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자궁경부암 병기판정 기초검사시 새로운 보조방법으로서 고주파 질식 초음파의 가치
유희석,이은주,장기홍,권혁찬,양정인,김행수,오기석 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1
To investigate the efficacy of endoluminal ultrasound system (EUS) as a surrogate for high frequency transvaginal ultrasonography and as an optional baseline study in determining parameirial and stromal invasion of early stage cervical cancer, 52 women suspected of cervical cancer underwent EUS. A 12 MHz endoscopic probe was employed to radially scan the cervix for possible lesions suspected to be invasive cancer during a period of 6 months from Feb. 1 to July 1, 1995. Patients also underwent magnetic resonance imaging (MRI) and/or computerized tomography (CT) as a routine mode of baseline study, and were clinically staged by 3 independent physicians specializing in Obstetrics and Gynecology at the Department of Obstetrics and Gynecology, School of Medicine, Ajou University, Suwon, Korea. Thirty one patients subsequently received surgery appropriate for the stage of the disease and the final pathology findings were compared with the results of clinical staging, EUS, MRI/CT by regression analysis. The results showed that there was statistically significant correlation between MRI/CT and pathology (r=0.660, p<0.02), between EUS and pathology (r=0.803, p<0.01), and between clinical staging and pathology (r=0.825, p<0.01). It is concluded that there was significant statistical correlation t>etween EUS, MRI/CT, clinical staging and pathology, but the question remained as to the statistical superiority of EUS over MRI/CT with regard to parametrial invasion and stromal invasion depth assessment. Finally, EUS is useful as an alternative optional diagnostic tool in the baseline study of cervical cancer.
홍사욱,장기원,정규혁 성균관대학교 약학연구소 1991 成均藥硏論文集 Vol.3 No.1
Abstract-The effects of Dichlorvos(DDVP) orally administered to male rats were studied over a period of 5 weeks. The experimental results were summerized as follows. Cholinesterase activities were decreased significantly in the liver and serum after treatment. The activities of AST, ALT, ALP and LDH increased significantly following the treatment. Glucose and lipid peroxidation also increased significantly. These results indicated that the observed changes in the activities of various enzymes may be due to physiological alterations in the liver induced by DDVP and that the toxicity of DDVP is related directly to cholinesterase inhibitions.
자궁경부 조직에서 산소 유리기 보집제 superoxide dismutase(SOD)의 측정
장기홍,정태영,김미란,오기석,유희석,권혁찬 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.1
The superoxide anion, hydrogen peroxide, and hydroxyl radical are oxygen free radicals which arise in cell metabolism and which are toxic to cells, with an important role in carcinogenesis. The measurement of the oxygen free radical is a problem due to the instantaneously changing nature, and therefore the superoxide dismutase(SOD) is employed which act as an oxygen free radical scavenger. The authors quantitatively analyzed the SOD levels in normal uterine cervix epithelium, cervical intraepithelial neoplasia, and in invasive cervical cancer patients by the SOD-525R spectrophotometric assay and compared the results between each group with respect to prognostic variables such as stage of disease, cell typ~e, lymph node involvement, and SCC Ag(TA-4 Ag) levels. The mean SOD levels were 0.41U/ml, 0.39U/ml and 0.73U/ml in the normal uterine cervix, intraepithelial neoplasia, and invasive cervical cancer groups, respectively, showing statistically significant difference by the Oneway anova test(p=0.05). The mean SOD levels according to the stage of disease were 0.5U/ml, 0.62U/ml, and 1.15U/ml for stages Ia, Ib, and stage II and above(p=0.029). For the cell type the SOD levels were 0.77U/ml for squamous cell carcinoma and 0.57U/ml for adenocarcinoma(p=0.15). For cancer cell lymph node involvement cases, the mean SOD levels were 0.75U/ml and 0.57U/ml for lymph node involvement and no onvolvement respectively(p=NS). The mean SOD levels also did not show any significance when compared with SCC Ag lovels where SOD was 0.78U/ml for SCC Ag levels of more than 2.0U/ml, and 0.77U/ml for SCC Ag levels of less than 2.0ng/ml. From the above results the authors conclude that SOD levels were higher in invasive cervical cancer tissues compared to intraepithelial neoplasia and that there was no relationship between SOD levels and known prognostic variables such as type, lymph node involvement and SCC Ag level.
SOX18 as a potential biomarker in asthma
( Jisu Hong ),( An-soo Jang ),( Pureun-haneul Lee ),( Yun-ki Lee ),( June-hyuck Lee ),( Sung-woo Park ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Asthma characterized by airway hyperresponsiveness, increased inflammatory cells, and fibrosis and angiogenesis. SRY-related HMG-box 18 (SOX18) is an important transcription factor involved in the development of cardiovascular and lymphatic vessels during embryonic development and wound-healing processes. SOX18 remains to be clarified in asthma. Objective: In this study we aimed to elucidate the role of SOX18 in the pathogenesis of bronchial asthma. Methods: Using an established mouse model of ovalbumin (OVA)-induced chronic allergic asthma, we investigated whether SOX18 is involved in pathogenesis of asthma. Airway hyperresponsiveness (AHR) was measured and bronchoalveolar lavage fluid was collected, lung tissue was processed for protein and RNA, and hematoxylin and eosin stain. Collagen was measured by trichrome stain and sircol assay. SOX18 level checked in lung human microvascular endothelial cells (HMVEC-L) and normal human bronchial epithelial (NHBE) cells treated with house dust mite (HDM). Moreover, we observed SOX18 levels in blood from asthmatic patients between stable and exacerbated state. Results: The chronic asthma mice showed that SOX18, PROX1, COUP-TFII, mucous gland hyperplasia and collagen deposition in lung tissue were significantly increased after OVA challenge. SOX18 protein in HMVEC-L and NHBE cells was increased following HDM treatment. PROX1 and COUP-TFII protein in HMVEC-L were decreased and increased in NHBE cells following HDM treatment. SOX18 in blood from exacerbated asthmatics was increased compared with those from stable asthmatics. Conclusion: These results suggesting that SOX18 may be associated with asthma exacerbation and can be a biomarker for asthma.