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      • I-Muscone의 심혈관계에 관한 약리연구

        조태순,김낙두,허인회,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

        In order to investigate the pharmacological properties of l-muscone, effects of l-muscone and musk were studied on the cardiovascular system with various experimental models. In isolated rat aorta, l-muscone and musk made the relaxation of blood vessels in maximum contractile response to phenylephrin (10^-6M) in endothelium-containing rings of the rat aorta, but not in endothelium-denuded rings. However, l-muscone and musk in the presence of the inhibitor of NO synthase and guanylate cyclase did not make the relaxation of blood vessel. In spontaneously hypertensive rats (SHRs), l-muscone and musk slightly reduced blood pressure but significantly decreased heart rate. In the isolated perfused rat hearts. l-muscone and musk did not affect significantly on LVDP, contractile force, coronary flow and (-dp/dt)/(+dp/dt). These results suggest that l-muscone and musk have weak cardiovascular effects with relaxation of blood vessel and decrease of heart rate, but without significant cardiac functions.

      • 마이크로센서 응용을 위한 실리콘 미세가공 기술

        고희선,김영민,권대혁,도양회,이광만 濟州大學校 産業技術硏究所 1999 산업기술연구소논문집 Vol.10 No.2

        Silicon micromachining technology can be used to build microsensors and actuators by using tools derived from standard IC processing. For the silicon micromachining the etching characteristics of tetramethyl ammonium hydroxide (TMAH) by dissolving silicon powder or silicic acid have been studied. The 3. 5 and l0wt.% TMAH solutions, with dissolved silicon powder (6g/l) or with dissolved silicic acid(Si(OH)_(4), 16g/1) were used. And ammonium peroxydisulfate (APODS. 2g/l) dissolved in the solutions were also used. The etch rates of silicon and the etched surface roughness were observed with various etching conditions. The crystallographical aspect on the crystal orientation of silicon have been studied. With sufficiently fresh solutions, these TMAH concentration and combination of etchants. provide repeatable etch properties. does not attack exposed aluminum or silicon dioxode. and provide smooth (100) silicon surfaces.

      • KCI등재후보

        돈육의 저장중 이화학적 성질에 미치는 토코페롤 급여효과

        진상근,김일석,송영민,하경희,이성대,김회윤 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.1

        비육후기 돼지 사료에 첨가되는 우지 함량 중 2%를 들깨유로 대체 급여한 돈육(T1), T1처리구에 비타민 E 250ppm 첨가 급여한 돈육(T2), 우지함량 중 2%를 오징어유로 대체 급여한 돈육(T3), T3에 비타민 E 250ppm 첨가 급여한 돈육(T4)을 1±1℃에서 28일간 저장하면서 육질특성을 조사한 결과는 다음과 같다. 저장기간에 따라 육색 L^*과 b^*값, 지방색 b^*값 및 drip loss는 증가하였다. 총단백질추출성과 보수력은 14일까지 증가 후 감소하였으며, 염용성 단백질추출성 및 지방색 L^*값은 감소하였다. 근절길이에서는 저장기간에 따라 T3구는 감소하였다. 총단백질추출성은 T1보다는 T2가 낮은 반면 T3보다는 T4가 높았다. 염용성단백질추출성은 비타민 E 첨가구들이(T2, T4) 첨가하지 않은 구들(T1, T3)에 비하여 높았으며, drip loss와 육색 a^*값은 비타민 첨가구들이 첨가하지 않은 구들에 비해 낮게 나타났다. 보수력은 T1보다는 T2가 낮은 반면 T3보다는 T4가 높았다. 지방색 L^*값은 저장 1일째는 비타민을 첨가한 처리구들이 첨가하지 않은 처리구들에 비해 높았으나, 저장 28일째에는 낮게 나타났고, b^*값은 비타민을 첨가한 처리구들이 낮게 나타나 비타민 첨가구가 drip loss, 육색과 염용성단백질 추출성에서 좋은 효과를 나타내었다. The quality of pork meat was determined as following treatments. The meat samples were obtained from pigs which had been fed finishing pig diets containing 2% perillar seed oil in beef tallow(T1), 250ppm vitamin E in T1(T2), 2% squid oil substituted of beef tallow(T3), 250ppm vitamin E in T3(T4). During storage period, meat color L^*, b^* value, fat color b^* value and drip loss were increased. The extraction amount of total protein and water holding capacity were increased until 14 days after then were decrease. The extraction amount of salt soluble protein and fat color L^* value were decreased and sarcomere length were decrease in T2 as well. T1 was higher than T2 in the extraction amount of total protein and its of T4 was higher than T3. The extraction amount of salt soluble protein of the T2 and T4 was higher than that of T1 and T3. The drip loss and the a^* value of meat color were lower in vitamin treated one than non treated one. On water holding capacity. T1 was higher than T2 and T3 was lower than T4. The L^* value of fat in vitamin treated ones was shown higher than that of non treated ones on day 1, however, it and the b^* value of the meat were low on day 28.

      • 마이크로센서 응용을 위한 실리콘 미세가공 기술

        고희선,김영민,권대혁,도양희,이광만 제주대학교 산업기술연구소 1999 尖端技術硏究所論文集 Vol.10 No.2

        Silicon micromachining technology can be used to build microsensors and actuators by using tools derived from standard IC processing. For the silicon micromachining the etching characteristics of tetramethyl ammonium hydroxide (TMAH) by dissolving silicon powder or silicic acid have been studied. The 3, 5 and 10wt.% TMAH solutions, with dissolved silicon powder (6g/l) or with dissolved silicic acid(Si(OH)4, 16g/l) were used. And ammonium peroxydisulfate (APODS, 2g/l) dissolved in the solutions were also used. The etch rates of silicon and the etched surface roughness were observed with various etching conditions. The crystallographical aspect on the crystal orientation of silicon have been studied. With sufficiently fresh solutions, these TMAH concentration and combination of etchants, provide repeatable etch properties, does not attack exposed aluminum or silicon dioxode, and provide smooth (100) silicon surfaces.

      • 신원방우황청심원의 심혈관계에 관한 약효

        조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

        Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

      • 건식경량벽체의 내충격성능 평가방법에 관한 연구 (Ⅰ) : 인간이 벽체에 가하는 충격하중의 분석을 위한 실험 및 고찰 An Experiment to Analyze the Human Impact Load Applied to Framed Walls

        신윤호,안정업,김대희,최수경 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

        The purpose of this study is to establish an evaluation method of fracture of light-weight framed walls by human impact load. In this paper, part (I), we analyzed human impact load applied to framed walls. At first, we made original measuring equipment of impact load, and carried out the experiment on human impact load in various action. After the experiment, we extracted the essential characteristics. And grasped the property of human impact load systematically based on the relation between maximum load and load velocity.

      • 신우황청심원액의 심혈관계에 관한 약효연구

        조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

        In order to investigate the pharmacological properties of New Woohwangchungsimwon Liquid (NCL), efects of Woohwangchungsimwon Liquid (CL) and NCL were compared. In isolated rat aorta, NCL and CL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^6M) without regard to intact endothelium or denuded rings of the rat aorta. Furthemore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxation of NCL and CL. NCL and CL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dosedependent manner. In conscious spontaneously hypertensive rats (SHRs), NCL and CL significantly decreased heart rate. NCL and CL, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NCL and CL had no efects on parameters of action potential at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NCL and CL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between two preparations.

      • 신원방우황청심원액의 심혈관계에 관한 약효

        조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

        In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

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