정상 백서 및 담즙성 간경변증을 유발시킨 백서에서 간문맥 결찰시 간장변화에 관한 실험적 연구

채권묵,송훈섭,소병준,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

Portal vein branch ligation has been implicated to stimulate the hypertrophy of the unaffected lobe of the liver, but it has been suggested that the degree of the hypertrophy of the cirrhotic liver would be less than that of the normal liver. So, we tried to induce biliary cirrhotic liver by ligation of the common bile duct for this experiment and to evaluate the difference of the effect of the portal vein ligation among the different experimental rat liver groups. For the experimental study, we used Sprague - Dawley rats which were classified into the two groups. Group A (N = 16): Rats with portal venous branch ligation only. Group B (N=16): Rats with portal venous branch ligation after biliary cirrhosis were made by common bile duct ligation. In order to induce biliary cirrhosis, we ligated the common bile duct ligation in 135 rats and exploratory laparotomy for biopsy was done 3 weeks later after common bile duct ligation and the incidence of biliary cirrhosis was about 40%(54/135). 16 rats with the biliary cirrhotic liver were chosen for further study and one of 5 portal branches was ligated and the rats were sacrificed at different time point(1st, 3rd, 5th, 8th week) after initiation of the experiment, and the livers were removed and examined to find out the gross and histologic changes of the livers. The same procedures were performed in 16 normal rats for control study. In the Group A, the severe inflammatory changes and multiple necrotic foci were shown in the ligated lobe from the 3rd week, and firm nodularity was palpated but hypertrophic changes were not noticed in the unaffected lobe. In the group B, ligated lobe showed the same findings with the group A, but unaffected lobe did not reveal any specific findings. In our experiment, we could induce biliary cirrhosis after common bile duct ligation but we could not examine any hypertrophic changes in the both groups-normal and cirrhotic livers - after portal vein branch ligation. This might suggest that only small portion of necrosis - less than 20% - can not induce compensatory hypertrophy in the unaffected lobe.

Rate capability for Na-doped Li_1.167Ni_0.18Mn_0.548Co_0.105O₂ cathode material and characterization of Li-ion diffusion using galvanostatic intermittent titration technique

Lim, Sung Nam,Seo, Jung Yoon,Jung, Dae Soo,Ahn, Wook,Song, Hoon Sub,Yeon, Sun-Hwa,Park, Seung Bin Elsevier 2015 JOURNAL OF ALLOYS AND COMPOUNDS Vol.623 No.-

<P><B>Abstract</B></P> <P>Spherical Li<SUB>1.167</SUB> <SUB>−</SUB> <I> <SUB>x</SUB> </I>Na<I> <SUB>x</SUB> </I>Ni<SUB>0.18</SUB>Mn<SUB>0.548</SUB>Co<SUB>0.105</SUB>O<SUB>2</SUB> (0⩽ <I>x</I> ⩽0.1) particles were prepared by spray pyrolysis, and subjected to electrochemical characterization for lithium battery applications. It was confirmed that Na doping enhances the charge/discharge rate capability. The structure of prepared samples was characterized by XRD: the <I>c</I>-axis lattice parameter increases with increase in the amount of Na ions (parameterized by <I>x</I>, above). The Na-doped sample with <I>x</I> =0.05 shows capacities of 208 and 184mAhg<SUP>−1</SUP> at high current densities of 1.0C and 2.0C, respectively. These values are enhanced, compared to values of 189 and 167mAhg<SUP>−1</SUP> for the bare sample. The ratio of the capacity at 1.0C to that at 0.1C is enhanced from 77% for the bare sample to 84% for the Na-doped sample with <I>x</I> =0.05. The Li diffusion coefficients obtained from the galvanostatic intermittent titration technique (GITT) are higher for Na-doped samples than for the bare sample. In particular, the Na-doped sample (<I>x</I> =0.05), in the potential range around 4V, has a higher <I>D</I> <SUB>Li+</SUB> value of 3.34×10<SUP>−9</SUP> cm<SUP>2</SUP> s<SUP>−1</SUP>, compared with 1.35×10<SUP>−9</SUP> cm<SUP>2</SUP> s<SUP>−1</SUP> for the bare sample. The Na-doped samples (0< <I>x</I> <0.075) show high capacity retention: the Na-doped sample (<I>x</I> =0.05) shows a capacity retention of 92% compared to 83% for the bare sample.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Spherical Na-doped Li-rich cathode material prepared by spray pyrolysis. </LI> <LI> Na-doped samples show better rate capability than that of bare sample. </LI> <LI> Na-doped sample has higher <I>D</I> <SUB>Li+</SUB> value at 4V compared with that of the bare sample. </LI> <LI> The cycle performance was enhanced from 83% to 92%. </LI> </UL> </P>

