산후 출혈로 적출된 자궁에 대한 임상 및 병리학적 고찰 : Review of 13 cases

양정인,주희재,김종한,김행수,장기홍,권혁찬,유희석,심철,오기석 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1

A retrospective clinicopathologic review of 13 women who taken postpartum hysterectomy at Ajou University Hospital during 18 months from June 1994 to Dec. 1995 is presented. The results obtained are as follows: 1) There were 2,577 deliveries during this period. 2) Postpartum hysterectomy was performed in 13 cases, an incidence of 0.5%, following 5 cases of vaginal delivery(0.3%) and 8 cases of cesarean delivery. 3) The indication for postpartum hyslerectomy were 9 cases of uterine atony(69.2%), 2 cases of placenta previa(15.4%) and 1 case of placenta accreta, 1 case of abruptio placenta, respectively. 4) The relationship of 13 postpartum hysterectomy cases between preoperative clinical indication and pathologic diagnosis were as follows : among the 9 cases of preoperative uterine atony, the pathologic diagnosis consisted of 6 cases of subinvolurion, 2 cases of placenta accreta and I case of amniotic fluid embolism. Two cases of placenta previa in preoperative indication were associated with placenta accreta in pathologic examination. Especially, one case of abruptio placenta was revealed lo be diffuse intramyometrial massive hemorrhage in pathologic diagnosis. 5) The 11 cases(84.6%) experienced postoperative complications, most common complication being febrile morbidity(41.9%) followed by disseminated intravascular coagulopathy(29.2%), superficial wound infection (12.5%) and pleural effusion(8.3%), without maternal mortality.

Convenient Synthesis of Novel Phenylpyrimido[1,2-c]thienopyrimidinones as IL-6/STAT3 Inhibitors

Song, Yang-Heon,Hoo Park, Jae,Young Hong, So,Kim, Jungah,Joo Lee, Hyuck,Ho Lee, Hyun,Young Kim, Ka,Woong Lee, Seung,Oh, Hyun-Mee,Rho, Mun-Chul,Lee, Beom-Gyu Japan Institute of Heterocyclic Chemistry 2015 Heterocycles Vol.91 No.4

<P>New phenylpyrimido[1,2-c]thienopyrimidinones 4A and 4B were easily prepared in good yields by the one-pot reaction of formamidine derivatives 2 of 4-aminothienopyrimidine 1 with phenylacetyl chlorides. The application of this convenient and reliable method could be used for the synthesis of a variety of pyrimido[1,2-c]thienopyrimidinone derivatives of biological importance. Some of the compounds synthesized showed strong IL-6/STAT3 inhibition.</P>

OxyR Regulon Controls Lipid Peroxidation - mediated Oxidative Stress in Escherichia coli

(Seon Joo Yoon),(Ji Eun Park),(Joon Hyuck Yang),(Jeen Woo Park) 생화학분자생물학회 2002 BMB Reports Vol.35 No.3

Membrane lipid peroxidation processes yield products that may react with DNA and proteins to cause oxidative modifications. The oxyR gene product regulates the expression of enzymes and proteins that are needed for cellular protection against oxidative stress. Upon exposure to tert-butylhydroperoxide (t-BOOH) and 2,2’-azobis (2-amidinopropane) hydrochloride (AAPH), which induce lipid peroxidation in membranes, the Escherichia coli oxyR overexpression mutant was much more resistant to lipid peroxidation-mediated cellular damage, when compared to the oxyR deletion mutant in regard to growth kinetics, viability, and DNA damage. The deletion of the oxyR gene in E. coli also resulted in increased susceptibility of superoxide dismutase to lipid peroxidation-mediated inactivation. The results indicate that the peroxidation of lipid is probably one of the important intermediary events in free radical-induced cellular damage. Also, the oxyR regulon plays an important protective role in lipid peroxidation-mediated cellular damage.

