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Constrained Model Predictive Contour Error Control for Feed Drive Systems with Uncertainties
Yu Gao,Jun Huang,Liang Chen 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1
In this paper, a model predictive control algorithm is developed for the regulation problem of a biaxialfeed drive system. The orthogonal error component in the moving frame is considered as an approximation ofthe real contour error. Then, the control policy is derived from the worst-case optimization of a quadratic costfunction, which penalizes transformed errors, velocity errors and control variables in each sampling time overa finite horizon. In addition, the constraint is satisfied to ensure the convergence against uncertain but boundeddisturbances. The good performance of the proposed control algorithm is verified via computer simulations withpredefined trajectories. Furthermore, the result shows the improvement of the tracking accuracy by comparing withthe unconstrained predictive control methods
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Yu-Shuai Wang,Yin-Ping Jin,Wei Gao,Sheng-Yuan Xiao,Yu-Wei Zhang,Pei-He Zheng,Jia Wang,Jun-Xia Liu,Cheng-He Sun,Ying-Ping Wang 고려인삼학회 2016 Journal of Ginseng Research Vol.40 No.3
Background: Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. Methods: Medium-pressure liquid chromatography and semipreparative high-performance liquid chromatography were used to isolate purified compounds and their structures determined by extensive one-dimensional- and two-dimensional nuclear magnetic resonance (NMR) experiments. Results: A new saponin, namely malonyl-ginsenoside Re, was isolated from the fresh flower buds of Panax ginseng, along with malonyl-ginsenosides Rb1, Rb2, Rc, Rd. Some assignments for previously published ¹H- and <SUP>13</SUP>C-NMR spectra were found to be inaccurate. Conclusion: This study reports the complete NMR assignment of malonyl-ginsenoside Re, Rb₁, Rb₂, Rc, and Rd for the first time.
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Yu-yan Zhao,Lei Guo,Xiao-juan Zhao,Hong Liu,Tian Lei,Dong-jie Ma,Xiao-yu Gao 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.7
Osteoblasts can synthesize the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs), which may either enhance or attenuate IGF-stimulated bone cell proliferation. Since estrogen induced osteoblastic differentiation and proliferation through an estrogen- responsive gene in target cells, we investigated the effects of estrogen on IGFBP-6 expression in the human osteoblastic-like cell line SaOS-2. Expressions of IGFBP-6 protein and mRNA increased 2.8 and 2-fold, respectively, in the presence of 17-β-estradiol (E2) (0.01 to 1 μM) and estrogen receptor (ER) in SaOS-2 cells. On the other hand, E2 induced a 2-fold increase in SaOS-2 cell proliferation. To identify genomic sequences associated with estrogen responsiveness, the 5'-promoter region (-44 to +118) of the IGFBP-6 gene was cloned into a chloramphenicol acetyltransferase (CAT) reporter vector. E2 induced a 3-fold increase in CAT activity in SaOS-2 cells transiently transfected with this construct. Identification of the estrogen- responsive element (ERE) [5'-CCTTCA CCTG-3'] (-9 to +1) in this IGFBP-6 gene promoter region was confirmed using electromobility shift assays and deletion analysis. This functional ERE was important for E2-induced trans-activation of the IGFBP-6 gene. These results demonstrate that E2 exhibits a positive effect on IGFBP-6 gene transcription through estrogen- liganded ER binding to the functional ERE in the IGFBP-6 gene promoter in SaOS-2 cells. Osteoblasts can synthesize the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs), which may either enhance or attenuate IGF-stimulated bone cell proliferation. Since estrogen induced osteoblastic differentiation and proliferation through an estrogen- responsive gene in target cells, we investigated the effects of estrogen on IGFBP-6 expression in the human osteoblastic-like cell line SaOS-2. Expressions of IGFBP-6 protein and mRNA increased 2.8 and 2-fold, respectively, in the presence of 17-β-estradiol (E2) (0.01 to 1 μM) and estrogen receptor (ER) in SaOS-2 cells. On the other hand, E2 induced a 2-fold increase in SaOS-2 cell proliferation. To identify genomic sequences associated with estrogen responsiveness, the 5'-promoter region (-44 to +118) of the IGFBP-6 gene was cloned into a chloramphenicol acetyltransferase (CAT) reporter vector. E2 induced a 3-fold increase in CAT activity in SaOS-2 cells transiently transfected with this construct. Identification of the estrogen- responsive element (ERE) [5'-CCTTCA CCTG-3'] (-9 to +1) in this IGFBP-6 gene promoter region was confirmed using electromobility shift assays and deletion analysis. This functional ERE was important for E2-induced trans-activation of the IGFBP-6 gene. These results demonstrate that E2 exhibits a positive effect on IGFBP-6 gene transcription through estrogen- liganded ER binding to the functional ERE in the IGFBP-6 gene promoter in SaOS-2 cells.
