일부 자동차 공장 근로자들의 職業的 特性과 社會 心理的 Stress의 相關性 硏究

김성삼,홍지우,한현정,최희석,권소희,정해경,김삼태,송용선,이기남 한국전통의학연구소 2004 한국전통의학지 Vol.14 No.1

〈Objective〉 This study were carried out to study to assess the relationship between job characteristics, general characteristics, health behaviors, and psychosocial distress and suggested the preventive oriental medicine approaches in occupational health area. 〈Methods〉 We measured job characteristics(job demand, job control, jop insecurity) by The Karasek's Job Content Questionnaire, health behaviors(smoking, drinking, exercise, coffee), general characteristics at work by a self-administered questionnaire. Psycho social distress was measured by PWI(Psychosocial Well-being Index), a 18-item self- administered instrument. 370 data for research were collected through the process of oriental health examination with questionnaire in workplace. Statistical analysis was done by t test, oneway ANOVA, and hierarchical multiple regression analysis with SPSSWIN (version 10.0) 〈Results〉 Among the 152 respondents, the prevalence of high job strain was 27%(41 persons). The Odds ratio of high job strain was 3.11(95 2.12~4.11), and those of passive group and active group were 2.01(95 0.83~2.76) and 1.80(95 0.83~2.76), respectively. Our results supported the association between psychosocial distress and job strain. 〈Conclusion〉 The odds ratio of high strain isolated group(high strain group+low social support) was 3.59(95 2.05 5.13), but the odds ratio of high strain collective group was 1.32(95 0.23 2.41). Social support at work was modifing factor of the association between psycho social distress and job strain. Therefore we reviewed the evidence that economic depression was associated with psycho social distress in this study, and that the strength of the social support was important in maintain health.

正四角덕트의 入口領域에서 코너流動에 관한 硏究

유영태,이충주,김지환 조선대학교 생산기술연구소 1996 生産技術硏究 Vol.18 No.2

The corner flow characteristics of curved square duct is applied to a miniature, high effectiveness, automatic control of mechanical facilities and architectural facilities on industrial scene. It is necessary to analyze exactly the flow characteristics of a square duct using 5-hole pitot tube. Because these can be applied to energy problem of air conditioning system. The governing equations (Continuity & Navier-Stokes equations) are solved theore- tically by using a toroidal coordinate system in a square duct. The experimental study using air in a square duct carried out to measure corner flow characteristics by 5-hole pitot tube with 3-D traverse system, blower, pressure transducer, A/D converter, amplifier, power supply and oscilloscope.

기포검출을 위한 광섬유 센서 연구

강덕지,고영주,이경진,김신 제주대학교 공과대학 첨단기술연구소 2003 尖端技術硏究所論文集 Vol.14 No.2

Bubble detection is one of the most important measurements in the two-phase flows. For the purpose of the bubble detection, an optical fiber is used based on the fact that. An intensity of attenuated light varies according to the surrounding medium at the exposed core. Experiments are conducted to investigate. (1) the effect of length and diameter of the exposed core, (2) the effect of the shape of the exposed core (3) the effect of the size of the bubble, on the detection capability. The possibility of bubble detection with optical fibers is present in some geometrical conditions of optical fibers.

전해중합법에 의한 폴리피롤 전극 제조 및 전기화학적 특성

박종호,김지윤,조영일 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

본 연구에서는 도펀트를 달리하여 정전류법으로 폴리피롤 막을 ITO 전극위에 제조하였다. 4단자법으로 전도도를 측정한 결과, BDS를 도핑물질로 하는 폴리피롤 필름의 전도도가 0.3S/㎝로 가장 우수하였다. BDS를 도펀트로 사용한 폴리피롤 제조 조건으로 BDS 농도, 전류 밀도, 전기량에 대한 영향을 고찰하였다. 또한 양이온 교환 특성을 향상시키기위해 BDS를 도펀트로 사용한 폴리피롤 위에 거대 음이온 PVS를 도펀트로 적층 중합한 복합체 필름을 제조하였으며, 양이온에 대한 교환 특성이 향상되는 것을 확인할 수 있었다. In the present study, the polypyrrole films were prepared by constant current method on indium tin oxide electrode with doping materials. From the results of measurements by the four-point probe method, the maximum electrical conductivity of polypyrrole doped with 1, 3-benzenedisulfonic acid(BDS) was 0.3S/㎝. In the case of BDS, the effects of polymerization variable were examined with respect to BDS concentration, current density, and electricity. In order to improve the cation exchange property, the layered polypyrrole composite films were fabricated by electrochemical oxidation of pyrrole in BDS solutions as dopant material followed by electropolymerization in polyvinylsulfonic acid(PVS) solutions. The resulting composite films showed higher redox behaviors for cation transfer than polypyrrole film doped with PVS.

