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Dynamic measurement of stress optical behavior of three amorphous polymers
Inki Min,Kyunghwan Yoon 한국유변학회 2012 Korea-Australia rheology journal Vol.24 No.1
In the present study, rheo-optical and mechanical properties of three amorphous polymers, i.e., PS (polystyrene), PC(polycarbonate) and COC(cyclo olefin copolymer), widely used for optical products have been investigated. Accurate measurement of stress optical coefficients and elastic modulus data across the glass transition region are essential for predicting optical anisotropy in many injection molded optical products like pickup lenses and waveguide in LCD module since the final products have both flow and thermal history from the melt to glass. To obtain stress optical behavior in wide range of frequency and temperature including rubbery, glassy and glass transition regime, frequency sweep tests with extensional bar and shear sandwich tools were undertaken. As a result, glassy and melt extreme values of stress optical coefficient of PS and PC were evaluated as well as master plots in wide frequency region. The sign change of stress optical coefficient was shown clearly for PS as the frequency increased. On the other hand, the sign of stress optical coefficient over the whole frequency region is always positive for PC. For COC's of different composition, even though the glass transition temperature can vary, the stress optical coefficient of COC's with different composition stays almost constant at two extremes
Moon Inki,Kong Min Gyu,Ji Young Sok,Kim Se Hyung,Park Seong Kyu,Suh Jon,Jang Mi-Ae 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.2
Background: Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of blood cells originating from somatically mutated hematopoietic stem cells, is common among the elderly and is associated with an increased risk of hematologic malignancies. We investigated the clinical, mutational, and transcriptomic characteristics in elderly Korean individuals with CHIP mutations. Methods: We investigated CHIP in 90 elderly individuals aged ≥60 years with normal complete blood counts at a tertiary-care hospital in Korea between June 2021 and February 2022. Clinical and laboratory data were prospectively obtained. Targeted next-generation sequencing of 49 myeloid malignancy driver genes and massively parallel RNA sequencing were performed to explore the molecular spectrum and transcriptomic characteristics of CHIP mutations. Results: We detected 51 mutations in 10 genes in 37 (41%) of the study individuals. CHIP prevalence increased with age. CHIP mutations were observed with high prevalence in DNMT3A (26 individuals) and TET2 (eight individuals) and were also found in various other genes, including KDM6A, SMC3, TP53, BRAF, PPM1D, SRSF2, STAG1, and ZRSR2. Baseline characteristics, including age, confounding diseases, and blood cell parameters, showed no significant differences. Using mRNA sequencing, we characterized the altered gene expression profile, implicating neutrophil degranulation and innate immune system dysregulation. Conclusions: Somatic CHIP driver mutations are common among the elderly in Korea and are detected in various genes, including DNMT3A and TET2. Our study highlights that chronic dysregulation of innate immune signaling is associated with the pathogenesis of various diseases, including hematologic malignancies.
Kim Dong-Eon,Moon Inki,Park Suyeong,Park Minae,Park Sojeong,Kwon Seong Soon,Kong Min Gyu,Park Hyun Woo,Choi Hyung Oh,Seo Hye-Sun,Cho Yoon Haeng,Lee Nae Hee,Suh Jon 대한의학회 2023 Journal of Korean medical science Vol.38 No.31
Background: Large-scale studies about epidemiologic characteristics of renal infarction (RI) are few. In this study, we aimed to analyze the incidence and prevalence of RI with comorbidities in the South Korean population. Methods: We investigated the medical history of the entire South Korean adult population between 2013 and 2019 using the National Health Insurance Service database (n = 51,849,591 in 2019). Diagnosis of RI comorbidities were confirmed with International Classification of Disease, Tenth Revision, Clinical Modification codes. Epidemiologic characteristics, distribution of comorbidities according to etiologic mechanisms, and trend of antithrombotic agents were estimated. Results: During the 7-years, 10,496 patients were newly diagnosed with RI. The incidence rate increased from 2.68 to 3.06 per 100,000 person-years during the study period. The incidence rate of RI increased with age peaking in the 70s with 1.41 times male predominance. The most common comorbidity was hypertension, followed by dyslipidemia and diabetes mellitus. Regarding etiologic risk factor distribution, high embolic risk group, renovascular disease group, and hypercoagulable state group accounted for 16.6%, 29.1%, and 13.7% on average, respectively. For the antithrombotic treatment of RI, the prescription of antiplatelet agent gradually decreased from 17.0% to 13.0% while that of anticoagulation agent was maintained around 35%. The proportion of non-vitamin K antagonist oral anticoagulants remarkably increased from only 1.4% to 17.6%. Conclusion: Considering the progressively increasing incidence of RI and high prevalence of coexisting risk factors, constant efforts to raise awareness of the disease are necessary. The current epidemiologic investigation of RI would be the stepping-stone to establishing future studies about clinical outcomes and optimal treatment strategies.
