Effects of Biologically Active Substances in Natural Products on the Hepatic Detoxication Mechanism : In Vivo Production and Enzyme-Inducing activity of Indolo[3,2-b]carbazole

Kwon,Chong-Suk(권정숙),Grose,Karl R,Riby,Jacques,Chen,Yue-Hwa,Bjeldanes,Leonard F. 韓國營養學會 1994 Journal of Nutrition and Health Vol.27 No.4

죽순대숯의 製造에 關한 硏究

권수덕,박종열 경상대학교 농업생명과학연구원 2001 농업생명과학연구 Vol.35 No.-

재질이 연하고 할렬성이 나빠 왕대나 솜대에 비해 죽세가공용으로 이용되지 못하고, 또는 죽순으로서의 이용 외에 버려지거나 방치되고 있는 죽순대의 부가 가치를 높이고자 대나무숯을 제조하고자 하였다. 이를 위해 본 연구에서는 산업용 대나무숯 탄화로 개발, 제탄스케줄 구명, 대나무의 형태별 대나무숯 제조에 따른 탄화율 및 제탄수율 조사 등을 통하여 죽순대에 대한 제탄기술 확립 및 이ㆍ화학적 성질을 구명하였으며 그 결과는 다음과 같다. 탄화로는 점화부, 탄화실, 배연부, 제어부의 4부분으로 이루어지며 용량 2㎥로 초고온 단열재와 스텐인레스 및 철재, 가열버너, 콘트롤박스 등을 조합하여 제작하였다. 또한 400℃-1,300℃까지 대나무숯 제조가 가능하며 산업용 탄화로의 특성과 제원을 구명하였다. 죽순대숯의 제조 스케줄은 적재→점화→탄화→정련→밀폐→냉각→출탄의 7단계를 기본으로 하며, 제탄시간은 입자숯 37.25시간, 조각숯 19.25시간, 마디숯 18.20시간, 통대숯 17.50시간, 제탄온도는 4형태별 모두 800℃-1,000℃였다. 1,000℃ 부근의 고온에서 죽순대의 탄화율 및 제탄수율을 조사한 결과, 탄화율 20.1-23.2%, 제탄수율 13.5-16.9%로서 일반목탄의 탄화율 20-25% 보다는 낮고, 참숯의 흑탄 제탄수율 15-20%보다는 회수율이 낮았으며, 참숯 백탄수율 12-14%보다는 높음을 알 수 있었다. 죽순대숯의 이ㆍ화학적 성질을 조사한 결과, 정련도는 낮고(0) 경도는 높아져(8) 단단한 숯을 얻을 수 있었다. 수축율과 보수력은 탄화온도의 상승과 함께 증가하였다. 그리고 일반목탄에 비해 수분이 5.3%정도로 적고 회분 함량은 4.1%에 달하였다. 탄화온도가 높아 질수록 휘발분은 10.2%로 감소하고 고정탄소는 80.4%로 증가하였다. For types of bamboo specimens such as particle, flat, short roll and long roll using Phyllostachys pubescens were burned and carbonized at the high(about 1,000℃) temperatures. Carbonization schedule on the process, time and temperature were investigated. The physical and chemical properties of these charcoals were analyzed. The microscopic observation of the charcoals was also carried out by a scanning electron microscope. Special properties such as absorptivities of gases and heavy metals, purification abilities of tap water and effects of far-infrared ray and anion emission and antibacterial were examined. Industrial carbonization kiln consists of four parts such as air controller, carbonizing chamber, chimney and control box. Loading box for supplying bamboo is laid in the chamber. Carbonization process for making P. pubescens charcoal has seven steps of charging→ignition→carbonization→refining→sealing→cooling→discharging, and bamboo charcoals are made in 18 to 37 hours of carbonization time and from 800℃ to 1,000℃ of carbonization temperature. Physical properties of P. pubescens charcoals showed 20.1% to 23.2% in carbonization ratio, 0 in refining degree, 8 in hardness. Shrinking ratios were 24.0% in length and 18.3% in thickness. Charcoal yield was about 13.5-16.9%. Roll type of bamboo showed a little higher yield that particle type of bamboo. A chemical analysis of P. pubescens charcoals showed 5.3% in water, 4.1% in ash, 10.2% in volatile material and 80.4% in fixed carbon.

X선 촬영인자의 변화에 따른 영상의 주관적인 화질 평가

권덕문,박명환,김성환,박종삼,이준일,남효덕 대구보건대학 2001 대구보건대학 論文集 Vol.21 No.-

In this study, visual recognition of X-ray images were estimated using hawlet charts. The resolution has achieved excellent result when densities of film were 1.0~1.5. The more thickness of object was increase, the more the resolution was decrease, because scattered X-ray were increased. The more distance of object to film was increase, the more the resolution was decrease, because groedel effect. The more focal spot size was increase, the more resolution was decrease, because unsharpness was increase. The more field size was increase and grid ratio was decrease, the more resolution was decrease, because scattered X-ray were increase. As a result, we could to improve image quality by determination of resolution according to Radiography parameters. And, we proved that hawlet charts were useful for estimate of image quality and set up x-ray radiography.

