한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰

우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2

P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.

AI7075합금의 고온 최소 크리프 변형속도와 파단수명에 관한 연구

우태수,이치우 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.1

크리프 수명 예측에 관한 연구로서 Larson Miller는 수명 예측식 t=T(C+log t)으로 시간-온도의 개념을 도입했고 Orr-Sherby와 Dorn은 크리프파단매개변수를 [ log t-(ΔH/RT)]라고 정의한바 있으며 본 연구에서는 고온 구조용 재료로 많이 사용되는 A17075-T651 합금을 사용하여 최근 크리프 파단 수명 해석에 많이 사용되는 수정 Mokman-Grant 관계식을 사용하였다. 수명 예측에 필요한 상수 m', C'를 각각 구하고 크리프 속도에 대한 온도와 응력의 의존성과 제3기 크리프 변형과정에서의 크리프 파단기구를 분석하였다. Modtechnological progress demands the use of materials at high temperature and high pressure. Constant load creep tests have carried out over a range of stresses at high temperatures. One of the most critical factors in considering such applications perhaps the most critical one is creep behavior. In this study, the stress exponents n were determined during creep over the temperature range of 275℃ to 325℃ and stress range of 36㎫ to 72㎫ in order to investigate the creep behavior. And the applicability of modified Monkman-Grant relationship was discussed.

醱酵에 의한 紡織用 靭皮纖維의 精練에 관한 硏究 (第2報) : 選定된 有用菌 Bacillus Subtilis Var. R-5의 苧麻纖維에 대한 精練作用에 관하여 Degumming Action of Useful Bacillus "Bacteria Subtilis Var R-5" Selected for Ramie Fibers

禹志亨 단국대학교 1971 論文集 Vol.5 No.-

The study was made on fermentation of ramie-fibre by Bacteria "Bacillus Subtilis Var. R-5" which has isolated from various micro-organisms forming pectinase whish fermentates ramie, as reported in the previous study. The results are as follows: 1. The experimentation on formenting bast fibres for textile use showed optimun temperature 30℃ to 35℃ and optimun pH 7.0 respectively. 2. Degumming of crude ramie fibre were only required about 4 days with the Bacillus Subtilis Var. R-5 to ferment. However, the conventional system of fermentation which has been made with spontaneous bacterias generated in fermenting tank were required more than around 7 days. 3. Finished degumming, the ramie fibres Fermented with the selected Bacteria R-5 showed the tensile strength and elongation of them very good, comparing conventional fermenting with alkaline degumming. 4. Determining the tensile strength and elongation for degummed ramie fibers, the largest results both in the tensile strength and elongation were brought in fermenting with "R-5" as following table. ◁표 삽입▷(원문을 참조하세요)

스파크 점화 방식의 정적 연소기에서 CH₄O 연료의 연소특성에 관한 연구

김치원,이치우 경남대학교 공업기술연구소 2001 硏究論文集 Vol.19 No.-

최근 국내외에서 대체연료에 관한 많은 연구가 진행되고 있으며, 특히 고출력, 저연비 및 저공해에 관한 관심이 집중되고 있다 본 연구는 희박연소기의 설계와 개발에 관심을 두고 기초 연소특성을 해석하기 위하여 실험장치로써 정적 연소기, 흡기 압축기, 직류 전동 제어기 및 화염 전파 속도를 측정하기 위한 이온프로브 회로를 제작하였다. 실험방법으로는 혼합기의 당량비, 연소기의 온도와 압력, 유동강도를 변화시키면서 연소기내의 압력과 화염전파 속도를 측정하고 연소특성을 해석하였다. 본 연구의 해석 결과로는 연소특성 중에서 배기 생성의 조성 및 화염전파의 속도는 혼합기 유동 연소실내의 압력과 연료공기의 당량비의 영향을 받게 됨을 확인 할 수 있었다. Recently, many researches are in progress to develop the substitute fuel which is satisfied to high power, low fuel consumption and low air pollution for alcohol fuel, also are insterested in the lean burn. Those regards are raised in domestic and foreign country. Experimental apparatus is constant volume combustor, air compressor direct-current motor controller for variable flow intensity, ion-probe for measurement of flame propagation velocity. Experimental method is belows ; fuel supply constant volume combustor with equivalence ratio of experimental conditions, air compressor supply combustor with pressurized gas of setting pressure and temperature, direct current motor controller varied with the speed of fan motor, trigger signal of computer with spark ignition, ion-probe signal and pressure variation was stored. As a result in this study, it is found that the combustion characteristics, especially emission were remarkably affected by mixture motion, pressure inside cylinder and equivalence ratio using methanol fuels.