Synthesis Gas Production via Partial Oxidation, CO₂ Reforming, and Oxidative CO₂ Reforming of CH₄ over a Ni/Mg-Al Hydrotalcite-type Catalyst

Song, Hoon Sub,Kwon, Soon Jin,Epling, William S.,Croiset, Eric,Nam, Sung Chan,Yi, Kwang Bok The Korean Society of Clean Technology 2014 청정기술 Vol.20 No.2

합성가스를 생산하기 위한 부분산화, 이산화탄소 리포밍, 메탄에 의한 산화$CO_2$ 리포밍 공정들은 니켈 하이드로탈사이트($Ni_{0.5}Ca_{2.5}Al$) 촉매를 이용하여 수행되었고 안정한 이중층 구조를 형성시키기 위한 금속지지체(Mg, Ca)의 영향에 대해서도 다양한 연구가 진행되었다. 지지체전구물질(Mg, Ca)에 따라 메탄 리포밍의 안정성은 활성니켈이온과 지지체금속이온 사이의 결합강도차이에 의해 영향을 받는다. Ni-Mg-Al 구성체는 가장 안정한 하이드로탈사이트 이중층 구조이지만 Ni-Ca-Al 구성체는 그렇지 않다. 이산화탄소 리포밍 장기테스트에서 Ni-Mg-Al 촉매는 약 100시간 동안 80%의 효율을 유지하면서 탁월한 안정성을 보였지만 Ni-Ca-Al 촉매는 반응초기에 불활성화됨을 확인할 수 있었다. 활성금속 Ni과 지지체 Mg-Al 사이의 결합강도를 확인하기 위해 승온 환원(temperature-programmed reduction, TPR) 분석을 시행하였다. 이를 통해 Ni-Mg-Al 촉매가 Ni-Ca-Al 촉매보다 Ni의 환원온도가 더 높음을 확인할 수 있었다. $Ni_{0.5}Ca_{2.5}Al$ 촉매는 가장 높은 초기반응성을 보였지만 코크형성으로 인해 반응성이 빠르게 감소하였다. 결론적으로 $Ni_{0.5}Ca_{2.5}Al$ 촉매가 코크형성에 대한 강한 저항성을 갖고 있기 때문에 다른 촉매들보다 높은 반응성과 안정성을 갖는 것으로 보여진다. Partial oxidation, $CO_2$ reforming and the oxidative $CO_2$ reforming of $CH_4$ to produce synthesis gas over supported Ni hydrotalcite-type ($Ni_{0.5}Ca_{2.5}Al$ catalyst) catalysts were carried out and the effects of metal supports (i.e.; Mg and Ca) on the formation of a stable double-layer structure on the catalysts were evaluated. The $CH_4$ reforming stability was determined to be affected by the differences in the interaction strength between the active Ni ions and support metal ions. Only a Ni-Mg-Al composition produced a highly stable hydrotalcite-type double-layered structure; while the Ni-Ca-Al-type composition did not. Such structure provides excellent stability for the catalyst (-80% efficiency) as confirmed by the long-term $CO_2$ reforming test (-100 h), while the Ni-Ca-Al catalyst exhibited deactivation phases starting at the beginning of the reaction. The interaction strength between the active metal (Ni) and the supporting components (Mg and Al) was determined by temperature-programed reduction (TPR) analyses. The affinity was also confirmed by the TPR temperature because the Ni-Mg-Al catalyst required a higher temperature to reduce the Ni relative to the Ni-Ca-Al catalyst. The highest initial activity for synthesis gas production was observed for the $Ni_{0.5}Ca_{2.5}Al$ catalyst; however, this activity decreased quickly due to coke formation. The $Ni_{0.5}Ca_{2.5}Al$ catalyst exhibited a high reactivity and was more stable than the other catalysts because it had a higher resistance to coke formation.

Synthesis Gas Production via Partial Oxidation, CO<SUB>2</SUB> Reforming, and OxidativeCO<SUB>2</SUB> Reforming of CH<SUB>4</SUB> over a Ni/Mg-Al Hydrotalcite-type Catalyst

Hoon Sub Song,Soon Jin Kwon,William S. Epling,Eric Croiset,Sung Chan Nam,Kwang Bok Yi 한국청정기술학회 2014 청정기술 Vol.20 No.2