술폰기가 도핑된 폴리피를 제조 및 전기화학적 특성

박종호,김지윤,장순호,조영일 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.4

정전류 중합법으로 도펀트의 화학적 구조와 크기에 따라 폴리피롤 막을 ITO 전극위에 합성하고 전기화학적 특성을 알아보았다. 전해중합 효율은 SBA, PVS, BDS 순으로 증가하였고 합성 전기량의 증가에 따라서는 변화되지 않았다. SBA를 도펀트로 제조된 폴리피롤 막은 산화 과정에서 음이온 및 양이온 교환특성이 나타남을 CV를 통해 알 수 있었다. 도펀트가 BDS인 폴리피롤 막은 전류밀도 1 mA/㎠에서 가장 높은 속도 상수 값을 나타내었다. 또한 선형분극 법으로 측정한 확산계수는 이중층 용량 성분 때문에 임피던스 법으로 구한 값보다 크게 나타났다. According to chemical structure and size of dopant, the polypyrrole films were prepared by constant current polymerization method on ITO electrode and its electrochemical properties were investigated. The current efficiency of polymerization of pyrrole was increased in the sequence 4-sulfobenzoic acid(SBA), polyvinylsulfonic acid(PVS), 1.3-benzenedis-ulfonic acid(BDS) and was unchanged with electricity of polymerization. As a result of cyclic voltammetry of polypyrrole film prepared with SBA as dopant, ion-exchange behavior both of anion and cation was observed during oxidation process. The maximum rate constant of polypyrrole doped with BDS was obtained at 1 ㎃/㎠. In addition, the diffusion coefficient calculated by linear polarization method was more large than that measured by impedance analysis due to double layer capacitance.

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

特發性 食道破裂(2例 報告)

徐景弼,池英煥,金源弼,李寧均 醫藥係社 1955 綜合 醫學 Vol.12 No.11

Three-dimensional accuracy of different correction methods for cast implant bars

Ji-Yung Kwon,Chang-Whe Kim,Young-Jun Lim,Ho-Beom Kwon,Myung-Joo Kim 대한치과보철학회 2014 The Journal of Advanced Prosthodontics Vol.6 No.1

PURPOSE. The aim of the present study was to evaluate the accuracy of three techniques for correction of cast implant bars. MATERIALS AND METHODS. Thirty cast implant bars were fabricated on a metal master model. All cast implant bars were sectioned at 5 mm from the left gold cylinder using a disk of 0.3 mm thickness, and then each group of ten specimens was corrected by gas-air torch soldering, laser welding, and additional casting technique. Three dimensional evaluation including horizontal, vertical, and twisting measurements was based on measurement and comparison of (1) gap distances of the right abutment replica-gold cylinder interface at buccal, distal, lingual side, (2) changes of bar length, and (3) axis angle changes of the right gold cylinders at the step of the post-correction measurements on the three groups with a contact and non-contact coordinate measuring machine. One-way analysis of variance (ANOVA) and paired t-test were performed at the significance level of 5%. RESULTS. Gap distances of the cast implant bars after correction procedure showed no statistically significant difference among groups. Changes in bar length between pre-casting and post-correction measurement were statistically significance among groups. Axis angle changes of the right gold cylinders were not statistically significance among groups. CONCLUSION. There was no statistical significance among three techniques in horizontal, vertical and axial errors. But, gas-air torch soldering technique showed the most consistent and accurate trend in the correction of implant bar error. However, Laser welding technique, showed a large mean and standard deviation in vertical and twisting measurement and might be technique-sensitive method.