??형 超音波 噴霧器에 依한 세탄液滴의 微粒化 特性

李智弘,鄭鎭度,羅又禎 慶尙大學校 1991 論文集 Vol.30 No.2

This study was performed to figure out the atomization characteristics of free-falling oetane droplets from a π-type ultrasonic vibrator dircted downwards. Droplets were collected by the magnesium oxide immersion method. The diameter and distribution of droplets were measured and analyzed. The results are summarized as following : 1. The shape of free-falling oetane droplets in space from the π-type ultrasonic vibrator was fully developed promixed spray column, showing almost the same diameter as the outer diameter of the horn through its whold length. 2. The mean of the Sauter mean diameter of the collected cetane droplets was 52.8㎛, and, its maximum and minimum droplet diameters were approximately 95 ㎛ and 15 ㎛, respectively. 3. The distribution types of droplet size were right-skewed Gaussian distribution curve in all cases with small variace. The Sauter mean diameters ranged from 48 ㎛ to 59 ㎛.

굽힘모우멘트를 받는 혼합형모드의 외부크랙에 대한 응력확대계수

이치우,김태규 慶南大學校 附設 工業技術硏究所 1986 硏究論文集 Vol.4 No.-

파괴역학에서 크랙첨단부근의 응력분포는 응력확대계수로 표시함은 잘 알려진 사실이다. 임의의 경사각을 가지는 혼합형모드(Mixed Mode)에 대해서 외부직선크랙, 반원형외부크랙, 외부노치크랙을 갖는 판이 순수굽힘, 3점굽힘, 등분포하중을 받는 경우에 대한 해석을 광탄성적인 방법(Photoelastic Method)으로써 응력확대계수를 결정하였다.. 특히 외부직선크랙을 가진 판이 개구형모드(Opening Mode) 상태에서 순수굽힘 및 3점굽힘을 받을때의 결과는 Gross, Srawley, Wilson 등이 연구한 경계분할법(Boundary Collocation Method)과 잘 일치함을 관찰할 수 있었다. The stress distribution in the vicinty of the crack tip in Fracture Mechanics ordinary indicated by stress intensity factors K which have been Proposed by Irwin. In the analysis of stress intensity factors, there are many theoretical and experimental method. This paper was stuided for stress intensity factors of a steet with inclined crack of a subjected to pure bending moment, 3-points bending moment and Uniform distributed load by photoelastic method. The results of this method, the stress intensity factors subjected to pure bending moment and 3-points bending moment were very coincided result of the Gross and Srawley by Boundary Collocation method.

Aromatic hydrocabon 분해세균의 검출과 그 plasmid 유전자의 특성

김치경, 김종우, 김영창, 민태익 忠北大學校 遺傳工學硏究所 1987 遺傳工學硏究 Vol.1 No.1

본문참고

CrMoV 로우터강의 크리이프-피로 상호작용하에서 비탄성구성 방정식 및 수명평가에 관한 연구

이치우 慶南大學校 附設 工業技術硏究所 1989 硏究論文集 Vol.7 No.-

본 연구는 국내에서 제작된 증기터어빈로우터용 CrMoV강을 시료로 하여 작동온도 550℃에서 크리이프-피로상호작용하에서 선형손상누적법칙 및 변형율범위분할법에 의하여 수명평가를 적용한 결과 2정도의 안전계수를 갖는 재질로 규명되었다. In this study, elevated temperature low cycle fatigue test were performed at operation temperature 550℃ under creep-fatigue interaction using the specimens of CrMoV steel for the turbine rotor manufactured by domestic. Life predicted by Linear Damage Summation Method and Strain Range Partitioning Method therefore it shows that the CrMoV rotor steel having a safety factor over 2 was possible.

양극성 장애와 Monocyte Chemoattractant Protein-1 유전자 다형성

배치운,김태석,장우영,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter-2518 and BD. Methods : Patients with BD (n=92) in accordance with DSM-FV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method. Results : Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587 ; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups. Conclusion : Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.

Silicon-Nitrogen 결합을 갖는 새로운 Complex의 합성

한치선,이은주,김우선 연세대학교 자연과학연구소 1983 學術論文集 Vol.11 No.-

Trialkylsilane을 출발물질로 하여 Si←N 배위결합을 함유하는 5배위자 규소착화합물인 1-organosilatrane을 합성하였다. Si←N 배위결합의 형성은 얻어진 silatrane의 IR 및 NMR spectra에 의하여 확인하였다. 1-Organosilatrane의 합성에 사용한 용매는 methanol과 ethanol이었는데 얻어진 결과에서는 별다른 차이를 찾을 수 없었다. 얻어진 silatsane은 뜨거운 DMF로 재결정하였다. 1-Organosilatrane which has a pentacoordination bond was synthesized from trimethylsilane. The formation of Si←N coordination bond was indentified by IR and NMR spectra of the product. Solvents used for the synthesis were methanol and ethanol, and none of the solvent effect has been found. The product was recrystalized from hot DMF.