작업치료사를 위한 노인우울증 평가도구의 개관

허지원,김환,권혁철 대구대학교 특수교육재활과학연구소 2012 再活科學硏究 Vol.30 No.1

이 연구는 그동안의 연구를 바탕으로 노인의 우울증과 관련하여 작업치료영역에서 노인 우울증환자의 효율적 접근을 위해 평가 도구를 정리하고자 하였다. 관련문헌을 수집한 후 연구자 별로 평가도구를 표로 나열하고 그 중 대표적인 평가도구는 구체적인 특징을 기술하였다. 앞으로 임상가들 및 연구자들은 우울증을 효율적으로 판별하기위하여 평가도구에 대한 충분한 이해를 바탕으로 판별 목적에 알맞으며 타당성이 검증된 도구를 사용할 필요가 있다. The aim of this study was to review the assessment tools of depression in elderly for effective access in the occupational therapy field. Associated literature was reviewed and each researcher listed the assessment tools in a table form and described the characteristics of representative assessment tools. In the future it is important that clinicians and researchers understand the assessment tools fully to differentiate depression effectively and to utilize tools that have proven validity.

폴리머형 습도센서의 선형성 개선에 관한 연구

허원녕,이지공,이성필 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.1

poly-4 vinylpyridine과 1.4-dichlorobutane의 조성을 변화시켜 공중합(co-polymerizaton)시키고 methanol (+PVP)에 용해시켜 감습물질을 제조하였다. 알루미나 기판에 Au전극을 형성한 후 제조된 감습물질을 dipping함으로써 폴리머형 습도센서를 제작하였다. Poly-4 vinylpyridine, 1.4-dichlorobutane 및 methanol의 함량비에 따른 감습특성을 조사한 결과 poly-4 vinylpyridine : 1.4-dichlorobutane : methanol의 중량비가 1: 1: 0.5인 소자의 경우, 상대습도 30%-90%로 변화했을 때 임피던스 변화는 275 ㏀에서 2.5 ㏀으로 변화하였다. PCB 기판 보다 알루미나 기판에서 히스테리시스 특성이 우수함을 알 수가 있었고, poly-4 vinylpyridine : 1.4-dichlorobutane : methanol의 중량비가 1: 1: 0.5인 소자의 경우 히스테리시스가 1.5% 이하로 나타났다. Humidity sensing materials which were co-polymerized poly-4 vinylpyridine. 1.4-dichlorobutane and methanol(+PVP) were prepared. Polymer humidity sensors were fabricated as dipping method on alumina substrates formed Au electrode. When the content ratio of poly-4 vinylpyridine, 1,4-dichlorobutane and methanol was 1: 1: 0.5, the impedance of the sample changed 275 ㏀ to 2.5 ㏀ in the relative humidity range of 30% - 90%. We can observe that the hysteresis characteristics of sensors with alumina substrate were less than 1.5% and better than the sensor with PCB one.

다중주파수·다중성분 고막운동도에 관한 연구

소원섭,이지연,강희라,손원진,허승덕 대구대학교 특수교육재활과학연구소 2012 再活科學硏究 Vol.30 No.1

이 연구는 이학적·청각학적 정상 소견을 가진 성인들의 다중주파수 고막운동도(multi-frequency tympanogram, MFT)와 다중성분 고막운동도(multi-component tympanogram, MCT)의 특성을 알아보고자 하였다. 연구 참여자는 D대학교 재학 중인 19명(M:F=9:10, 만 19∼23세)으로 하였다. MCT는 각 성분(admittance; Y, susceptance; B, conductance; G)별 정점의 수를 확인하였고, MFT는 200 ㎐부터 2 ㎑ 순음에 대한 고막 긴장 및 이완상태에서 전도율을 통해 공명주파수와 ΔB, Δ∅를 각각 구하였다. MCT는 668 ㎐ 자극에 대해 47.4 %가 1Y1B1G를, 52.6 %가1Y3B1G를 보였고, MFT의 공명주파수는 829~1,213(1,021±192) ㎐, ΔB와 Δ∅의 평균은 각각 –0.18, -19.3으로 관 찰되었다. This study will be to confirm the characteristic of Multi-component tympanogram(MCT) and Multi-frequency tympanogram(MFT) of adults who have physical and audiological normal findings. Participants were 19 students(M:F = 9:10) who are attending D-university. MCT checked the number of peaks per each component(admittance; Y, susceptance; B, conductance; G) and MFT got the resonance frequency through the conductivity rate of tympanic membrane's tense and relaxation state, and ΔB, Δ∅ respectively. 47.4% of MCT showed 1Y1B1G about 668 ㎐ stimulus and 52.6% of that showed 1Y3B1G. Resonance frequency of MFT was 829~1,213(1,021±192) ㎐, and the average of ΔB and Δ∅ was observed -0.18, -19.3 respectively.

