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Di-2-ethylhexyl phthalate 처리 남아프리카산발톱개구리에서의 vitellogenin 발현
박응로,이철우,류지성,남성숙,전성환,나진균,최덕일,박광식 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.1
The estrogenic potency of di-2-ethylhexyl phthalate (DEHP) using reverse transcriptase-PCR response of liver vitellogenin mRNA in male African clawed frog (Xenopus laevis) was studied. Male frogs were injected with DEHP at dose of 300 ㎍/kg and 300 mg/kg body weight through the dorsal lymph sac. After 4 days, using suitable pair of RT-PCR primers, vitellogenin mRNA induction in the liver was measured and DEHP showed vitellogenin mRNA induction in only the group treated with 300 mg/kg. Any significant histological abnormalities by the exposure of DEHP was not shown in both testis and liver.
남성숙,이철우,류지성,박응로,남규찬,류홍일,전성환,나진균,최덕일,박광식 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.2
To evaluate the arsenic effect of fish endocrine disruption, crucian carp (Carassius auratus) were treated with 0.5 mg/L and 3.0mg/L of As₂O₃ for 14 days and gonadal development was examined by histological analysis. In ovaries from female crucian carps exposed to 3.0mg/L, immature follicles and atretic follicles were appeared while various normal developmental stages of oocytes were shown in control group. Body weight and Gonadosomatic Index (GSI) of treated carp were also decreased compared to control group. However, no other significant histological changes in liver or kidney were shown in this exposure scheme, This means that reproductive organs are more sensitive than other organs and arsenic may exert endocrine disrupting effect through inhibiting the development of reproductive organ in fish.
구자민,류지성,정규혁,이철우,박응로,박광식 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4
Endocrine disruption in crucian carp (Carassius auratus) living in the branch of Han River were examined. Vitellogenin level in plasma was measured using ELISA system and aromatase mRNA level in brain was observed using RT-PCR technique. In all female fish, vitellogenin levels were in the range of 20-40㎍/ml and aromatase mRNA expression could be detected on the agarose gel after RT-PCR. However, in case of males, vitellogenin level was elevated in only one fish, while vitellogenin was hardly detected in others. Aromatase was expressed in all males although the levels were relatively lower than the level in female fish. Testis-ova and any other histological changes of reproductive organ were not shown in both sexes.
박순응(Soon-Eung Park),박문호(Moon-Ho Park),김진규(Jin-Kyu Kim),노우혁(Woo-Hyuk Roh),조성욱(Seong-Uk Cho),류지영(Ji-Young Ryu) 한국산업융합학회 2010 한국산업융합학회 논문집 Vol.13 No.3
Recently, bridges have been momenttous as not only regarding function but also concerning aesthetics. However, when beauty is considered in the bridge, it is also essential that stability and economics be considered. Besides, when considering stability, an arch bridge is one of the most stable structures. The most important element is a rise ratio when regarding beauty and economics of arch bridges. The effect of dead load and DB24 load have been considered to decide proper rise ratio. Therefore, in this study, examined the value of moment, displacement and member forces, in the variation of the rise ratio of arch bridges. The most optimum shape of Nielsen arch bridges has determined by analyzing member forces, moments and displacement with parameters of rise ratio and angle of vertical members. By comparison between values, the hanger types have been also considered to derive the optimum shape of Nielsen arch bridge.
