형제에 발생한 Achalasia 2예

최층언(Choong Eon Choi),김인철(In Cheol Kim),박영식(Young Sik Park) 대한외과학회 1995 Annals of Surgical Treatment and Research Vol.48 No.4

소아외과 질환 1,639예에 대한 임상적 고찰

최충언(Choong Eon Choi),김인철(In Cheol Kim),박영식(Young Sik Park),조평래(Pyung Rae Cho) 대한외과학회 1995 Annals of Surgical Treatment and Research Vol.49 No.5

An Open Gradient Magnetic Separator Assembled Using NdFeB Magnets for a Use of Fine Particles Remover

Eon Byung Park,Seung Duck Choi,Choong Jin Yang,Won Sub Lee 한국자기학회 1998 Journal of Magnetics Vol.3 No.3

A drum type magnetic separator was designed and optimized by computer simulation. The separator consisted of rotating outer shell of drum, magnetic flux generator drum which was assembled with numbers of disk type magnet holders, and drum axis around which the magnet holders were fixed. NdFeB magnet blocks were inserted into the disks, and the disks were assembled layer by layer along the drum axis. Magnetic circuits of the separator were simulated on the basis of highest magnetic strength, least cost, and high yield of separation by using a Vector Field S/W employing the Opera-2D program. The separator proved a separation yield of 95% in removing fine iron-base particles, and installed at Hot Rolling Mill of Pohang Iron & Steel Co. in Korea.

Nanoparticle Phosphors Synthesized by Inductively Controlled Plasma Process for Plasma Based Display

Yang, Choong-Jin,Park, Jong-Il,Choi, Seung-Dueg,Park, Eon-Byeong,Lee, Young-Joo The Korean Ceramic Society 2008 한국세라믹학회지 Vol.45 No.7

Optimized volume production of nanoscale phosphor powders synthesized by radio frequency (RF) plasma process was developed for the application to plasma display panels. The nano powders were synthesized by feeding the both solid and liquid type precursors, and nanoparticle phosphors were characterized in terms of particle size, shape, and photoluminescence (PL) intensities. Computer simulation was performed in advance to determine the process parameters, and nano phosphors were evaluated by comparing with current commercial micron-sized phosphor powders. Practical feeding of both solid and liquid type precursor was proved to be effective for volume production.The developed process showed a potential as a production method for red, blue and green phosphor although the PL intensity still needs further improvement.

2경간 연속 강합성거더의 개선된 부정정력 계산 방법

지구삼,김충언,신동기,최동호,Ji, Gu Sam,Kim, Choong Eon,Shin, Dong Ki,Choi, Dong Ho 대한토목학회 2013 대한토목학회논문집 Vol.33 No.2

k-factor법은 합성교량의 설계에서 부정정 응력을 산정하는 방법으로 널리 사용되고 있다. 이 방법의 적정성을 평가하기 위하여 2경간 연속 강합성거더에 대하여 등가하중법과 비교하였다. k-factor법은 크리프에 대해서는 강재응력을 과소평가하고, 부모멘트 구간에서는 응력의 방향을 반대로 산정하며, 건조수축이나 온도차에 대해서는 단면변화를 고려하지 못하는 것을 확인하였다. 이 논문에서는 k-factor법의 정확성을 개선하면서, 계산의 편리성은 유지할 수 있는 j-factor법을 제안하였고, 그 효과를 2경간 연속 강합성거더에 적용하여 검증하였다. The k-factor method has been widely used in design of steel-concrete composite bridges to determine indeterminate stresses. The accuracy of k-factor method is examined by a comparative analysis with the equivalent load method in a continuous 2-span composite bridge. To improve the accuracy, the direction of creep stress has to be modified and the variety of section must be considered. This paper suggests j-factor method which can improve the accuracy of k-factor method with simple modification.

Synergic Effect of Trimebutine Combined with Mosapride on Gastrointestinal Dysfunction and Visceral Pain Induced in Stress Models

( Young Joon Park ),( Uy Dong Sohn ),( Ji Hoon Jeong ),( Yoon Hee Chung ),( Sung Up Choi ),( Moo Yeol Lee ),( Eon Sub Park ),( Hyun Dong Je ),( Yun Sung Nam ),( Choong Ho Lee ),( Yong Sul Park ),( Zoo 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.1

The present study was undertaken to determine whether combined treatment with prokinetic trimebutine and mosapride has a synergic effect on gastrointestinal motility and visceral pain associated with gastrointestinal dysfunction. To develop effective gastroprokinetic agents with greater potencies than trimebutine or mosapride for the treatment of gastrointestinal tract disease, a mixture of trimebutine and mosapride was designed and prepared. In the present study, treatment with trimebutine alone showed a dose-dependent effect on propelling movements of normal small and large intestine in mice, whereas mosapride effected only small intestine motility. Co-administration of trimebutine with mosapride, a well-established prokinetic drug, produced a synergistic influence on normal small intestine motility, but demonstrated an unclear effect on large intestine motility, with a slight tendency to reduce the propelling time. In a stress model, the small and large intestine motilities were significantly decreased. The reduction of intestine motility was restored to a normal level and the restoring effect was more pronounced in the combined treatment with trimebutine plus mosapride than treatment with trimebutine or mosapride alone. Furthermore, treatment with trimebutine plus mosapride significantly decreased acute visceral pain which was not controlled by trimebutine or mosapride alone. These data suggest that combination therapy with trimebutine plus mosapride has a synergic effect on small and large intestine motility and visceral pain control in gastrointestinal disorders

