多樣한 黃芩藥鍼製劑의 安全性 및 效能에 關한 硏究

김호경,마진열,전원경,윤수영,강은정,주혜정,고병섭 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

In order to detect the safety and effect of various aqua-acupunctures from Scutellariae Radix, the modifications of boiling, filtration and dilution were employed for the manufacture of aqua-acupunctures. We injected 0.2cc of aqua-acupunctures into Joksamri(足三里) of rat, repeatedly. we compared subacute toxicity of them with saline group, distilled water(D.W.) group, acupuncture group and control group. The results were summarized as follows: 1. The groups were all healthy and alive, and there was no special abnormality in physical condition and autopsy. And there were not any toxic symptoms in repeating application of aqua-acupunctures to the rat, including changes of body weight, organ weight, haematological examination and serum biochemical test. 2. There was slight change of body weight in acupuncture group : We could see significance after 3 days (p<0.05) and after 7 days (p<0.001) in body weight loss. After 9 days, all tested groups were suppressed in body weight increment. 3. Result of organ weight: In Palking aqua-acupuncture(D-2 group), saline group and acupuncture group there were some statistical significance. Especially, acupuncture group revealed significant result in liver and spleen than aqua-acupunctures. From this result, we could suggest that the efficacy of acupuncture was preceded herbal medicine. 4. In serum biochemical test, we examined glucose(GLU), triglyceride(TG) and cholesterol(CHOL). In comparison with control group, the diluted 10 times of hwanggum aqua-acupuncture (× 10 group) was recognized significant decrease of glucose, but the diluted 100 times of Hwanggum aqua-acupuncture (× 100 group), D-2 group, saline group were confirmed significant increment. There was not any meaningful change of CHOL in all of tested group, excepting the acupuncture group was exhibited statistically significant decrease(p<0.05). In TG level all tested group except complex injection of standard compound (CPA group) and HG, there were significant value in statistically. The diluted solution was more significant decrease than Hwanggaum aqua-acupuncture(HG). The mutual relationship of components of aqua-acupuncture tended to decrease level of TG, regardless of its concentration. In acupuncture group, we gained some interesting result in meaningful decrease in TG. 5. Haematological examination showed significant increment of gramulocytes(GR) in all tested groups except Hwanggum aqua-acupuncture. And the diluted solutions of HG expressed very high increment of them(p<0.001). The GR and Mean Corpuscular Volume(MCV) of acupuncture group showed statistical significance.

Long-term Stability after Reduction of Mandible Fracture by Keyhole Plate: Evaluation at the Time of Plate Removal

Cheon, Kyeong-Jun,Cho, Seoung-Won,Jang, Won-Seok,Kim, Ju-Won,Yang, Byoung-Eun Korean Association of Maxillofacial Plastic and Re 2020 Maxillofacial Plastic Reconstructive Surgery Vol.42 No.-

Background: Various types of miniplates have been developed and used for the reduction of facial bone fractures. We introduced Yang's Keyhole (YK) plate, and reported on its short-term stability. The purpose of this study was to evaluate the long-term stability of the YK plate, as a follow-up study, by examining the patients who had used the YK plate among the patients with the reduction of mandible fractures and who visited for plate removal. Methods: We reviewed the medical records of 16 patients who underwent mandibular fracture fixation using a YK plate (group I) and 17 patients who underwent mandibular fracture fixation using a conventional plate (group II). Assessment was then made on malunion, occlusal stability, discomfort during the application, and clinical symptoms. Results: From January 2015 to December 2017, a total of 36 patients underwent mandibular fracture surgery using a YK plate. A total of 16 patients received plate removal. Among them, 15 were male and 1 female. The average age was 26 years. The applied surgical sites were the 12 on mandibular angle, 4 on mandibular symphysis, and 2 on subcondyle. The application period of YK plate was an average of 335 days. During the same period, 45 people underwent surgery on the conventional plate. A total of 17 patients received plate removal. Among them, 15 were male and 2 females. The average age was 36 years. The applied surgical sites were the 8 on mandibular angle, 4 on mandibular symphysis, and 2 on subcondyle. The application period of the conventional plate was an average of 349 days. No malocclusion occurred at the time of removal, and occlusion was stable. No patient complained of joint disease or discomfort. Conclusion: The YK plate system, in which the screw was first inserted and the plate was applied, for clinical convenience did not cause any particular problem and no significant difference from the conventional plate.

