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Sarcoma-180 세포를 이용한 고등균류의 항암효과
배만종,이재성,김선희,박무희 경산대학교 생명자원개발연구소 1998 생명자원과 산업 Vol.2 No.-
상황버섯과 버들송이 균사체를 중심으로 하여 이들 균사체로부터 열수 추출된 세포내다당류와 배양액에서 회수된 다당류를 이용하여 sarcoma180에 대한 항암효과를 실험한 결과는 다음과 같다. Sarcoma-180 cell-line으로 복수임을 유발시킨 mice에 균사체와 배양액으로부터 회수한 다당체를 50㎍/㎏ 투여시의 체중증가량은 대조군에 비하여, 현저하게 체중증가량이 감소하였으며, 균사체에서 보다 배양액에서의 다당류에서 더욱 효과 있는 것으로 나타났다. 수명연장 효과를 살펴본 결과는 대조군에 비하여 상황과 버들송이 균사체의 세포외단백다당체에서 각각 47.8%, 69.6%, 32.2% 및 23.9%의 생존율을 나타내었다. In vitro에서의 S-180에 대한 증식 억제효과는 대조군에 비하여 모든 군에서 억제효과가 나타났으며, 시료의 농도에 비례하여 억제되는 것으로 나타났다. This study examine antitumor effects, the intracellular and extracellular, extracts from the liquid culture of the Phellinius igniarius and the Agrocybe cylindracea by using sarcoma180 tumor cells. The experimented was carred out by mice body weight increation, the life prolongation and tumor cell groth inhibition in vitro. The resultes obtained from the experiment as follows; Total body weight of mice, inoculated with sarcoma-180ascites tumor cells challenge, were decreased significantly in experimental groups, intracellular and extracellular polysaccharide extracts from the liquid culture of the Phellinius igniarius and the Agrocybe cylindracea than control groups. The life prolongation effects were 47.8%, 69.6%, 32.2% and 23.9%, respectively when intracellular and extracellular, extracts from the liquid culture of the Phellinius igniarius and the Agrocy cylindracea were administrated to the mice. Inhibitory efect on the growth rate of the sarcoma-180 was stronger in intracellular and extracellular, extracts from the liquid culture of the Phellinius igniarius and the Agrocybe cylindracea than control group. The growth rates of the sarcoma-180 in medium containing samples were inhibited gradually to a significant degree in proportion to the increase of the samples concentration in vitro.
최한철,고영무,정재헌,신종연,김일선,최성욱,정효수 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.4
Dental magnetic materials have been applied to removable prosthetic appliances, maxillofacial prostheses, obturator and dental implant but they still have some problems such as low corrosion resistance in oral environments. To increase the corrosion resistance of dental magnetic materials, surfaces of Sm-Co and Nd-Fe-B based magnetic materials were plated with TiN and then electrochemical corrosion test were performed in 4 kinds of electrolyte solutions(0.9% NaCl. 1% lactic acid, 0.05% HCl and modified Fusayama's artificial saliva). From this study, corrosion behavior, amount of elements released, mean average surface roughness values and the changing of mean surface microhardness values were measured comparing with control group of non-sputtered plating magnetic materials. The results were as follows: 1. TiN layer coated on magnet grows into preferred direction with lamellar structure and its thickness is 3.0㎛. 2. Sm-Co base magnetic materials coated with TiN have good corrosion resistance in 1% lactic acid and their pitting corrosion can not be seen. 3. Nd-Fe-B base magnetic materials coated with TiN showed good tendency of corrosion resistance in 0.05% HCl solution. 4. The amount of elements released from both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were more significantly decreased than that of uncoated magnetic materials. 5. The mean surface roughness values of both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were smooth than that of uncoated magnetic materials after corrosion test. 6. The decreasing rate of microhardness of both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were lower than that of uncoated magnetic materials after corrosion test. 7. Dental magnetic materials coated with TiN produced various corrosion products such as TiO, TiO₂, Ti₂O₃on the surface and resulted in better corrosion resistance than uncoated magnetic materials. In conclusion, it is considered that the corrosion problem of dental magnetic materials could be solved to some extent by EB-PVD with TiN on the surface of dental magnetic materials.
