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Won Hui Do,이철재,김동엽,Maeng Joon Jung 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.6
In this study, the 2-mercaptopyridine (2-MPY) and 4-mercaptopyridine (4-MPY) on to silver mirror and silver sol substrates have been studied by surface enhanced Raman scattering (SERS). The surface enhanced properties of 2-MPY and 4-MPY showed that the substrate of silver mirror was superior to the sliver sol. The silver mirror and silver sol substrates were prepared by Tollen’s and gamma irradiation method respectively. UV-visible spectra indicate that Ag nanoparticles were produced by this method. Considerable differences were found in the SERS spectra of 2-MPY and 4-MPY molecules onto silver mirror and silver sol substrates. From the analysis of the SERS data, it was evidenced that 2-MPY was chemisorbed through its S atom to Ag surfaces at a perpendicular orientation, whereas 4-MPY was bonded to Ag surface via the S atom and N atom assuming a tilted orientation.
연안개발공사로 인한 부유토사의 환경 악영향 저감방안 고찰
송원오,진재율,채장원,안희도,맹준호,오재경,Song, Won-Oh,Jin, Jae-Youll,Chae, Jang-Won,Ahn, Hee-Do,Maeng, Jun-Ho,Oh, Jae-Kyung 한국해양과학기술원 2003 Ocean and Polar Research Vol.25 No.suppl3
Coastal development works generally increase the suspended sediment concentration of the ambient water, causing environmental impacts in various manners. The most active measures in three sides have been reviewed for their applicabilities in Korea. Referring to the cases in the USA, the legislation of environmental windows seems to be not proper for Environmentally Sound and Sustainable Developments (ESSD) until sufficient scientific data are obtained to address the individual issues of potential negative impacts. Feedback monitoring can be regarded as the best way for ESSD. Korea also has the basic legal system for the feedback monitoring as well as Environmental Impact Assessments (EIA). However, the frequency, period and parameter of related surveys should be improved for the true ESSD. Moreover, environmental facilities such as environmental dredgers should be widely used for mitigating environmental Impacts caused by coastal development works.
Antitumor activity of ZD6474 in a metastatic orthotopic brain tumor model.
Kong, Doo-Sik,Kim, Mi-Hyun,Jeon, Ji-Won,Kim, Shi-Yeon,Kim, Maeng Sup,Joo, Kyeung Min,Park, Kwan,Nam, Do-Hyun D. A. Spandidos 2008 MOLECULAR MEDICINE REPORTS Vol.1 No.3
<P>The objective of this study was to examine the antitumor effect of ZD6474, an orally available inhibitor of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the epidermal growth factor receptor (EGFR), on tumor growth in an orthotopic metastatic brain tumor model. In order to determine the antitumor mechanism of ZD6474 treatment, in vitro and in vivo studies were performed. Human breast carcinoma cells (MDA-MB-435) were injected using direct intracranial (IC) inoculation (5x105 cells/100 ?l) and internal carotid artery (ICA) injection (5x104 cells/100 ?l) in Balb/c-nu female mice. Daily oral treatment with ZD6474 (50 mg/kg) was initiated on day 14 after the establishment of micrometastasis. Mice (n=12 per group) were sacrificed on day 28. Western blot analysis revealed that the autophosphorylation of EGFR and Akt was increasingly decreased with ZD6474 treatment in lung and brain endothelial cells and the MDA-MB-435 cell line. MTT assay also showed that the in vitro antitumor activity of ZD6474 was dependent on EGFR tyrosine kinase inhibition at a higher dose. Daily oral treatment with ZD6474 led to marked inhibition of metastatic tumor growth in the ICA injection and the direct IC inoculation models (median size 3.5 mm3, range 1.6-13.9 mm3) as compared to the control group (median size 62.4 mm3, range 11.5-206.9 mm3). These results suggest that simultaneous inhibition of both the EGFR and VEGFR-2 signaling pathways has a valuable therapeutic effect through its inhibition of the growth of metastatic brain tumors.</P>