독도의 국제법적 지위

권문상,최정옥 인천대학교 법학연구소 2000 仁川法學論叢 Vol.3 No.-

韓國人에서 多重增幅 重合酵素反應으로 分析한 STRs 遺傳座位의 遺傳的 多樣性

권국환,이혜린,박종진,황적준,이희석,송은섭 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

The tetrameric STRs loci were studied in a population of Korean(n=223) for allele frequency distribution and applicability to identity and paternity testing, using multiplex PCR with electrophoresis of the PCR products in DNA sequencing gels and subsequent detection of allelic fragments by silver staining. The STRs loci analyzed were HUMCSF1PO, HUMTPOX, and HUMTHO1 ; in the Korean population, 9 alleles with their frequency range of 0.002-0.363 are detected in the HUMCSF1PO, 5 alleles with those of 0.020-1.480 in the HUMTPOX, and 6 alleles with those of 0.002-0.489 in the HUMTHO1. The highest observed heterozygosity is found at the locus HUMCSF1PO(0.709), those of the loci HUMTPOX and HUMTHO1 being 0.646 and 0.632, respectively. All loci meet Hardy-Weinberg expectations ; there are good agreement between the observed and expected values under Hardy-Weinberg equilibrium. Moreover, pairwise comparisons between loci show allelic independence for all the 3 loci comparisons. The power of discrimination (PD) determined for the locus HUMCSF1PO is 0.8896 (88.96%), that of the HUMTPOX is 0.8818(88.18%), and that for the HUMTHO1 is 0.8367(83.67%) ; the combined power of discrimination for the triplex is 0.9976(99.76%). The power of exclusion(PEX) calculated for the loci HUMCSF1PO, HUMTPOX, and HUMTHO1, being prior probability that a falsely accused father will be excluded, and 0.5173(51.73%), 0.4610(46.10%), and 0.5101(510.01%), respectively, and the cummulative power of exclusion(CPE) for all the three loci is 0.8726(87.26%). Thus, these allelic frequency data can be used to construct the database of the multiplex PCR-based DNA profile in the Korean population. The calculated parameter, "power of discrimination(PD)" and "power of exclusion(PEX)", show the informativeness of these loci for the determination of identity and relatedness of individuals.

몇 가지 전이금속, Ni(II) 및 Zn(II) 3,6-bis(2'-pyridyl)pyridazine 착 화합물들의 세포 독성효과

권병목,이정옥,최상운,성낙도 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

A series of cytotoxic activities (ED_(50)) in vitro against six human cancers (lung cancer, uterine cancer, skin cancer, brain cancer, colon cancer and adenocarcinoma) and their seventeen cell lines of 3,6-bis(2'-pyridyl)pyridazine, 1, 3,6-bis-(6'-methyl-2'-pyridyl)pyridazine, 2 and their transition metal, Ni(II), Cu(II) and Zn(II) complexes, 3~6 were measured. Particularly, the results revealed that the cytotoxic activities against the brain cancer cell line (SNB-19) and the colon cancer cell line (SW62) of bis-[3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-k^(2)N^(2),N^(3)]chlorocopper(II)perchlorate, 4 were shown to be higher than that of the first generation anticancer agent, Cis-platin. 6종의 인체 암(폐암, 피부암, 결장암, 자궁암, 선암 및 뇌암)과 그의 17가지 세포주들에 대한 리간드 화합물 3,6-bis(2'­pyridyl)pyridazine(1)과 3,6-bis(6'-methyl-2'-pyridyl)pyridazine(2) 그리고 그들의 전이금속(Ni(II), Cu(II) 및 Zn(II)) 착 화합물들 (3~6)의 세포독성을 각각 측정하였다. 그 결과, 특히 Cu(II) 착화합물, bis-[3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-k^(2)N^(2),N^(3)]chlorocopper(II)perchlorate (4)는 뇌암(SNB-19)과 결장암(SW-62) 세포주에 대하여 제1세대 항암제인 Cis-platin보다 높은 세포독성을 나타내었다.