Sun, Jong-Mu,Ahn, Jin Seok,Jung, Sin-Ho,Sun, Jiyu,Ha, Sang Yun,Han, Joungho,Park, Keunchil,Ahn, Myung-Ju American Society for Clinical Oncology 2015 Journal of clinical oncology Vol.33 No.22
<P>Purpose We investigated whether thymidylate synthase (TS) expression is a predictive marker for the clinical outcome of pemetrexed/cisplatin in patients with nonsquamous non-small-cell lung cancer. Patients and Methods Eligible patients were tested for TS expression by immunohistochemistry and stratified into either a TS-negative or a TS-positive group. After stratification, patients in each group were randomly assigned (1:1 ratio) to receive either pemetrexed/cisplatin or gemcitabine/cisplatin for a maximum of six cycles until disease progression. The primary end point was evaluation of the interaction between TS groups and treatment allocation for objective response rate. Results Of 321 enrolled patients with nonsquamous non-small-cell lung cancer, 315 received at least one dose of study chemotherapy and were analyzed. By investigator assessment, response rates were 47% for the pemetrexed/cisplatin arm and 21% for the gemcitabine/cisplatin arm in the TS-negative group and 40% and 39%, respectively, for the TS-positive group (interaction P = .0084). By independent reviewers, response rates of pemetrexed/cisplatin and gemcitabine/cisplatin were 39% and 21%, respectively, in the TS-negative group and 40% and 48% in the TS-positive group (interaction P = .0077). The median progression-free survival times for the pemetrexed/cisplatin and the gemcitabine/cisplatin arms were 6.4 and 5.5 months, respectively, in the TS-negative group and 5.9 and 5.3 months in the TS-positive group (interaction P = .07). Conclusion With regard to response rate and progression-free survival, pemetrexed/cisplatin was superior to gemcitabine/cisplatin in the TS-negative group but not in the TS-positive group, indicative of TS expression as a potential predictive marker. Additional prospective studies involving larger cohorts are warranted to confirm the predictive role of TS expression. (C) 2015 by American Society of Clinical Oncology</P>
선종무 ( Jong Mu Sun ),정현채 ( Hyun Chae Jung ) 대한소화기학회 2004 대한소화기학회지 Vol.44 No.2
Carcinoid tumors originate from the neuroendocrine cells throughout the body and occur most frequently (74%) in the gastrointestinal tract. The clinical course is often indolent but can also be aggressive and resistant to therapy. Clinical manifestations
호장으로부터 분리한 Polydatin의 미백 및 주름억제 효능에 대한 연구
진무현 ( Mu Hyun Jin ),정의택 ( Eui Taek Jeong ),김미선 ( Mi-sun Kim ),송혜진 ( Hye Jin Song ),곽택종 ( Taek-jong Kwak ),박선규 ( Sun Gyoo Park ),이상민 ( Sang Min Lee ) 대한화장품학회 2011 대한화장품학회지 Vol.37 No.4
5,4'-dihydroxystilbene-3-O-D-glucopyranoside (polydatin)는 호장(Polygonum cuspidatum)에 존재하는 stilbenes류의 하나로 지금까지 피부에서의 효능이 잘 알려지지 않았다. 우리는 호장으로부터 Polydatin을 분리하여 얻었으며, 피부유래의 멜라노사이트와 fibroblast를 이용하여 효능을 검증하였다. 실험결과 멜라노사이트에서 polydatin은 타이로시네이즈 활성과 멜라닌 생성을 억제하였고, 멜라닌 생합성 과정에 관여하는 타이로시네이즈와 전사인자인 microphthalmia-associated transcription factor (MITF)의 발현을 억제하는 것을 확인하였다. 미백효과가 확인된 polydatin에 대하여 human fibroblast를 대상으로 type I procollagen 생합성에 미치는 영향을 분석한 결과 polydatin은 농도 의존적으로 콜라젠 합성을 촉진함을 알 수 있었다. 또한 polydatin의 피부에서의 효능을 검증하기 위해 인체효력시험을 통해 주름개선과 미백개선 효능을 검증하였으며 이를 통해 주름과 미백기능에 있어 유의한 효과를 확인하였다. 이상의 결과로부터 polydatin은 안전한 피부 미백 개선제 및 주름개선제로 사용될 수 있는 후보물질임을 제안하며, 상업적으로 활용하기 위해 원료화를 성공하였다. 5,4'-dihydroxystilbene-3-O-β-D-glucopyranoside (Polydatin) is one of the stilbenes found in Polygonum cuspidatum (P. cuspidatum), however, the effects of polydatin on skin biology remain to be elucidated. In this study, we obtained polydatin from P. cuspidatum and investigated the effects of polydatin in skin-derived melanocytes and fibroblasts. In melanocytes, polydatin inhibited not only the tyrosinase activity and melanin production but the expression of melanogenic factors, tyrosinase and microphthalmia-associated transcription factor (MITF). In addition, the level of type I procollagen in fibroblasts was analyzed, and polydatin significantly induced the production of type I procollagen in a dose-dependent manner. Finally we conformed that topical treatment of polydatin improved wrinkle and induced whitening of human skin in vivo. These data provide evidence that polydatin can be a potent candidate for the improvement of both skin wrinkle and whitening from the point of industry view.
Subchronic toxicity evaluation of ethanol extract of <i>Cassia tora</i> L. seeds in rats
Lee, Mu-Jin,Nho, Jong-Hyun,Yang, Beo-Deul,Park, Ho,Lee, Hyun-Joo,Lee, Ki-Ho,Jang, Ji-Hun,Jung, Ho-Kyung,Kim, Sun-Ra,Cho, Hyun-Woo,Park, Hae-Sung,Lim, Je-Oh,Kim, Jong-Choon Elsevier 2019 Regulatory toxicology and pharmacology Vol.109 No.-
<P><B>Abstract</B></P> <P> <I>Cassia tora</I> Linn. is an annual or perennial plant of the Fabaceae/Leguminosae family. It is used in traditional medicine for various biological activities including anti-constipation, anti-inflammatory, visual acuity, and hepato-protective activities. The present study was carried out to investigate the potential toxicity of <I>C. tora</I> L. seed ethanol extract (CTSEE) following a 13-week repeated oral administration to Sprague-Dawley rats. CTSEE was administered orally to male and female rats for 13 weeks at 0 (control), 500, 1000, and 2000 mg/kg/day (<I>n</I> = 10, for male and female rats for each dose). Additional recovery groups from the control group and high dose group were observed for a 4-week recovery period. At the end of the treatment and recovery periods, animals were sacrificed, and their organs were weighed and blood samples collected. There were no treatment-related adverse effects in clinical signs, body weight, food consumption, estrous cycle, sperm parameters, urinalysis, hematology, serum biochemistry, necropsy findings, organ weight, and histopathology at any doses tested. Under the present experimental conditions, the no-observed-adverse-effect level of the CTSEE was >2000 mg/kg/day in both genders, and no target organs were identified.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Subchronic toxicity of <I>Cassia tora</I> L. seed ethanol extract (CTSEE) were investigated. </LI> <LI> No significant adverse effects were observed in the repeated dose toxicity study. </LI> <LI> The oral NOAEL of CTSEE was >2000 mg/kg/day in rats of both genders. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>