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기저세포암 및 편평세포암에서 미세혈관밀도와 p53 단백 발현에 관한 연구
어수락,조규성,안호범,김대영,이삼용,조백현 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3
Basal cell carcinoma(BCC) and squamous cell carcinoma (SCC) are very prevalent neoplasms of the human skin. Ultraviolet radiation in sunlight is a well-established mutagen of the p53 gene and is one of basal cell carcinoma and squamous cell carcinoma. The newly-formed vascular network is important for neoplasms to grow beyond a size of about 1 ㎣. Recent reports have suggested the hypothesis that a mutant p53 protein is closely related with capillary density. Immumohistochemistry for p53 protein and CD34 was performed in 20 cases of BCCs and 14 SCCs to evaluated the relationship between p53 protein and capillary density. The results were as follows:1. The microvessels stained by CD34 were mainly located in the interface of tumor cells and stroma. 2. There was no difference in the microvessel density according to the histologic types and age of the patients, but a higher microvessel density was noted in male patients. 3. The aggressive BCCs and the less-differentiated SCCs showed higher p53 immunostaining. 4. The mean microvessel density of cases showing strong positive immunostaining of the p53 gene(54.73±17.75) was higher than that of others(39.75±18.30). These results suggested that p53 protein expression and microvessel density are not related to the histologic types and age of the patients, but that differentiation and biologic behavior such as the infiltrating property of tumors and the microvessel density are closely related to p53 protein expression.
최대 오차 벡터를 이용한 최적 공간 벡터 변조 기법에 관한 연구
안호균,김태엽,진승오,남징락 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-
This study proposes a optimized space vector modulation(SVM), which makes a good output current with low total harmonic distortion(THD) and introduces the concept of maximum error vector for new method. The performance of the new modulation technique using maximum error vector is shown by simulation and experiments.
마이크로프로세서를 이용한 UTILITY CAR용 CONTROLLER 개발에 관한 연구
안호균,남징락,김태엽 國立 昌原大學校 産業技術硏究所 1999 産技硏論文集 Vol.13 No.-
This paper describes the development of Controller for the Utility Car using Microprocessor. The Utility Car is composed of Controller, separately excited DC motor, battery and potbox. It is easier for a digitalized controller using microprocessor to append new function than an analogized controller. For sensorless current control, the driver is used the feedback voltage of battery.
김경곤 ( Kyong Gon Kim ),김준형 ( Jun Hyung Kim ),김성민 ( Song Min Kim ),전규락 ( Gyu Rak Chon ),김영욱 ( Young Wook Kim ),이호학 ( Ho Hak Lee ),박상준 ( Sang Joon Park ),김윤권 ( Yun Kwon Kim ),김소연 ( So Yon Kim ),김영중 ( You 대한내과학회 2002 대한내과학회지 Vol.63 No.6
목적: 저자들은 전투 경찰에서 흔히 실시되는 훈련 후 횡문근융해증과의 연관성을 알아보고자 하였다. 방법: 전투경찰 173명을 대상으로 6일간 평균 매일 8시간에 걸쳐 PT체조훈련이 시행하였고,설문조사를 통해 개인당 훈련량을 조사하였다. 결과: 검사 결과 173명 중 98명에서 횡문근융해증을 진단 할 수 있었다. 혈중 마이오글로빈은 훈련량이 증가함에 따라 상승하는 소견을 보였다. 시간 경과에 따른 진행 과정을 볼 때, CPK, AST, 혈중 마이오글로빈은 Background: It is important to recognize rhabdomyolysis in clinical settings, because 10∼30% of rhabdomyolysis patients develop acute renal failure as a complication and patients with such complication have risk of high mortality. Recently, there have bee
Kim, Yeon-Kye,Jeong, Eun-Ji,Lee, Min-Sup,Yoon, Na-Young,Yoon, Ho-Dong,Kim, Jae-Il,Kim, Hyeung-Rak The Korean Society of Fisheries and Aquatic Scienc 2011 Fisheries and Aquatic Sciences Vol.14 No.4
Inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) have been implicated in various inflammatory diseases. In this study, we investigated the anti-inflammatory activities of Chondria crassicaulis ethanolic extract (CCE) by measuring its effects on the expression of iNOS and COX-2 proteins in lipopolysaccharide (LPS)-treated RAW 264.7 murine macrophages. CCE significantly and dose-dependently inhibited the LPS-induced release of nitric oxide and prostaglandin $E_2$, and suppressed the expression of iNOS and COX-2 proteins in LPS-stimulated RAW 264.7 cells, without causing any cytotoxicity. It also inhibited the production of the pro-inflammatory cytokines such as interleukin (IL)-$1{\beta}$, IL-6, and tumor necrosis factor (TNF)-${\alpha}$ in LPS-stimulated RAW 264.7 cells. Moreover, treatment with CCE strongly suppressed nuclear factor-${\kappa}B$ (NF-${\kappa}B$) promoter-driven expression in LPS-treated RAW 264.7 cells. CCE treatment blocked nuclear translocation of the p65 subunit of NF-${\kappa}B$ by preventing proteolytic degradation of inhibitor of ${\kappa}B-{\alpha}$. These results indicate that CCE regulates iNOS and COX-2 expression through NF-${\kappa}B$-dependent transcriptional control, and identifies potential candidates for the treatment or prevention of inflammatory diseases.