가정 내 유통채널 간 소비자 정보탐색과 구매행동과의 관계에 대한 연구

주영혁(Joo Young-Hyuck),양석준(Yang Suk-Joon) 한국유통학회 2008 流通硏究 Vol.13 No.3

본 연구는 가정 내 유통업체(In-home shopping channel)의 다채널 고객관리에 시사점을 제공하기 위하여 가정 내 쇼핑채널로서 TV, 카탈로그 및 인터넷 쇼핑채널 간 소비자의 정 보탐색과 구매행동과의 관계를 고찰하였다. 가정 내 쇼핑채널들의 정보탐색과 구매행동과의 관련성을 채널 내 고객 고정(channel lock-in)과 채널 간 시너지(cross-channel synergy)로 구분하여 영향력을 비교 평가하였다. 이를 위하여 1개월 동안의 가정 내 쇼핑채널 이용에 대한 자료를 346명의 가정주부를 대상으로 수집하였다. 소바자의 구매채널 이용행동을 선택, 빈도 및 지출행동으로 구분하여 분석을 수행한 결과 가정 내 쇼핑채널 간 정보탐색과 구매행동 간에는 높은 채널 내 고객 고정 효과가 나타나고 있으며 낮은 채널 간 시너지 효과가 나타나고 있었다. 또한 TV 채널의 경우 카탈로그와 인터넷 채널 간 대체성이 나타나는 반면에 카탈로그와 인터넷 채널은 보완성이 나타나고 있다. 이러한 결과는 가정내 다채널 유통기업에게 채널 간 조정과 통합 및 고객관리에 많은 시사점을 제공하고 있다. This study explored the relationship between information search and purchasing behavior across in-home shopping channels to give multi-channel retailer an implication of multichannel customer management. We analyzed the relationship between consumer's information search and purchase behavior (choice, frequency, and expenditure) 'With a view to channel lock-in and cross-channel synergy. This study was carried out using survey data about in-home shopping behavior of housewives. Results of the study showed that (l) there was channel lock-in between information search and purchase behavior across in-home shopping channels, (2) catalog channel and the Internet channel were a alternative channels of TV home shopping channel and (3) catalog channel and the Internet channel were an complementary channels. This results can provide meaningful implication for multi-channel retailers.

OxyR Regulon Controls Lipid Peroxidation-mediated Oxidative Stress in Escherichia coli

Yoon, Seon-Joo,Park, Ji-Eun,Yang, Joon-Hyuck,Park, Jeen-Woo 생화학분자생물학회 2002 Journal of biochemistry and molecular biology Vol.35 No.3

Membrane lipid peroxidation processes yield products that may react with DNA and proteins to cause oxidative modifications. The oxyR gene product regulates the expression of enzymes and proteins that are needed for cellular protection against oxidative stress. Upon exposure to tert-butylhydroperoxide (t-BOOH) and 2,2'-azobis (2-amidinopropane) hydrochloride (AAPH), which induce lipid peroxidation in membranes, the Escherichia coli oxyR overexpression mutant was much more resistant to lipid peroxidation-mediated cellular damage, when compared to the oxyR deletion mutant in regard to growth kinetics, viability, and DNA damage. The deletion of the oxyR gene in E. coli also resulted in increased susceptibility of superoxide dismutase to lipid peroxidation-mediated inactivation. The results indicate that the peroxidation of lipid is probably one of the important intermediary events in free radical-induced cellular damage. Also, the oxyR regulon plays an important protective role in lipid peroxidation-mediated cellular damage.

다낭성 난소 증후군 환자에서 체중과 임신이 내분비 양상 및 당 대사에 미치는 영향

황경주(Kyung Joo Hwang),오기석(Kie Suk Oh),김세광(Sei Kwang Kim),권혁찬(Hyuck Chan Kwon),박영한(Young Han Park),양정인(Jung In Yang),유희석(Hee Suk Rhyu) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3

