상악동에 발생한 거대한 Cholesterol 육아종 1례

김승찬,박형욱,김용기,나한조,도남용 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The cholesterol granuloma is not a specific clinical or pathologic entity but merely a term used to describe a tissue response to cholesterol crystal. The cholesterol granuloma in paranasal sinuses is rare disease. Recently the authors had experienced a case of huge cholesterol granuloma, which involved the right maxillary sinus. The cholesterol granuloma was removed successfully by mean of enucleation through the Caldwell-Luc approach. So, we report a case with brief review of the literature.

발달성협응장애(Developmental Coordination Disorder) 의 선별과 진단

양한나,김의수 서울대학교 스포츠과학연구소 2007 스포츠과학리뷰 Vol.1 No.2

Deficits of motor development and performance of children with developmental coordination disorder affect negatively to both physical, social, and psychological aspects. According to research tendency of developmental coordination disorder since 2000, study in Korea was few compare to the studies of overseas were plenty. Also, only motor skill test is used to be classified as developmental coordination disorder in Korea whereas at least 3~4 strict tests of screening process is used in overseas. To activate the research about developmental coordination disorder in Korea and to classify developmental coordination disorder with confidence, more various but accurate and standardized tests should be developed. 발달성협응장애(DCD) 아동의 운동발달 지체 및 운동기술의 부족은 신체적, 사회심리학적 측면에 부정적인 영향을 미친다. 국내외 연구 경향을 살펴본 결과 외국에서는 2000년 이후에 다양한 분야에서 활발히 연구가 진행되고 있는 반면 국내의 연구는 매우 부진한 상태이다. 또한 외국의 연구는 발달성협응장애(DCD) 아동의 선별과 진단과정이 엄격하고 최소 3-4단계 이상의 과정을 거치는데 반해 국내의 연구는 운동기술검사만으로 발달성협응장애(DCD)를 선별하고 있다. 국내 발달성협응장애(DCD) 관련 연구의 활성화를 위해서는 보다 정확한 대상자에 대한 선별기준이 설정되어야 하며 보다 다양한 운동기술 검사도구의 한국형 표준화 과정이 이루어져야 할 것이다.

Surgical Management of Unruptured Intracranial Anerysms

Nah, Jong Han,Kim, Jung Hoon,Kim, Chang Jin,Kwon, Yang,Rhim, Seung Chul,Lee, Jung Kyo,Kwun, Byung Duck,Whang, Jin 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3