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Detection of Powdery Mildew of Bitter Gourd Based on NIR/Fluorescence Spectra
Gao Jia Yu,Wei Dong Zheng,Wang Xiang,Tang Jin Cheng,Xu Ji Tong,Zhao Ping,Ning Xiao Feng 한국농업기계학회 2023 바이오시스템공학 Vol.48 No.3
Purpose Powdery mildew as one of the common vegetable diseases has very rapid infection. Its outbreak will bring about disastrous consequences to vegetable output; thus, it is of key importance to do rapid identifi cation and prevention of powdery mildew. Methods In this test, 100 bitter gourd leaves were collected as research samples, and the data of near-infrared spectra, fl uorescence spectra, and chromatic values L*a*b* , and the classic K-S algorithm was adopted to divide the sample sets; then, the quantitative forecasting and qualitative discrimination models were established. First, Pearson’s correlation analysis was carried out to fi nd the feasibility of taking a * as the modeling parameter, through cross-validation; the quantitative forecasting model was optimized by the PLSR (partial least squares regression) method. The model is also optimized by extracting the spectral feature bands using the continuous projection SPA method. Results The optimization results showed that the MSC + SPA + PLSR quantitative forecasting model of near-infrared spectra could eff ectively improve model precision, which was signifi cantly higher than that of fl uorescence spectra. Classifi cation Leaner was used to establish the quantitative forecasting model. Compared with the model of near-infrared spectra, the SPA + SVM qualitative discrimination model of fl uorescence spectra could improve the identifi cation precision of powdery mildew of bitter gourd as high as 98% through training. Conclusion This study proposed diff erent combination methods based on quantitative forecasting and qualitative discrimination and could provide a method and reference to the identifi cation of powdery mildew of bitter gourd.
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Gao Yu,Wang Lingyan,Qin Bingbing 한중경제문화학회 2023 한중경제문화연구 Vol.24 No.-
In recent years, safety recalls have occurred frequently in the biopharmaceutical industry, which affects the health of consumers. This article attempts to use the fsQCA method to draw a conclusion through the study of ESG and its quantification system, as well as the study of data samples related to MES and GMP processes, that is, MES-DPT has a positive impact on process safety management, and GMP-DPT has a positive impact on process safety. Management has a positive and positive impact, and ESG-DPT has a positive and positive impact on process safety management. Finally, this article puts forward suggestions for improving ESG-DPT, MES-DPT, GMP-DPT and the biomedical ESG-DPT model. Future research hopes to further study ESG -DPT model and ESG biomedical industry indicators.
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Government–Business Relations and Corporate Cash Holdings: Evidence from China
Gao Yu,Cai Yan,Teng Zhuoqi,Fang Yuantao 한국증권학회 2022 Asia-Pacific Journal of Financial Studies Vol.51 No.6
This study employs data of Chinese firms between 2017–2019 to explore how government–business relations affect corporate cash holdings. We find that healthy government– business relations have a significantly positive impact on corporate cash holdings. The mechanism test 2 reveals that the former affects the latter through the channel of investment opportunities. Furthermore, product market competition positively moderates the relationship between government–business relations and corporate cash holdings, but financial constraints negatively moderate this relationship.The results of our research have implications for the government to optimize the quality of governance and for enterprises to adjust their business strategies
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Yu Gao,Xuefeng Xu,Yan Liang,Dianhua Jiang,Huaping Dai 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.2
Purpose: The present study was designed to determine whether rapamycin could inhibit transforming growth factor β1 (TGF-β1)-induced fibrogenesis in primary lung fibroblasts, and whether the effect of inhibition would occur through the mammalian target of rapamycin (mTOR) and its downstream p70S6K pathway. Materials and Methods: Primary normal human lung fibroblasts were obtained from histological normal lung tissue of 3 patients with primary spontaneous pneumothorax. Growth arrested, synchronized fibroblasts were treated with TGF-β1 (10 ng/mL) and different concentrations of rapamycin (0.01, 0.1, 1, 10 ng/mL) for 24 h. We assessed m-TOR, p-mTOR, S6K1, p-S6K1 by Western blot analysis, detected type III collagen and fibronectin secreting by ELISA assay, and determined type III collagen and fibronectin mRNA levels by real-time PCR assay. Results: Rapamycin significantly reduced TGF-β1-induced type III collagen and fibronectin levels, as well as type III collagen and fibronectin mRNA levels. Furthermore, we also found that TGF-β1-induced mTOR and p70S6K phosphorylation were significantly down-regulated by rapamycin. The mTOR/p70S6K pathway was activated through the TGF-β1-mediated fibrogenic response in primary human lung fibroblasts. Conclusion: These results indicate that rapamycin effectively suppresses TGF-β1-induced type III collagen and fibronectin levels in primary human lung fibroblasts partly through the mTOR/p70S6K pathway. Rapamycin has a potential value in the treatment of pulmonary fibrosis.
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