N/A Objective: The purpose of this study attempts to determine the endocrinologic characteristics and changes in glucose metabolism before/during pregnancy according to different body weights in women with Polycystic ovarian syndrome (PCOS). Methods: 94 women dia with PCOS were evaluated through measuring serum hormone levels and oral glucose tolerance tests preconceptionally and gestationally. Results: In patients who were of normal weight showed significantly increased serum LH levels compared to those who were overweight (12.8+-0.9 Vs. 7.1+-0.8 mIU/ml, p= 0.000), and the serum levels of insulin was increased significantly in the overweight group (7.1+-0.7 Vs. 15.2+-2.8 ulU/ml, p= 0.000). the IGFBP-I (32.8+-10.6 Vs. 8.3+-2.5 ng/ml, p=0.034) and SHBG (55.8+-4.2 Vs. 37.1+-3.1 nmol/ml, p= 0.001) were significantly lower in the ovnweight group. The oral glucose tolerance test before/after pregnancy showed increased frequency of abnormal glucose metabolism, in both of the non-obese group (38.8%, 26,9%) and the obese group (64.2%, 53.9%) compared with normal population. Conclusion: It is thought that in the normal weight group with polycystic ovarian syndrome androgen production is stimulated in the theca cells by abnormally high LH secretion, while in the overweight group the hyperinsulinemia state which decreases the SHBG and IGFBP-I, lead to increase biologically active hee androgens and IGF-I and increase insulin binding to its receptor. And during/before pregnancy, women with PCOS showed that incidence of abnormal glucose metabolism was significantly increased in both of non-obese and obese groups.

가정 내 쇼핑채널 이용비중 및 이용다양성에 관한 연구

주영혁(Young Hyuck Joo),양석준(Suk Joon Yang) 한국유통학회 2006 流通硏究 Vol.11 No.3

본 연구에서는 최근 물류시스템과 통신매체의 급격한 발달로 인하여 보편화된 가정 내 쇼핑채널을 연구함에 있어서 새로운 접근방법이 필요함을 제시하고 있다. 가정 내 쇼핑채널 각각에 구매의도에 대한 영향요인을 검토하는 채널중심 연구는 가정 내 쇼핑채널이 보편화된 현재에는 큰 의미를 가지기 어렵다고 볼 수 있다. 본 연구에서는 고객중심 채널연구의 필요성을 제기하고 가정 내 쇼핑채널 이용비중과 이용다양성에 대한 고객특성과 쇼핑특성의 영향을 고객 중심적으로 검토하였다. 표본의 선택성을 고려하고 종속변수 간 인과관계를 모델에 반영하기 위하여 선택성을 가진 동시방정식 모델을 통하여 실증분석을 수행하였다. 연구결과 첫째로 가정 내 쇼핑채널 이용비중과 이용다양성은 서로 영향이 없는 것으로 나타나고 있으며, 둘째로 점포형 쇼핑채널 중에서 특히 백화점 이용이 증가할수록 가정 내 쇼핑채널 이용비중은 감소하는 것으로 나타나고 있으며, 셋째로 고객특성 및 쇼핑특성은 가정 내 쇼핑채널 이용다양성에 영향을 미치지 않는 것으로 나타나고 있다. Recently, in-home shopping channel has become a popular shopping channel. This study develops and tests a model of the share and variety of in-home shopping channel. We explore the effects of demographic characteristics and shopping behavior characteristics to the share and variety of in-home shopping channel. As a research methodology, we choose the simultaneous equation model with selectivity to consider both sample selection and effects between dependent variables. The result of study can be summarized as follows. First, there are no effects between the share and variety of in-home shopping channel. Second, the share of in-home shopping channel decreases when consumers visit department store more than discount store. Third, the demographic characteristics and the shopping behavior characteristics don't affect the variety of in-home shopping channel. Some managerial implications for manufacturers and distributors are discussed.

[ I - 123 ] IPT SPECT를 이용한 도파민 재섭취부위의 영상화 : 반정성적 분석방법을 이용한 정상인과 파킨슨병 환자의 차이

양승오(Seoung Oh Yang),최윤영(Yun Young Choi),이희경(Hee Kyung Lee),김희중(Hee Joung Kim),류진숙(Jin Sook Ryu),임주혁(Joo Hyuck Im),이명종(Myung Chong Lee) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1

