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Polymeric Gene Carrier as a mean of targeting to Artery Wall Cells
Choi, Hey Young,Bae, Eun Yeong,Choi, Chang Yong,Jang, Mi Kyeong,Kim, Myung Yul,Nah, Jae Woon 한국공업화학회 2002 응용화학 Vol.6 No.2
Non-viral gene carriers continue to attract a great deal of interest due to advantageous safety profile. Among the non-viral gene carriers, cationic liposomes or synthetic gene carriers are efficient DNA carriers in vitro, but there in vivo applications are greatly hampered because of their low bioavailability. On the other hand, chitosan, a natural cationic polysaccharide, is a candidate non-viral vector for gene delivery because of its high positive charges and low cytotoxicity. In this work, AWBP-PEG-LMWSC was synthesized by conjugation the arterial wall binding peptide (AWBP), a specific targeting peptide, to the end of PEGylation low molecular water soluble chitosan (LMWSC) as a gene carrier to target artery wall cells. Chatacters of the synthesized AWBP-PEG-LMWSC were analyzed by measuring FT-IR, ^1H-NMR, zeta-potentiometer, atomic force microscopy (AFM), transmittance electro microscopy (TEM). And the physical and biochemical properties of AWBP-PEG-LMWSC/pDNA complexes will be also investigated.
장은석(Eun Suk Chang),안혜진(Hey Jin Ahn) 한국일러스아트학회 2002 일러스트레이션학 연구 Vol.10 No.-
Nowaday the most of local government have been developed the character for the Identity of its region. It contains the unlimited capability that the ultility and PR effect created high value added. But we must once think that how much helped to make known the image of its region because the some of it was plannned by take advantage of periodicaliy. Accordingly in order to improve this we try to find the solution to a design problem to maximize the image of local government and aid to impress effectively its natural shape and creative image.
Kim, Hong-Gyun,Park, Hey-Jung,Kang, Hyun-Jung,Lim, Hye-Won,Kim, Kyung-Hoon,Park, Eun-Hee,Ahn, Ki-Sup,Lim, Chang-Jin The Microbiological Society of Korea 2005 The journal of microbiology Vol.43 No.1
In our previous study, the first structural gene (GGTI) encoding ${\gamma}-glutamyl$ transpeptidase was cloned and characterized from the fission yeast Schizosaccharomyces pombe, and its transcription, using the GGTI-lacZ fusion gene, containing the 1,085 bp upstream region from the translational initiation point, was found to be enhanced by sodium nitroprusside and L-buthionine-(S,R)-sulfoximine (BSO). In the present work, regulation of the GGTI gene was further elucidated. Non-fermentable carbon sources, such as acetate and ethanol, markedly enhanced the synthesis of ${beta}-galactosidase$ from the GGTI-lacZ fusion gene. However, its induction by non-fermentable carbon sources appeared to be independent of the presence of the Pap1 protein. Nitrogen starvation also gave rise to induction of GGTI gene expression in a Pap1-independent manner. The three additional fusion plasmids, carrying 754, 421 and 156 bp regions, were constructed. The sequence responsible for the induction by non-fermentable carbon sources and nitrogen starvation was identified to exist within a -421 bp region of the GGTI gene. Taken together, the S. pombe GGTI gene is regulated by non-fermentable carbon sources and nitrogen starvation.
Hwa-young Kim,김중학,Seong-Ae Lee,Hey-eun Chang,Mi-hyoun Park,Sung-joo Hwang,Ju-yeon Lee,목철균,Seong-gil Hong 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
Saengshikis a Korean noncooked food made with of more than 30 different whole gains, vegetables, fruits,mushrooms, and seaweeds. All of these ingredients are frozen and dried to minimize the loss of nutrients. Saengshikhas be-come popular among health-conscious people in the Republic of Korea. The study aims to investigate antioxidant effects ofSaengshikby in vivo and human experiments. In in vivo tests, mice were fed Saengshikfor 4 weeks, and oxidative damagewas induced by CCl4. Then the effects of Saengshikon oxidative damage were examined. It was found that plasma lipid hy-droperoxide and protein oxidative damages were significantly suppressed and antioxidants, glutathione, and thiol groups wereincreased. The activity of the antioxidant enzyme superoxide dismutase was increased, and the level of glutamate pyruvatetransaminase was decreased. In a human study, elderly people were given Saengshikfor 24 weeks, and changes in antioxi-dant defense of the body were examined. Antioxidant activities in plasma were enhanced, although the difference was notsignificant. Therefore, it is expected that Saengshikis effective at removing oxidants from body tissues, preventing oxidativedamage, and eventually boosting the antioxidant capacity of the body.