새로운 진단방사선기술의 개발에 의한 두 개강내 비파열 뇌동맥류의 발견이 증가함에 따라 이에 대한 치료가 중요하게 되었다. 그러나 여전히 비파열 뇌동맥류에 대한 수술적 치료는 논쟁거리로 남아있어, 특별한 치료없이 경과를 관찰할지, 혈관내색전술을 시행할지, 또는 미세현미경학적 수술을 시행할지 아직 명확한 기준이 뚜렷치 않다. 이에 저자들은 1989년 6월부터 1995년 5월까지 비파열 뇌동맥류로 본원 신경외과에 입원하여 수술적 치료를 받았던 41예에 환자들을 대상으로 수술 결과에 영향을 미칠 수 있는 요인들을 분석하여 보았다. 이들의 발견동기를 incidental, multiple, 그리고 mass effect 등으로 구분하였을 때, 다른 파열 뇌동맥류에 의한 지주막하출혈의 뇌혈관조영술중 발견된 경우(multiple)가 가장 많았으며(19예), incidental하게 발견된 경우 및 mass effect로 발견된 경우가 각각 11예 이었다. 37예의 환자에서 direct neck clipping이 가능하였으며, 2예에서 trapping을 1예에서 wrapping을 시행하였다. 직경이 25㎜이상 되었던 1예의 vertebrobasialr artery aneurysm의 경우 적절한 치료를 시행할 수 없었다. Cranial nerve palsy, hemiparesis, major hemispheric swelling, hematoma 등의 합병증 등을 관찰할 수 있었다. 직경 25㎜ 이상되었던 1예의 proximal internal carotid artery aneurysm 수술후 major hemispheric infarction으로 사망하였으며, 또한 2예의 giant vertebrobasila artery aneurysms 수술후 결과가 불량하였다. 전체적인 수술결과는 양호하여 38예(92.7%)의 환자에서 excellent 또는 good outcome을 얻을 수 있었다. 뇌동맥류의 크기와 수술결과와 상당한 연관성이 관찰되어 직경이 25㎜ 이하인 비파열 뇌동맥류인 경우 100%에서 excellent 또는 good outcome을 얻을 수 있었으나, 직경이 25㎜ 이상인 경우 그 수술결과는 불량하여 75%에서 poor 또는 dead outcome을 관찰할 수 있었다. 저자들은 위험부담이 적은 비파열 뇌동맥류의 수술은 반드시 시행되어져야 한다고 생각하며, 뇌동맥류의 크기 및 위치가 수술결과에 영향을 미칠 수 있는 요인들이라고 생각한다. With the ever-increasing number of intact aneurysms revealed by modern imaging, the options for their management are assuming greater importance. The surgical management of patients with unruptured intracranial aneurysms continues to be controversial, and the criteria for withholding treatment or choosing between endovascular embolization and conventional microsurgery are not will delineated. In order to define the surgical result for unruptured intracranial aneurysms. 41 patients(from June 1989 to May 1995) with surgically treated unruptured aneurysms were analyzed. They were categorized as incidental, multiple or aneurysm with mass effect. Subarachnoid hemorrhage from another aneurysm(multiple) was the most common presentation(19 patients). Eleven patients were presented with incidental findings unrelated to aneurysmal subarachnoid hemorrhage or direct aneurysmal mass effect, and 11 patients were presented with mass effect such as cranial nerve palsy for brain stem compression. We could perform direct neck clipping with/without wrapping in 37 patients, trapping in 2, and wrapping in 1. One patient with giant vertebrobasilar artery aneurysm(greater than 25㎜ in diameter) which was presented with mass effect could not be treated adequately. Instances of morbidity included cranial nerve injury in 4 patients, hemiparesis in 3, hematoma in 2, and major hemispheric infarction in 1. One patient presented with mass effect, died from major hemispheric infarction after surgery of proximal internal carotid artery aneurysm with a size greater than 25㎜ in diameter. Two patients, who underwent surgery for giant vertebrobasilar artery aneurysms presented with mass effect, were in poor state due to persistent cranial nerve palsy and hemiparesis. In general overall outcome was very good. Excellent or good outcome was achieved in 38 patients(92.7%) while 3 patients(7.3%) either died or was/were in poor condition. The aneurysm size was correlated well with the surgical outcome. We have achieved excellent or good out comes in 100% of patients with aneurysms 25㎜ or less in diameter. However, with aneurysms greater than 25㎜ in diameter, the outcomes were very poor with 75% of these patients in poor state or dead. "Surgery in unruptured aneurysms?" The answer was "Yes". We believe the size and location of the aneurysm are the key predictions of risk for surgical morbidity.

Early efficacy and safety of statin therapy in Korean patients with hypercholesterolemia: Daegu and Gyeongbuk Statin Registry

Han Joon Bae,Yun-Kyeong Cho,Hyoung-Seob Park,Hyuck-Jun Yoon,Hyungseop Kim,Seongwook Han,Seung-Ho Hur,Yoon-Nyun Kim,Kwon-Bae Kim,Jae-Kean Ryu,Deug Young Nah,Chang-Wook Nam 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2

Background/Aims: To date, prospective data are limited on efficacy and safety profiles of statin therapy in Korean hypercholesterolemic patients. Hence, the aim of this study was to evaluate the practice patterns of statin therapy and its efficacy and safety through the prospective Daegu and Gyeongbuk statin registry. Methods: Statin naïve patients who were prescribed statins according to the criteria of Korean Guidelines for Management of Dyslipidemia were enrolled. Clinical and laboratory evaluations were performed at baseline and at week 8, where the efficacy was assessed with the same guidelines. Results: Of 908 patients, atorvastatin and rosuvastatin were most frequently prescribed statins (63.1% and 29.3%, respectively). High intensity statins (atorvastatin 40 mg or rosuvastatin 20 mg) were prescribed in 24.7% of all patients and in 79.5% of high and very high risk groups. The total and low density lipoprotein (LDL) cholesterol levels decreased from 203.7 ± 43.0 to 140.6 ± 28.6 mg/dL and 134.4 ± 35.7 to 79.5 ± 21.3 mg/dL, respectively. The achievement rate of the LDL target goal was 98.6% in low risk, 95.0% in moderate risk, 88.1% in high risk, and 42.1% in very high risk patients (59.7% in overall). There was no significant difference in the efficacy between atorvastatin and rosuvastatin. Adverse events were observed in 12.0% of patients and led to 1.4% of treatment cessation. Conclusions: The efficacy of the usual starting dose of statins in daily practice was relatively insufficient for Korean hypercholesterolemic patients with high or very high risks. Short-term adverse events of statin therapy were not common in Korean patients with a low discontinuation rate.

