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류마티스 활막염에 있어 염증매개물질에 의한 Transforming Growth Factor-β-inducible Gene-h3 (βig-h3) 생산 조절 기전
강영모 ( Young Mo Kang ),김성일 ( Sung Il Kim ),김정섭 ( Jeong Seup Kim ),유동완 ( Dong Wan You ),사금희 ( Kheum Hee Sa ),박은주 ( Eun Ju Park ),김성욱 ( Sung Uk Kim ),서재석 ( Jae Seok Seo ),한승우 ( Seung Woo Han ),남언정 ( Eon 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2
Objective: To investigate the expression pattern of transforming growth factor-β-inducible gene-h3 (βig-h3) within rheumatoid synovial tissue and the regulation of βig-h3 synthesis in fibroblast-like synoviocyte (FLS). Methods: Synovial tissues obtained from patients with rheumatoid arthritis and osteoarthritis were obtained during joint replacement surgery. βig-h3 expression was evaluated with immunohistochemical stain. FLS was isolated from synovial tissues and stimulated with cytokines including TGF-β, TNF-α, IL-1β, IFN-γ, IL-6, IL-4, and IL-10. βig-h3 synthesis was measured using semiquantitative RT-PCR, ELISA, immunofluorescence stain, and flow cytometry. Results: Expression of βig-h3 was diffuse and abundant in both lining and sublining layers of rheumatoid synovium, which was more prominent than those of osteoarthritis. Production of βig-h3 in FLS was regulated by TGF-β1 in a dose-dependent manner and was highest at 5 ng/mL of TGF-β1. TNF-α and IL-1β upregulated the production of βig-h3 from FLS synergistically with TGF-β1 but other cytokines such as IL-4, IL-6, IL-10 did not affect. βig-h3 synthesis was efficiently inhibited by dexamethasone at higher dose (100 nM) but not by cyclosporine-A. Conclusion: Production of βig-h3, which is highly upregulated in rheumatoid synovitis, is differentially regulated by inflammatory cytokines.
기관지천식 환자에서 Furosemide, Disodium cromoglycate 및 Heparin 흡입이 고장액 식염수 기관지유발검사에 미치는 영향
강천일,현상훈,남언정,김건우,윤종수,서영익,이종명,김능수 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3
목적 : 기관지천식 환자에서 고장액 식염수의 흡입은 기도수축을 유발할 수 있으며 이는 운동유발성 천식반응과 밀접한 관계가 있는 것으로 알려져 있다. 저자들은 알레르겐 흡입이나 운동에 의해 유발되는 천식에 예방효과가 있는 것으로 알려진 disodium cromoglycate(DSCG), furosemide 및 heparin 흡입이 4.5% NaCl 기관지유발검사(BPT)에 미치는 영향을 조사하였다. 대상 및 방법 : 4.5% NaCl BPT에서 양성반응을 보이는 기관지천식 환자 13명을 대상으로 하였으며 사용된 약물은 furosemide 40㎎, DSCG 40㎎ 및 heparin 1,000μ/㎏이었다. 먼저baseline 4.5% NaCl BPT를 시행한 다음 이들 약물로 전처치후 다시 4.5% NaCl BPT를 시행하여 약물의 효과를 관찰하였다. 결과 : Furosemide 40㎎, DSCG 40㎎및 heparin 1,000μ/㎏의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였다. Furosemide와 DSCG로 전처치한 군(n=6)에서 이들의 기도수축 방어율은 각각 100.6±6.6%, 91.1±17.2%였으며 furosemide와 heparin으로 전처치한 군(n=7)에서는 각각 58.7±29.2%, 59.0±51.1%로서 각 군에서 이들 약제간의 방어율에는 유의한 차이가 없었다. 결론 : Furosemide(40㎎), DSCG(40㎎) 및 heparin(1000μ/㎏)의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였으며, 적어도 이 용량에서 기도수축 예방 정도에는 유의한 차이가 없음을 알 수 있었다. Background: Hypertonic saline (4.5% NaCl) inhalation is known to induce broncho-constriction by affecting mast cell, epithelial cell and vagal afferent pathway in some asthmatics. Disodium cromoglycate (DSCG) is known to have a preventive effect on allergic asthma and exercise induced asthma, and recently it was reported that furosemide and heparin had similar effect. The purpose of this study was to evaluate the effects of furosemide, DSCG and heparin on hypertonic saline provocation test in asthmatics. Methods: Thirteen asthmatics with a positive response to hypertonic saline challenge were enrolled. Hypertonic saline and test drugs were generated by ultrasonic nebulizer. After taking baseline 4.5% NaCl challenge, subjects were rechallenged with 4.5% NaCl after inhalation of furosemide 40㎎, DSCG 40㎎ or heparin 1,000μ/㎏. Results: 1. There was a significant positive relationship between PC_20-methacholine and PTM-4.5% NaCl(r=0.5575, p = 0.024). 2. Furosemide, DSCG and heparin had no direct bronchodilating effects. 3. Premedication of furosemide and DSCG(n=6) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 100.6±6.6% and 91.1±17.2%, respectively. 4. Premedication of furosemide and heparin(n=7) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 58.7±29.2% and 59.0±51.1%. respectively. Conclusions: Furosemide(40㎎), DSCG(40㎎) and heparin(1.000μ/㎏) had significant protective effects on hypertonic saline induced broncho-constriction in asthmatics, and there were no significant differences in their potency of protection rate.
