical center trended improving of urgent patients(improvement rate was 72.5%)

발작과 의식저하를 동반한 급성 Methyl Bronmide 중독 2예

조광덕,임수빈,이순금,최성훈,김태훈,한군희,송경일 대한간질학회 2003 대한간질학회지 Vol.7 No.2