INTERNATIONAL COLLABORATION FOR SILICON CARBIDE MIRROR POLISHING AND DEVELOPMENT

HAN, JEONG-YEOL,CHO, MYUNG,POCZULP, GARY,NAH, JAKYUNG,SEO, HYUN-JOO,KIM, KYUNG-HWAN,TAHK, KYUNG-MO,KIM, DONG-KYUN,KIM, JINHO,SEO, MINHO,LEE, JONGGUN,HAN, SUNG-YEOP The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

For research and development of Silicon Carbide (SiC) mirrors, the Korea Astronomy and Space Science Institute (KASI) and National Optical Astronomy Observatory (NOAO) have agreed to cooperate and share on polishing and measuring facilities, experience and human resources for two years (2014-2015). The main goals of the SiC mirror polishing are to achieve optical surface figures of less than 20 nm rms and optical surface roughness of less than 2 nm rms. In addition, Green Optics Co., Ltd (GO) has been interested in the SiC polishing and joined the partnership with KASI. KASI will be involved in the development of the SiC polishing and the optical surface measurement using three different kinds of SiC materials and manufacturing processes (POCO$^{TM}$, CoorsTek$^{TM}$ and SSG$^{TM}$ corporations) provided by NOAO. GO will polish the SiC substrate within requirements. Additionally, the requirements of the optical surface imperfections are given as: less than 40 um scratch and 500 um dig. In this paper, we introduce the international collaboration and interim results for SiC mirror polishing and development.

Biomarkers and genetic factors for early prediction of pre-eclampsia

Han nah Kim,Sung Shin Shim 대한의학유전학회 2017 대한의학유전학회지 Vol.14 No.2

Pre-eclampsia is known to cause considerable maternal morbidity and mortality. Thus, many studies have examined the etiopathogenesis of pre-eclampsia. While many pathophysiological factors related to pre-eclampsia have been identified, the precise etiopathogenesis of pre-eclampsia remains unclear. Numerous studies have identified factors for the early prediction for pre-eclampsia to lead to preparation and closer observation on pre-eclampsia when it occurs. This article reviews on current studies of biomarkers and genetic factors related to pre-eclampsia, which may be important for developing strategies for early prediction of pre-eclampsia.

Oral Administration of Gintonin Attenuates Cholinergic Impairments by Scopolamine, Amyloid-β Protein, and Mouse Model of Alzheimer's Disease

Kim, Hyeon-Joong,Shin, Eun-Joo,Lee, Byung-Hwan,Choi, Sun-Hye,Jung, Seok-Won,Cho, Ik-Hyun,Hwang, Sung-Hee,Kim, Joon Yong,Han, Jung-Soo,Chung, ChiHye,Jang, Choon-Gon,Rhim, Hyewon,Kim, Hyoung-Chun,Nah, S Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.9

Gintonin is a novel ginseng-derived lysophosphatidic acid (LPA) receptor ligand. Oral administration of gintonin ameliorates learning and memory dysfunctions in Alzheimer's disease (AD) animal models. The brain cholinergic system plays a key role in cognitive functions. The brains of AD patients show a reduction in acetylcholine concentration caused by cholinergic system impairments. However, little is known about the role of LPA in the cholinergic system. In this study, we used gintonin to investigate the effect of LPA receptor activation on the cholinergic system in vitro and in vivo using wild-type and AD animal models. Gintonin induced $[Ca^{2+}]_i $ transient in cultured mouse hippocampal neural progenitor cells (NPCs). Gintonin-mediated $[Ca^{2+}]_i $ transients were linked to stimulation of acetylcholine release through LPA receptor activation. Oral administration of gintonin-enriched fraction (25, 50, or 100 mg/kg, 3 weeks) significantly attenuated scopolamine-induced memory impairment. Oral administration of gintonin (25 or 50 mg/kg, 1 2 weeks) also significantly attenuated amyloid-${\beta}$ protein ($A{\beta}$)-induced cholinergic dysfunctions, such as decreased acetylcholine concentration, decreased choline acetyltransferase (ChAT) activity and immunoreactivity, and increased acetylcholine esterase (AChE) activity. In a transgenic AD mouse model, long-term oral administration of gintonin (25 or 50 mg/kg, 3 months) also attenuated AD-related cholinergic impairments. In this study, we showed that activation of G protein-coupled LPA receptors by gintonin is coupled to the regulation of cholinergic functions. Furthermore, this study showed that gintonin could be a novel agent for the restoration of cholinergic system damages due to $A{\beta}$ and could be utilized for AD prevention or therapy.

