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Ze Wang,Wei-Bo Zhang,Shuyong Jia,Yu-Ying Tian,Guang-Jun Wang,Hongyan Lin 사단법인약침학회 2015 Journal of Acupuncture & Meridian Studies Vol.8 No.6
This study investigated whether a meridian-like distribution of Alcian blue (AB) existed after it was injected into a fish's body and suggested a new animal model for meridian study. Twenty Gephyrocharax melanocheir fish with translucent bodies were injected with AB at a point near the spinal column or the dorsal fin. Distribution of AB was observed using a digital camera and a stereomicroscope. Three or more obvious blue tracks were found: one along the spinal column, another along the posterior margin of the abdomen extending to the superior margin of the anal fin, and a third along both sides of the dorsal fin. They were similar to the locations of the governor, conceptual vessel, and urinary bladder meridians, respectively, on the human body according to the classic theory of traditional Chinese medicine. A few other blue tracks were also found, which apparently did not correspond to any known meridians. The results show that the tracks of AB share important similarities with the locations of classically described meridians and that they are mainly distributed in the interstitial space around bones and blood vessels and inside muscular interstices. This study may provide a new experimental animal model for exploring acupuncture meridians.
Jia-Yu Lv,Ning-Ning Zhang,Ya-Wei Du,Ying Wu,Tian-Qiang Song,Ya-Min Zhang,Yan Qu,Yu-Xin Liu,Jie Gu,Ze-Yu Wang,Yi-Bo Qiu,Bing Yang,Da-Zhi Tian,Qing-Jun Guo,Li Zhang,Ji-San Sun,Yan Xie,Zheng-Lu Wang,Xin 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1
Purpose: The aim of this study was to compare the efficacy of liver transplantation (LT) and liver resection (LR) for hepatocellularcarcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and to investigate risk factors affecting prognosis. Materials and Methods: A total of 94 HCC patients with PVTT type I (segmental PVTT) and PVTT type II (lobar PVTT) were involvedand divided into LR (n=47) and LT groups (n=47). Recurrence-free survival (RFS) and overall survival (OS) were comparedbefore and after inverse probability of treatment weighting (IPTW). Prognostic factors for RFS and OS were explored. Results: Two treatment groups were well-balanced using IPTW. In the entire cohort, LT provided a better prognosis than LR. Among patients with PVTT type I, RFS was better with LT (p=0.039); OS was not different significantly between LT and LR(p=0.093). In subgroup analysis of PVTT type I patients with α-fetoprotein (AFP) levels >200 ng/mL, LT elicited significantly longermedian RFS (18.0 months vs. 2.1 months, p=0.022) and relatively longer median OS time (23.6 months vs. 9.8 months, p=0.065). Among patients with PVTT type II, no significant differences in RFS and OS were found between LT and LR (p=0.115 and 0.335,respectively). Multivariate analyses showed treatment allocation (LR), tumor size (>5 cm), AFP and aspartate aminotransferase(AST) levels to be risk factors of RFS and treatment allocation (LR), AFP and AST as risk factors for OS. Conclusion: LT appeared to afford a better prognosis for HCC with PVTT type I than LR, especially in patients with AFP levels>200 ng/mL.
시선추적기법을 활용한 노인의 주거환경 내 색 인지에 대한 연구
왕택우(Wang, Ze-Yu),조지영(Cho, Ji Young) 한국주거학회 2022 한국주거학회 학술대회논문집 Vol.33 No.2
As people get old, people experience the decline of physiological functions which may increase the incidence of dementia and cognitive impairment. This will greatly affect the care burden of the elderly themselves and their family members. At the same time, in severe cases, there will be problems such as going out alone and getting lost. The purpose of this study is to understand the gaze of the elderly on the elements in the space through the application of eye tracking technology, especially through the change of color, to explore the degree of attention to the door. This study conducted experiments on 9 elderly people. The experimental stimuli were two groups of pictures with different colors in entry doors, with 7 pictures in each group. The results from this eye tracking research shows that: (1) The application of color can effectively change the attention of the elderly, and the probability of being observed is higher in red doors with contrasting white walls than white doors in white walls; (2) Red doors are noticed faster than white doors; and (3) Compared with normal elderly, people with cognitive impairment showed the attention to the images were not obvious, and their eye movement were more spread than those with healthy. The results from this research highlights the necessity to plan colors of entry doors carefully depending on the intention in expecting more usage or less usage for their safety and protection from way loss.
동시출현단어 분석을 이용한 노인주거디자인 국내외 연구동향 비교 - Web of Science Core Collection과 KCI-Korean 저널 데이터베이스를 중심으로 -
왕택우(Wang, Ze-Yu),조지영(Cho, Ji Young),홍이경(Hong, Yi-Kyung) 한국주거학회 2021 한국주거학회 논문집 Vol.32 No.6
In aging society, providing comfortable and optimized residential environment for the elderly is essential task for policy makers, designers, and researchers. The purpose of this research was to identify research trends in housing design for the elderly, both domestically in South Korea and in international, in order to propose a future research and a strategy for the research community. For this goal, we analyzed research documents published in domestic and international journal articles retrieved from Web of Science databases, using VOSviewer software for keyword co-occurrence analysis. The results show that international studies categorized as follows: (a) systems, services, and technologies, (b) care and health, (c) illness and life of the elderly (dementia, depression, etc.), and (d) macroperspective (population, project, government, and public-private partnership); domestic studies were categorized as (a) characteristics of residential environment, (b) studies on elderly care facilities, (c) architecture and interior design for the elderly, and (d) user needs and design elements. Compared to international research trends, those of domestic research tended to lack convergence of diverse areas and interest; thus, expansion of research interest towards more diverse disciplines including technology, health, medicine, nursing, and policy is necessary. The results provide insights for the direction of future research on the aging society of South Korea.
