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Yu, Suyun,Wang, Siliang,Huang, Shuai,Wang, Wei,Wei, Zhonghong,Ding, Yushi,Wang, Aiyun,Huang, Shile,Chen, Wenxing,Lu, Yin The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.4
Background: Radix et Rhizoma Ginseng (thereafter called ginseng) has been used as a medicinal herb for thousands of years to maintain people's physical vitality and is also a non-organ-specific cancer preventive and therapeutic traditional medicine in several epidemiologic and preclinical studies. Owing to few toxic side effects and strong enhancement on body immunity, ginseng has admirable application potential and value in cancer chemoprevention. The study aims at investigating the chemopreventive effects of ginseng on cutaneous carcinoma and the underlying mechanisms. Methods: The mouse skin cancer model was induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate. Ultraperformance liquid chromatography/mass spectrometry was used for identifying various ginsenosides, the main active ingredients of ginseng. Comprehensive approaches (including network pharmacology, bioinformatics, and experimental verification) were used to explore the potential targets of ginseng. Results: Ginseng treatment inhibited cutaneous carcinoma in terms of initiation and promotion. The content of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginseng and its active components well maintained the redox homeostasis and modulated the immune response in the model. Specifically, ginseng treatment inhibited the initiation of skin cancer by enhancing T-cell-mediated immune response through upregulating HSP27 expression and inhibited the promotion of skin cancer by maintaining cellular redox homeostasis through promoting nuclear translocation of Nrf2. Conclusion: According to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets, and links.
Yu-Shuai Wang,Yin-Ping Jin,Wei Gao,Sheng-Yuan Xiao,Yu-Wei Zhang,Pei-He Zheng,Jia Wang,Jun-Xia Liu,Cheng-He Sun,Ying-Ping Wang 고려인삼학회 2016 Journal of Ginseng Research Vol.40 No.3
Background: Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. Methods: Medium-pressure liquid chromatography and semipreparative high-performance liquid chromatography were used to isolate purified compounds and their structures determined by extensive one-dimensional- and two-dimensional nuclear magnetic resonance (NMR) experiments. Results: A new saponin, namely malonyl-ginsenoside Re, was isolated from the fresh flower buds of Panax ginseng, along with malonyl-ginsenosides Rb1, Rb2, Rc, Rd. Some assignments for previously published ¹H- and <SUP>13</SUP>C-NMR spectra were found to be inaccurate. Conclusion: This study reports the complete NMR assignment of malonyl-ginsenoside Re, Rb₁, Rb₂, Rc, and Rd for the first time.
Yu-shuai Wang,Min-zhe Fang,Sheng-dao Zheng,조진경,이태후 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.10
Tea is one of the most widely consumed aromaticbeverages in the world because of its taste and flavor,as well as due to many potential health beneficial properties. Metabolomics focuses on an in-depth analysis of allmetabolites in living organisms. In this study, 29 primarymetabolites and 25 secondary metabolites were identifiedusing GC/MS and UPLC-QTOF/MS, respectively. Further,PCA analysis showed conspicuous discrimination for theten varieties of green tea with metabolite profiling. Amongthem, organic acids, amino acids, flavan-3-ols, and flavonolglycosides varied greatly through checking the VIP valuesof the PLS-DA model. Moreover, the intrinsic and/orextrinsic factors characterizing each type of green tea werealso discussed. The chemical component marker derivedhere should be used as an important detection index, whileevaluating the tea quality, as well as while establishing thetea quality standard.
Chemical Vapor Deposition Growth of Graphene Domains Across the Cu Grain Boundaries
Yang Wang,Yu Cheng,Yunlu Wang,Shuai Zhang,Chen Xu,Xuewei Zhang,Miao Wang,Yang Xia,Qunyang Li,Pei Zhao,Hongtao Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.08
Many aspects in the chemical vapor deposition (CVD) growth of graphene remain unclear such as its behavior near the catalyst grain boundaries. Here we investigate the CVD growth mechanism of graphene across the Cu grain boundaries using unidirectional aligned graphene domains, which simplifies the analysis of both graphene and Cu to a large extent. We found that for a graphene domain grown across the Cu grain boundary, the domain orientation is determined by the Cu grain where the domain nucleation center is located, and the Cu grain boundary will not change the growth behavior for this graphene domain. This growth mechanism is consistent with the Custep-attached nucleation and edge-attachment-limited growth mechanism for H-terminated graphene domains and will provide more guidance for the synthesis of high-quality graphene with less domain boundaries.