Potent anti-adhesion agent using a drug-eluting visible-light curable hyaluronic acid derivative

Han, Ga-Dug,Kim, Jae-Won,Noh, Seung-Hyun,Kim, Shin-Woong,Jang, Eui-Chan,Nah, Jae-Woon,Lee, Young-Gi,Kim, Mi-Kyung,Ito, Yoshihiro,Son, Tae-Il Elsevier 2019 Journal of industrial and engineering chemistry Vol.70 No.-

<P><B>Abstract</B></P> <P>Post-operative adhesion is a very serious complication in the clinical field, frequently occurring after surgery. In severe cases, reoperation may be required. In this study, a visible light-curable furfuryl hyaluronic acid derivative was prepared and combined with ibuprofen for anti-adhesion and anti-inflammatory applications. A furfuryl isocyanate moiety was introduced in hyaluronic acid affording furfuryl hyaluronic acid (F-HA). The anti-adhesion and anti-inflammatory effects of F-HA were examined in chickens at 2, 4, and 8 weeks postoperation. It was concluded that F-HA combined with ibuprofen is a suitable anti-adhesion and anti-inflammation agent.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Biocompatible, drug-loaded anti-adhesion barrier using visible-light curable furfuryl gelatin derivative

Kim, Eun-Hye,Kim, Jae-Won,Han, Ga-Dug,Noh, Seung-Hyun,Choi, Jae-Hee,Choi, ChangSun,Kim, Mi-Kyung,Nah, Jae-Woon,Kim, Tae-Yeon,Ito, Yoshihiro,Son, Tae-Il Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.120 No.1

<P><B>Abstract</B></P> <P>Recently, many of studies have been attempted to determine how to decrease adhesion. To effectively prevent adhesion, decrease in unnecessary surgical procedures, prevention of contact with other tissue, and drug treatment for inflammation are required. However, current anti-adhesion materials have disadvantages. To solve current problems, we prepared a biocompatible drug-loaded anti-adhesion barrier using a visible-light curable furfuryl gelatin derivative. We used riboflavin as a photo-initiator in the photo-curing process. The biocompatibility of riboflavin was estimated compared with that of Rose Bengal. In addition, the curing ratio was measured to determine whether riboflavin initiated photo-curing. We also evaluated the curing ratio of riboflavin according to the concentration of F-gelatin and the photo-irradiation time. A drug used to decrease inflammation that causes adhesion should not disappear from the surgical site and should also be released consistently. For this, we observed the release profiles of photo-immobilized ibuprofen with different concentrations of F-gelatin. Because an anti-adhesion barrier should protect from bacterial infection we evaluated the protective ability of a barrier formed by F-gelatin. In conclusion, a drug-loaded anti-adhesion barrier was prepared using a visible-light curable furfuryl gelatin derivative, with riboflavin as a photo-initiator. We expect that this drug-loaded anti-adhesion barrier effectively decrease adhesion formation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Riboflavin showed the better photo-curable property and biocompatibility as photo-initiator than Rose Bengal. </LI> <LI> As concentration of furfuryl gelatin and photo-irradiation time increase, the photo-curing ratio increase. </LI> <LI> Release profile of photo-immobilized ibuprofen can be controlled by changing the concentration of furfuryl gelatin. </LI> <LI> Surgical site can be protected from bacterial infection by furfuryl gelatin barrier and adhesion also can be decreased. </LI> <LI> Drug-loaded anti-adhesion barrier can protect surgical site and prevent inflammation. </LI> </UL> </P>

Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary Lesions

( Han Nah Seok ),( Eun Young Lee ),( Eun Yeong Choe ),( Woo In Yang ),( Joo Young Kim ),( Dong Yeob Shin ),( Ho Jin Cho ),( Tae Sung Kim ),( Mi Jin Yun ),( Jong Doo Lee ),( Eun Jig Lee ),( Sung Kil Li 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.1

Background/Aims: Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions. Methods: 18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed. Results: Of 24 patients with piuitary adenomas, 19 (79.2%) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50%) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7% sensitivity and 100% specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans. Consclusions: About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.