합성가스를 생산하기 위한 부분산화, 이산화탄소 리포밍, 메탄에 의한 산화CO2 리포밍 공정들은 니켈 하이드로탈사이트 (Ni0.5Mg2.5Al) 촉매를 이용하여 수행되었고 안정한 이중층 구조를 형성시키기 위한 금속지지체(Mg, Ca)의 영향에 대해서도 다양한 연구가 진행되었다. 지지체전구물질(Mg, Ca)에 따라 메탄 리포밍의 안정성은 활성니켈이온과 지지체금속이온 사이의 결합강도차이에 의해 영향을 받는다. Ni-Mg-Al 구성체는 가장 안정한 하이드로탈사이트 이중층 구조이지만 Ni-Ca-Al 구성체는 그렇지 않다. 이산화탄소 리포밍 장기테스트에서 Ni-Mg-Al 촉매는 약 100시간 동안 80%의 효율을 유지하면서 탁월한 안정성을 보였지만 Ni-Ca-Al 촉매는 반응초기에 불활성화됨을 확인할 수 있었다. 활성금속 Ni과 지지체 Mg-Al 사이의 결합강도를 확인하기 위해 승온 환원(temperature-programmed reduction, TPR) 분석을 시행하였다. 이를 통해 Ni-Mg-Al 촉매가 Ni-Ca-Al 촉매보다 Ni의 환원온도가 더 높음을 확인할 수 있었다. Ni0.5Ca2.5Al 촉매는 가장 높은 초기반응성을 보였지만 코크형성으로 인해 반응성이 빠르게 감소하였다. 결론적으로 Ni0.5Mg2.5Al 촉매가 코크형성에 대한 강한 저항성을 갖고 있기 때문에 다른 촉매들보다 높은 반응성과 안정성을 갖는 것으로 보여진다. Partial oxidation, CO2 reforming and the oxidative CO2 reforming of CH4 to produce synthesis gas over supported Ni hydrotalcite-type (Ni0.5Mg2.5Al catalyst) catalysts were carried out and the effects of metal supports (i.e.; Mg and Ca) on the formation of a stable double-layer structure on the catalysts were evaluated. The CH4 reforming stability was determined to be affected by the differences in the interaction strength between the active Ni ions and support metal ions. Only a Ni-Mg-Al composition produced a highly stable hydrotalcite-type double-layered structure; while the Ni-Ca-Al-type composition did not. Such structure provides excellent stability for the catalyst (-80% efficiency) as confirmed by the long-term CO2 reforming test (-100 h), while the Ni-Ca-Al catalyst exhibited deactivation phases starting at the beginning of the reaction. The interaction strength between the active metal (Ni) and the supporting components (Mg and Al) was determined by temperature-programed reduction (TPR) analyses. The affinity was also confirmed by the TPR temperature because the Ni-Mg-Al catalyst required a higher temperature to reduce the Ni relative to the Ni-Ca-Al catalyst. The highest initial activity for synthesis gas production was observed for the Ni0.5Ca2.5Al catalyst; however, this activity decreased quickly due to coke formation. The Ni0.5Mg2.5Al catalyst exhibited a high reactivity and was more stable than the other catalysts because it had a higher resistance to coke formation.

Enhanced Hydrogen Sulfide Adsorption on Zinc Oxide/Graphene Composite at Moderate Temperature

( Song Hoon Sub ),남성찬,이광복 한국공업화학회 2013 한국공업화학회 연구논문 초록집 Vol.2013 No.-

Phase II trial of preoperative sequential chemotherapy followed by chemoradiotherapy for high-risk gastric cancer

Kim, Hyo Song,Koom, Woong Sub,Baek, Song-Ee,Kim, Hyoung-Il,Jung, Minkyu,Beom, Seung-Hoon,Kang, Beodeul,Kim, Hyunki,Chang, Jee Suk,Choi, Yoon Young,Son, Taeil,Cheong, Jae-Ho,Noh, Sung Hoon,Kim, Eun Hye Elsevier Science Publishers 2019 Radiotherapy and oncology Vol.140 No.-

