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Bing Jia,Zhaoyang Cheng,Qi Wang,Shujun Zhang,Wei Heng,Liwu Zhu 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.1
‘Dangshansuli’ pear is a yellow–green fruit when mature, whereas that of the mutant ‘Xiusu’ is russeted. In this study, thecontents of glucose, fructose and sucrose in the exocarp of ‘Xiusu’ were found to be lower than those in ‘Dangshansuli’ at75–100 days after full bloom (DAFB) but were higher at 150 DAFB. Additionally, the contents of six polysaccharides inthe exocarp of ‘Xiusu’ were higher than those in ‘Dangshansuli’ at 75 DAFB, the stage at which ‘Xiusu’ becomes russetin color, as well as at 150 DAFB; however, this was not observed for xylose. The contents of type I and II amino acids inthe exocarp of ‘Xiusu’ were higher than those in ‘Dangshansuli’ at diff erent stages, except for at 150 DAFB. The entiresequences of eight genes involved in the shikimate pathway and cell wall structure were cloned, and expression of thesegenes in the exocarp of ‘Dangshansuli’ and ‘Xiusu’ were signifi cantly diff erent during fruit development, indicating thatthese genes might be involved in the russeting process. It is speculated that the shikimate pathway connects primary andsecondary metabolism and that high contents of sugars as carbon sources provide precursors for suberin, lignin and lignanto generate russet skin in pear.
An Elastic Modulus Developing Model of Fly Ash Concrete under Sustained Load
Si-yi Jia,Ming-hui Liu,Bing Han,Hui-bing Xie 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.7
This paper focuses on the developing rule of elastic modulus of Fly Ash Concrete (FAC) under sustained load. Mechanism of theaction of sustained load on concrete is discussed and a new model for the elastic modulus of FAC is constructed based on the TriplephaseSpherical Model (TSM). An experiment with three concrete mix designs and five testing groups were conducted. Theexperimental compressive strength and elastic modulus at six different ages were used to calibrate the parameters in the model. Influences of two important parameters (loading age and loading level) in the model were analyzed. Test data confirmed the fact thatelastic modulus for the loaded concrete have a small increment compared to the non-loaded, which is more evident for youngerconcrete, and calculation results showed that the newly constructed model can well predict the elastic modulus of concrete undersustained load. Besides, compared to the loading age, the loading level was proved to be a more important factor in deciding thedevelopment rule of elastic modulus for the loaded concrete.
Efficient Synthesis and in vitro PDT Effect of Purpurin-18-N-Aminoimides
Bing Cun Cui,Min Uk Cha,Jia Zhu Li,Ho Sung Park,윤일,Young Key Shim 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A simple and efficient synthetic route for making purpurin-18-N-aminoimides is described. The purpurin-18-Naminoimides are obtained by treatment of purpurin-18 methyl ester with various amines. These new compounds have long wavelength absorptions in the range of 706 - 711 nm. In preliminary screening, the purpurin-18-N-aminoimides have shown promising photosensitizing activity for the cancer cell by in vitro study in photodynamic therapy.
Jia-Yu Lv,Ning-Ning Zhang,Ya-Wei Du,Ying Wu,Tian-Qiang Song,Ya-Min Zhang,Yan Qu,Yu-Xin Liu,Jie Gu,Ze-Yu Wang,Yi-Bo Qiu,Bing Yang,Da-Zhi Tian,Qing-Jun Guo,Li Zhang,Ji-San Sun,Yan Xie,Zheng-Lu Wang,Xin 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1
Purpose: The aim of this study was to compare the efficacy of liver transplantation (LT) and liver resection (LR) for hepatocellularcarcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and to investigate risk factors affecting prognosis. Materials and Methods: A total of 94 HCC patients with PVTT type I (segmental PVTT) and PVTT type II (lobar PVTT) were involvedand divided into LR (n=47) and LT groups (n=47). Recurrence-free survival (RFS) and overall survival (OS) were comparedbefore and after inverse probability of treatment weighting (IPTW). Prognostic factors for RFS and OS were explored. Results: Two treatment groups were well-balanced using IPTW. In the entire cohort, LT provided a better prognosis than LR. Among patients with PVTT type I, RFS was better with LT (p=0.039); OS was not different significantly between LT and LR(p=0.093). In subgroup analysis of PVTT type I patients with α-fetoprotein (AFP) levels >200 ng/mL, LT elicited significantly longermedian RFS (18.0 months vs. 2.1 months, p=0.022) and relatively longer median OS time (23.6 months vs. 9.8 months, p=0.065). Among patients with PVTT type II, no significant differences in RFS and OS were found between LT and LR (p=0.115 and 0.335,respectively). Multivariate analyses showed treatment allocation (LR), tumor size (>5 cm), AFP and aspartate aminotransferase(AST) levels to be risk factors of RFS and treatment allocation (LR), AFP and AST as risk factors for OS. Conclusion: LT appeared to afford a better prognosis for HCC with PVTT type I than LR, especially in patients with AFP levels>200 ng/mL.