Mycoplasma pneumoniae의 분리 및 항생제 감수성 검사(III)

장명웅,김광혁,박인달,송갑영,김성원,이은영,김문찬,조명훈,김규언,최충언,박선영,조현장,Chang Myung-Woong,Kim Kwang-Hyuk,Park In-Dal,Song Gap-Young,Kim Sung-Won,Lee Eun-young,Kim Moon-Chan,Cho Myung-Hoon,Kim Kyu-Earn,Choi Choong-Eon,Park Se 한국생명과학회 2005 생명과학회지 Vol.15 No.3

2002년 2월부터 2005년 2월까지 성인 및 소아 호홉기질환자 994명의 상기도 도말물에서 M. pneumoniae 균주를 분리하고, 분리 균주의 ciprofloxacin, ofloxacin, minecline, tetracycline, sparfloxacin, josamycin, erythromycin에 대한 감수성 검사를 실시하였으며, 분리된 균주의 235 rRNA domain II와 V에서 erythromycin저항성 변이가 일어났는가를 PCR과 유전자 염기서열분석으로 erythromycin에 감수성인 M. pneumonine균주의 염기서열과 비교분석하여 확인하였다. 호흡기질환자에서 M. pneumoniae의 분리율은 123/994$(12.4\%)$이었으며, 분리된 M. pneumoniae 균주의 minocycline, sparfloxacin, tetracycline, ciprofloxacin, ofloxacin, josamycin, erythromycin MIC 범위는 각각 $0.015\~0.25,\;0.06\~0.5,\;0.06\~0.5,\;0.25\~0.5,\;0.25\~0.5,\;0.015\~8.0,\;0.015\~8.0{\mu}m$이었다. 분리 동정된 M. pneumoniae 균주 중에서 erythromycin에 저항성인 균주가 60주$(48.8\%)$였으며, 모두가 ribosomal protein L4 영역과 23S rRNA domain V에 내성변이가 일어났으며, 이 중 2균주는 23S rRNA domain II에도 변이가 일어난 균주도 있었다. 국내에서 분리되는 M. pneumoniae균주의 $48\%$가 erytomycin에 저항성인 균주이므로 앞으로 이 균에 의한 폐렴의 치료에 주의가 요구된다. The 994 throat swabs obtained from 688 adults and 306 children patients with respiratory diseases were examined for Mycoplasma pneumoniae infection by culture method. Antimicrobial susceptibilities of the resulting 123 M. pneumoniae isolates were evaluated by testing minimum inhibitory concentrations (MICs) of erythromycin, minocycline, tetracycline, josamycin, sparfloxacin, ofloxacin, and ciprofloxacin by a broth micro-dilution method. The erythromycin resistant strains of M. pneumoniae was determined above $1.0{\mu}g/ml$ of MIC for erythromycin. The erythromycin resistant strains of M. pneumoniae was confirmed resistant gene mutation of the portions of genes 23S rRNA (domain II and V), and ribosomal protein 14 and L22 by PCR amplified and their nucleotide sequenses were compared to those of the susceptible strain M129. The isolation rate of M. pneumoniae was $12.9\%$ (89/688) for the adults and $11.1\%$ (34/306) for the children. The $MICs_{90}$ of the M. pneumoniae isolates were $0.12{\mu}g/ml$ for minocycline, $0.25{\mu}g/ml$ for sparfloxacin, $0.5{\mu}g/ml$ for ciprofloxacin, ofloxacin, and tetracycline, respectively, and $2.0{\mu}g/ml$ for josamycin and erythromycin, respectively. The isolation rate of erythromycin resistant M. pneumoniae from patients was $49.4\%\;(44/89)$ for the adults, $47.1\%\;(16/34)$ for children, and $48.8\%\;(60/123)$ for the total. No mutation could be detected in the ribosomal protein L22 region, but all strains were mutated in the ribosomal protein L4 as two point mutation M144V. Two point mutations in domain V of 23S rRNA were selected in the presense of erythromycin resistant M. pneumoniae isolates, such as one strain was G2057C mutant, two strains were A2059C mutants, three strains were C2611G mutants, four strains were A2058C mutants, five strains were A2058T mutants, twenty strains were A2059G mutants, and twenty-five strains were A2058G mutants, respectively. These results show that erythromycin was not the most active compound against M. pneumoniae infection in Korea and clinical studies of macrolides in human patients are demanded.