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이응룡,강근호,강용진,김우열,최혜연,김봉우,정효순,조쌍구 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
Many studies revealed the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. The plausible mechanistic interpretation of the various effects of flavonoids was concentrated on the anti-oxidant or free radical-scavenging properties of these phytochernicals, both in model systems and under in vivo conditions. While there has been a major focus on the anti-oxidant properties. there is an emerging view that flavonoids and their in vivo metabolites. do not act as conventional hydrogen-donating anti-oxidants. but they may exert regulatory functions in cells through actions at protein kinase or lipid kinase signaling pathways. Flavonoids and more recently their metabolites. have been reported to act at phosphoinositide 3-kinase(PI 3-kinase). Akt/protein kinase B(Akt/PKB), protein kinase C (PKC), mitogen activated protein kinase(MAP kinase), and various tyrosine kinases signaling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as anti-oxidants or modulators of cellular signaling pathways, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anti-cancer agents, cardio-protectants, and inhibitors of neurodegeneration.
황상일,김혜령,윤순옥 경북대학교 사회과학대학 지리학과 2003 地理學論究 Vol.- No.23
한강하류부에 위치한 김포시 고촌면 김포평야의 충적충과 사면퇴적충에서 퇴적상 분석 및 화분 분석을 실시하여 식생환경, 해면변동, 기후변화와 같은 자연환경인화를 검토하고 이것을 선사시대 인간활동과의 관계에서 살펴보았다. 최종빙기 이래 형성된 연구지역의 퇴적상은 빙기의 선상지성사면퇴적층과 흘로세 충적충으로 구분되며, 화분분석은 흘로세 충적충의 유기질이 다소 포함된 회색실트충, 분해되지 않은 토탄충, 분해된 토탄충에서 이루어졌다. 화분조성은 흘로세 중기 이후 해면미변동을 반영하며, 화분대GP-Ⅰ은 흘로세 해진의 영향으로 수심이 있는 저습지 환경에서 Alnus를 중심으로 한 목본 우점기에 퇴적되었고, 화분대GP-ll시기는 해면의 지속적인 정체와 하강에 따른 지하수위 저하 그리고 활발해진 인간활동의 영향으로 목본이 크게 줄고, 포자와 초본류가 우점하게 되었다. The environmental change such as vegetation environment, sea-level change, climate change and human impact was restored at Gimpo alluvial plain on the upper Han river according to the results of sedimentary facies and pollen analysis. The sedimentary facies which has been constructed since the last glacial stage is composed of the hillslope deposits as the alluvial fan during the glacial stage and Holocene alluvium. Materials for pollen analyses were sampled from gray organic silt layer, peat I layer(abundant fibroid material included the branches of trees and roots of grasses) and peat Ⅱ layer(decomposed peat including organic clay) in the alluvium of the Holocene. The change of the pollen composition reflected sea-level change and vegetation environment during the Holocene. Pollen zone GP-Ⅰ was the period of AP-dominance, including mostly Alnus. Study area was under the lagoon or swamp environment influenced by Flandrian transgression. Pollenzone Ⅱ was the period of Spore & NAP-dominance. It represents that vegetation environment was changed to drier condition by falling the surface of ground-water caused by sea-level regression after long-term stability, and influenced of human activity.
Kim, Hye-Ryoung,Kim, Bang-Sil,Bae, You-Chan,Moon, Oun-Kyoung,Oem, Jae-Ku,Kang, Hyun-Mi,Choi, Jun-Gu,Lee, O.-Soo,Lee, Youn-Jeong Elsevier 2011 Veterinary microbiology Vol.151 No.3
<P><B>Abstract</B></P><P>On December 7, 2010, H5N1 highly pathogenic avian influenza virus was isolated from a healthy mallard captured at the Mankyung River in South Korea. Phylogenetic analysis showed that this virus was classified into clade 2.3.2 and closely related to H5N1 viruses isolated from wild birds in Mongolia, Russia and China in 2009 and 2010.</P>
Hye Ryoung Kim,Mi Ja Shim,Jung Woo Kim,Ha Won Kim,Chong Ock Lee,Eung Chil Choi,Byong Kak Kim 한국생약학회 1984 생약학회지 Vol.15 No.2
To investigate antitumor component of Lyophyllum decastes, the aqueous extract of its shake-cultured mycelia was subjected to antitumor test against sarcoma 180 cells implanted in ICR mice. The extract showed an inhibition ratio of 65.4% and was found to consist of a polysaccharide moiety and a protein moiety. After purification with DEAE-Sephadex A-50 ion exchange chromatography, Fraction D showed the highest inhibition ratio of 75.7%. The antitumor constituent was examined for immunoaccelerating activity and was found to increase macrophage accumulation in the peritoneal cavity and plaque forming cells of the spleen cells. It was named lyophyllan after the genus name.
Kim, Hye-Ryoung,Kwon, Yong-Kuk,Il-Jang,,Lee, Youn-Jeong,Kang, Hyun-Mi,Lee, Eun-Kyoung,Song, Byung-Min,Jung, Suk-Chan,Lee, Kyung-Hyun,Lee, Hyun-Kyoung AMERICAN ASSOCIATION OF AVIAN PATHOLOGISTS 2016 Avian diseases Vol.60 No.2
<P>Highly pathogenic avian influenza (HPAI) virus of the H5N8 subtype was isolated from a young ostrich in South Korea in March 2014. Clinical signs characterized by anorexia, depression, and signs of nervousness were observed. The isolated A/ostrich/Korea/H829/2014 (H5N8) virus had a cleavage site motif containing multiple basic amino acids, typical of HPAI virus. The phylogenetic tree of the hemagglutinin gene of the H5 HPAI virus showed that this ostrich H5N8 virus belongs to clade 2.3.4.4 viruses together with H5N8 strains isolated from ducks and wild birds in South Korea in 2014. Pathologically, redness of pancreas, enlargement and hemorrhage of spleen, friability of brain, and hydropericardium were prominently found. Histologic legions were observed in pancreas, spleen, liver, lung, heart, and brain, and influenza A nucleoproteins were detected in the same organs by immunohistochemistry. Other ostriches farmed together in open camps were not infected with HPAI virus based on the serologic and virologic tests. The findings indicate that ostriches are susceptible to H5N8 HPAI virus, but this virus does not spread efficiently among ratites.</P>