Case Reports : A Case of Pulmonary Cryptococcosis by Capsule-deficient Cryptococcus neoformans

Won Seok Cheon,Kwang Seok Eom,Byoung Kwan Yoo,Seung Hun Jang,Joon Woo Bahn,Dong Gyu Kim,Ki Suck Jung 대한내과학회 2006 The Korean Journal of Internal Medicine Vol.21 No.1

Characteristics of Vitrification Process for Mixture of Simulated Radioactive Waste Using Induction Cold Crucible Melter

Cheon-Woo Kim,Kyung-Hwa Yang,Byoung-Chul Park,Seung-Chul Park,Tae-Won Hwang,Jong-Kil Park,Sang-Woon Shin,Jong-Hyun Ha,Myung-Jae Song 한국방사성폐기물학회 2004 방사성폐기물학회지 Vol.2 No.3

원자력발전소에서 발생하는 이온교환수지와 가연성잡고체 혼합폐기물을 유리화하기 위하여 유도 가열식 저온용융로를 이용한 실증시험을 수행하였다. 금속 티타늄 고리(Ti-ring)를 이용한 유리의 초기점화에 필요한 에너지는 약 290 kWh로 평가되었다. 혼합폐기물의 투입 중 고주파발생기의 출력은 160∼190 kW로 임피던스는 0.55∼0.65 범위 내에서 안정적으로 유지되었다. 이온교환수지 단독투입 시 보다 가연성잡고체와 혼합 할 경우 CO 발생농도는 1/40 정도로 낮아졌는데, 이는 1.8배 정도 높은 연소에너지를 갖는 가연성잡고체가 혼합폐기물의 완전연소를 유도한 것으로 평가되었다. 혼합폐기물의 공급량에 적당한 최적 산소 버블링에 의해 유리 용탕 내부로의 미연폐기물의 함침은 발생하지 않았으며 유리 용탕은 지속적으로 공정 건전성을 유지하였다. 유리 용탕의 부피가 증가하는 팽창(swelling) 현상 때와 정상 일 때 발생가스를 측정, 비교한 결과 swelling 현상 때는 NO와 같이 환원성 가스의 농도 보다 산화성 기체인 의 농도가 높은 것으로 나타났다. 실증시험에 사용된 이온교환 수지와 가연성잡고체의 각각 투입량은 368kg과 751kg 이었으며, 74 정도의 감용비를 달성하였다. In order to simultaneously vitrify the ion exchange resin(IER) and combustible dry active waste(DAW) generated from Korean nuclear power plants, a vitrification pilot test was conducted using an induction cold crucible melter(CCM) . The energy necessary for startup of the glass using a Ti-ring was evaluated as about 290 kWh. The power supplied from a high frequency generator to melt the glass properly was ranged from 160 to 190 kW without any interruption. When the mixture of the IER and DAW was fed into the CCM, the concentration of CO was lowered up to 1/40 compared to feeding the IER solely. It may be caused by the DAW which can produce about 1.8 times higher heat compared to the IER. When the swelling phenomenon occurred in the glass melt, the concentration of , oxidizing gas, was higher than NO, reducing gas. Total feed amounts of the IER and DAW were 368 and 751 kg, respectively. And then, about 74 of volume reduction factor was achieved.

Electrochemical behavior of Calcium Titanate Coated Ti-6Al-4V Substrate in Artificial Saliva

Lee, Byoung-Cheon,Balakrishnan, A.,Ko, Myung-Won,Choi, Je-Woo,Park, Joong-Keun,Kim, Taik-Nam Materials Research Society of Korea 2008 한국재료학회지 Vol.18 No.1

In this study, calcium titanate $(CaTiO_3)$ gel was prepared by mixing calcium nitrate and titanium isopropoxide in 2-methoxy-ethanol. $CaTiO_3$ gel was single-layer coated on Ti-6Al-4V using a sol-gel dip-coating technique. The coating was calcined at $750^{\circ}C$ in air by utilizing a very slow heating rate of $2^{\circ}C/min$. The crystalline phases of the coating were characterized by x-ray diffraction using a slow scan rate of $1^{\circ}/min$. The morphology of the coating was analyzed by scanning electron microscopy. The corrosion behavior of Ti-6Al-4V samples coated with $CaTiO_3$ films were tested in an artificial saliva solution by potentiodynamic polarization and were quantified by the Tafel extrapolation method. The electrochemical parameters showed a considerable increase in the corrosion resistance for the $CaTiO_3$-coated Ti-6Al-4V samples compared to bare substrates.

윈도우 마스킹을 이용한 종단형 감정 음성합성시스템의 강인한 주의집중 정렬 기법

최병진(Byoung Jin Choi),천성준(Sung Jun Cheon),조원익(Won Ik Cho),김석민(Seok Min Kim),손병찬(ByungChan Son),김남수(Nam Soo Kim) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2

본 논문은 윈도우 마스킹을 이용하여 종단형 감정 음성합성시스템(end-to-end speech synthesis system)의 강인한 어텐션 정렬 기법을 제안한다. 딥러닝을 이용한 종단형 음성합성 시스템에서는 주의집중 기법 (attention mechanism)을 통해 텍스트와 오디오의 시퀀스 사이의 정렬을 학습한다. 하지만, 주의집중을 통한 정렬은 추론시 단일 프레임에서 전체 텍스트 시퀀스에 대한 소프트맥스 값을 구하기 때문에 단어, 글자 등을 건너뛰는 skipping과 반복하는 repeating등의 문제가 발생한다. 본 논문에서는 윈도우 마스킹을 통해 텍스트와 오디오 시퀀스 사이의 단조로운(monotonic) 정렬을 만들며, 위의 skipping과 repeating등의 문제를 해결하는 강인한 주의집중 정렬 기법을 적용해 보았다. 다감정 데이터셋을 이용한 실험을 통해 종단형 음성합성시스템에서의 주의집중 정렬이 개선됨을 확인 할 수 있었다.