난원공 개존을 통한 우심방에서 좌심방으로의 단락 진단에 있어 경흉부 심초음파 하모닉 영상의 유용성

신미승,강석민,장길진,변기현,하종원,정남식,허지회,이병인 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

우리나라 사람면역결핍바이러스(Human Immunodeficiency Virus) 감염환자에서 발병한 악성종양

최평균,송진수,조재현,김성한,박경화,방지환,박완범,김홍빈,김동완,김태유,허대석,오명돈,김남중,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background : Since highly active antiretroviral therapy has lengthened the life span of individuals infected with human immunodeficiency virus (HIV), the importance of malignancy associated with HIV has been increased. The relative frequencies of malignancies in HIV infected patients may vary in different race and region. The aim of this study is to determine the prevalence and characteristics of malignancies in patients with HIV infection in South Korea. Materials and Methods : To identify HIV patients with malignancy, we reviewed the electronic database of pathological reports for all HIV-infected patients seen from January 1986 to December 2005 at the Seoul National University Hospital. We retrospectively reviewed the medical records of them. Results : Among 850 patients infected with HIV, 33 episodes of malignant diseases were diagnosed in 32 patients (3.76%). Thirty were males, and median age was 46 years (range 29-70). At the time of the diagnosis of malignancy, median CD4^(+) lymphocytes count was 100/uL (range 5-620) and in 27 (82%) patients, CD4^(+) lymphocytes count were less than 200/uL. For 13 patients (40%), malignancy was initial presentation of HIV infection. Excluding patients initially diagnosed as malignancy, median follow-up duration from the first visit to diagnosis of malignancy was 36 months (range 3-96). Non-Hodgkin's lymphoma was the most frequent malignancy (13 patients), followed by Kaposi's sarcoma (7), Hodgkin‘s disease (3), acute myeloid leukemia (1), and other solid cancer (9) including one case of anal cancer associated with human papillomavirus. Among 13 patients with non- Hodgkin's lymphoma, 4(31%) achieved the complete remission after chemotherapy and/or radiation therapy, and had been followed without evidence of recurrence. Conclusion : Malignancy was diagnosed in 3.76% of patients infected with HIV. Non-Hodgkin‘s lymphoma is the most prevalent malignancy in HIV patients in South Korea. 목적 : 효과적인 항레트로바이러스 다제요법이 도입됨에 따라, HIV 감염환자들의 수명이 증가되었고, 이에 따라 HIV 감염환자에서 악성종양의 중요성 또한 증가하고 있다. 본 연구의 목적은 우리나라 HIV 감염환자에서 악성종양의 유병률과 호발하는 악성종양의 특성을 밝히는 것이다. 재료 및 방법 : 1986년부터 2005년까지 서울대학교병원에서 치료를 받은 HIV 감염환자의 의무기록을 후향적으로 분석하였고, 병리학적 검사 결과를 검토하여 악성종양이 진단된 환자들을 대상으로 연구를 시행하였다. 결과 : 총 850명의 환자 중, 32명(3.76%)에서 33예의 악성종양이 진단되어, 악성종양의 발병률은 1,000인년 당13.0명(95% 신뢰구간: 8.6∼17.4명)이었다. 그 중 남자는 30명이었고, 악성종양 진단 당시 연령의 중간값은 46 (29-70)세이었다. 악성종양 진단받을 당시, CD4 림프구 수의 중간값은 lOO/uL (5-620 uL) 이었고, CD4 림프구수가 200/ uL 미만인 환자가 27명(82%)이었다. 악성종양에 대한 검사 도중에 HIV 감염사실이 밝혀진 환자가 13명(40%)이었다. HIV를 진단 받은 후 악성종양이 발병한 환자들에서, HIV 진단 후 악성종양의 발병까지는 평균 36개월(3-96개월)이 걸렸다. 13명의 HIV 감염 환자에서 진단된 비호지킨림프종이 가장 흔한 악성종양이었고, 이외에 카포시육종이 7명, 호지킨병이 3명, HPV와 연관된 항문암이 1명의 HIV 환자에서 진단되었다. 그 밖에 급성백혈병, 방광암, 췌장장, 폐암, 진행성위암, 갑상선암, 간세포암, 후두암이 각각 1예씩 진단되었다. 비호지킨림프종이 진단된13명 환자 중, 4명(31%)은 항암치료 및 방사선치료를 받아 완전관해가 되었고, 현재 재발의 증거 없이 외래에서 경과 관찰 중이다. 결론 : 우리나라 HIV 감염환자에서 악성종양의 유병률은 3.76%이었고, 비호지킨림프종이 가장 흔한 악성종양이었다.