세신추출물이 α-MSH 자극에 의한 B16F10 세포의 멜라닌생성에 미치는 영향

Ji Yeon Jang(장지연),Ha Neui Kim(김하늬),Yu Ri Kim(김유리),Byung Woo Kim(김병우),Yung Hyun Choi(최영현),Byung Tae Choi(최병태) 한국생명과학회 2010 생명과학회지 Vol.20 No.11

α-MSH는 세포내 cAMP를 증폭시켜 멜라닌세포의 증식과 색소 증가에 관여한다. 본 연구에서는 α-MSH로 자극한 B16F10 세포에서 세신추출물의 hypopigmenting 효과를 조사하고 그 억제기전에 대하여 조사하였다. 세신 추출물은 α-MSH에 의해 유도된 tyrosinase 활성과 멜라닌생성을 효과적으로 억제시켰으며, 이는 tyrosinase 발현을 조절하는 전사인자인 MITF의 발현억제와 연관성이 있었다. 즉 세신추출물은 MEK/ERK와 PI3K/Akt의 활성화를 통하여 MITF를 조절함으로서 α-MSH에 의해 유도되는 tyrosinase, TRP-1, Dct 등 멜라닌생성관련 단백질을 억제함으로서 멜라닌생성을 저해하는 것으로 사료된다. Recently, it has been found that Asiasari radix showed a hypopigmenting effect on melanogenesis through activation of mitogen-activated protein kinase (MEK)/extracellular signal-activated kinase (ERK) in B16F10 melanoma cells. However, the hypopigmenting effect of A. radix on the α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis has remained unknown. The purpose of this study was to investigate the inhibitory mechanism of the partially purified A. radix (PPAR)-induced hypopigmentating effects on α-MSH-stimulated melanogenesis in B16F10 mouse melanoma cells. PPAR strongly inhibited tyrosinase activity and leads to decreased melanin synthesis in α-MSH-stimulated B16F10 melanoma cells. PPAR also decreased the α-MSH-induced over-expression of the melanogenic enzymes, tyrosinase, tyrosinase-related protein (TRP)-1, dopachrome tautomerase (Dct) and microphthalmia-associated transcription factor (MITF). We further showed that PPAR inhibits α-MSH-induced melanogenesis via phosphorylation of MEK/ERK and PI3K/Akt, and that their activation was blocked by MEK inhibitors, PD98059 and PI3K inhibitors, LY294002 in α-MSH-stimulated B16F10 melanoma cells. These results suggest that PPAR inhibits α-MSH-induced melanogenesis by activation of MEK/ERK and PI3K/Akt through MITF degradation, which may lead to down-regulation of tyrosinase.

ABCB1, FCGR2A, and FCGR3A Polymorphisms in Patients with HER2-Positive Metastatic Breast Cancer Who Were Treated with First-Line Taxane plus Trastuzumab Chemotherapy

Kim, Ji-Won,Kim, Jee Hyun,Im, Seock-Ah,Kim, Yu Jung,Han, Hye-Suk,Kim, Jin-Soo,Han, Sae-Won,Jeon, Yoon Kyung,Oh, Do-Youn,Han, Wonshik,Kim, Tae-You,Park, In Ae,Noh, Dong-Young,Bang, Yung-Jue S. Karger AG 2012 Oncology Vol.83 No.4

<P>Abstract</P><P><B><I>Objective:</I></B> The aim of this study was to elucidate clinical implications of ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer (MBC) after taxane plus trastuzumab (TH) chemotherapy. <B><I>Methods:</I></B> Using genomic DNA samples extracted from mononuclear cells of consecutive patients with HER2-positive MBC who received first-line TH, we analyzed five polymorphisms (ABCB1 1236C>T, ABCB1 2677G>T/A, ABCB1 3435C>T, FCGR2A 131H/R, and FCGR3A 158V/F) and then correlated them with the response rate, progression-free survival (PFS), overall survival (OS), and adverse events of patients. <B><I>Results:</I></B> A total of 57 women were analyzed. The median age was 46 years (range 27–72). ABCB1 2677T carriers had a longer PFS (p = 0.037) along with a tendency toward a longer OS (p = 0.057). ABCB1 3435CC genotype carriers had a shorter PFS (p = 0.039) along with a tendency toward a shorter OS (p = 0.093). In combined analysis, PFS was significantly longer in ABCB1 1236CC and/or 2677TT carriers compared to the others (p = 0.006). FCGR2A 131H/R and FCGR3A 158V/F polymorphisms were not significantly associated with response rate, PFS, and OS. <B><I>Conclusions:</I></B> Our data support that ABCB1 polymorphisms may predict PFS after first-line TH chemotherapy in patients with HER2-positive MBC. In contrast, FCGR2A 131H/R and FCGR3A 158V/F polymorphisms could not predict treatment outcomes.</P><P>Copyright © 2012 S. Karger AG, Basel</P>