KI-180과 KI-188 칼슘조성물이 어린쥐의 성장발육에 미치는 영향

박승만(Seung-Man Park),성기승(Ki-Seung Seong),이종석(Jong-Seok Lee),이옥환(Ok-Hwan Lee),한찬규(Chan-Kyu Han) 한국식품과학회 2014 한국식품과학회지 Vol.46 No.3

본 연구에서는 KI-188 칼슘과 KI-180 조성물이 성장발육에 미치는 효과를 조사하였다. 시험기간중 KI-188 칼슘과 KI-180 식이군이 대조군 보다 성장률과 평균 식이섭취량은 증가하였다. 체장은 KI-188 칼슘과 KI-180 식이군이 대조군에 비해 평균 3.55 mm 더 길었고, 등뼈길이는 KI-180 식이군이 대조군 보다 통계적인 차이는 없었지만 0.5 mm 더 길었다. 대퇴골 무게는 KI-188 칼슘과 KI-180 식이군이 대조군에 비해 통계적으로 무거웠으며, 대퇴골길이는 대조군에 비해 각각 평균 0.89, 1.09 mm 더 길었다. 혈당, 총콜레스테롤 및 중성지방 농도는 차이가 없었고, 칼슘농도는 KI-188 칼슘과 KI-180 식이군 보다 대조군이 유의하게 높았다. 백혈구와 혈소판수는 차이가 없었고, 적혈구, 혈색소 및 헤마토크릿치는 대조군이 KI-188 칼슘과 KI-180 식이군 보다 통계적으로 높았다. ALP활성은 KI-180 식이군이 대조군 보다 통계적으로 높았고, osteocalcin농도는 KI-188 칼슘과 KI-180 식이군이 대조군에 비해 통계적으로 유의하게 높았다. 혈청 testosterone 농도는 KI-188 칼슘과 KI-180 식이군과 대조군 간에 차이가 없었다. IGF-1과 IGFBP-3 농도는 KI-180 조성물이 대조군 보다 각각 20%, 11% 정도 유의하게 더 높았다. 이상의 결과를 검토할 때 KI-188 칼슘과 KI-180 조성물은 어린쥐의 성장과 골격의 발달을 촉진시키고, 성장호르몬의 분비능을 양적으로 유도하여 전반적인 성장발육에 유효한 작용이 있는 것으로 사료된다. Herbs have active components that promote the growth rate of both animals and human. The KI-180 and KI-188 calcium food formulae contain Acanthopanacis cortex, Bombysis corpus and hoelen, seaweed calcium, chlorella extract, spirulina, colostrum powder, and other natural and functional components. We evaluated the growth-promoting effects of these formulae by analyzing the weight, femur and backbone, alkaline phosphatase, osteocalcin, testosterone, insulin-like growth factor (IGF)-1, and IGF binding protein-3 (IGFBP-3) of growing rats. Growing rats administered with KI-180 and KI-188 calcium showed the increase of body weight, body length, and femur weight and length of growing rats. In addition, administration of KI-180 and KI-188 calcium increased the alkaline phosphatase activity, the levels of osteocalcin and the growth hormones IGF-1 and IGFBP-3 of growing rats. The impact of KI-180 and KI-188 calcium on the physical development of growing rats suggests that the incorporation of these food formulae in the diets of growing children may promote the physical development.

직장 카르시노이드 종양에서 Ki-67 발현의 예후적 중요성

홍수민 ( Su Min Hong ),김유선 ( You Sun Kim ),문정섭 ( Jung Seop Moon ),김진남 ( Jin Nam Kim ),오명기 ( Myoung Ki Oh ),권선옥 ( Sun Ok Kwon ),정성연 ( Seong Yeon Jeong ),홍성우 ( Seong Woo Hong ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Background/Aims: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. Methods: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. Results: The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed. Conclusions: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.

RBL-2H3 세포에서 Spermine에 의한 히스타민 유리와 칼슘유입에 미치는 상백피의억제효과

채옥희,강경진,신인호,김영기,이무삼,전병득 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.2

인체대장암에서의 Cyclin 유전자의 발현

백원기,서민호,서성일,문성희,박종욱,최병길,배옥석 대한대장항문학회 1996 Annals of Coloproctolgy Vol.12 No.2

여성 외음부에 발생한 선상 편평상피세포암종

김창옥,양기화,강석진,이안희,김병기,김선무 대한병리학회 1991 Journal of Pathology and Translational Medicine Vol.25 No.1