반가,박혜령,김은하,이창식,Pan, Ge,Park, Hey-Ryung,Kim, Eun-Ha,Lee, Chang-Seek 대한산업경영학회 2020 산업융합연구 Vol.18 No.2
본 연구는 한·중 여대생의 결혼관과 웨딩드레스 디자인 선호도를 비교하는데 연구의 목적을 두었다. 이를 위하여 한국 여대생 191명과 중국 여대생 199명을 대상으로 설문조사를 통하여 자료를 수집하였다. 자료는 SPSS PC+ 25.0을 활용하여 분석하였으며, 분석방법은 신뢰도 분석, 교차분석, 평균비교분석이었고, 검증은 카이 스퀘어 및 t검증으로 하였다. 주요 연구결과는 다음과 같다. 첫째, 한국 여대생은 결혼하겠다는 응답이 중국 여대생보다 높았다. 중국 여대생은 결혼을 희망하는 이유로 경제, 생활, 부모 관련 문항에서 한국 여대생보다 높았다. 또한 결혼을 희망하지 않는 이유로는 배우자에 관한 걱정, 일에 대한 걱정, 경력에 관한 걱정 등에서 중국 여대생이 높았다. 둘째, 한국과 중국 여대생이 선호하는 웨딩드레스 디자인은 네크라인에서 차이가 있었다. 끝으로 미래 웨딩산업의 중국 진출을 위한 방안을 논의하였다. The purpose of this study was to compare the perspective of marriage and preferences of wedding dress design for female college students in Korea and China. To this end, a questionnaire was administered for 191 Korean female college students and 199 Chinese female college students in Korea. The data were analyzed using SPSS PC + 25.0, and the applied statistical techniques were reliability analysis, cross-tab analysis, and mean comparison analysis. For statistical verification, chi-square and t-test were used. The main research results are as follows. First, Korean female college students were more likely to marry than Chinese female college students. For the reason of wishing to marry, Chinese female college students were higher than Korean female college students in economic, life, and parent-related items. The reason for not wanting to get married is that Chinese female college students were high in worrying about their spouse, work, and their career. Second, the wedding dress design preferred by Korean and Chinese female college students was different in the neckline. Finally, the policy measures for consumer preference and satisfaction in the future wedding industry were discussed.
( Ji Hyun Lee ),( Ki Nam Shim ),( Min Sun Ryu ),( Kwang Jin Woo ),( Jeon Mi Lee ),( Hey Won Yoon ),( Chung Hyun Tae ),( Chang Mo Moon ),( Seoung Eun Kim ),( Hye Kyung Jung ),( Sung Ae Jung ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Primary malignant melanoma of the esophagus is an extremely rare disease which counts for approximately 0.1-0.2% of all esophageal malignancies. It is also a very aggressive disease with a poor prognosis, with its 5yr survival rate ranging from 2.2% - 37.5%. Here we report a case of primary malignant melanoma of the esophagus in a patient whose diagnosis was made relatively early and thus total resection by an Ivor Lewis procedure was possible. A 51 year old Asian woman visited our hospital with epigastric discomfort. The patient had no noticeable medical history. She complained of mild nausea and dyspepsia, but there was no vomiting or weight loss. Physical examination showed no palpable lymph nodes in the head and neck region. There was no tenderness or rebound tenderness on the abdomen. For evaluation of her upper gastrointestinal symptoms, she had the upper endoscopy done. Endoscopy identifi ed a few dark pigmented, polypoid lesions scattered from 22cm to 30cm from the incisor tooth. The lesions were various in size, ranging from 0.2cm to 4-5cm and were fl at, slightly elevated with a irregular base. Biopsy done from two spots showed a well demarcated, slightly elevated and black pigmented tumor. For stage work-up, additional examinations were performed. The chest CT showed no abnormal thickening of the esophagus or any enlarged lymph nodes in the mediastinum. The PET-CT showed a mild focal abnormal uptake in the upper thoracic esophagus. The patient underwent an Ivor-Lewis procedure in June, 2013. Pathologic examination revealed spindle shaped malignant melanocytes with hyperchromated nucleis and black pigmentation. The lesion had invaded the submucosal layer. Thus the patient was diagnosed as esophageal malignant melanoma, stage T2N0M0. She is now under close observation at the out-patient department and has been disease free for 13 months.e
Idiopathic severe hypermagnesemia in an extremely low birth weight infant on the first day of life
Hyun, Hye-Sun,Choi, Hyun-Sin,Kim, Jin-Kyu,Ahn, So-Yoon,Yoo, Hey-Soo,Kim, Eun-Sun,Chang, Yun-Sil,Park, Won-Soon The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.7
A preterm female infant born at 27 weeks of gestation with a birth weight of 990 g developed acute hypotonia, apnea, hypotension and bradycardia mimicking septic shock syndrome at 14h after birth. Laboratory tests indicated a severe hypermagnesemia of 45 mg/dL. The renal function, complete blood count and maternal blood concentrations of magnesium were normal, and the blood cultures were negative. The patient recovered with treatment including exchange transfusion. However, the etiology of the severe hypermagnesemia remains unknown.