N/A Dopamine transporter concentrations have been known to decrease in Parkinson's disease (PD) or increase in Tourette's disorder. The purpose of this study was to evaluate the effectiveness of [I-123]N-(3-iodopropene-2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl) tropane (IPT) as an imaging agent for measuring changes in transporter concentrations with PD. IPT labelled with 6.69+/-0.64 mCi (247.53+/-23.68 MBq) of I-123 was intravenously injected into ten patients(age: 55+/-11) with PD, and six normal controls(NC)(age: 46+/-14) as a bolus. Dynamic SPECT scans of the brain were then performed for 5 minutes each over 120 minutes on a triple headed camera. Time activity curves were generated for the left basal ganglia(LBG), right basal ganglia(RBG), and occipital cortex(OCC). The statistical parameters included the time to peak activity, the contrast ratio of LEG and RBG to OCC at several time points, and the accumulated specific binding counts/mCi/pixel (ASBC) from 0 to 115 minutes. The uptake of IPT in the brains of PD and NC peaked within 10 minutes of injection in all subjects. The maximum target to background ratio in the basal ganglia of PD and NC occurred at 85+/-20 min and 110-+/-6 min of injection, respectively. The BG/OCC ratios at 115 minutes for PD and NC were 2.15+/-0.54 and 4.26+/-0.73, respectively. The ASBC at 115 minutes for PD and NC were 152.91+/-50.09 and 289.51+/-49.00, respectively. The ratio of BG/OCC for the NC was significantly higher than the ratio for PD. SPECT data matched with clinical diagnosis for PDs. The ratio between BG and OCC and the ASBC for PD were clearly separated from NC and may be useful outcome measures for clinical diagnosis. The findings suggest that IPT may be a very useful tracer for early diagnosis of PD and study of dopamine reuptake site.

단어의 의미와 문맥을 고려한 순환신경망 기반의 문서 분류

주종민,김남훈,양형정,박혁로,Joo, Jong-Min,Kim, Nam-Hun,Yang, Hyung-Jeong,Park, Hyuck-Ro 한국정보처리학회 2018 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.7 No.7

In this paper, we propose a method to classify a document using a Recurrent Neural Network by extracting features considering word sense and contexts. Word2vec method is adopted to include the order and meaning of the words expressing the word in the document as a vector. Doc2vec is applied for considering the context to extract the feature of the document. RNN classifier, which includes the output of the previous node as the input of the next node, is used as the document classification method. RNN classifier presents good performance for document classification because it is suitable for sequence data among neural network classifiers. We applied GRU (Gated Recurrent Unit) model which solves the vanishing gradient problem of RNN. It also reduces computation speed. We used one Hangul document set and two English document sets for the experiments and GRU based document classifier improves performance by about 3.5% compared to CNN based document classifier. 본 논문에서는 단어의 순서와 문맥을 고려하는 특징을 추출하여 순환신경망(Recurrent Neural Network)으로 문서를 분류하는 방법을 제안한다. 단어의 의미를 고려한 word2vec 방법으로 문서내의 단어를 벡터로 표현하고, 문맥을 고려하기 위해 doc2vec으로 입력하여 문서의 특징을 추출한다. 문서분류 방법으로 이전 노드의 출력을 다음 노드의 입력으로 포함하는 RNN 분류기를 사용한다. RNN 분류기는 신경망 분류기 중에서도 시퀀스 데이터에 적합하기 때문에 문서 분류에 좋은 성능을 보인다. RNN에서도 그라디언트가 소실되는 문제를 해결해주고 계산속도가 빠른 GRU(Gated Recurrent Unit) 모델을 사용한다. 실험 데이터로 한글 문서 집합 1개와 영어 문서 집합 2개를 사용하였고 실험 결과 GRU 기반 문서 분류기가 CNN 기반 문서 분류기 대비 약 3.5%의 성능 향상을 보였다.

그람양성균이 의심되거나 증명된 피부 및 연조직 감염증의 치료에 대한 Linezolid의 효능과 안전성

엄중식,이혁,신동현,김양리,김신우,이충기,송재훈,김준명,강문원,김우주 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