담도계 세균증

노병선(Byoung Seon Rhoe),문승상(Sung Sang Moon),조남천(Nam Cheon Cho),윤광수(Kwang Soo Yoon),김대성(Dae Sung Kim),이경원(Kyung Won Lee) 대한외과학회 1992 Annals of Surgical Treatment and Research Vol.43 No.3

담관염에 연관된 총담관의 자연 천공

유병관 ( Byoung Kwan Yoo ),김종혁 ( Jong Hyeok Kim ),문홍주 ( Hong Ju Moon ),천원석 ( Won Seok Cheon ),유지연 ( Ji Youn Yoo ),김종표 ( Jong Pyo Kim ),김경오 ( Kyoung Oh Kim ),박철희 ( Cheol Hee Park ),한태호 ( Tae Ho Hahn ),유교상 대한소화기학회 2005 대한소화기학회지 Vol.45 No.5

Spontaneous perforation of the common bile duct (CBD) is a rare event in adults. Most cases of CBD perforation are iatrogenic after invasive procedures such as endoscopic retrograde cholangiopancreatography (ERCP) or cholecystectomy. We report a case of a

Stenotrophomonas maltophilia 감염의 임상 양상

이원욱(Won Uk Lee),김병준(Byoung Joon Kim),안우석(U . Seouk Ahn),원현상(Hyun Sang Won),김기중(Ki Joong Kim),성낙천(Nak Cheon Seong),김구엽(Gu Yeup Kim),서환조(Hwan Jo Suh) 대한내과학회 1997 대한내과학회지 Vol.53 No.3

N/A Objective: Stenotrophomonas maltophilia has been emerging as an important nosocomial pathogen in recent years in patients with impaired host- defense mechanism or who has been exposed to large amount of inocula. This organism is usually resistant to multiple (commonly used) antimicrobial agents, particularly to those of the beta-lactam class. To evaluate the clinical feature of Stenotrophomonas maltophilia infection and in vitro anti- microbial susceptibility, we performed a retrospective study. Methods: We analyzed the result of in vitro antimicrobial susceptibility test for 200 isolates of S. maltophilia and the annual isolation rate during the period between January 1990 and December 1994 in our institution, and performed a retrospective study for the available records of 165 cases among them. The data were obtained with only the first isolation of the organism for each patients. Results : Total of 165 initial isolates, the isolates were from wounds in 50(30.3%), urine in 47(28.5%), the respiratory tract in 37(22.4%), blood in 9(5.5%), bile in 6(3.6%), and miscellaneous sources in 16(9.7%). The 84.2% of isolates were hospital-acquired isolate and 58.3% of these patients had received antecedent antibiotic therapy: polymicrobial growth was demonstrated in 61.9% of the cases. In vitro antimicrobial susceptibiiity test, ofloxacin was active against the isolates in 89.2%, moxalactam in 85.9%, ciprofloxacin in 83.9%, TMP-SMX(trimethoprim-sulfamethoxazole) in 64.2%, As expected, S. maltophilia isolates were, in general, not susceptible to cephalosporins, penicillins. The annual isolation rate at Kyung Hee University hospital was not increased significantly from 1990 to 1994, 19.53 per 10,000 patients dismissals in 1990, 13.56 in 1994. The major underlying diseases of patients were malignancy(17.6%), cerebrovascular disorder(17%), diabetic mellitus(13.3%). Mortality rate is 10.3%. Conclusion: S. maltophilia has been emerging as an important nosocomial pathogen in immunocompromised patients, especially those receiving broad-spectrum antimicrobial therapy. And this organism is resistant to multiple antimicrobial agents, particularly to those of the beta-lactam class. When antimicrobial treatment is necessary, the clinician should be guided by results of in vitro susceptibility testing because of the notable in vitro resistance of S. maltophilia to commonly used antibiotics. And when S. maltophilia has been recovered from a patient, wound and contact isolation is warranted.

A Study of the Bronchial Provocation Test with Methacholine in Patients with Active Pulmonary Tuberculosis

In Won Park,Seung Ho Kim,Eun Ha Chang,Byoung Whui Choi,Sung Ho Hue,Seung Cheon Seo 대한내과학회 1989 The Korean Journal of Internal Medicine Vol.4 No.1