체육수업에서의 운동상해에 관한 연구

윤기대,양정옥,김영수 신라대학교 교육과학연구소 2004 교육과학연구 Vol.- No.9

인라인 스케이트 T300m 출발동작시 신체중심과 하지관절의 속도 분석

양정옥,이중숙,박기범 신라대학교 자연과학연구소 2003 自然科學論文集 Vol.12 No.-

This study is to present more effective starting skills through analysis of kinematic characteristics of starting motions in 300m Time Trials of Inline Skating. To achieve the goal, 6 athletes, 3 in the national team and 3 in business teams were chosen and their starting motions were examined with three-dimensional image analyses. The results of analyses in regard of speed of the body center and linear velocity of articulations of lower limbs by sections of starting motions are as follows: 1) Acceleration in the starting section is determined by the speed and the position of bodily center at the moment of leaving the ground not by the aerial movements. In case of the central position, though it is effective to reduce the air resistance by lowering the upper part of the body maximumly, it is reasonable to accelerate by raising the upper part of the body to some degree for the running posture at the lower speed in the starting section. At the lower speed in the starting section, since the push-off motions are made with the front part of skates at a point, not while gliding, the angle in the articulations of lower limbs is bigger. This shows that the faster changes from the running posture to the gliding skills is made, the more effective motions can be made. 2) At the moment of starting, acceleration by reducing the angles of knees to increase safety on the ground is reasonable, but wheels should touch more with the ground to minimize the impact and friction of skates. In the starting section, it is efficient to minimize the period of time in touching the ground. For this, it is necessary to train for taking motions without slippage while touching the ground. 3) While 3 athletes in business teams kicked the ground as running right after the starting, the others in the national team slid on the ground. As the number of steps increased, the movable speed changed quickly. Thus the movable speed of athletes in the national team indicated big differences in two to three steps. If these factors are well supported, the push-away starting method might be better than the running starting method in terms of improvement of records.

제주도 중산간지대 지하수의 수리특성

진기옥,양성기 제주대학교 해양연구소 2001 해양자원연구소연구보고 Vol.25 No.-

교사 효과성에 관한 연구 : 그 발달 및 앞으로의 연구에 대한 시사점 It's Development and Implications for Future Studies

尹基玉 仁川敎育大學校 1986 論文集 Vol.20 No.1

各種 胃疾患에서 胃粘膜의 Campylobacter pylori 檢出에 관한 硏究

洪起淑,金玉經 梨花女子大學校 韓國生活科學硏究院 1989 韓國生活科學硏究院 論叢 Vol.43 No.-

1983년 Marshall과 Warren에 의해 소화성궤양과 활동성 만성위염소견을 보이는 조직에서 나선형균을 발견하고 세균의 배양분리를 통해 Campylobacter pylori임을 밝히고 이균이 위염 및 소화성궤양의 원인균이 될 수 있다는 것을 알게된 이후 이에 대한 병원성여부, 배양방법, 조직 및 전자현미경소견, 혈청학적소견 등에 대한 연구가 급속히 대두되고 있다. 이에 저자들은 1988년 6월부터 12월 사이에 이화여자대학교 부속병원에서 상부 위장관 증상으로 인해 위내시경검사를 시행했던 검체를 대상으로 병리조직검사, 균배양검사 및 전자현미경검사를 시행한 결과 다음과 같은 결론을 얻었다. 1. 위내시경검사를 시행했던 206예 중 133예(65%)에서 C. pylori가 검출되었고, 활동성 만성위염에서는 79예 중 72예(91%), 소화성궤양에서는 37예 중 27예(73%)의 양성을 보였고, 정상조직소견을 보였던 5예에서는 균을 관찰할 수 없었다. 2. C. pylori는 18세 이후의 전연령층에 분포하고 있었으며, 연령간 양성율의 유의한 차이는 없었으나 41∼50세 사이에서 급격한 위염의 증가와 함께 73%의 높은 균검출율을 보이고 있었다. 3. H &E, W-S 염색을 49예에서 시행하였던 바 W-G염색의 예민도가 가장 높았다. 4. 세균배양상 C. pylori의 분리는 135예 중 18예로 13%의 분리율을 보였고, touch 후의 gram염색 결과는 높은 예민도를 나타내었다. 5. 전자현미경소견상 이 세균들은 위점막상피세포 표면의 microvilli 사이사이로 위치해 있었고, 활면의 세포벽과 sheathed된 1∼4개의단극성 편모가 관찰되었다. 이상의 결과로 미루어 C. pylori는 위점막의 microvilli 사이사이를 따라 손상을 주어서 활동성 만성위염 및 소화성궤양 유발의 한 요인이 될 수 있다고 간주된다. 본 연구를 진행하는 과정에서 위내시경검사를 통해 많은 검체를 제공해 주신 이화대학부속병원 내과 문일환교수님께 깊은 감사를 드립니다. Campylobacter pylori was known to be associated with chronic active gastritis and peptic ulcer. To access the detection rate of Campylobacter pylori in normal histology, chronic gastritis. active chronic gastritis, peptic ulcer and gastric carcinoma, we studied 206 patients, who were admitted to Ewha Womans university hospital between June and December in 1988. 1. C. pylori was isolated in 133 of the 206 patients(65%). C. pylori was frequently isolated in active chronic gastritis(91%) and peptic ulcer(73%). In normal histologic findings, any organism was not detected. 2. C. pylori was isolated in all ages after 18years old and there was no significant difference of detection rate in each decades. 3. Fourty-nine consecutive gastric antral biopsies were stained with H & E, Warthin-Starry Silver, and Wright-Giemsa stains. The Wright-Giemsa stain was shown highest sensitivity. 4. C. pylori was isolated in 18 of the 135 patients(13%) by culture. The gram staining if the touch preparation was shown high sensitivity in detection of the organisms. 5. These organisms were curved bacilli and had a smooth surface with 1 to 4 unipolar flagella of sheathed type and located along the microvilli in the mucosal surface. In view of the above results, Campylobacter pylori might result mucasal epithelial cell injury on the level of microvilli of the mucosal surface, so that it could be a contributing factor to induce the active chronic gastritis and peptic ulcer.