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이금단,오상우 圓光大學校 醫科學硏究所 2001 圓光醫科學 Vol.16 No.1-2
배경 : MMPI는 임상장면에서 가장 유용한 진단도구 중의 하나로 알려져 왔다. 본 연구에서는 정신과에 입원하고 있는 정신분열증 환자들의 MMPI 프로파일이 어떤 유형들로 분류되는 지를 알아보고, 이에 따라 분류된 MMPI 프로파일 유형을 토대로 분할점을 제시하고자 하였으며, 각 프로파일 유형에 따른 내용척도, 인구통계학적 특징 및 증상들을 살펴보았다. 방법 : 본 연구의 대상은 1998년 1월부터 2000년 8월까지 원광대학교병원 신경정신과에 입원하여 임상심리검사에 의뢰된 환자들 중 임상심리전문가와 정신과 주치의에 의해 정신분열증으로 진단된 환자 61명으로 남자 37명, 여자 24명으로, 이들의 MMPI와 정신분열증 프로토콜 자료를 수집하여 분석 하였다. 결과 : 정신분열증으로 입원한 환자들을 대상으로 하여 MMPI 상에서 분할점을 T점수 65점으로 잡았을 때 이들은 F-6은 유형을 보였고, 군집분석결과, 잠재성 정신분열증 유형, 편집형 정신분열증 유형 및 정상 유형이 확인되었다. 의뢰사유에 있어서는 불안/신경예민, 짜증, 과대망상에서만 각 군집간에 차이를 보였다. 결론 : 입원한 정신과 환자 중 MMPI의 F-6-8 척도치가 T점수 65점 이상을 보이는 경우에는 정신분열증으로 진단을 내릴 수 있음이 확인되었다. 그렇지만 정신분열증 환자 집단은 동질적인 특성을 지닌 집단이 아니라 이질적인 특성을 지닌 집단이므로 이들에 대한 치료와 재활을 제대로 수행하기 위해서는 환자의 개별적인 정신병리와 성격특성을 우선 파악하는 것이 중요하다. Background : The MMPI has known one of the most powerful diagnostic tools in clinical setting. This study was to identify the distinct MMPI profile, the cut-off score and chief complaints in inpatients with schizophrenia. Methods : 61 patients with schizophrenia (male 37, female 24) administered the MMPI and Symptom Check Lists were collected by the authors. Results : The MMPI profile of patients with schizophrenia showed F-6-8 profile and 65 T was identified as the cut-off score. K-mean cluster analysis showed three sub-clusters, which were latent schizophrenia profile, paranoid schizophrenia profile and normal profile. And only a few chief complaints were found the differences among sub-clusters. Conclusion : This study concluded that elevations above 65 T in F-6-8 profile could be diagnosed as schizophrenia. However, patients with schizophrenia are not homogeneous but heterogeneous. Thus, it is suggested that their individual psychopathology and psychological characteristics should be examined prior to therapy or rehabilitation.
High Pressure Liquid Chromatography를 이용한 인진호의 유효성분 확인
박남선,박성옥,안영은,이진희,장수자,정은진,지경단 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-
In present day, components of Artemisiae Carpillaris Herba(A.C.H) was investigated by HPLC method. On condition of ODS-10column, 25% acetonitrile for mobile phase, 254nm of UV Detector, the extracts of A.C.H was analyzed. As the result, peaks of coumarin derivatives, at retention time 2.16 and 2.18, were found.
급성 구강감염부위에서 Staphylococcus lugunensis 의 특성
유용욱,이미성,차정단,김기경,신상희,문상은,김강주 원광대학교 생명공학연구소 1999 생명공학연구소보 Vol.6 No.1
Staphylococcus lugdunensis (S. lugdunensis) is a newly identified pathogenic species of coagulase negative staphylococci and an occasional but not rare cause of severe infections, such as infective endocarditis after dental extraction, bacteremia, osteomyelitis, peritonitis, and soft tissue infections. As antibiotic use increased, resistance rapidly developed. Some strains have plasmids related to antibiotic resistance. To characterize S. lugdunensis in acute oral infection, S. lugdunensis was isolated from the patients with acute oral abscess, osteomyelitis, and normal persons. Antibiotic resistance, in vitro cellular toxicity, in vivo virulence, δ-like hemolysin activity, and synergistic hemolysis on sheep blood agar plates were investigated. The dot blot analysis and Southern blot analysis of staphylococcal DNA was performed with δ-hemolysin gene probe of Staphylococcus aureus. (S. aureus) Staphylococcal DNA was cloned, nucleotide sequence was analysed, and homology was compared with other sequence in Gene Bank. S. aureus, S. lugdunensis, Staphylococcus cohnii (S. cohnii), and other coagulase negative staphylococci (CNS) were isolated from the patients with acute oral infection. The isolation ratio of S. lugdunensis in the patients with infection was higher than that of healthy persons, but the isolation ratio of S. aureus in the patients with infection was similar to that of healthy persons. S. lugdunensis from the patients with acute oral infection showed the resistance to penicillin, methicillin, cephalothin, and clindamycin. S. lugdunensis in the patients had cellular toxicity in vitro and virulence in vivo. All strains of S. lugdunensis had δ-like hemolysin activity against rabbit erythrocytes. Four of the six strains of S. lugdunensis gave synergistic hemolysis with S. aureus on sheep blood agar plates. In dot blot analysis, all strains of S. lugdunensis showed the positive reaction with the probe of δ-hemolysin gene in S. aureus, but a 7.3 kb HindⅢ fragment was observed in the DNA of S. lugdunensis that gave synergistic hemolysis in a Southern blot analysis. The molecular size of partially purified δ-hemolysin was about 50 kd. The cloned fragments from the chromosomal DNA of S. lugdunensis showed the partial homology with the insulin receptor-related and dopamine receptor of humans. These results suggest that S. lugdunensis might be an important pathogen in acute oral infection and show some homology with eukaryotes.
ESHAP Salvage Therapy for Refractory and Relapsed Non-Hodgkin`s Lymphoma: A Single Center Experience
( Sang Hyoung Park ),( Shin Kim ),( Ok Bae Ko ),( Ja Eun Koo ),( Dan Bi Lee ),( Yong Pil Jeong ),( Joo Ryung Huh ),( Sung Bae Kim ),( Sang We Kim ),( Jae Lyun Lee ),( Cheol Won Suh ) 대한내과학회 2006 The Korean Journal of Internal Medicine Vol.21 No.3
Background: The ESHAP chemotherapy regimen, that is, the combination of the etoposide, methylprednisolone, high-dose cytarabine and cisplatin, has been shown to be active against relapsing or refractory non-Hodgkin`s lymphoma (NHL) in previous therapeutic trials. We attempted to determine whether ESHAP therapy would be effective and well-tolerated in Korean patients. Methods: Twenty two patients with refractory or relapsed NHLs (all aggressive types) were enrolled in this study. We retrospectively evaluated the treatment response, the survival rate and the time to progression. Results: Six patients (27.3%) attained complete remission and eight patients (36.4%) attained partial remission. The overall response rate was 63.6%. The median survival duration was 15.5 months (95% confidence interval; 10.7 to 20.3 months), and the median duration of the time to progression was 8.3 months (95% confidence interval; 0.3 to 16.3 months). Myelosuppression was the major toxicity, but severe neutropenia or thrombocytopenia was rare, and renal toxicity was also infrequent. Conclusions: ESHAP regimen is effective in Korean patients suffering with relapsed or refractory NHLs, but a more effective salvage modality is needed because of the short duration of remission and the insignificant impact on long-term survival.