( Su Yeong Park ),( Min Gyu Kong ),( Inki Moon ),( Hyun Woo Park ),( Hyung-oh Choi ),( Hye Sun Seo ),( Yoon Haeng Cho ),( Nae-hee Lee ),( Kwan Yong Lee ),( Ho-jun Jang ),( Je Sang Kim ),( Ik Jun Choi 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.5
Background/Aims: We aimed to analyze the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) by the disease course of heart failure (HF). Methods: We evaluated 227 patients with HF in a multi-center retrospective cohort that included those with left ventricular ejection fraction (LVEF) ≤ 40% undergoing ARNI treatment. The patients were divided into patients with newly diagnosed HF with ARNI treatment initiated within 6 months of diagnosis (de novo HF group) and those who were diagnosed or admitted for HF exacerbation for more than 6 months prior to initiation of ARNI treatment (prior HF group). The primary outcome was a composite of cardiovascular death and worsening HF, including hospitalization or an emergency visit for HF aggravation within 12 months. Results: No significant differences in baseline characteristics were reported between the de novo and prior HF groups. The prior HF group was significantly associated with a higher primary outcome (23.9 vs. 9.4%) than the de novo HF group (adjusted hazard ratio 2.52, 95% confidence interval 1.06-5.96, p = 0.036), although on a higher initial dose. The de novo HF group showed better LVEF improvement after 1 year (12.0% vs 7.4%, p = 0.010). Further, the discontinuation rate of diuretics after 1 year was numerically higher in the de novo group than the prior HF group (34.4 vs 18.5%, p = 0.064). Conclusions: The de novo HF group had a lower risk of the primary composite outcome than the prior HF group in patients with reduced ejection fraction who were treated with ARNI.
연속마이크로렌즈를 이용한 네비게이터용 7인치 LCD-BLU용 금형개발
김종선(JongSun Kim),고영배(YoungBae Ko),민인기(InKi Min),유재원(JaeWon Yu),윤경환(KyungHwan Yoon),황철진(ChulJin Hwang) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
LCD-BLU (Back Light Unit) is one of kernel parts of LCD unit. The fabrication method of a 3-D micro mold patterned with optical pattern for the LGP (Light Guiding Plate), one of the most important parts of LCD-BLU, was resented. Instead of dot pattern made by etching, 3-D optical pattern design with 200 ㎛ continuous micro-lens was applied in the present study. The continuous micro-lens pattern fabricated by modified LiGA with thermal reflow process was applied to the optical design of LGP. and The manufacturing process using LIGA-reflow is made up of three stages as in the following:(ⅰ) the stage of lithography, (ⅱ) the stage of thermal reflow process and (ⅲ) the stage of electroplating. The continuous micro-lens patterned LGP was fabricated with injection molding process.
승용차용 현가시스템의 동하중 저감을 위한 다중 목적함수 최적설계
김용연(YongYun Kim),허승진(SeungJin Heo),김민수(Min-Soo Kim),전인기(InKi Jun),최재민(JaeMin Choil) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
In this study, a virtual simulation is conducted using the Virtual Proving Ground. The roads used in the simulation are Belgian roads and single lane roads. These two particular roads are simulated using the VPG technique. Through the simulation, the dynamic load on each component is estimated, and means by which the estimated dynamic load can be decreased is determined. At the time of optimum designing such as this, many objective functions may exist, therefore, multi objective function technique is used for the optimum design. Also, by evaluating the control stability of the model with optimum design and the existing model, the control stability performance of the optimum design model was verified.
Park, Soonchan,Lee, Sang-Wook,Lim, Ok Kyun,Min, Inki,Nguyen, Minhtuan,Ko, Young Bae,Yoon, Kyunghwan,Suh, Dae Chul Korean Society of Interventional Neuroradiology 2013 Neurointervention Vol.8 No.1
<P><B>Purpose</B></P><P>Image-based computational models with fluid-structure interaction (FSI) can be used to perform plaque mechanical analysis in intracranial artery stenosis. We described a process in FSI study applied to symptomatic severe intracranial (M1) stenosis before and after stenting.</P><P><B>Materials and Methods</B></P><P>Reconstructed 3D angiography in STL format was transferred to Magics for smoothing of vessel surface and trimming of branch vessels and to HyperMesh for generating tetra volume mesh from triangular surface-meshed 3D angiogram. Computational analysis of blood flow in the blood vessels was performed using the commercial finite element software ADINA Ver 8.5. The distribution of wall shear stress (WSS), peak velocity and pressure was analyzed before and after intracranial stenting.</P><P><B>Results</B></P><P>The wall shear stress distributions from Computational fluid dynamics (CFD) simulation with rigid wall assumption as well as FSI simulation before and after stenting could be compared. The difference of WSS between rigid wall and compliant wall model both in pre- and post-stent case is only minor except at the stenosis region. These WSS values were greatly reduced after stenting to 15~20 Pa at systole and 3~5 Pa at end-diastole in CFD simulation, which are similar in FSI simulations.</P><P><B>Conclusion</B></P><P>Our study revealed that FSI simulation before and after intracranial stenting was feasible despite of limited vessel wall dimension and could reveal change of WSS as well as flow velocity and wall pressure.</P>