ASGO 7th International Workshop on Gynecologic Oncology

Jie Yang,Yang Xiang,Beihua Kong 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.6

The 7th International Workshop of the Asian Society of Gynecologic Oncology (ASGO) was held by the Chinese Society of Gynecologic Oncology (CSGO) and Peking Union Medical College Hospital on 27th to 28th August 2022. The 2022 workshop was the first ASGO congress that was held in mainland China. Due to the COVID situation, this workshop was conducted virtually. Five hundred eighty-seven participants from 13 countries/regions (Hong Kong, India, Indonesia, Italy, Japan, Korea, Mainland China, Malaysia, Singapore, Taiwan, Thailand, United Kingdom, and United State of America) attended the meeting (Table 1). Dr. Beihua Kong (Shandong, China), president of CSGO, served as the president. Dr. Yang Xiang, president-elect of Chinese Medical Association (CMA) Gynecologic Oncology division, served as the executive president of the 7th ASGO workshop. Following the 18th ASGO council meeting on August 26th (Fig. 1), the workshop was grandly held on August 27th and 28th virtually.

Design of Remote Fire Automatic Alarm System Based on Zigbee Technology and TC35i Module

Ling-jie Kong 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.11

In order to realizing double function of monitoring home interior fire danger and automatic SMS alarm by using Zigbee networking technology, we propose the remote fire automatic alarm system based on Zigbee chip CC2530F256 and GSM wireless communication module TC35i. And on this basis, we give a detailed description of components selection, hardware design and software design of the system. The system testing results demonstrate that this system has good stability and response precision, anti-interference ability, which easy to be extended and applied.

Modified Procedures for ALPPS Based on a Risk-Reduced Strategy: Paralleled Clinical Evaluation at Multiple Institutions

Ya-Lin Kong,Ying Xing,Jie Li,Cheng-Li Liu,Xiao-Jun He,Cheng Wang,Jiang-Min Chen,Ling-Hong Kong,Xu Han,Hong-Yi Zhang 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.10

Purpose: We compared the clinical outcomes of modified procedures for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) based on a risk-reduced strategy with those of classic ALPPS procedures in treating large liver carcinoma. Materials and Methods: Short-term outcomes, increases in future liver remnant (FLR) and functional FLR (FFLR), and overall survival (OS) were compared between 45 consecutive patients treated with modified ALPPS procedures and 34 patients treated with classic ALPPS procedures. Results: Clinical outcomes after the 1st-stage operation markedly improved with the modified procedures. Although the proportions of liver cirrhosis and hepatocellular carcinoma were higher in the modified group, the mortality and incidence of severe complications did not increase. FLR and FFLR hypertrophy at 1 week after the 1st-stage operation were similar in both groups; however, kinetic growth rates in the modified group were lower. OS rates were similar. Conclusion: Modified ALPPS procedures could be safely applied to provide long-term survival for patients with liver cirrhosis without sufficient FLR.

Antitumorigenic and antiangiogenic efficacy of apatinib in liver cancer evaluated by multimodality molecular imaging

Jie Tian,Qian Liang,Lingxin Kong,Yang Du,Xu Zhu 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Sorafenib is the standard first-line treatment for advanced HCC, but its efficacy is limited. Apatinib is a small-molecule tyrosine kinase inhibitor that has shown promising antitumor effects in gastric and non-small cell lung cancers in clinical trials, but there have been only a few studies reporting its anti-HCC effects in vitro and in HCC xenograft models. Hence, our present study systemically investigated and compared the antitumorigenic and antiangiogenic efficacy of apatinib and sorafenib in HCC in vitro and in vivo using multimodality molecular imaging, including bioluminescence imaging (BLI), bioluminescence tomography (BLT), fluorescence molecular imaging (FMI), and computed tomography angiography (CTA). Moreover, the safety and side effects of the two drugs were systemically evaluated. We found that apatinib showed a comparable therapeutic efficacy to sorafenib for the inhibition of HCC. The drug safety evaluation revealed that both of these drugs caused hypertension and mild liver and kidney damage. Sorafenib caused diarrhea, rash, and weight loss in mice, but these effects were not observed in mice treated with apatinib. In conclusion, apatinib has similar antitumorigenic and antiangiogenic efficacy as sorafenib in HCC with less toxicity. These findings may provide preclinical evidence supporting the potential application of apatinib for the treatment of HCC patients.