Folliscope analysis of temporal involvement in Korean with androgenetic alopecia

( Ji Hye Heo ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Ji Won Byun ),( Jeonghyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Androgenetic alopecia (AGA) shows the patterned hair loss. AGA in men usually start in the frontal hairline and/or vertex and progress to severe hair loss usually sparing of the occiput. Unlike this, female-pattern hair loss (FPHL) affect the central portion of the scalp sparing the frontal hairline. The temporal area also can be affected by hair loss. But, the degree of temporal involvement is not evaluated. Objectives: The aim of the study was to evaluate the degree of temporal hair loss involvement and suggest a revised BASP classification including temporal area in AGA. Methods: Total of 120 men and 108 women with AGA were enrolled in this study. All subjects were classified according to the BASP classification. We also evaluated the temporal involvement and added one more specific type T to BASP classification. We measured hair density and thickness in four scalp sites including frontal, vertex, occipital and temporal area using folliscope. Results: Only 3 out of 120 male with AGA showed temporal involvement. 29/108 (26.8%) subjects with FPHL showed temporal involvement. 24 /84 (28.6%) subjects with frontal involvement and 20/66 (30.3%) subjects with vertex involvement also had temporal involvement. 18/59 (30.5%) subjects involving both frontal and vertex also involved temple. Conclusion: This study shows that the proportion of the temporal involvement is significantly higher in women. To evaluate FPHL, we suggest adding specific type T to BASP classification.

Production of Cloned Piglets from Human CD59-Transgenic Embryonic Germ Cells for Reduction of Hyperacute Rejection in Pig-to-Human Xenotransplantation

Won, Ji-Young,Ahn, Kwang-Sung,Heo, Soon-Young,Park, Jin-Ki,Chang, Won-Kyong,Shim, Ho-Sup 한국수정란이식학회 2006 한국수정란이식학회 학술대회 Vol.2006 No.1

A heptameric peptide purified from <i>Spirulina</i> sp. gastrointestinal hydrolysate inhibits angiotensin I-converting enzyme- and angiotensin II-induced vascular dysfunction in human endothelial cells

Heo, Seong-Yeong,Ko, Seok-Chun,Kim, Chang Su,Oh, Gun-Woo,Ryu, Bomi,Qian, Zhong-Ji,Kim, Geunhyung,Park, Won Sun,Choi, Il-Whan,Phan, Thi Tuong Vy,Heo, Soo-Jin,Kang, Do-Hyung,Yi, Myunggi,Jung, Won-Kyo UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.5