Suyun Yu,Siliang Wang,Shuai Huang,Wei Wang,Zhonghong Wei,Yushi Ding,Aiyun Wang,Shile Huang,Wenxing Chen,Yin Lu 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.4
Background: Radix et Rhizoma Ginseng (thereafter called ginseng) has been used as a medicinal herb forthousands of years to maintain people’s physical vitality and is also a noneorgan-specific cancer preventiveand therapeutic traditional medicine in several epidemiologic and preclinical studies. Owing tofew toxic side effects and strong enhancement on body immunity, ginseng has admirable applicationpotential and value in cancer chemoprevention. The study aims at investigating the chemopreventiveeffects of ginseng on cutaneous carcinoma and the underlying mechanisms. Methods: The mouse skin cancer model was induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate. Ultraperformance liquid chromatography/mass spectrometry was used foridentifying various ginsenosides, the main active ingredients of ginseng. Comprehensive approaches(including network pharmacology, bioinformatics, and experimental verification) were used to explorethe potential targets of ginseng. Results: Ginseng treatment inhibited cutaneous carcinoma in terms of initiation and promotion. Thecontent of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginseng and its active components well maintained the redox homeostasis and modulated the immuneresponse in the model. Specifically, ginseng treatment inhibited the initiation of skin cancer byenhancing T-cellemediated immune response through upregulating HSP27 expression and inhibited thepromotion of skin cancer by maintaining cellular redox homeostasis through promoting nuclear translocationof Nrf2. Conclusion: According to the study results, ginseng can be potentially used for cutaneous carcinoma as achemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis withmultiple components, targets, and links.
Preparation and antimicrobial assay of ceramic brackets coated with TiO₂ thin films
Shuai Cao,Ye Wang,Lin Cao,Yu Wang,Bingpeng Lin,Wei Lan,Baocheng Cao 대한치과교정학회 2016 대한치과교정학회지 Vol.46 No.3
Objective: Different methods have been utilized to prevent enamel demineralization and other complications during orthodontic treatment. However, none of these methods can offer long-lasting and effective prevention of orthodontic complications or interventions after complications occur. Considering the photocatalytic effect of TiO₂ on organic compounds, we hoped to synthesize a novel bracket with a TiO₂ thin film to develop a photocatalytic antimicrobial effect. Methods: The sol-gel dip coating method was used to prepare TiO₂ thin films on ceramic bracket surfaces. Twenty groups of samples were composed according to the experimental parameters. Crystalline structure and surface morphology were characterized by X-ray diffraction and scanning electron microscopy, respectively; film thickness was examined with a surface ellipsometer. The photocatalytic properties under ultraviolet (UV) light irradiation were analyzed by evaluating the degradation ratio of methylene blue (MB) at a certain time. Antibacterial activities of selected thin films were also tested against Lactobacillus acidophilus and Candida albicans . Results: Films with 5 coating layers annealed at 700°C showed the greatest photocatalytic activity in terms of MB decomposition under UV light irradiation. TiO₂ thin films with 5 coating layers annealed at 700°C exhibited the greatest antimicrobial activity under UV-A light irradiation. Conclusions: These results provide promising guidance in prevention of demineralization by increasing antimicrobial activities of film coated brackets.
Use of autonomous maximal smile to evaluate dental and gingival exposure
Shuai Wang,Hengzhe Lin,Yan Yang,Xin Zhao,Li Mei,Wei Zheng,Yu Li,Zhihe Zhao 대한치과교정학회 2018 대한치과교정학회지 Vol.48 No.3
Objective: This study was performed to validate the autonomous maximal smile (AMS) as a new reference for evaluating dental and gingival exposure. Methods: Digital video clips of 100 volunteers showing posed smiles and AMS at different verbal directives were recorded for evaluation a total of three times at 1-week intervals. Lip-teeth relationship width (LTRW) and buccal corridor width (BCW) were measured. LTRW represented the vertical distance between the inferior border of the upper vermilion and the edge of the maxillary central incisors. Intraclass correlation coefficients (ICCs) for reproducibility, and the m-value (minimum number of repeated measurements required for an ICC level over 0.75), were calculated. Results: LTRW and BCW of the AMS were 1.41 and 2.04 mm, respectively, greater than those of the posed smile (p < 0.05), indicating significantly larger dental and gingival exposure in the AMS. The reproducibility of the AMS (0.74 to 0.77) was excellent, and higher than that of the posed smile (0.62 to 0.65), which had fair-to-good reproducibility. Moreover, the m-value of the AMS (0.88 to 1.05) was lower than that of the posed smile (1.59 to 1.85). Conclusions: Compared to the posed smile, the AMS shows significantly larger LTRW and BCW, with significantly higher reproducibility. The AMS might serve as an adjunctive reference, in addition to the posed smile, in orthodontic and other dentomaxillofacial treatments.