Weak screening of a large dipolar molecule adsorbed on graphene

Kong, Lingmei,Perez Medina, G.J.,Coló,n Santana, J.A.,Wong, F.,Bonilla, M.,Coló,n Amill, D.A.,Rosa, L.G.,Routaboul, L.,Braunstein, P.,Doudin, B.,Lee, Chang-Mook,Choi, Jaewu,Xiao, Jie,Dowbe Elsevier 2012 Carbon Vol.50 No.5

<P><B>Abstract</B></P><P>We compare the electronic structure of a quinonoid zwitterionic type molecule adsorbed on both gold and graphene on copper substrates. This (6<I>Z</I>)-4-(butylamino)-6-(butyliminio)-3-oxocyclohexa-1,4-dien-1-olate, C<SUB>6</SUB>H<SUB>2</SUB>(⋯_NHR)<SUB>2</SUB>(⋯_O)<SUB>2</SUB> where R=<I>n-</I>C<SUB>4</SUB>H<SUB>9</SUB>, film is made of small molecules with a large intrinsic dipole of 10Debyes. We find that the photoemission and inverse photoemission final states are well screened for these dipolar molecules on gold. This is not observed when they are adsorbed on graphene on copper. This weaker screening results in a larger highest occupied molecular orbital to lowest unoccupied molecular orbital gap for the molecules on graphene.</P>

Modification of Fe/Cu Multilayers under 2-MeV Xe20+ Irradiation

Kong-Fang Wei,Zhi-Guang Wang,Jie Gou,Yan-Bin Sheng,Gen-Ming Jin,Hang Zang,Cun-Feng Yao,Yi-Zhun Ma,Tie-Long Shen 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.6

Multilayers with a structure of Si/[Fe(10 nm)/Cu(10 nm)]5 were deposited on Si(100) substrates and then irradiated at room temperature by using 2-MeV Xe20+. The modifications of the multilayers were characterized using a depth profile analysis of the Auger electron spectroscopy (AES) data and the evolution of crystallite structures of the multilayers were analyzed by using X-ray diffraction (XRD). The AES depth profiles indicated that de-mixing of the Fe and the Cu layers was observed at low ion fluences, but inter-mixing of the Fe and the Cu layers was found at high ion fluences and destroyed the layered structure of the multilayers. The obtained XRD patterns showed that, after irradiation by 2-MeV Xe20+ at 2 × 1016 ions/cm2, the peaks of the multilayers related to a Cu-based fcc solid solution and an Fe-based bcc solid solution phase became visible, which implied that the inter-mixing at the Fe/Cu interface resulted in the formation of new phases. A possible mechanism of modification in the Fe/Cu multilayers induced by ion irradiation is briefly discussed. Multilayers with a structure of Si/[Fe(10 nm)/Cu(10 nm)]5 were deposited on Si(100) substrates and then irradiated at room temperature by using 2-MeV Xe20+. The modifications of the multilayers were characterized using a depth profile analysis of the Auger electron spectroscopy (AES) data and the evolution of crystallite structures of the multilayers were analyzed by using X-ray diffraction (XRD). The AES depth profiles indicated that de-mixing of the Fe and the Cu layers was observed at low ion fluences, but inter-mixing of the Fe and the Cu layers was found at high ion fluences and destroyed the layered structure of the multilayers. The obtained XRD patterns showed that, after irradiation by 2-MeV Xe20+ at 2 × 1016 ions/cm2, the peaks of the multilayers related to a Cu-based fcc solid solution and an Fe-based bcc solid solution phase became visible, which implied that the inter-mixing at the Fe/Cu interface resulted in the formation of new phases. A possible mechanism of modification in the Fe/Cu multilayers induced by ion irradiation is briefly discussed.