Nam, Eon Jeong,Sa, Keum Hee,You, Dong Wan,Cho, Jang Hee,Seo, Jae Seok,Han, Seung Woo,Park, Jae Yong,Kim, Sung Il,Kyung, Hee Soo,Kim, In San,Kang, Young Mo Wiley Subscription Services, Inc., A Wiley Company 2006 Vol.54 No.9
<B>Objective</B><P>To delineate the expression of transforming growth factor β–inducible gene h3 (βIG-H3) in rheumatoid synovitis and to determine the regulatory role of βIG-H3 in the adhesion and migration of fibroblast-like synoviocytes (FLS).</P><B>Methods</B><P>Synovial tissue was obtained from patients with rheumatoid arthritis (RA) during joint replacement surgery, and FLS were isolated using enzymatic treatment. Immunohistochemical staining was performed to show the expression of βIG-H3 within rheumatoid synovium. Synthesis of βIG-H3 from FLS was determined by semiquantitative reverse transcription–polymerase chain reaction, Western blot analysis, and enzyme-linked immunosorbent assay. Cell adhesion and migration assays were performed using the YH18 peptide in the fourth fas-1 domain of βIG-H3 and function-blocking antibodies to integrins.</P><B>Results</B><P>Expression of βIG-H3 was up-regulated in RA synovial tissue compared with synovial tissue from patients with osteoarthritis. FLS isolated from RA synovial tissue constitutively produced βIG-H3, which was up-regulated by transforming growth factor β1, interleukin-1β, and tumor necrosis factor α. Although FLS expressed a variety of integrins, βIG-H3 mediated adhesion and migration of FLS through interaction with αvβ3 integrin. Cytokines failed to affect the βIG-H3–mediated adhesion. However, migration of FLS guided by βIG-H3 was enhanced by interferon-γ and platelet-derived growth factor type BB. The YH18 peptide in the fourth fas-1 domain of βIG-H3 inhibited adhesion and migration in a dose-dependent manner.</P><B>Conclusion</B><P>The results suggest that βIG-H3, which is abundantly expressed in RA synovial tissue, plays a regulatory role in chronic destructive inflammation through the modulation of the adhesion and migration of FLS. This finding indicates the relevance of βIG-H3 and αvβ3 integrin–interacting motifs as potential therapeutic targets in this disease.</P>
무기계 결합재 비율에 따른 섬유보강 복합재료의 압축 및 인장 특성
최정일 ( Jeong-il Choi ),박세언 ( Se Eon Park ),이방연 ( Bang-yeon Lee ) 한국구조물진단유지관리공학회 2019 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.23 No.2
이 연구에서는 무기계 결합재 비율에 따른 섬유보강 복합재료의 압축 및 인장 특성을 조사하였다. 실험 결과, 무기계 분말 재료를 시멘트의 30 % 대체 혼입할 경우, 압축강도, 인장강도 및 인장변형성능은 각각 93.2 MPa, 6.71 MPa, 및 7.65 %로 나타났다. 이는 시멘트만 사용한 복합재료보다 인장변형성능이 약 2.2배 향상된 결과이다.
Impact resistant properties of Kagome truss reinforced composite panels
Choi, Jeong-Il,Park, Se-Eon,Lee, Sang-Kyu,Kim, Gyu-Yong,Hwang, Jae-Seung,Lee, Bang Yeon Techno-Press 2021 Advances in concrete construction Vol.12 No.5
This paper presents an experimental study exploring impact resistant properties of Kagome truss reinforced composite panels. Three types of panels with different materials and reinforcements, i.e., ultra-high-performance mortar, steel fiber, and Kagome truss, were designed and manufactured. High-velocity projectile impact tests were performed to investigate the impact response of panels with dimensions of 200 mm×200 mm×40 mm. The projectile used in the testing was a steel slug with a hemispherical front; the impact energy was 1 557 J. Test results showed that the Kagome truss reinforcement was effective at improving the impact resistance of panels in terms of failure patterns, damaged area, and mass loss. Synergy effects of a combination of Kagome truss and fiber reinforcements for the improvement of impact resistance capacity of ultra-high-performance mortar were also observed.
나트륨계 알칼리 활성화제 조합에 따른 섬유보강 무시멘트 복합재료의 압축 및 인장특성
최정일(Jeong-Il Choi),박세언(Se-Eon Park),이방연(Bang-Yeon Lee) 한국건설순환자원학회 2017 한국건설순환자원학회 논문집 Vol.5 No.1
이 연구의 목적은 알칼리 활성화제의 종류와 양생방법에 따라 나타나는 고로슬래그 기반 섬유보강 복합재료의 압축강도 및 인장거동에 대해 실험적으로 조사하는 것이다. 이를 위하여 알칼리 활성화제 2종류의 배합과 2가지 양생방법을 결정하였고, 밀도 실험, 압축강도 실험과 일축인장 실험을 수행하였다. 실험 결과, 규산나트륨을 사용한 경우 수산화칼슘과 탄산나트륨을 혼합하여 사용한 경우에 비하여 강도, 인장변형성능, 인성 측면에서 우수한 것으로 나타났으며, 활성화제 종류에 따라 양생방법에 의한 영향이 다르게 나타나는 것을 확인하였다. The purpose of this study is to investigate experimentally the effect of types of alkali-activators and curing conditions on the compressive and tensile behavior of fiber-reinforced cementless composites. Two types of alkali-activators and two curing conditions were determined and density test, compressive strength test, and uniaxial tension test were performed. Test results showed that the cementless composite with sodium silicate showed higher performance in terms of strength, tensile strain capacity, and toughness than that with calcium hydroxide and sodium carbonate. The effect of curing conditions depends on the types of alkali-activators.