中性子 및 감마線에 대한 線量率 換算因子 計算

權奭根,李秀容,陸鍾澈 대한방사선 방어학회 1981 방사선방어학회지 Vol.6 No.1

This paper presents flux-to-dose-rate conversion factors for neutrons and gamma rays based-on the Americaan National Standard Institute(ANSI) N666. These data are used to calculated the dose rate distribution of neutron and gamma ray in radiation fileds. Neutron flux-to-dose-rate conversion factors for energies from ?? to 20 MeV are presented; the corresponding energy range for gamma rays is 0.01 to 15Mev. Flux-to-dose-rate conversion factors were calculated, under the assumption that radiation energy distribution has nonlinearity in the phantom, have different meaning from those values obtained by monoenergetic radiation. Especially, these values were determined with the cross section library. The flux-to-tose-rate conversion factors obtained in this work were in a good aggreement to the values presented by ANSI. Those data will be a useful for the radiation shielding analysis and the radiation dosimetry in the case of continuous energy distribution.

복부 X선촬영에서의 결석의 확대율 검토

권덕문,박종삼,박명환,이준일 대구보건대학 1995 대구보건대학 論文集 Vol.15 No.-

This experiment was done in order to give some help for stone doigonosis. After calculating theoretical value and interposition stone at the phantom which set at the same position with human and radiography, we compared both magnification degree and the conclusion is like this. 1. The average distance from dorsal to kidney pelvis is 7.7㎝, to middle ureter is 11. 1㎝ and to ureter bladder jucntion is 9.5㎝. 2. In the case of the same abdomen thickness, the distance error at each part and in personal was ± 5%. 3. Magnification degree at each part of abdomen was shown that it was 1.17 times at kidney plvis, 1.12 times at middle urter and 1.2 times ureter bladder junction.

Star Test Pattern을 이용한 X-선관 등가초점의 측정

권덕문,박종삼,이준일,남효덕 대구보건대학 1999 대구보건대학 論文集 Vol.19 No.-

In this study, equivalent focal spot sizes of X-ray tube were measured by star test pattern. As a result, the focal size was proportional to tube current and inversely proportional to tube voltage. Although tube current was increased the focal size was almost constant, when tube voltage is large than 80kVp. And, focal size was more increased at high tube current or low tube voltage. Resolution was more excellent if focal size was small. We confirmed what the radiation energy was distributed as edge band distribution in focus, because the intensity of energy at side was larger than in center.

유치 수복물에 따른 주변 법랑질의 탈회 저항성 : QLF를 이용한 연구

권해숙,현홍근,김영재,김정욱,장기택,김종철,한세현,이상훈 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구에서는 유치 수복물의 불소 방출 여부에 따른 주변 법랑질의 탈회 저항성과 재광화 효과를 살펴보고자 하였다. 건전 유전치 48개를 16개씩 임의로 세 군으로 나누어, FiltekTM Z250(1군), F2000(2군), KetacTM N100(3군)을 사용하여 제조사의 지시에 따라 충전하였다. 3일 동안 인공 우식 병소를 유발한 후, 14일 동안 인공 타액에 담가 재광화를 유발하였다. Quantitative light-induced fluorescence(QLF)를 이용하여 실험 단계와 시간에 따른 무기질 소실량(ΔQ)의 변화를 관찰한 결과는 다음과 같다. 1. 탈회가 일어난 인공 우식 병소의 ΔQ 값은 3군, 2군, 1군 순으로 작게 나타났고, 이 중 3군은 1군에 비해 유의한 탈회 저항성을 보였다. 2. 1군, 2군, 3군 모두 재광화 1일 후부터 초기 인공 우식 병소의 ΔQ 값과 비교 시 유의한 차를 보였으며, 관찰 기간 동안 지속적인 증가 양상을 나타내었다. 3. 재광화 속도를 의미하는 Δ(ΔQ)/일 값은 각 군에서 처음 1일 동안 유의성 있게 크게 나타났으며, 그 이후 급속히 감소하였다. 4. 수복 재료에 따른 재광화 정도는 각 군 간에 유의한 차이가 없었다. The objective of this in vitro study was to detect and monitor demineralization and remineralization of primary teeth according to restorative materials using quantitative light-induced fluorescence (QLF). A single bur hole was drilled on the each sound forty eight primary anterior teeth, and the specimens were divided into three groups. The cavity was restored with FiltekTM Z250(Group 1), F2000(Group 2), KetacTM N100(Group 3) following the manufacturer's instructions. The teeth were subjected to the demineralizing buffer for 3 days, and then subjected to a remineralizing buffer for 14 days. The change of mineral loss(ΔQ) according to the stages was evaluated by QLF and the following results were obtained: 1. When demineralization was done, ΔQ was increased as follows. : Group 1 (-110.79 ± 27.77) < Group 2 (-104.84 ± 28.95) < Group 3 (-90.16 ± 21.87) : Resistance to demineralization was statistically significant in Group 3. 2. There was a statistically significant increase in ΔQ of all groups since 1st day of remineralization 3. The rate of remineralization, Δ(ΔQ)/day, showed significant high value in each group on the 1st day then decreased rapidly. 4. There was no statistically significant difference in the degree of remineralization among restorative materials.