MUTYH Association with Esophageal Adenocarcinoma in a Han Chinese Population

Kong, Feng,Han, Xue-Ying,Luan, Yun,Qi, Tong-Gang,Sun, Chao,Wang, Jue,Hou, Hua-Ying,Jiang, Yu-Hua,Zhao, Jing-Jie,Cheng, Guang-Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.

Damage monitoring of variable cross-section region in a column-drilled shaft assembly using smart aggregates

Jie Tan,Mahadi Masud,Xiaoming Qin,Cheng Yuan,Qingzhao Kong,Y.L.Mo 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.5

Pier column, as the most critical load-bearing member of bridge, can bear multiple loads including axial forces,shear forces, bending moments, etc. The varied cross section at the column interface and bearing platform or drilled shaft leads to harmful stress concentration that can potentially compromise the structural integrity. In order to improve the ductility of bridge structure, a pier column is often designed with a variable cross-section region to dissipate energy through plastic deformation. For better understanding the health condition of pier column in its service life, it is of great significance to obtain the damage severity information in the variable cross-section region. This study utilizes an active sensing method enabled by distributed Lead Zirconate Titanate (PZT)-based Smart Aggregate (SA) sensors to monitor the damage initiation and development near the bottom of a pier column. Crack damage in variable cross-section region functions as a stress relief that attenuates propagating stress wave energy between SA pairs. Both the numerical and experimental results show that the reduction ratio of the stress wave energy is consistent with the crack development, thus validating the reliability of the investigated approach. SA-based technology can be used as a potential tool to provide early warning of damage in variable cross-section region of bridge structures.

Optimal design of a plate-fin heat sink on the hot side of thermoelectric generator module for the recovery of waste heat

Jie Liu,Saurabh Yadav,Young Gyoon Yoon,Man Sik Kong,Sung Chul Kim 대한설비공학회 2021 대한설비공학회 학술발표대회논문집 Vol.2021 No.6

In this study, a plate fin heat sink is utilized for a TEG system to recover the waste heat which generated from a bronze ingot casting furnace with an impingement flow direction. Three-dimensional (3D) numerical model for the heat recovery system including the TEG module and the heat sink are developed and solved by using the commercial software ANSYS Icepak 19.2. Both of the effects of convection and radiation are considered. The ideal maximum power output of TEG module is evaluated by one dimensional model based on the temperature distribution of the TEG module which obtained from the 3D numerical simulation. The net power output of the TEG module is obtained by subtracting the pumping power from the ideal power output of the TEG module. The effect of operating parameters (velocity and temperature of waste heat flow) and fin parameters (fin height and numbers) on the heat transfer, TEG power output and efficiency are determined. The obtained conclusions in this research could provide valuable information for the design of an industrial TEG and waste heat recovery system.

Development of a Molecular Marker for Fruiting Body Pattern in Auricularia auricula-judae

( Fang-jie Yao ),( Li-xin Lu ),( Peng Wang ),( Ming Fang ),( You-min Zhang ),( Ying Chen ),( Wei-tong Zhang ),( Xiang-hui Kong ),( Jia Lu ),( Yoichi Honda ) 한국균학회 2018 Mycobiology Vol.46 No.1

The fruiting body pattern is an important agronomic trait of the edible fungus Auricularia auricula-judae, and an important breeding target. There are two types of fruiting body pattern: the cluster type and the chrysanthemum type. We identified the fruiting body pattern of 26 test strains, and then constructed two different near-isogenic pools. Then, we developed sequence characterized amplified region (SCAR) molecular markers associated with the fruiting body pattern based on sequence-related amplified polymorphism (SRAP) markers. Ten different bands (189-522 bp) were amplified using 153 pairs of SRAP primers. The SCAR marker “SCL-18” consisted of a single 522-bp band amplified from the cluster-type strains, but not the chrysanthemum strains. This SCAR marker was closely associated with the cluster- type fruiting body trait of A. auricula-judae. These results lay the foundation for further research to locate and clone genes controlling the fruiting body pattern of A. auricula-judae.