Background : Linezolid, an oxazolidinone, has shown efficacy in the treatment of adults with nosocomial or community-acquired pneumonia, skin and soft tissue infections (SSTI), and infections due to methicillin-resistant Staphylococcus aureus. We have taken part in the study for evaluation of efficacy and safety of linezolid for the treatment of suspected or proven gram-positive SSTI in Asia. We sub-analyzed and reported the results of the study among Korean patients. Materials and Methods : A total of 60 patients were enrolled in the study for evaluation of efficacy and safety of linezolid for the treatment of gram-positive SSTI at eight teaching hospitals in Korea. We investigated patients' medical history, physical examination and laboratory study. Patients were regularly followed up to evaluate clinical response, laboratory changes, and adverse event up to 4 weeks after treatment. When possible, we performed microbiological study before and after treatment. Results : A total of 60 patients were enrolled. Average age of the patient was 50.9±15.3 years old with male to female ratio being 1.3 : 1. Cellulitis, open wound infection, skin abscess, and other clinical manifestations were observed in 47 (78.3%), 6 (10.0%), 2 (3.3%), and 5 (8.3%) patients, respectively. Forty two patients completed both follow-up and treatment and among them, treatment was successful in 38 patients (90.5%) and unsuccessful in 4 patients (9.5%). Microoranisms were isolated from seven patients and 14 isolates were documented; 11 S. aureus, 3 coagulase-negative staphylococcus. Among the seven patients, bacteria were eradicated in four patient and the organism proved to be colonization in three patients. The most frequent drug-related adverse events were gastrointestinal (21.7%), hematologic and biochemical (21.7%) and neurologic (3.3%), in decreasing order. Nausea (15%) was the most frequent symptom and there were no serious side effects related to linezolid. Conclusion : Linezolid was effective and safe in treatment of gram-positive SSTI. 배경 : Linezolid (Zyvox^(R))는 oxazolidmone 계열의 그람양성균 감염증에 대한 새로운 치료제로 그람양성균, 특히 메티실린 내성 포도구균과 반코마이신 내성 장구균에도 효과적인 것으로 알려져 있다. 연구자들은 아시아 지역에서 제 4상, 개방형, 공개, 다기관 연구로 진행되었던 "그람양성균이 의심되거나 증명된 피부 및 연조직 감염증에 대한 linezolid의 치료 효능 및 안전성"의 국내 연구결과를 분석하여 그람양성균에 의한 피부 및 연조직 감염증에 대한 linezolid의 치료 효과와 안전성을 평가하였다. 재료 및 방법 : 국내 8개 종합병원에서 피부 및 연조직 감염증의 원인으로 그람양성균이 의심되거나 증명된 입원 환자 중 사전동의를 하여 연구에 참가한 60명을 대상으로 하였다. 치료는 linezolid 주사제 1회 600 mg을 1일 2회 투여하였고 상태 호전시 연구자의 판단에 따라 동량을 경구로 전환할 수 있도록 하였다. 치료 시작부터 종료 후 4주까지 환자의 병력, 이학적 검사, 이상반응 증상 및 징후의 유무를 정기적으로 조사하였고 혈액학검사, 생화학검사, 소변검사 등의 결과를 평가하여 linezolid의 임상적 효과와 안전성을 판정하였다. 원인균의 분리를 위하여 가능한 경우 감염 병변으로 부터 그람염색 및 배양검사를 시행하였고 혈액배양검사를 함께 실시하여 미생물학적 근절여부를 판정하였다. 결과 : 환자군의 평균연령은 50.9±15.3세였고 남녀비는 1.3:1이었다. 진단별로 연조직염 47명(78.3%), 개방창생감염 6명(10.0%), 피하농양 2명(3.3%), 기타 5명(8.3%)이었고, linezolid의 평균 투여 횟수는 41.2±19.3회였다. 60명의 환자 중 추적 관찰을 포함한 모든 치료 일정을 마친 환자는 42명(70.0%)이었고 치료 성공은 38명(90.5%)이었고 4명(9.5%)이 치료에 실패하였다. 배양검사에서 7명의 환자로부터 원인균이 분리되어 4명이 미생물학적으로 박멸되었고 3명은 집락 형성으로 판정되었다. Linezolid와 관련된 이상반응은 소화기계 이상 13명(21.7%), 혈액 및 생화학적 이상 13명(21.7%), 감각신경계 이상 2명(3.3%)순이었고 단일 이상 반응으로는 오심(15%)이 가장 흔하였으나 linezolid와 관련이 증명된 중대한 이상반응은 없었다. 결론 : Linezolid는 그람양성균에 의해 발생되는 피부 및 연조직 감염증의 치료에 우수한 효과가 있었으며, 비교적 안전한 것으로 평가되었다.