<P><B>Abstract</B></P> <P><B>Background and purpose</B></P> <P>To evaluate the safety and efficacy of preoperative chemotherapy (CTx) followed by chemoradiotherapy (CCRT) for high-risk gastric cancer (GC).</P> <P><B>Methods and materials</B></P> <P>The inclusion criteria were as follows: (1) Borrmann type 4; (2) large Borrmann type 3 (≥8 cm); (3) single bulky (≥3 cm × 1) or multiple lymph nodes (≥1.5 cm × 3). Patients received two 21-day courses of induction CTx of TS-1 (35 mg/m<SUP>2</SUP>, p.o, twice daily on days 1–14), docetaxel (30 mg/m<SUP>2</SUP>, i.v., days 1 and 8), and cisplatin (30 mg/m<SUP>2</SUP>, i.v., days 1 and 8) followed by CCRT (two courses of TS-1 and cisplatin in combination with 45 Gy radiation).</P> <P><B>Results</B></P> <P>Forty-two patients were enrolled between March 2014 and February 2016, and 39 of these completed sequential CTx and CCRT. Among the 33 patients who underwent R0 resection, the pathologic response rate was 39.4% [no residual carcinoma (<I>n</I> = 5, 15.2%), with 1–10% residual carcinoma (<I>n</I> = 8, 24.2%)]. Overall, 4 patients (12.1%) were pathologic stage 0, 7 (21.2%) were stage I, 10 (30.3%) were stage II, and 12 (36.4%) were stage III. The overall survival rate at 3 years was 77.9% for stages 0 and I, 66.8% for stages II–III, and 33.3% for unresectable cases (<I>P</I> = 0.001). Toxicity was mild to moderate with grade 4 neutropenia (<I>n</I> = 1) and neutropenic fever (<I>n</I> = 1) as the most prominent side-effects.</P> <P><B>Conclusions</B></P> <P>Sequential CTx and CCRT prior to surgery are feasible and effective for high-risk GC.</P> <P>Trial registration number: NCT02495493.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A complex preoperative staging was adopted for high-risk GC. </LI> <LI> We adopted an intensive, weekly-split, triplet regimen with favorable toxicities. </LI> <LI> Induction chemotherapy and chemoradiotherapy indicate a promising outcome. </LI> </UL> </P>

Aptamer-Immobilized Surface Plasmon Resonance Biosensor for Rapid and Sensitive Determination of Virulence Determinant

Song, Myeong-Sub,Sekhon, Simranjeet Singh,Shin, Woo-Ri,Rhee, Sung-Keun,Ko, Jung Ho,Kim, Sang Yong,Min, Jiho,Ahn, Ji-Young,Kim, Yang-Hoon American Scientific Publishers 2018 Journal of Nanoscience and Nanotechnology Vol.18 No.5

<P>Shigella sonnei isolate invasion plasmid antigen protein, IpaH, was successfully expressed in recombinant overexpression bacterial system. The soluble expression IpaH was enhanced with molecular chaperon co-expressed environment. Specific aptamer IpaH17 was isolated through the SELEX process and showed fM binding affinity. IpaH17-SPR biosensor platform was involved to verify the binding sensitivity and specificity. The IpaH concentration dependent IpaH17-SPR sensor response was highly linear with a linear regression constant of 99.4% in the range between 0 and 100 ng/mL. In addition, S. sonnei revealed the specific RU value and detected in a real-time manner within 1 hour. Our study indicated that IpaH17-SPR sensor can allow for rapid, sensitive and specific determination of Shigella sonnei virulent factor.</P>

폐와 위장의 전이성 석회화를 동반한 부갑상선 선종 1 예

송건훈,이지현,허갑범,이현철,임승길,송영득,남문석,차봉수,변영섭 대한내과학회 1996 대한내과학회지 Vol.51 No.3

Metastatic calcification of soft tissues due to hypercalcemia is a well-recognized complication of various malignancies and renal failure. It results from metabolic derangement in which calcium salts are deposited in otherwise normal tissuel. The calcific process principally affects lungs, stomach, kidneys and other soft tissues. With advance of nuclear imaging modalities, metastatic calcification can be detected earlier so that appropriate therapy may be instituted. A case of parathyroid adenoma with metastatic pulmonary and gastric calcification is presented. She showed intense concentrations of bone-seeking radionuclide( ^(99m)Technetium) in both lungs and stomach on routine bone scan. Renal function of the patient was moderately impaired, Right inferior parathyroidectomy was performed. Her serum calcium concentration decreased postoperatively and had to be maintained with orally administered calcium and aldactazide. After the operation the clinical course has been uneventful. Follow-up bone scan performed lo days following the operation revealed persistence of lung uptake despite restoration of normal blood calcium concentration, but disappearance of gastric uptake. So we report the case of parathyroid adenoma complicating metastatic pulmonary and gastric calcification with review of literature.

Cloning and Expression of Invasion Plasmid Antigen H (ipaH) Gene of Shigella sonnei

Myung-Sub SONG,Hyun-Ju UM,Hongik KIM,Jiho MIN,Yang-Hoon KIM 한국생물공학회 2011 한국생물공학회 학술대회 Vol.2011 No.10

Genetic Relationship of Hibiscus syriacus L. Varieties Analyzed by Physiological and Morphological Characteristics

Sang Hoon Kim,Geung-Joo Lee,In Sook Park,Hi Sup Song,Sung Jin Chung,Dong Sub Kim,Jin Baek Kim,Si-Yong Kang 한국원예학회 2009 한국원예학회 학술발표요지 Vol.2009 No.5