<P>In this study, a marine microalga <I>Spirulina</I> sp.-derived protein was hydrolyzed using gastrointestinal enzymes to produce an angiotensin I (Ang I)-converting enzyme (ACE) inhibitory peptide. Following consecutive purification, the potent ACE inhibitory peptide was composed of 7 amino acids, Thr-Met-Glu-Pro-Gly-Lys-Pro (molecular weight, 759 Da). Analysis using the Lineweaver-Burk plot and molecular modeling suggested that the purified peptide acted as a mixed non-competitive inhibitor of ACE. The inhibitory effects of the peptide against the cellular production of vascular dysfunction-related factors induced by Ang II were also investigated. In human endothelial cells, the Ang II-induced production of nitric oxide and reactive oxygen species was inhibited, and the expression of inducible nitric oxide synthase (iNOS) and endothelin-1 (ET-1) was downregulated when the cells were cultured with the purified peptide. Moreover, the peptide blocked the activation of p38 mitogen-activated protein kinase. These results indicated that this <I>Spirulina</I> sp.-derived peptide warrants further investigation as a potential pharmacological inhibitor of ACE and vascular dysfunction.</P>

A case of capecitabine-induced discoid lupus erythematosus

( Ji Hye Heo ),( Han Na Hyun ),( Seon Bok Lee ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Jeonghyun Shin ),( Gwang Seong Choi ),( Ji Won Byun ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

There are a few reports of capecitabine-induced cutaneous lupus erythematosus (CLE), of which most of are subacute CLE. In particular, only one case showed discoid lupus erythematosus (DLE)-like features. Capecitabine is an oral fluoropyrimidine carbamate designed to generate 5-fluorouracil preferentially in tumor tissue through exploitation of higher intratumoral concentrations of thymidine phosphorylase and has less systemic toxicity than 5-fluorouracil administered through intravenous processes. The occurrence of druginduced CLE is related to the use of the drug in a timely manner, followed by the improvement of skin symptoms after discontinuation of the offending drug within several weeks. Stopping implicated medication is the initial management of drug-induced CLE. We report an interesting case of oral capecitabine-induced DLE with discoid and malar rashes, which had not occurred using LF protocol (leucovorin plus 5-fluorouracil) previously, that could not be provoked after changing chemotherapy from a capecitabine (a pro-drug of 5-fluorouracil) to FOLFIRI regimen containing leucovorin, 5-fluorouracil, and irinotecan. This case is meaningful for considering the unknown metabolic components acting on converting capecitabine to 5-fluorouracil of CLE induced by oral capecitabine.

[P345] A case of pseudovascular squamous cell carcinoma

( Ji Hye Heo ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Ji Won Byun ),( Gwang Seong Choi ),( Jeonghyun Shin ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Pseudovascular squamous cell carcinoma (SCC) is one of the rare variant of acantholytic SCC. It usually arises in sun-exposed sites such as head and neck in middle-aged or elderly patients. The histologic findings are pseudovascular channels lined with neoplastic cells and acantholytic cells moving from squamous nest. Immunohistochemical findings are positivity with monoclonal antibodies to cytokeratin and vimentin and negativity in vascular markers. Mohs micrographic surgery or surgical excision which is available to access the tumor margin is the primary management of high-risk cutaneous SCC. Radiation therapy is also used in cases suspected incomplete surgical removal. We report a case of a 67-year-old man presented with pruritic and painful erythematous grouped papules on the right chin area for two months ago and also in the right oral mucosa where the lesion had started first. Skin biopsy findings showed overlying epidermis permeating down with irregular shaped cellular proliferation, neoplastic cells with pleomorphic nuclei and acantholytic cells in cleft of dilated vessels. Stains for high-molecular weight cytokeratin and p63 were all positive in tumor cells and Ki-67 was presented approximately 10% positivity. It was consistent with pseudovascular SCC. We could not monitor the patient because of failure to follow up. To our best knowledge, this is the first case report on pseudovascular SCC in Korean dermatologic literature.