시선추적기법을 활용한 노인의 주거환경 내 색 인지에 대한 연구
왕택우(Wang, Ze-Yu),조지영(Cho, Ji Young) 한국주거학회 2022 한국주거학회 학술대회논문집 Vol.34 No.1
As people get old, people experience the decline of physiological functions which may increase the incidence of dementia and cognitive impairment. This will greatly affect the care burden of the elderly themselves and their family members. At the same time, in severe cases, there will be problems such as going out alone and getting lost. The purpose of this study is to understand the gaze of the elderly on the elements in the space through the application of eye tracking technology, especially through the change of color, to explore the degree of attention to the door. This study conducted experiments on 9 elderly people. The experimental stimuli were two groups of pictures with different colors in entry doors, with 7 pictures in each group. The results from this eye tracking research shows that: (1) The application of color can effectively change the attention of the elderly, and the probability of being observed is higher in red doors with contrasting white walls than white doors in white walls; (2) Red doors are noticed faster than white doors; and (3) Compared with normal elderly, people with cognitive impairment showed the attention to the images were not obvious, and their eye movement were more spread than those with healthy. The results from this research highlights the necessity to plan colors of entry doors carefully depending on the intention in expecting more usage or less usage for their safety and protection from way loss.
왕택우(Wang, Ze-Yu),조지영(Cho, Ji Young),홍이경(Hong, Yi-Kyung) 한국주거학회 2021 한국주거학회 학술대회논문집 Vol.33 No.1
In aging society, providing comfortable and optimized residential environment for the elderly is one of the essential tasks for researchers. This is a comparative study of research trends of Elderly Residential Design in Korea and China using co-occurrence analysis method. By comparing themes of existing studies conducted in both countries and looking at the areas that are active and those that are not, this study aims to present the direction of future research on residential design for the elderly in both countries. We searched for Elderly Residential Design as a keyword on academic sites in both countries (KISS in Korea and CNKI in China) to obtain research data, and then input them into VOSviewer, a software tool for constructing and visualizing bibliometric networks. The results show that existing studies on Elderly Residential Design in Korea were mainly about semi-self-care elderly living, elderly housing theory method, elderly housing design, and elderly physiology and psychology. In contrast in China, development policy, residential design project, residential design for the elderly, and housing theory for the elderly were the main directions. It is hoped that the findings from this study will provide implications for the research direction of the residential design for the elderly in both countries.
Ze-Qin Dai,Hang Su,Min Luo,Yu Ou,Xiao-Zhong Fu,Yong-Xi Dong,Yu-Feng Cha,Shun Zhang,Yong Huang,Yong-Lin Wang 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.8
A series of 4′-N-substituted (aminomethyl)benzoate derivatives of scutellarein were designed and synthesized. Evaluation of their physiochemical properties showed that the designed target compounds 5a–e exhibit higher chemical stability and aqueous solubility than scutellarin and scutellarein. The permeability (Papp AP to BL ) of 5c–e in Caco-2 cells were 2.8, 8.1, and 12.6 times higher than that of scutellarin and 1.3, 4.1, and 6.0 times higher than that of scutellarein; especially, 5e had the highest P app AP to BL value (7.19 ± 0.31 × 10−6 cm/s) and the lowest ER (P app BL to AP /P app AP to BL ) value of 0.17. In vitro antioxidative evaluation results revealed that 5e could protect against H2O2 -induced PC12 cells’ oxidative damage by attenuating mitochondrial membrane potential loss and decreasing H2O2 -induced reactive oxygen species (ROS) production.
( Ze Min Huang ),( Zheng Cai Jia ),( Jun Tang ),( Yi Zhang ),( Yi Tian ),( Dong Jing Ni ),( Fang Wang ),( Yu Zhang Wu ),( Bing Ni ) 생화학분자생물학회(구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.7
Almost all melanoma cells express at least one member of the MAGE-A antigen family, making the cytotoxic T cells (CTLs) epitopes with cross-immunizing potential in this family attractive candidates for the broad spectrum of anti-melanoma immunotherapy. In this study, four highly homologous peptides (P264: FLWGPRALA, P264I9: FLWGPRALI, P264V9: FLWGPRALV, and P264H8: FLWGPRAHA) from the MAGE-A antigens were selected by homologous alignment. All four peptides showed high binding affinity and stability to HLA-A*02:01 molecules, and could prime CTL immune responses in human PBMCs and in HLA-A*02:01/Kb transgenic mice. CTLs elicited by the four epitope peptides could cross-lyse tumor cells expressing the mutual target antigens, except MAGE-A11 which was not tested. However, CTLs induced by P264V9 and P264I9 showed the strongest target cell lysis capabilities, suggesting both peptides may represent the common CTL epitopes shared by the eight MAGE-A antigens, which could induce more potent and broad-spectrum antitumor responses in immunotherapy. [BMB Reports 2012; 45(7): 408-413]