Jia-He Wang,Ke Zhang,Nan Wang,Xiao-Min Qiu,Yi-Bing Wang,Ping He 한국미생물학회 2013 The journal of microbiology Vol.51 No.5
The invasion of Staphylococcus aureus into alveolar epithelial cells is regarded as the key step for S. aureus lung infection. However, the mechanism of internalization of S. aureus by alveolar epithelial cells is not clear, and was the aim of this investigation Human lung adenocarcinomic epithelial cells and A549 cells were used. Human β1 integrin and rat β1 integrin were detected by real-time reverse transcription (RT)-PCR. The expressions of β1 integrin, Akt and p-Akt were detected by Western blot analysis. To further investigate the role of β1 integrin in S. aureus internalization by alveolar epithelial cells, we next performed siRNA-mediated knockdown of β1 integrin expression. In this study, we found that S. aureus invades human alveolar epithelial cells and rat primary alveolar epithelial cells. The β1 integrin ligand competitive inhibitor, GRGDS-peptide, blocked the internalization of S. aureus by A549 cells. Knockdown of β1integrin also inhibited the internalization of S. aureus. In addition, the PI3K/Akt signaling pathway in alveolar epithelial cells was activated by the infection with S. aureus. Furthermore, Akt phosphorylation was abolished by transient transfection with β1 integrin siRNA in A549 cells challenged with S. aureus. Our results suggest that the phosphatidylinositol 3-kinase/Akt signaling pathway plays an important role in β1 integrin-mediated internalization of S. aureus by alveolar epithelial cells.
Jia Han,Rui Zhang,Dina Muheyati,Mei Xia Lv,Wubulikasimu Aikebaier,Bing Xin Peng 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.2
Hyperlipidemia is a metabolic disorder characterized by high lipid levels, which may lead to cardiovascular diseases. Evidence suggests that improving the gut microbiota homeostasis is of great importance in lipid metabolism. Dietary fiber may positively regulate blood lipid and intestinal microbiota, therefore, we have investigated the effect of chickpea dietary fiber (CDF) on high-fat diet (HFD)-induced hyperlipidemia and gut bacterial dysbiosis. Fifty male Sprague Dawley rats purchased for this study were randomly divided into 5 groups of 10 rats each. The control group was fed with normal diet (ND), while the other four groups were all fed with HFD for inducing hyperlipidemia. Then one of the four HFD groups continued to be fed with only HFD, and the other three groups were fed with CDF in different doses: high CDF (30 g CDF/kg of HFD), medium CDF (15 g CDF/kg of HFD), and low CDF (5 g CDF/kg of HFD). After CDF treatment, the lipid level in serum was determined through biochemical methods, and microbial content of the fecal sample was determined by 16S rDNA sequencing. We found that CDF could decrease the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol and increase the level of high-density lipoprotein cholesterol significantly. The diversity of gut microbiota in the ND group and CDF-treated groups were higher than HFD group. The β-diversity analysis showed that there were significant differences in gut microbiota among HFD-, ND-, and CDF-treated groups. Rats in CDF groups tended to be similar and interactive. CDF can effectively increase the abundance of Bacteroides and Lactobacillus in rats and increase the level of propionic acid. These results indicated that CDF might affect serum lipid and gut bacterial ecosystem positively.
( Jia Cheng ),( Na Sun ),( Xin Zhao ),( Li Niu ),( Mei Qin Song ),( Yao Gui Sun ),( Jun Bing Jiang ),( Jian Hua Guo2 ),( Yuan Sheng Bai ),( Jun Ping He ),( Hong Quan Li ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8
Seventeen compounds derived from traditional Chinese medicines (TCMs) were tested for their antiviral activity against porcine reproductive and respiratory syndrome virus (PRRSV) in vitro. Visualization with the cytopathologic effect (CPE) assay and the 3-(4, 5-dimethyithiazol- 2-yl)-2,5-diphenyltetrazolium bromide test were used to determine the 50% cytotoxic concentration (CC50) and 50% effective concentration (EC50) in cultured Marc-145 cells. Among the tested compounds, chlorogenic acid and scutellarin showed potential anti-PRRSV activity. The EC50 values were 270.8 ± 14.6 μg/ml and 28.21 ± 26.0 μg/ml and the selectivity indexes were >5.54 and 35.5, respectively. The time-of-addition and virucidal assay indicated that the anti-PRRSV activity of the two compounds could be due to their inhibiting the early stage of virus replication and/or inactivating the virus directly. The inhibition of the virus attachment was not observed in the adsorption inhibition assay. The inhibition ratios of chlorogenic acid and scutellarin were, respectively, 90.8% and 61.1% at the maximum non-cytotoxic concentrations. The results have provided a basis for further exploration of their antiviral properties and mechanisms in vivo. We believe that the chlorogenic acid and scutellarin have a great potential to be developed as new anti-PRRSV drugs for clinical application.