Porcine nuclear transfer using somatic donor cells altered to express male germ cell function
Roh, Sangho,Choi, Hye-Yeon,Park, Sang Kyu,Won, Cheolhee,Kim, Bong-Woo,Kim, Jung-Hyun,Kang, Hoin,Lee, Eung-Ryoung,Cho, Ssang-Goo CSIRO Publishing 2009 Reproduction, fertility, and development Vol.21 No.7
<P> Recent studies reported that the direct transformation of one differentiated somatic cell type into another is possible. In the present study, we were able to modulate the cell fate of somatic cells to take on male germ cell function by introducing cell extracts derived from porcine testis tissue. Fibroblasts were treated with streptolysin O, which reversibly permeabilises the plasma membrane, and incubated with testis extracts. Our results showed that the testis extracts (TE) could activate expression of male germ cell-specific genes, implying that TE can provide regulatory components required for altering the cell fate of fibroblasts. Male germ cell function was sustained for more than 10 days after the introduction of TE. In addition, a single TE-treated cell was injected directly into the cytoplasm of in vitro-matured porcine oocytes. The rate of blastocyst formation was significantly higher in the TE-treated nuclear donor cell group than in the control cell group. The expression level of Nanog, Sox9 and Eomes was drastically increased when altered cells were used as donor nuclei. Our results suggest that TE can be used to alter the cell fate of fibroblasts to express male germ cell function and improve the developmental efficiency of the nuclear transfer porcine embryos. </P>
( Nam Kyung Roh ),( Song Hee Han ),( Min Jung Kim ),( Gyeong-hun Park ),( Bark-lynn Lew ),( Eung Ho Choi ),( Hyun Chang Ko ),( Young Lip Park ),( Sang Wook Son ),( Young Jun Seo ),( Yang Won Lee ),( S 대한피부과학회 2016 Annals of Dermatology Vol.28 No.6
Background: Physicians can play a crucial role in the knowledge that patients have about a disease and its prognosis. Recently, patients with atopic dermatitis (AD) are increasingly turning from western medicine to oriental herbal medicine. However, their awareness of AD and attitude toward Western medicine and oriental herbal medicine clinics are scarcely reported. Objective: The aim of this study was to determine the understanding of AD among patients and their parents and to identify their awareness of and attitude toward Western medicine and oriental herbal medicine as treatments for AD. Methods: An online questionnaire was administered to 500 consenting respondents with AD (age, 16∼49 years) and parents of children with AD (age, 0∼15 years). Results: The mean percentage of correct answers to questions about AD was 52.54%. A parental history of AD was independently associated with higher respondent`s knowledge about the disease and its treatment. The satisfaction with treatment outcomes was highest among patients treated at private clinic of dermatology specialists (49.4%), while lowest among those treated at oriental herbal medicine clinics (38.4%). Many participants were aware that oriental herbal medicine requires a longer treatment period for a cure and does not burden the skin, while steroid phobia was seen in most of participants. Conclusion: Physicians need to educate AD patients and their parents about the disease and its treatment. Misconceptions for Western medicine and oriental herbal medicine among AD patients and parents should be corrected to improve their prognosis. (Ann Dermatol 28(6) 725∼732, 2016)
증례 : 순환기 ; 영구적 심장 박동 조율기 이식 후의 재발성 리드(lead) 파손(fracture)과 완전 이탈 1예
노승영 ( Seung Eung Roh ),박희남 ( Hui Nam Park ),김지박 ( Ji Bak Kim ),문재영 ( Jae Young Moon ),이광노 ( Kwnag No Lee ),김영훈 ( Young Hoon Kim ) 대한내과학회 2010 대한내과학회지 Vol.78 No.6
우리는 완전 방실 차단 환자에서 반복적으로 발생한 유도절단과 이탈을 확인하였으며, 그 이유로 환자가 버스 운전을 하면서 과도하게 팔을 움직인 것과 삽입시 접근 방법을 생각해 볼 수 있었다. 새로운 유도를 겨드랑이 정맥 접근법으로 삽입하고 직업을 교체함으로써 문제는 해결되었다. With the increased use of implantable cardiac devices, the incidence of hardware problems has also increased. Some of the hardware problems might be induced by patient factors. We experienced recurrent pacemaker lead fracture and dislocation after permanent pacemaker implantation. The patient was a bus driver who used his left arm vigorously when he turned the steering wheel. After a new lead was inserted via an axillary vein approach and the patient changed his occupation, no more lead problems have occurred. When a recurrent hardware problem with an implantable pacemaker or defibrillator occurs, patient factors related to anatomy or behavior must be considered. (Korean J Med 78:747-750, 2010)
박왕견(Wang Kyun Park),김응(Eung Kim),김준명(June Myeong Kim),박형근(Hyung Geun Park),노형근(Hyung Geun Roh),홍천수(Chein Soo Hong) 대한내과학회 1989 대한내과학회지 Vol.37 No.4
N/A Salmonellosis is an infection caused by bacteria of the genus Salmonella, which consists of more than 2,000 serotypes. The clinical syndromes they prduce are gastroenteritis, enteric fever, bacteremia with and without focal extra-intestinal infection, and the asymptomatic carrier state. Reports concerning the simultaneous isolation of more than one Salmonella type from the same individual are not unusual. But dual infection including Salmonella typhi, which is considered to be a humanspecific pathogen, is rare. We report a case of dual Salmonella infection of Salmonella typhi and Salmonella paratyphi A in a 39 -year-old female, which was confirmed by blood, bone marrow and stool culture.